Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human achilles tendon

Histology and Histopathology

Volumn 23, Issue 2, 2008, Pages 197-208

  Bjur, Dennis ^a   Danielson, Patrik ^a   Alfredson, Håkan ^a   Forsgren, Sture ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Achilles tendon; Sympathetic innervation; Tendinopathy; Tenocytes; Tyrosine hydroxylase

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CATECHOLAMINE; MESSENGER RNA; NEUROPEPTIDE Y; TYROSINE 3 MONOOXYGENASE;

ACHILLES TENDON; ADRENERGIC SYSTEM; ADULT; ARTICLE; BIOPSY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INNERVATION; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; TENDINITIS;

ACHILLES TENDON; ADULT; BIOPSY; CATECHOLAMINES; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; NEUROPEPTIDE Y; RECEPTORS, ADRENERGIC, ALPHA-1; RNA, MESSENGER; SYMPATHETIC NERVOUS SYSTEM; TENDINOPATHY; TYROSINE 3-MONOOXYGENASE;

EID: 38449112301     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ackermann P.W., Finn A. and Ahmed M. (1999). Sensory neuropeptidergic pattern in tendon, ligament and joint capsule. A study in the rat. Neuroreport 10, 2055-2060.
2. Ackermann P.W., Li J., Finn A., Ahmed M. and Kreicbergs A. (2001). Autonomic innervation of tendons, ligaments and joint capsules. A morphologic and quantitative study in the rat. J. Orthop. Res. 19, 372-378.
3. Alfredson H. (2005). The chronic painful Achilles and patellar tendon: research on basic biology and treatment. Scand. J. Med. Sci. Sports. 15, 252-259.
4. Andersson G., Danielson P., Alfredson H. and Forsgren S. (2007). Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis. Knee Surg. Sports Traumatol. Arthrosc. 15, 1272-1279.
5. Andres K.H., von During M. and Schmidt R.F. (1985). Sensory innervation of the Achilles tendon by group III and IV afferent fibers. Anat. Embryol. (Berl). 172, 145-156.
6. Anesini C. and Borda E. (2002). Modulatory effect of the adrenergic system upon fibroblast proliferation: participation of beta 3-adrenoceptors. Auton. Autacoid Pharmacol. 22, 177-186.
7. Astrom M. and Rausing A. (1995). Chronic Achilles tendinopathy. A survey of surgical and histopathologic findings. Clin. Orthop. Relat. Res. 151-164.
8. Bjur D., Alfredson H. and Forsgren S. (2005). The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation. Cell Tissue Res. 320, 201-206.
9. Burniston J.G., Tan L.B. and Goldspink D.F. (2005). beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle. J. Appl. Physiol. 98, 1379-1386.
10. Cook J.L., Feller J.A., Bonar S.F. and Khan K.M. (2004). Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. J. Orthop. Res. 22, 334-338.
11. Danielson P., Alfredson H. and Forsgren S. (2006). Immuno-histochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc. Res. Tech. 69, 808-819.
12. Danielson P., Alfredson H. and Forsgren S. (2007a). Importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. Microsc. Res. Tech. 70, 310-324.
13. Danielson P., Alfredson H. and Forsgren S. (2007b). In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. Microsc. Res. Tech. 70, 908-911.
14. Enriquez de Salamanca A., Siemasko K.F., Diebold Y., Calonge M., Gao J., Juarez-Campo M. and Stern M.E. (2005). Expression of muscarinic and adrenergic receptors in normal human conjunctival epithelium. Invest. Ophthalmol. Vis. Sci. 46, 504-513.
15. Hansson M. and Forsgren S. (1995). Immunoreactive atrial and brain natriuretic peptides are co-localized in Purkinje fibres but not in the innervation of the bovine heart conduction system. Histochem. J. 27, 222-230.
16. Ippolito E. and Postacchini F. (1986). Anatomy. In: The tendons: Biology-pathology-clinical aspects. Perucia L., Postacchini F. and Ippolito E. (eds). Editrice Kurtis. Milano. pp 9-36.
17. Jozsa L. and Kannus P. (1997). Human tendons: anatomy, physiology, and pathology. Human Kinetics, Champaign, IL, USA.
18. Khan K.M., Cook J.L., Bonar F., Harcourt P. and Astrom M. (1999). Histopathology of common tendinopathies. Update and implications for clinical management. Sports. Med. 27, 393-408.
19. Lian Ö., Dahl J., Ackermann P.W., Frihagen F., Engebretsen L. and Bahr R. (2006). Pronociceptive and antinociceptive neuromediators in patellar tendinopathy. Am. J. Sports Med. 34, 1801-1808
20. Luther H.P., Podlowski S., Schulze W., Morwinski R., Buchwalow I., Baumann G. and Wallukat G. (2001). Expression of alpha1-adrenergic receptor subtypes in heart cell culture. Mol. Cell.Biochem. 224, 69-79.
21. McGrath J.C., Mackenzie J.F. and Daly C.J. (1999). Pharmacological implications of cellular localization of alpha1-adrenoceptors in native smooth muscle cells. J. Auton. Pharmacol. 19, 303-310.
22. McMahon S.B. (1991). Mechanisms of sympathetic pain. Br. Med. Bull. 47, 584-600.
23. Movin T., Gad A., Reinholt F.P. and Rolf C. (1997). Tendon pathology in long-standing achillodynia. Biopsy findings in 40 patients. Acta Orthop. Scand. 68, 170-175.
24. Oben J.A. and Diehl A.M. (2004). Sympathetic nervous system regulation of liver repair. Anat. Rec. A Discov. Mol. Cell Evol. Biol.280, 874-883.
25. Oben J.A., Roskams T., Yang S., Lin H., Sinelli N., Torbenson M., Smedh U., Moran T.H., Li Z., Huang J., Thomas S.A. and Diehl A.M.(2004). Hepatic fibrogenesis requires sympathetic neurotransmitters.Gut 53, 438-445.
26. Panoskaltsis-Mortari A. and Bucy R.P. (1995). In situ hybridization with digoxigenin-labeled RNA probes: facts and artifacts. Biotechniques 18, 300-307.
27. Rieske P., Krynska B. and Azizi S.A. (2005). Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation 73, 474-483.
28. Shalabi A. (2004). Magnetic resonance imaging in chronic Achilles tendinopathy. Thesis. Karolinska University Press, Stockholm.
29. Staudt Y., Mobini R., Fu M., Felix S.B., Kuhn J.P. and Staudt A. (2003).Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes. Eur. J. Pharmacol. 466, 1-6.
30. Wall M.E., Faber J.E., Yang X., Tsuzaki M. and Banes A.J. (2004).Norepinephrine-induced calcium signaling and expression of adrenoceptors in avian tendon cells. Am. J. Physiol. Cell. Physiol.287, C912-918.
31. Yuan J., Wang M.X. and Murrell G.A. (2003). Cell death and tendinopathy. Clin. Sports Med. 22, 693-701.
32. Zhang H. and Faber J.E. (2001). Trophic effect of norepinephrine on arterial intima-media and adventitia is augmented by injury and mediated by different alpha1-adrenoceptor subtypes. Circ. Res. 89,815-822.