Qualitative analysis of substance P, NK1-receptor and nerve ingrowth in substance P-treated ruptured rat achilles tendon

Acta Orthopaedica Belgica

Volumn 76, Issue 3, 2010, Pages 387-395

  Steyaert, Adeiheid ^a   Burssens, Peter ^a,b   Forsyth, Ramses ^a   Vanderstraeten, Guy ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b Sint Jozef Hospital   (Belgium)

Author keywords

Achilles tendon rupture; Immuno fluorescence; NK 1 receptor; PGP 9.5; SP

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; NEUROKININ 1 RECEPTOR; PGP9.5 PROTEIN, RAT; SUBSTANCE P; UBIQUITIN THIOLESTERASE;

ACHILLES TENDON; ANIMAL; ARTICLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE; INJURY; MALE; MICROBIOLOGY; RAT; SPRAGUE DAWLEY RAT; WOUND HEALING;

ACHILLES TENDON; ANIMALS; CELL PROLIFERATION; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE; MALE; NEUROTRANSMITTER AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SUBSTANCE P; UBIQUITIN THIOLESTERASE; WOUND HEALING;

EID: 77954569119     PISSN: 00016462     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Ackermann PW, Li J, Lundeberg T, Kreicbergs A. Neuronal plasticity in relation to nociception and healing of rat Achilles tendon. J Orthop Res 2003 ; 21: 432-441.
2. Almeida TA, Rojo J, Nieto PM et aClin Tachykinins and tachykinin receptors: structure and activity relationships. Cur Med Chem 2004; 11: 2045-2081.
3. Andersson G, Danielson P, Alfredson H, Forsgren S. Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept 2008; 150: 81-87.
4. Aspenberg P, Virchencko O. Platele concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand 2004 ; 75 : 93-99.
5. Bae SJ, Matsunaga Y, Takenaka M et al. Substance P induced preprotachykinin-A mRNA, neutral endopeptidase mRNA and substance p in cultured normal fibroblasts. Int Arch Allergy Immunol 2002; 127: 316-321.
6. Bowden JJ, Baluk P, Lefevre PM et aClin Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa. Am J Physiol 1996; 270: L404-L414. (Pubitemid 126756415)
7. Bring DK, Kreicbergs A, Renstrom PA, Ackermann PW. Physical activity modulates nerve plasticity and stimulates repair after Achilles tendon rupture. JOrthop Res 2007 ; 25: 164-172.
8. Bring D, Reno C, Renstrom P et al. Joint immobilization reduces the expression of sensory neuropeptide receptors and impairs healing after tendon rupture in a rat model. J Orthop Res 2009; 27: 274-280.
9. Bruggeman NB, Turner NS, Dahm DClin ef al. Wound complications after open Achilles tendon repair: an analysis of risk factors. Clin Orthop Relat Res 2004 ; 427: 63-66.
10. Burssens P, Steyaert A, Forsyth R et al Exogenously administered substance P and neutral endopeptidase inhibitor stimulate fibroblast proliferation, angiogenesis and collagen organisation during Achilles tendon healing. Foot Ankle Int 2005 ; 26: 832-839.
11. Campbell LK, Thomas JR, Lamps LW, Smoller BR, Folpe AL. Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neo plasms. Mod Pathol 2003; 16: 963-969.
12. Forsgren S, Danielson P, Aifredson H. Vascular NK1 receptor occurrence in normal and chronic painful Achilles and patellar tendons : studies on chemically unfixed as well as fixed specimens. Reg Pept 2005; 126: 173-18 1.
13. Forslund C. BMP treatment for improving tendon repair. Studies on rat and rabbit Achilles tendons. Acta Orthop Scand Suppl 2003 ; 74: 1-30.
14. Forslund C, Aspenberg P. Improved healing of transected rabbit Achilles tendon after a single injection of cartilage- derived morphogenetic protein-2. Am J Sports Med 2003; 31: 555-559.
15. Forslund C, Bylander B, Aspenberg P. Indomethacin and celecoxib improve tendon healing in rats. Acta Orthop Scand 2003 ; 74 : 465-469.
16. Forslund C, Rueger D, Aspenberg P. A comparative dose-response study of cartilage-derived morphogenetic protein (CDMP)-l,-2, and -3 for tendon healing in rats. J Orthop Res 2003 ; 21: 617-621.
17. Gause A. Role of B cells in the pathogenesis of rheumatoid arthritis: potential implications for treatment. Bio Drugs 2001; 15 : 73-79.
18. Hershey AD, Krause .JE. Molecular characterization of a functional cDNA encoding for the rat substance P receptor. Science 1990; 247: 958-962.
19. Hökfelt T, Pernow B, Wahren J. Substance P : A pioneer amongst neuropeptides. J Intern Med 2001; 249: 27-40.
20. Ismail M, Karim A, Shulman R, Amls A, Calder J. The Achillon tendon repair: is it strong enough ? Foot Ankle Int 2008 ; 28: 808-813.
21. Joos GF, Pauwels RA. The in vivo effect of tachykinins on airway mast cells of the rat. Am Rev Respir Dis 1993 ; 148: 922-926.
22. Khalil Z, Helme R. Sensory peptides as neuromodulators of wound healing in aged rats. J Gerontol A Biol Sci Med Sci 1996;51 :354-361.
23. Maffulli N, Barras V, Ewen SWB. Light microscopic histology of Achilles tendon ruptures. A comparison with unruptured tendons. Am J Sports Med 2000; 28: 857-863.
24. Matayoshi T, Goto T, Fukuhara E et al. Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cells. Biochem Biophys Res Commun 2005 ; 327 : 756-764.
25. Nilsson J, Von Euler AM, Dalsgaard CJ. Stimulation of connective tissue cell growth by substance P and substance K. Nature 1985 ; 315 : 61-63.
26. O'Donoghue DH, Rockwood CA, Zaricznyj B, Kenyon R. Repair of knee ligaments in dogs: the lateral collateral ligament. J Bone Joint Surg 1961 ; 43-A: 1167-1178.
27. Pernow B. Substance P. Pharmacol Rev 1983; 35: 85-141.
28. Schiäffer M, Beiter T, Becker HD, Hunt TK. Neuropeptides. Mediators of inflammation and tissue repair? Arch Surg 1998; 133: 1107-1116.
29. Schwartz JP. Neurotransmitters as neurotrophic factors: a new set of functions. Int Rev Neumbiol 1992; 34: 1-23.
30. Staresinic M, Sebecic B, Patrlj Let al. Gastric pentapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res 2003 ; 21: 976-983.
31. Steyaert AE, Burssens PJ, Vercruysse CW et al The effects of substance P on the biomechanical properties of ruptured rat Achilles' tendon. Arch Phys Med Rehabil 2006; 87 : 254
32. Strand FL. Neuropeptide hormones as neurotrophic factors. Physio Rev 1991 ; 71: 1017-1046.
33. Strand FL. Neuropeptides: Regulators of Physiological Processes. Mit Press, London, 1999.
34. Suchak AA, Spooner C, Reid DC, Jomha NM. Postoperative rehabilitation protocols for Achilles tendon ruptures. Clin Orthop Relat Res 2006 ; 445 : 2 16-221.
35. Virchenko O, Skoglund B, Aspenberg P. Parecoxib impairs early tendon repair but improves later remodelling. Am J Sports Med 2004; 32: 1743-1747.
36. Young RG, Butler DL, Weber W et al. Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J Orthop Res 1998; 16 : 406-413.
37. Zhang F, Liu H, Stile F et al. Effect of vascular endothelial growth factor on rat Achilles tendon healing. Plast Reconst Surg 2003; 112: 1613-1619. (Pubitemid 39202113)
38. Ziche M, Morbidelli L, Pacini M et al. NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. Br J Pharmacol 1990; 100: 11-14.