Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 34, 2008, Pages 12605-12610

  Lai, Jian Ping ^a   Lai, Saien ^a   Tuluc, Florin ^a   Tansky, Morris F ^b   Kilpatrick, Laurie E ^a   Leeman, Susan E ^b   Douglas, Steven D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium mobilization; Cell signaling; G protein coupled receptor; Substance P; Truncated neurokinin 1

Indexed keywords

CALCIUM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NEUROKININ 1 RECEPTOR; PROTEIN KINASE C DELTA; SUBSTANCE P;

ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

CALCIUM; CELL LINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-8; MUTANT PROTEINS; PROTEIN KINASE C-DELTA; RECEPTORS, NEUROKININ-1; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBSTANCE P; TRANSFECTION;

EID: 50449086944     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806632105     Document Type: Article

References (39)

1. Chang MM, Leeman SE (1970) Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as Substance P. J Biol Chem 245:4784-4790.
2. Fong TM, Anderson SA, Yu H, Huang RR, Strader CD (1992) Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. Mol Pharmacol 41:24-30.
3. Gerard NP, et al. (1991) Human Substance P receptor (NK-1): Organization of the gene, chromosome localization, and functional expression of cDNA clones. Biochemistry 30:10640-10646.
4. Hopkins B, Powell SJ, Danks P, Briggs I, Graham A (1991) Isolation and characterisation of the human lung NK-1 receptor cDNA. Biochem Biophys Res Commun 180:1110-1117.
5. Takeda Y, Chou KB, Takeda J, Sachais BS, Krause JE (1991) Molecular cloning, structural characterization and functional expression of the human Substance P receptor. Biochem Biophys Res Commun 179:1232-1240.
6. Caberlotto L, et al. (2003) Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain. Eur J Neurosci 17:1736-1746.
7. Kage R, Leeman SE, Boyd ND (1993) Biochemical characterization of two different forms of the Substance P receptor in rat submaxillary gland. J Neurochem 60:347-351.
8. Baker SJ, Morris JL, Gibbins IL (2003) Cloning of a C-terminally truncated NK-1 receptor from guinea pig nervous system. Brain Res Mol Brain Res 111:136-147.
9. Sasakawa N, Sharif M, Hanley MR (1994) Attenuation of agonist-induced desensitization of the rat Substance P receptor by progressive truncation of the C terminus. FEBS Lett 347:181-184.
10. Lieb K, Fiebich BL, Berger M, Bauer J, Schulze-Osthoff K (1997) The neuropeptide Substance P activates transcription factor NF-κB and κB-dependent gene expression in human astrocytoma cells. J Immunol 159:4952-4958.
11. Williams R, Zou X, Hoyle GW (2007) Tachykinin-1 receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-κB via a G(q)-dependent pathway. Am J Physiol 292:L430-L437.
12. Chen F, Castranova V, Shi X, Demers LM (1999) New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45:7-17.
13. Zhao D, et al. (2002) Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochem J 368:665-672.
14. Koon HW, et al. (2005) Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cδ activation. J Pharmacol Exp Ther 314:1393-1400.
15. Karagiannides I, et al. (2006) Induction of colitis causes inflammatory responses in fat depots: Evidence for Substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci USA 103:5207-5212.
16. Page K, et al. (2003) Regulation of airway epithelial cell NF-δB-dependent gene expression by protein kinase Cδ. J Immunol 170:5681-5689.
17. Yamaguchi K, Richardson MD, Bigner DD, Kwatra MM (2005) Signal transduction through Substance P receptor in human glioblastoma cells: Roles for Src and PKCδ. Cancer Chemother Pharmacol 56:585-593.
18. Kulka M, Sheen CH, Tancowny BP, Grammer LC, Schleimer RP (2008) Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 123:398-410.
19. Tansky MF, Pothoulakis C, Leeman SE (2007) Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci USA 104:10691-10696.
20. Tran MT, Lausch RN, Oakes JE (2000) Substance P differentially stimulates IL-8 synthesis in human corneal epithelial cells. Invest Ophthalmol Visual Sci 41:3871-3877.
21. Palma C, Manzini S (1998) Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells. J Neuroimmunol 81:127-137.
22. Derocq JM, et al. (1996) Effect of Substance P on cytokine production by human astrocytic cells and blood mononuclear cells: Characterization of novel tachykinin receptor antagonists. FEBS Lett 399:321-325.
23. Schmidlin F, Roosterman D, Bunnett NW (2003) The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with β-arrestins. Am J Physiol 285:C945-C958.
24. Chen F (2004) Arresting NF-κB by β-arrestin2. Cell Death Differ 11:1155-1156.
25. DeFea KA, et al. (2000) The proliferative and antiapoptotic effects of Substance P are facilitated by formation of a β-arrestin- dependent scaffolding complex. Proc Natl Acad Sci USA 97:11086-11091.
26. Ahn S, Shenoy SK, Wei H, Lefkowitz RJ (2004) Differential kinetic and spatial patterns of β-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. J Biol Chem 279:35518-35525.
27. αo. FEBS Lett 428:291-294.
28. Holst B, Hastrup H, Raffetseder U, Martini L, Schwartz TW (2001) Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G protein fusions and mutagenesis. J Biol Chem 276:19793-19799.
29. Lai JP, et al. (2006) Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Proc Natl Acad Sci USA 103:7771-7776.
30. Babu PS, Krishnamurthy H, Chedrese PJ, Sairam MR (2000) Activation of extracellular-regulated kinase pathways in ovarian granulosa cells by the novel growth factor type 1 follicle-stimulating hormone receptor: Role in hormone signaling and cell proliferation. J Biol Chem 275:27615-27626.
31. Silver MR, Nucci NV, Root AR, Reed KL, Sower SA (2005) Cloning and characterization of a functional type II gonadotropin-releasing hormone receptor with a lengthy carboxyl-terminal tail from an ancestral vertebrate, the sea lamprey. Endocrinology 146:3351-3361.
32. Lin X, Conn PM (1999) Transcriptional activation of gonadotropin- releasing hormone (GnRH) receptor gene by GnRH: Involvement of multiple signal transduction pathways. Endocrinology 140:358-364.
33. Caunt CJ, et al. (2006) Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: Receptor-specific activation mechanisms and compartmentalization. J Biol Chem 281:2701-2710.
34. Smirnova OV, Bogorad RL (2004) Short forms of membrane receptors: Generation and role in hormonal signal transduction. Biochemistry (Mosc) 69:351-363.
35. Petrak D, Memon SA, Birrer MJ, Ashwell JD, Zacharchuk CM (1994) Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription. J Immunol 153:2046-2051.
36. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
37. Lai JP, Douglas SD, Wang YJ, Ho WZ (2005) Real-time reverse transcription-PCR quantitation of Substance P receptor (NK-1R) mRNA. Clin Diagn Lab Immunol 12:537-541.
38. Lai JP, et al. (2003) Quantification of CCR5 mRNA in human lymphocytes and macrophages by real-time reverse transcriptase PCR assay. Clin Diag Lab Immunol 10:1123-1128.
39. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408.