Pyridoxal 5′-phosphate is a selective inhibitor in vivo of DNA polymerase α and ε

Biochemical and Biophysical Research Communications

Volumn 312, Issue 4, 2003, Pages 1025-1032

  Mizushina, Yoshiyuki ^a   Xu, Xianai ^a   Matsubara, Kiminori ^b   Murakami, Chikako ^a   Kuriyama, Isoko ^a   Oshige, Masahiko ^c   Takemura, Masaharu ^d   Kato, Norihisa ^e   Yoshida, Hiromi ^a   Sakaguchi, Kengo ^f  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

^f TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE EPSILON; DNA POLYMERASE; ISOENZYME; PRIMER DNA; PYRIDOXAL; PYRIDOXAL 5 PHOSPHATE; PYRIDOXAMINE; PYRIDOXINE; TAQ POLYMERASE; UNCLASSIFIED DRUG; DNA DIRECTED DNA POLYMERASE BETA; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ESCHERICHIA COLI; EUKARYOTIC CELL; FISH; GENE REPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; INSECT; MAMMAL; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT; PRIORITY JOURNAL; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; HELA CELL; METABOLISM; SENSITIVITY AND SPECIFICITY;

ESCHERICHIA COLI; EUKARYOTA; HEXAPODA; MAMMALIA; PROKARYOTA; PROTISTA;

CELL SURVIVAL; DNA POLYMERASE I; DNA POLYMERASE II; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HELA CELLS; HUMANS; PYRIDOXAL; PYRIDOXAL PHOSPHATE; SENSITIVITY AND SPECIFICITY;

EID: 0344495342     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.11.027     Document Type: Article

References (32)

1. DiSorbo D.M., Litwack G. Vitamin B6 kills hepatoma cells in culture. Nutr. Cancer. 3:1982;216-222.
2. DiSorbo D.M., Nathanson L. High-dose pyridoxal supplemented culture medium inhibits the growth of a human malignant melanoma cell line. Nutr. Cancer. 5:1983;10-15.
3. DiSorbo D.M., Wagner R.J., Nathanson L. In vivo and in vitro inhibition of B16 melanoma growth by vitamin B6. Nutr. Cancer. 7:1985;43-52.
4. Gridley D.S., Stickney D.R., Nutter R.L., Slater J.M., Shultz T.D. Suppression of tumor growth and enhancement of immune status with high levels of dietary vitamin B6 in BALB/c mice. J. Natl. Cancer Inst. 78:1987;951-959.
5. Slattery M.L., Potter J.D., Coates A., Ma K.N., Berry T.D., Ducan D.M., Caan D.J. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). Cancer Causes Control. 8:1997;575-590.
6. Jansen M.C., Bueno-de-Mesquita H.B., Buzina R., Fidanza F., Menotti A., Blackburn H., Nissinen A.M., Kok F.J., Kromhout D. Dietary fiber and plant foods in relation to colorectal cancer mortality: the seven countries study. Int. J. Cancer. 81:1999;174-179.
7. 12, and folate with lung cancer risk in older men Am. J. Epidemiol. 153:2001;688-693.
8. Komatsu S., Watanabe H., Oka T., Tsuge H., Nii H., Kato N. Vitamin B-6-supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation. J. Nutr. 131:2001;2204-2207.
9. Komatsu S., Watanabe H., Oka T., Tsuge H., Kato N. Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice. J. Nutr. Sci. Vitaminol. 48:2002;65-68.
10. ′ -phosphate and pyridoxal inhibit angiogenesis in the serum-free rat aortic ring assay Int. J. Mol. Med. 8:2001;505-508.
11. Hubscher U., Maga G., Spadari S. Eukaryotic DNA polymerases. Annu. Rev. Biochem. 71:2002;133-163.
12. Tamai K., Kojima K., Hanaichi T., Masaki S., Suzuki M., Umekawa H., Yoshida S. Structural study of immunoaffinity-purified DNA polymerase α-DNA primase complex from calf thymus. Biochim. Biophys. Acta. 950:1988;263-273.
13. Date T., Yamaguchi M., Hirose F., Nishimoto Y., Tanihara K., Matsukage A. Expression of active rat DNA polymerase β in Escherichia coli. Biochemistry. 27:1988;2983-2990.
14. Masutani C., Kusumoto R., Iwai S., Hanaoka F. Mechanisms of accurate translesion synthesis by human DNA polymerase η EMBO J. 19:2000;3100-3109.
15. Tissier A., Frank E.G., McDonald J.P., Iwai S., Hanaoka F., Woodgate R. Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase ι EMBO J. 19:2000;5259-5266.
16. Ohashi E., Ogi T., Kusumoto R., Iwai S., Masutani C., Hanaoka F., Ohmori H. Error-prone bypass of certain DNA lesions by the human DNA polymerase κ Genes Dev. 14:2000;1589-1594.
17. Shimazaki N., Yoshida K., Kobayashi T., Toji S., Tamai T., Koiwai O. Over-expression of human DNA polymerase λ in E. coli and characterization of the recombinant enzyme. Genes Cells. 7:2002;639-651.
18. Tomikawa A., Seno M., Sato-Kiyotaki K., Ohtsuki C., Hirai T., Yamaguchi T., Kawaguchi T., Yoshida S., Saneyoshi M. Synthetic nucleosides and nucleotides. Nucleosides Nucleotides. 17:1998;487-501.
19. Aoyagi N., Matsuoka S., Furunobu A., Matsukage A., Sakaguchi K. Drosophila DNA polymerase δ: purification and characterization. J. Biol. Chem. 269:1994;6045-6050.
20. Aoyagi N., Oshige M., Hirose F., Kuroda K., Matsukage A., Sakaguchi K. DNA polymerase ε from Drosophila melanogaster. Biochem. Biophys. Res. Commun. 230:1997;297-301.
21. Sakaguchi K., Hotta Y., Stern H. Chromatin-associated DNA polymerase activity in meiotic cells of lily and mouse. Cell Struct. Funct. 5:1980;323-334.
22. Hamatake R.K., Hasegawa H., Clark A.B., Bebenek K., Kunkel T.A., Sugino A. Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae: identification of the catalytic core and a possible holoenzyme form of the enzyme. J. Biol. Chem. 265:1990;4072-4083.
23. Mizushina Y., Tanaka N., Yagi H., Kurosawa T., Onoue M., Seto H., Horie T., Aoyagi N., Yamaoka M., Matsukage A., Yoshida S., Sakaguchi K. Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. Biochim. Biophys. Acta. 1308:1996;256-262.
24. Mizushina Y., Yoshida S., Matsukage A., Sakaguchi K. The inhibitory action of fatty acids on DNA polymerase β Biochim. Biophys. Acta. 1336:1997;509-521.
25. Mizushina Y., Ohkubo T., Date T., Yamaguchi T., Saneyoshi M., Sugawara F., Sakaguchi K. Mode analysis of a fatty acid molecule binding to the N-terminal 8-kDa domain of DNA polymerase β: a 1:1 complex and binding surface. J. Biol. Chem. 274:1999;25599-25607.
26. ′ -triphosphates and related nucleotides on DNA-dependent RNA polymerases I and II from the cherry salmon (Oncorhynchus masou) J. Biochem. (Tokyo). 97:1985;1385-1389.
27. Lu B.C., Sakaguchi K. An endo-exonuclease from meiotic tissues of the basidiomycete Coprinus cinereus: its purification and characterization. J. Biol. Chem. 266:1991;21060-21066.
28. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
29. ′ -monophosphate form of bredinin selectively inhibits the activities of mammalian DNA polymerases in vitro Int. J. Mol. Med. 1:1998;83-90.
30. 6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle. Experientia. 50:1994;127-129.
31. 6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver. FEBS Lett. 331:1993;162-164.
32. 6 suppresses growth and expression of albumin gene in a human hepatoma cell line HepG2. Nutr. Cancer. 28:1997;206-211.