High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α

Journal of Nutritional Science and Vitaminology

Volumn 57, Issue 4, 2011, Pages 280-284

  Nakari, Miwa ^a   Kanouchi, Hiroaki ^a   Oka, Tatsuzo ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

IGFBP 3; MCF 7; p53; Pyridoxine; Vitamin B 6

Indexed keywords

(1,3 BENZOTHIAZOL 2 YL)[2 [2 (3 PYRIDINYL)ETHYLAMINO] 4 PYRIMIDINYL]ACETONITRILE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; BETA ACTIN; MESSENGER RNA; PIFITHRIN ALPHA; PROTEIN P53; PYRIDOXINE; SOMATOMEDIN BINDING PROTEIN 3;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA MICROARRAY; DRUG MEGADOSE; GENE EXPRESSION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ACETONITRILES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOTHIAZOLES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HUMANS; IMIDAZOLES; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PYRIDOXINE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53; VITAMIN B COMPLEX;

RODENTIA;

EID: 80055115610     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.57.280     Document Type: Article

References (31)

1. Oka T. 2009. A novel function of vitamin B6. Vitamins 83: 345-350 (in Japanese).
2. Martial J, Zaldivar J, Bull P, Venegas A, Valenzuela P. 1975. Inactivation of rat liver RNA polymerases I and II and yeast RNA polymerase I by pyridoxal 5a-phosphate. Evidence for the participation of lysyl residues at the active site. Biochemistry 14: 4907-4911.
3. Basu A, Modak MJ. 1987. Identification and amino acid sequence of the deoxynucleoside triphosphate binding site in Escherichia coli DNA polymerase I. Biochemistry 26: 1704-1709.
4. Mizushina Y, Xu X, Matsubara K, Murakami C, Kuriyama I, Oshige M, Takemura M, Kato N, Yoshida H, Sakaguchi K. 2003. Pyridoxal 5S-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon. Biochem Biophys Res Commun 312: 1025-1032.
5. Allgood VE, Powell-Oliver FE, Cidlowski JA. 1990. The influence of vitamin B6 on the structure and function of the glucocorticoid receptor. Ann N Y Acad Sci 585: 452-465.
6. Oka T, Komori N, Kuwahata M, Okada M, Natori Y. 1995. Vitamin B6 modulates expression of albumin gene by inactivating tissue-specific DNA-binding protein in rat liver. Biochem J 309: 243-248.
7. Oka T, Kuwahata M, Sugitatsu H, Tsuge H, Asagi K, Kohri H, Horiuchi S, Natori Y. 1997. Modulation of albumin gene expression by amino acid supply in rat liver is mediated through intracellular concentration of pyridoxal 5p-phosphate. J Nutr Biochem 8: 211-216.
8. Oka T. 2001. Modulation of gene expression by vitamin B6. Nutr Res Rev 14: 257-266.
9. Oka T, Komori N, Kuwahata M, Sassa T, Suzuki I, Okada M, Natori Y. 1993. Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver. FEBS Lett 331: 162-164.
10. Huq MD, Tsai NP, Lin YP, Higgins L, Wei LN. 2007. Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation. Nat Chem Biol 3: 161-165.
11. Potera C, Rose DP, Brown RR. 1977. Vitamin B6 deficiency in cancer patients. Am J Clin Nutr 30: 1677-1679.
12. Chrisley BM, Hendricks TS. 1986. Vitamin B-6 status of a group of cancer patients. Nutr Res 6: 1023-1029.
13. Johansson M, Relton C, Ueland PM, Vollset SE, Midttun Ø, Nygård O, Slimani N, Boffetta P, Jenab M, Clavel-Chapelon F, Boutron-Ruault MC, Fagherazzi G, Kaaks R, Rohrmann S, Boeing H, Weikert C, Bueno-de-Mesquita HB, Ros MM, van Gils CH, Peeters PH, Agudo A, Barricarte A, Navarro C, Rodríguez L, Sánchez MJ, Larrañaga N, Khaw KT, Wareham N, Allen NE, Crowe F, Gallo V, Norat T, Krogh V, Masala G, Panico S, Sacerdote C, Tumino R, Trichopoulou A, Lagiou P, Trichopoulos D, Rasmuson T, Hallmans G, Riboli E, Vineis P, Brennan P. 2010. Serum B vitamin levels and risk of lung cancer. JAMA 303: 2377-2385.
14. Komatsu SI, Watanabe H, Oka T, Tsuge H, Nii H, Kato N. 2001. Vitamin B-6-supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation. J Nutr 131: 2204-2207.
15. Shimada D, Fukuda A, Kawaguchi H, Kato N, Yoshida H, Kanouchi H, Oka T. 2005. Effect of high dose of pyridoxine on mammary tumorigenesis. Nutr Cancer 53: 202-207.
16. Molina A, Oka T, Muń oz SM, Chikamori-Aoyama M, Kuwahata M, Natori Y. 1997. Vitamin B6 suppresses growth and expression of albumin gene in a human hepatoma cell line HepG2. Nutr Cancer 28: 206-211.
17. Shimada D, Fukuda A, Kanouchi H, Matsumoto M, Oka T. 2006. Vitamin B6 suppresses growth of the feline mammary tumor cell line FRM. Biosci Biotechnol Biochem 70: 1038-1040.
18. Yang YW, Brown AL, Orlowski CC, Graham DE, Tseng LY, Romanus JA, Rechler MM. 1990. Identification of rat cell lines that preferentially express insulin-like growth factor binding proteins rlGFBP-1, 2, or 3. Mol Endocrinol 4: 29-38.
19. Grimberg A. 2000. p53 and IGFBP-3: apoptosis and cancer protection. Mol Genet Metab 70: 85-98.
20. Oy GF, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo GM, Flørenes VA. 2010. Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma. Int J Cancer 126: 350-361.
21. Kang YH, Lee SJ. 2008. The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells. J Cell Physiol 217: 23-33.
22. Beurel E, Blivet-Van Eggelpoël MJ, Kornprobst M, Moritz S, Delelo R, Paye F, Housset C, Desbois-Mouthon C. 2009. Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells. Biochem Pharmacol 77: 54-65.
23. Caughlan A, Newhouse K, Namgung U, Xia Z. 2004. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/ JNK MAP kinases. Toxicol Sci 78: 125-134.
24. Leibowitz BJ, Cohick WS. 2009. Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. J Cell Physiol 220: 182-188.
25. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N. 1995. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377: 646-649.
26. Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV. 1999. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285: 1733-1737.
27. Siu WY, Lau A, Arooz T, Chow JP, Ho HT, Poon RY. 2004. Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and-independent mechanisms. Mol Cancer Ther 3: 621-632.
28. Matsubara K, Matsumoto H, Mizushina Y, Lee JS, Kato N. 2003. Inhibitory effect of pyridoxal 5N-phosphate on endothelial cell proliferation, replicative DNA polymerase and DNA topoisomerase. Int J Mol Med 12: 51-55.
29. Vermeersch JJ, Christmann-Franck S, Karabashyan LV, Fermandjian S, Mirambeau G, Der Garabedian PA. 2004. Pyridoxal 52-phosphate inactivates DNA topoisomerase IB by modifying the lysine general acid. Nucleic Acids Res 32: 5649-5657.
30. Tergaonkar V, Perkins ND. 2007. p53 and NF-kappaB crosstalk: IKKalpha tips the balance. Mol Cell 26: 158-159.
31. Yanaka N, Koyama TA, Komatsu S, Nakamura E, Kanda M, Kato N. 2005. Vitamin B6 suppresses NF-kappaB activation in LPS-stimulated mouse macrophages. Int J Mol Med 16: 1071-1075.