Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Sun, Shihui ^a   Guo, Yan ^a   Zhao, Guangyu ^a   Zhou, Xiaojun ^a   Li, Junfeng ^a   Hu, Jingya ^a   Yu, Hong ^a   Chen, Yu ^b   Song, Hongbin ^a   Qiao, Fei ^c   Xu, Guilian ^d   Yang, Fei ^d   Wu, Yuzhang ^d   Tomlinson, Stephen ^c   Duan, Zhongping ^b   Zhou, Yusen ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C3A RECEPTOR ANTAGONIST; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT COMPONENT C5A RECEPTOR MONOCLONAL ANTIBODY; COMPLEMENT FACTOR H; COMPLEMENT INHIBITOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT RECEPTOR; CR2 FH; GALACTOSAMINE; UNCLASSIFIED DRUG; COMPLEMENT C3A RECEPTOR; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT BLOOD LEVEL; COMPLEMENT DEPOSITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG MECHANISM; FEMALE; FULMINANT HEPATIC FAILURE; HEPATITIS; IMMUNOPATHOGENESIS; LIVER INJURY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SURVIVAL TIME; WILD TYPE; ACUTE LIVER FAILURE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; IMMUNOLOGY; LIVER; METABOLISM; MORTALITY; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SURVIVAL RATE;

ANIMALIA; MUS;

ANIMALS; COMPLEMENT C3; COMPLEMENT MEMBRANE ATTACK COMPLEX; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; GALACTOSAMINE; LIPOPOLYSACCHARIDES; LIVER; LIVER FAILURE, ACUTE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 80055114012     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026838     Document Type: Article

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