Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression

Journal of Molecular Signaling

Volumn 2, Issue , 2007, Pages

  New, David C ^a   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34250814224     PISSN: None     EISSN: 17502187     Source Type: Journal    
DOI: 10.1186/1750-2187-2-2     Document Type: Review

References (106)

1. Marchese A George SR Kolakowski LF Jr Lynch KR O'Dowd BF Novel GPCRs and their endogenous ligands: Expanding the boundaries of physiology and pharmacology Trends Pharmacol Sci 1999 20 370-375 10.1016/ S0165-6147(99)01366-8 10462760
2. Venter JC Adams MD Myers EW Li PW Mural RJ Sutton GG Smith HO Yandell M Evans CA Holt RA The sequence of the human genome Science 2001 291 1304-1351 10.1126/science.1058040 11181995
3. Pierce KL Premont RT Lefkowitz RJ Seven-transmembrane receptors Nature Rev Mol Cell Biol 2002 3 639-650 10.1038/nrm908
4. Moolenaar WH G-protein-coupled receptors, phosphoinositide hydrolysis, and cell proliferation Cell Growth Differen 1991 2 359-64
5. Li S Huang S Peng SB Overexpression of G protein-coupled receptors in cancer cells: Involvement in tumor progression Int J Oncol 2005 27 1329-1339 16211229
6. Schoneberg T Schulz A Biebermann H Hermsdorf T Rompler H Sangkuhl K Mutant G-protein-coupled receptors as a cause of human diseases Pharmacol Therapeut 2004 104 173-206 10.1016/j.pharmthera.2004.08.008
7. Malumbres M Barbacid M Mammalian cyclin-dependent kinases Trends Biochem Sci 2005 30 630-641 10.1016/j.tibs.2005.09.005 16236519
8. Kristiansen K Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function Pharmacol Therapeut 2004 103 21-80 10.1016/ j.pharmthera.2004.05.002
9. Simon MI Strathmann MP Gautam N Diversity of G proteins in signal transduction Science 1991 252 802-808 10.1126/science.1902986 1902986
10. Radhika V Dhanasekaran N Transforming G proteins Oncogene 2001 20 1607-614 10.1038/sj.onc.1204274 11313908
11. Wong YH Chan JS Yung LY Bourne HR Mutant α subunit of Gz transforms Swiss 3T3 cells Oncogene 1995 10 1927-1933 7761094
12. Kiefer TL Lai L Yuan L Dong C Burow ME Hill SM Differential regulation of estrogen receptor α, glucocorticoid receptor and retinoic acid receptor α transcriptional activity by melatonin is mediated via different G proteins J Pineal Res 2005 38 231-239 10.1111/ j.1600-079X.2004.00198.x 15813899
13. Cini G Neri B Pacini A Cesati V Sassoli C Quattrone S D'Apolito M Fazio A Scapagnini G Provenzani A Quattrone A Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: A molecular basis for melatonin-induced oncostatic effects J Pineal Res 2005 39 12-20 10.1111/j.1600-079X.2004.00206.x 15978052
14. Pestell RG Albanese C Reutens AT Segall JE Lee RJ Arnold A The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation Endocrine Rev 1999 20 501-534 10.1210/ er.20.4.501
15. Suzuki A Palmer G Bonjour JP Caverzasio J Catecholamines stimulate the proliferation and alkaline phosphatase activity of MC3T3-E1 osteoblast-like cells Bone 1998 23 197-203 10.1016/S8756-3282(98)00099-4 9737341
16. Bohn LM Belcheva MM Coscia CJ Mitogenic signaling via endogenous κ-opioid receptors in C6 glioma cells: Evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade J Neurochem 2000 74 564-573 10.1046/ j.1471-4159.2000.740564.x 10646507
17. van Corven EJ Groenink A Jalink K Eichholtz T Moolenaar WH Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins Cell 1989 59 45-54 10.1016/0092-8674(89)90868-4 2551506
18. Rocha FG Shen KR Jasleen J Tavakkolizadeh A Zinner MJ Whang EE Ashley SW Glucagon-like peptide-2: Divergent signaling pathways J Surg Res 2004 121 5-12 10.1016/j.jss.2004.04.009 15313368
19. Thoreson WB Khandalavala BN Manahan RG Polyak IA Liu JL Chacko DM Lysophosphatidic acid stimulates proliferation of human retinal pigment epithelial cells Curr Eye Res 1997 16 698-702 10.1076/ceyr.16.7.698.5056 9222088
20. 12 Oncogene 2005 24 4597-4603 10.1038/sj.onc.1208665 15856019
21. Hanoune J Defer N Regulation and role of adenylyl cyclase isoforms Ann Rev Pharmacol Toxicol 2001 41 145 174 10.1146/annurev.pharmtox.41.1.145
22. Kip1 in osteoblast-like cells during differentiation with parathyroid hormone Endocrinol 1997 138 1995-2004 10.1210/en.138.5.1995
23. Tramontano D Chin WW Moses AC Ingbar SH Thyrotropin and dibutyryl cyclic AMP increase levels of c-myc and c-fos mRNAs in cultured rat thyroid cells J Biol Chem 1986 261 3919-3922 3005310
24. Yamamoto K Hirai A Ban T Saito J Tahara K Terano T Tamura Y Saito Y Kitagawa M Thyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin-like growth factor I stimulation in FRTL-5 cells Endocrinol 1996 137 2036-2042 10.1210/en.137.5.2036
25. Woloshin PI Walton KM Rehfuss RP Goodman RH Cone RD 3′,5′-cyclic adenosine monophosphate-regulated enhancer binding (CREB) activity is required for normal growth and differentiated phenotype in the FRTL5 thyroid follicular cell line Mol Endocrinol 1992 6 1725-1733 10.1210/me.6.10.1725 1333055
26. Filardo EJ Thomas P GPR30: A seven-transmembrane-spanning estrogen receptor that triggers EGF release Trends Endocrinol Metab 2005 16 362-367 10.1016/j.tem.2005.08.005 16125968
27. Chung JH Kang S Varani J Lin J Fisher GJ Voorhees JJ Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo J Investig Dermatol 2000 115 177-182 10.1046/j.1523-1747.2000.00009.x 10951233
28. Kanda N Watanabe S 17β-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression J Investig Dermatol 2004 123 319-328 10.1111/j.0022-202X.2004.12645.x 15245432
29. Lowes VL Ip NY Wong YH Integration of signals from receptor tyrosine kinases and G protein-coupled receptors NeuroSignals 2002 11 5-19 10.1159/000057317 11943878
30. Crespo P Cachero TG Xu N Gutkind JS Dual effect of β-adrenergic receptors on mitogen-activated protein kinase. Evidence for a βγ-dependent activation and a Gαs-cAMP-mediated inhibition J Biol Chem 1995 270 25259-25265 10.1074/jbc.270.42.25259 7559665
31. Zhao H Pang SF Poon AM MT1 receptor-mediated antiproliferative effects of melatonin on the rat uterine antimesometrial stromal cells Mol Reproduct Develop 2002 61 192-199 10.1002/mrd.1147
32. Kranenburg O Moolenaar WH Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists Oncogene 2001 20 1540-1546 10.1038/sj.onc.1204187 11313900
33. Pierce KL Luttrell LM Lefkowitz RJ New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades Oncogene 2001 20 1532-1539 10.1038/sj.onc.1204184 11313899
34. Luttrell LM Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors Can J Physiol Pharmacol 2002 80 375 382 10.1139/y02-045 12056542
35. Gesty-Palmer D Chen M Reiter E Ahn S Nelson CD Wang S Eckhardt AE Cowan CL Spurney RF Luttrell LM Lefkowitz RJ Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation J Biol Chem 2006 281 10856-10864 10.1074/ jbc.M513380200 16492667
36. DeFea KA Vaughn ZD O'Bryan EM Nishijima D Dery O Bunnett NW The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex Proc Nat Acad Sci USA 2000 97 11086-11091 27152 10995467 10.1073/pnas.190276697
37. Schafer B Gschwind A Ullrich A Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion Oncogene 2004 23 991-999 10.1038/sj.onc.1207278 14647423
38. Ohtsu H Dempsey PJ Eguchi S ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors Am J Physiol - Cell Physiol 2006 291 C1-10 10.1152/ajpcell.00620.2005
39. Schafer B Marg B Gschwind A Ullrich A Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival J Biol Chem 2004 279 47929-47938 10.1074/jbc.M400129200 15337756
40. Itoh Y Joh T Tanida S Sasaki M Kataoka H Itoh K Oshima T Ogasawara N Togawa S Wada T Kubota H Mori Y Ohara H Nomura T Higashiyama S Itoh M IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells Cytokine 2005 29 275-282 15749028
41. Santiskulvong C Sinnett-Smith J Rozengurt E EGF receptor function is required in late G1 for cell cycle progression induced by bombesin and bradykinin Am J Physiol - Cell Physiol 2001 281 C886-898
42. Buteau J Foisy S Joly E Prentki M Glucagon-like peptide 1 induces pancreatic β-cell proliferation via transactivation of the epidermal growth factor receptor Diabetes 2003 52 124-132 12502502
43. Gohla A Harhammer R Schultz G The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho J Biol Chem 1998 273 4653-4659 10.1074/ jbc.273.8.4653 9468525
44. Cechin SR Dunkley PR Rodnight R Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid Neurochem Res 2005 30 603-611 10.1007/s11064-005-2747-4 16176063
45. Croft DR Olson MF The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms Mol Cell Biol 2006 26 4612-4627 1489131 16738326 10.1128/MCB.02061-05
46. Piiper A Zeuzem S Receptor tyrosine kinases are signaling intermediates of G protein-coupled receptors Curr Pharmaceut Design 2004 10 3539-3545 10.2174/1381612043382936
47. Chan AS Wong YH Epidermal growth factor differentially augments Gi-mediated stimulation of c-Jun N-terminal kinase activity Br J Pharmacol 2004 142 635-646 10.1038/sj.bjp.0705851 15172963
48. Watanabe G Lee RJ Albanese C Rainey WE Batlle D Pestell RG Angiotensin II activation of cyclin D1-dependent kinase activity J Biol Chem 1996 271 22570-22577 10.1074/jbc.271.37.22570 8798425
49. Erlinge D Extracellular ATP: A growth factor for vascular smooth muscle cells Gen Pharmacol 1998 31 1-8 9595270
50. Ferjoux G Bousquet C Cordelier P Benali N Lopez F Rochaix P Buscail L Susini C Signal transduction of somatostatin receptors negatively controlling cell proliferation J Physiol, Paris 2000 94 205-210 10.1016/ S0928-4257(00)00206-0
51. Fujita T Meguro T Fukuyama R Nakamuta H Koida M New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP J Biol Chem 2002 277 22191-22200 10.1074/jbc.M110364200 11956184
52. Qin L Li X Ko JK Partridge NC Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase J Biol Chem 2005 280 3104-3111 10.1074/jbc.M409846200 15513917
53. oα chain Mol Biol Cell 2000 11 1129-1142 14836 10749919
54. 12-induced G1 to S phase cell cycle progression on both Ras/mitogen-activated protein kinase and Ras/Rac1/Jun N-terminal kinase cascades in NIH3T3 fibroblasts J Biol Chem 1997 272 4904-4910 10.1074/jbc.272.8.4904 9030549
55. q-induced inhibition of cell proliferation BiochemBiophys Res Comm 2001 281 1019-1023 10.1006/bbrc.2001.4472
56. Burdon D Patel R Challiss RA Blank JL Growth inhibition by the muscarinic M3 acetylcholine receptor: Evidence for p21(Cip1/Waf1) involvement in G1 arrest Biochem J 2002 367 549-559 1222904 12126481 10.1042/BJ20020446
57. Wang QJ PKD at the crossroads of DAG and PKC signaling Trends Pharmacol Sci 2006 27 317-323 10.1016/j.tips.2006.04.003 16678913
58. Zhukova E Sinnett-Smith J Rozengurt E Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells J Biol Chem 2001 276 40298-40305 11514571
59. Spitaler M Cantrell DA Protein kinase C and beyond Nature Immunol 2004 5 785-790 10.1038/ni1097
60. 2+/PKC, MAPKs, and NF-κB in mouse embryonic stem cells J Cell Physiol 2006 208 399-406 10.1002/jcp.20674 16688761
61. Guttridge DC Albanese C Reuther JY Pestell RG Baldwin AS Jr NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1 Mol Cell Biol 1999 19 5785-5799 84428 10409765
62. Liu AM Wong YH μ-opioid receptor-mediated phosphorylation of IκB kinase in human neuroblastoma SH-SY5Y cells NeuroSignals 2005 14 136-142 10.1159/000086296 16088228
63. 14 and multiple signaling components: A mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src J Biol Chem 2005 280 34617-34625 10.1074/jbc.M504264200 16115892
64. Liu AM Wong YH G16-mediated activation of nuclear factor κB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling J Biol Chem 2004 279 53196-53204 10.1074/jbc.M410196200 15485865
65. Parsons SJ Parsons JT Src family kinases, key regulators of signal transduction Oncogene 2004 23 7906-7909 10.1038/sj.onc.1208160 15489908
66. Luttrell DK Luttrell LM Not so strange bedfellows: G-protein-coupled receptors and Src family kinases Oncogene 2004 23 7969-7978 10.1038/ sj.onc.1208162 15489914
67. Sundberg LJ Galante LM Bill HM Mack CP Taylor JM An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells J Biol Chem 2003 278 29783-29791 10.1074/jbc.M303771200 12782622
68. Yu HG Schafer H Mergler S Muerkoster S Cramer T Hocker M Herzig KH Schmidt WE Schmitz F Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells Cell Signal 2005 17 1505-1515 10.1016/ j.cellsig.2005.03.009 15951156
69. Rozengurt E Guha S Sinnett-Smith J Gastrointestinal peptide signalling in health and disease Eur J Sur Acta Chirurgica 2002 Suppl 587 23-38
70. Cazaubon S Chaverot N Romero IA Girault JA Adamson P Strosberg AD Couraud PO Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways J Neurosci 1997 17 6203-6212 9236231
71. Bajetto A Barbero S Bonavia R Piccioli P Pirani P Florio T Schettini G Stromal cell-derived factor-1α induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway J Neurochem 2001 77 1226-1236 10.1046/j.1471-4159.2001.00350.x 11389173
72. Yamaguchi K Richardson MD Bigner DD Kwatra MM Signal transduction through substance P receptor in human glioblastoma cells: Roles for Src and PKCδ Cancer Chemother Pharmacol 2005 56 585-93 10.1007/ s00280-005-1030-3 16012865
73. Czifra G Toth IB Marincsak R Juhasz I Kovacs I Acs P Kovacs L Blumberg PM Biro T Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cδ Cell Signal 2006 18 1461-1472 10.1016/j.cellsig.2005.11.007 16403461
74. q Eur J Biochem 2001 268 5449-5459 10.1046/ j.0014-2956.2001.02486.x 11606208
75. 2+ and Src-dependent mechanisms FEBS Lett 2001 496 25-30 10.1016/S0014-5793(01)02396-1 11343700
76. B-adrenergic receptor to c-Jun N-terminal kinase Biochem Biophys Res Comm 2002 296 85-92 10.1016/ S0006-291X(02)00839-2 12147231
77. Weissman JT Ma JN Essex A Gao Y Burstein ES G-protein-coupled receptor-mediated activation of rap GTPases: Characterization of a novel Gαi regulated pathway Oncogene 2004 23 241-249 10.1038/ sj.onc.1207014 14712229
78. 4MN9D cells Mol Pharmacol 2001 60 857-864 11562449
79. Ma YC Huang XY Novel regulation and function of Src tyrosine kinase Cell Mol Life Sci 2002 59 456-462 10.1007/s00018-002-8438-2 11964124
80. Ferrand A Kowalski-Chauvel A Bertrand C Escrieut C Mathieu A Portolan G Pradayrol L Fourmy D Dufresne M Seva C A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: Implication of this signaling pathway in pancreatic tumor models J Biol Chem 2005 280 10710-10715 10.1074/jbc.M413309200 15640156
81. Burstein ES Hesterberg DJ Gutkind JS Brann MR Currier EA Messier TL The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors Oncogene 1998 17 1617-1623 10.1038/sj.onc.1202067 9794239
82. Buggy JJ Binding of α-melanocyte-stimulating hormone to its G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway Biochem J 1998 331 211-216 1219340 9512481
83. Ram PT Iyengar R G protein coupled receptor signaling through the Src and Stat3 pathway: Role in proliferation and transformation Oncogene 2001 20 1601-1606 10.1038/sj.onc.1204186 11313907
84. 14 involves multiple intermediates Mol Pharmacol 2004 65 1427-1439 10.1124/ mol.65.6.1427 15155836
85. Lo RK Cheung H Wong YH Constitutively active Gα16stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism J Biol Chem 2003 278 52154-52165 10.1074/jbc.M307299200 14551213
86. Wu EH Lo RK Wong YH Regulation of STAT3 activity by G16-coupled receptors Biochem Biophys Res Comm 2003 303 920-925 10.1016/ S0006-291X(03)00451-0 12670499
87. i2 proteins of v-fms-induced proliferation and transformation via Src-kinase and STAT3 Oncogene 1999 18 6335-6342 10.1038/sj.onc.1203010 10597233
88. Schwindinger WF Robishaw JD Heterotrimeric G-protein βγ-dimers in growth and differentiation Oncogene 2001 20 1653-1660 10.1038/sj.onc.1204181 11313913
89. Liang J Slingerland JM Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression Cell Cycle 2003 2 339-345 12851486
90. Lahlou H Saint-Laurent N Esteve JP Eychene A Pradayrol L Pyronnet S Susini C sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation J Biol Chem 2003 278 39356-39371 10.1074/jbc.M304524200 12878607
91. Sellers LA Alderton F Carruthers AM Schindler M Humphrey PP Receptor isoforms mediate opposing proliferative effects through Gβγ-activated p38 or Akt pathways Mol Cell Biol 2000 20 5974-5985 86074 10913180 10.1128/MCB.20.16.5974-5985.2000
92. Kip1 expression in the vasculature of hypertensive rats Circulation Res 2001 89 488-495 11557735
93. Phillips-Mason PJ Raben DM Baldassare JJ Phosphatidylinositol 3-kinase activity regulates α-thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity J Biol Chem 2000 275 18046-18053 10.1074/jbc.M909194199 10749883
94. Goel R Phillips-Mason PJ Raben DM Baldassare JJ α-Thrombin induces rapid and sustained Akt phosphorylation by β-arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progression J Biol Chem 2002 277 18640-18648 10.1074/jbc.M108995200 11901145
95. Keenan SM Bellone C Baldassare JJ Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase J Biol Chem 2001 276 22404-22409 10.1074/jbc.M100409200 11304535
96. Kluk MJ Hla T Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration Circulation Res 2001 89 496-502 11557736
97. i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons Mol Pharmacol 2005 67 1195-1205 10.1124/ mol.104.007237 15626752
98. Merighi S Benini A Mirandola P Gessi S Varani K Leung E Maclennan S Borea PA A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells J Biol Chem 2005 280 19516-19526 10.1074/jbc.M413772200 15774470
99. Aksoy MO Yang Y Ji R Reddy PJ Shahabuddin S Litvin J Rogers TJ Kelsen SG CXCR3 surface expression in human airway epithelial cells: Cell cycle dependence and effect on cell proliferation Am J Physiol - Lung Cell Mol Physiol 2006 290 L909-918 10.1152/ajplung.00430.2005
100. Waters C Pyne S Pyne NJ The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction Seminars Cell Development Biol 2004 15 309-323 10.1016/ j.semcdb.2003.12.020
101. Zhang L Bai J Undie AS Bergson C Lidow MS D1dopamine receptor regulation of the levels of the cell-cycle-controlling proteins, cyclin D, p27 and Raf-1, in cerebral cortical precursor cells is mediated through cAMP-independent pathways Cerebral Cortex 2005 15 74-84 10.1093/cercor/ bhh110 15238444
102. Ciullo I Diez-Roux G Di Domenico M Migliaccio A Avvedimento EV cAMP signaling selectively influences Ras effectors pathways Oncogene 2001 20 1186-1192 10.1038/sj.onc.1204219 11313862
103. Zhao WQ Alkon DL Ma W c-Src protein tyrosine kinase activity is required for muscarinic receptor-mediated DNA synthesis and neurogenesis via ERK1/ 2 and c-AMP-responsive element-binding protein signaling in neural precursor cells J Neurosci Res 2003 72 334 -342 10.1002/jnr.10591 12692900
104. Marques SA Dy LC Southall MD Yi Q Smietana E Kapur R Marques M Travers JB Spandau DF The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway J Pharmacol Exper Therap 2002 300 1026-1035 10.1124/jpet.300.3.1026
105. Thibonnier M Conarty DM Plesnicher CL Mediators of the mitogenic action of human V1 vascular vasopressin receptors Am J Physiol - Heart Circ Physiol 2000 279 H2529-2539
106. Ghosh PM Mikhailova M Bedolla R Kreisberg JI Arginine vasopressin stimulates mesangial cell proliferation by activating the epidermal growth factor receptor Am J Physiol - Renal Physiol 2001 280 F972-979