-
1
-
-
0031792685
-
Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae
-
Faruque SM, Albert MJ, Mekalanos JJ, (1998) Epidemiology, genetics, and ecology of toxigenic Vibrio cholerae. Microbiol Mol Biol Rev 62: 1301-14.
-
(1998)
Microbiol Mol Biol Rev
, vol.62
, pp. 1301-1314
-
-
Faruque, S.M.1
Albert, M.J.2
Mekalanos, J.J.3
-
2
-
-
1642493765
-
Cholera
-
Sack DA, Sack RB, Nair GB, Siddique AK, (2004) Cholera. Lancet 363: 223-33.
-
(2004)
Lancet
, vol.363
, pp. 223-233
-
-
Sack, D.A.1
Sack, R.B.2
Nair, G.B.3
Siddique, A.K.4
-
3
-
-
33644873697
-
The integrated microbial genomes (IMG) system
-
Markowitz VM, Korzeniewski F, Palaniappan K, Szeto E, Werner G, et al. (2006) The integrated microbial genomes (IMG) system. Nucleic Acids Res 34: D344-8.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 344-348
-
-
Markowitz, V.M.1
Korzeniewski, F.2
Palaniappan, K.3
Szeto, E.4
Werner, G.5
-
4
-
-
0011542799
-
The Pfam protein families database
-
Bateman A, Birney E, Cerruti L, Durbin R, Etwiller L, et al. (2002) The Pfam protein families database. Nucleic Acids Res 30: 276-80.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 276-280
-
-
Bateman, A.1
Birney, E.2
Cerruti, L.3
Durbin, R.4
Etwiller, L.5
-
5
-
-
33747843430
-
HHsenser: exhaustive transitive profile search using HMM-HMM comparison
-
Söding J, Remmert M, Biegert A, Lupas AN, (2006) HHsenser: exhaustive transitive profile search using HMM-HMM comparison. Nucleic Acids Res 34: W374-8.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 374-378
-
-
Söding, J.1
Remmert, M.2
Biegert, A.3
Lupas, A.N.4
-
6
-
-
39449115394
-
I-TASSER server for protein 3D structure prediction
-
Zhang Y, (2008) I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 9: 40.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 40
-
-
Zhang, Y.1
-
7
-
-
0028961335
-
SCOP: a structural classification of proteins database for the investigation of sequences and structures
-
Murzin AG, Brenner SE, Hubbard T, Chothia C, (1995) SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol 247: 536-40.
-
(1995)
J Mol Biol
, vol.247
, pp. 536-540
-
-
Murzin, A.G.1
Brenner, S.E.2
Hubbard, T.3
Chothia, C.4
-
8
-
-
43249097732
-
TMBETADISC-RBF: Discrimination of beta-barrel membrane proteins using RBF networks and PSSM profiles
-
Ou YY, Gromiha MM, Chen SA, Suwa M, (2008) TMBETADISC-RBF: Discrimination of beta-barrel membrane proteins using RBF networks and PSSM profiles. Comput Biol Chem 32: 227-31.
-
(2008)
Comput Biol Chem
, vol.32
, pp. 227-231
-
-
Ou, Y.Y.1
Gromiha, M.M.2
Chen, S.A.3
Suwa, M.4
-
9
-
-
67849103758
-
HHomp-prediction and classification of outer membrane proteins
-
Remmert M, Linke D, Lupas AN, Söding J, (2009) HHomp-prediction and classification of outer membrane proteins. Nucleic Acids Res 37: W446-51.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 446-451
-
-
Remmert, M.1
Linke, D.2
Lupas, A.N.3
Söding, J.4
-
10
-
-
3042521098
-
Improved prediction of signal peptides: SignalP 3.0
-
Bendtsen JD, Nielsen H, von Heijne G, Brunak S, (2004) Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340: 783-95.
-
(2004)
J Mol Biol
, vol.340
, pp. 783-795
-
-
Bendtsen, J.D.1
Nielsen, H.2
von Heijne, G.3
Brunak, S.4
-
11
-
-
0036922508
-
Signal peptidases
-
Paetzel M, Karla A, Strynadka NC, Dalbey RE, (2002) Signal peptidases. Chem Rev 102: 4549-80.
-
(2002)
Chem Rev
, vol.102
, pp. 4549-4580
-
-
Paetzel, M.1
Karla, A.2
Strynadka, N.C.3
Dalbey, R.E.4
-
12
-
-
0041341888
-
Prediction of lipoprotein signal peptides in Gram-negative bacteria
-
Juncker AS, Willenbrock H, Von Heijne G, Brunak S, Nielsen H, et al. (2003) Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Sci 12: 1652-62.
-
(2003)
Protein Sci
, vol.12
, pp. 1652-1662
-
-
Juncker, A.S.1
Willenbrock, H.2
Von Heijne, G.3
Brunak, S.4
Nielsen, H.5
-
13
-
-
78651324347
-
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
-
Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, et al. (2011) The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 39: D561-8.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 561-568
-
-
Szklarczyk, D.1
Franceschini, A.2
Kuhn, M.3
Simonovic, M.4
Roth, A.5
-
14
-
-
27644500162
-
Non-classical protein secretion in bacteria
-
Bendtsen JD, Kiemer L, Fausbøll A, Brunak S, (2005) Non-classical protein secretion in bacteria. BMC Microbiol 5: 58.
-
(2005)
BMC Microbiol
, vol.5
, pp. 58
-
-
Bendtsen, J.D.1
Kiemer, L.2
Fausbøll, A.3
Brunak, S.4
-
16
-
-
0035087954
-
A web-based program for the prediction of average hydropathy, average amphipathicity and average similarity of multiply aligned homologous proteins
-
Zhai Y, Saier MH Jr, (2001) A web-based program for the prediction of average hydropathy, average amphipathicity and average similarity of multiply aligned homologous proteins. J Mol Microbiol Biotechnol 3: 285-6.
-
(2001)
J Mol Microbiol Biotechnol
, vol.3
, pp. 285-286
-
-
Zhai, Y.1
Saier Jr., M.H.2
-
17
-
-
0038039279
-
Molecular analysis of transport and oligomerization of the Yersinia enterocolitica adhesin YadA
-
Roggenkamp A, Ackermann N, Jacobi CA, Truelzsch K, Hoffmann H, et al. (2003) Molecular analysis of transport and oligomerization of the Yersinia enterocolitica adhesin YadA. J Bacteriol 185: 3735-44.
-
(2003)
J Bacteriol
, vol.185
, pp. 3735-3744
-
-
Roggenkamp, A.1
Ackermann, N.2
Jacobi, C.A.3
Truelzsch, K.4
Hoffmann, H.5
-
18
-
-
10344232466
-
Type V protein secretion pathway: the autotransporter story
-
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D, (2004) Type V protein secretion pathway: the autotransporter story. Microbiol Mol Biol Rev 68: 692-744.
-
(2004)
Microbiol Mol Biol Rev
, vol.68
, pp. 692-744
-
-
Henderson, I.R.1
Navarro-Garcia, F.2
Desvaux, M.3
Fernandez, R.C.4
Ala'Aldeen, D.5
-
19
-
-
0037012970
-
Protein-translocating outer membrane porins of Gram-negative bacteria
-
Yen MR, Peabody CR, Partovi SM, Zhai Y, Tseng YH, et al. (2002) Protein-translocating outer membrane porins of Gram-negative bacteria. Biochim Biophys Acta 1562: 6-31.
-
(2002)
Biochim Biophys Acta
, vol.1562
, pp. 6-31
-
-
Yen, M.R.1
Peabody, C.R.2
Partovi, S.M.3
Zhai, Y.4
Tseng, Y.H.5
-
20
-
-
0023128808
-
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
-
Pohlner J, Halter R, Beyreuther K, Meyer TF, (1987) Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature 325: 458-62.
-
(1987)
Nature
, vol.325
, pp. 458-462
-
-
Pohlner, J.1
Halter, R.2
Beyreuther, K.3
Meyer, T.F.4
-
21
-
-
0035111746
-
Virulence functions of autotransporter proteins
-
Henderson IR, Nataro JP, (2001) Virulence functions of autotransporter proteins. Infect Immun 69: 1231-43.
-
(2001)
Infect Immun
, vol.69
, pp. 1231-1243
-
-
Henderson, I.R.1
Nataro, J.P.2
-
22
-
-
1942471665
-
Structure of the translocator domain of a bacterial autotransporter
-
Oomen CJ, van Ulsen P, van Gelder P, Feijen M, Tommassen J, et al. (2004) Structure of the translocator domain of a bacterial autotransporter. EMBO J 23: 1257-66.
-
(2004)
EMBO J
, vol.23
, pp. 1257-1266
-
-
Oomen, C.J.1
van Ulsen, P.2
van Gelder, P.3
Feijen, M.4
Tommassen, J.5
-
23
-
-
77949323924
-
Crystal structure of a full-length autotransporter
-
Van den Berg B, (2010) Crystal structure of a full-length autotransporter. J Mol Biol 396: 627-33.
-
(2010)
J Mol Biol
, vol.396
, pp. 627-633
-
-
van den Berg, B.1
-
24
-
-
36849016945
-
Autotransporter structure reveals intra-barrel cleavage followed by conformational changes
-
Barnard TJ, Dautin N, Lukacik P, Bernstein HD, Buchanan SK, (2007) Autotransporter structure reveals intra-barrel cleavage followed by conformational changes. Nat Struct Mol Biol 14: 1214-20.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1214-1220
-
-
Barnard, T.J.1
Dautin, N.2
Lukacik, P.3
Bernstein, H.D.4
Buchanan, S.K.5
-
25
-
-
0035035580
-
Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins
-
Jacob-Dubuisson F, Locht C, Antoine R, (2001) Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins. Mol Microbiol 40: 306-13.
-
(2001)
Mol Microbiol
, vol.40
, pp. 306-313
-
-
Jacob-Dubuisson, F.1
Locht, C.2
Antoine, R.3
-
26
-
-
33745818313
-
Translocator proteins in the two-partner secretion family have multiple domains
-
Surana NK, Buscher AZ, Hardy GG, Grass S, Kehl-Fie T, et al. (2006) Translocator proteins in the two-partner secretion family have multiple domains. J Biol Chem 281: 18051-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 18051-18058
-
-
Surana, N.K.1
Buscher, A.Z.2
Hardy, G.G.3
Grass, S.4
Kehl-Fie, T.5
-
27
-
-
34548128883
-
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily
-
Clantin B, Delattre AS, Rucktooa P, Saint N, Méli AC, et al. (2007) Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily. Science 317: 957-61.
-
(2007)
Science
, vol.317
, pp. 957-961
-
-
Clantin, B.1
Delattre, A.S.2
Rucktooa, P.3
Saint, N.4
Méli, A.C.5
-
28
-
-
0032991297
-
The haemolysin-secreting ShlB protein of the outer membrane of Serratia marcescens: determination of surface-exposed residues and formation of ion-permeable pores by ShlB mutants in artificial lipid bilayer membranes
-
Könninger UW, Hobbie S, Benz R, Braun V, (1999) The haemolysin-secreting ShlB protein of the outer membrane of Serratia marcescens: determination of surface-exposed residues and formation of ion-permeable pores by ShlB mutants in artificial lipid bilayer membranes. Mol Microbiol 32: 1212-25.
-
(1999)
Mol Microbiol
, vol.32
, pp. 1212-1225
-
-
Könninger, U.W.1
Hobbie, S.2
Benz, R.3
Braun, V.4
-
29
-
-
0034669051
-
Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins
-
Hoiczyk E, Roggenkamp A, Reichenbecher M, Lupas A, Heesemann J, (2000) Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins. EMBO J 19: 5989-99.
-
(2000)
EMBO J
, vol.19
, pp. 5989-5999
-
-
Hoiczyk, E.1
Roggenkamp, A.2
Reichenbecher, M.3
Lupas, A.4
Heesemann, J.5
-
30
-
-
33748655033
-
Protein-translocating trimeric autotransporters of gram-negative bacteria
-
Kim DS, Chao Y, Saier MH Jr, (2006) Protein-translocating trimeric autotransporters of gram-negative bacteria. J Bacteriol 188: 5655-67.
-
(2006)
J Bacteriol
, vol.188
, pp. 5655-5667
-
-
Kim, D.S.1
Chao, Y.2
Saier Jr., M.H.3
-
31
-
-
18044363515
-
Trimeric autotransporters: a distinct subfamily of autotransporter proteins
-
Cotter SE, Surana NK, St Geme JW 3rd, (2005) Trimeric autotransporters: a distinct subfamily of autotransporter proteins. Trends Microbiol 13: 199-205.
-
(2005)
Trends Microbiol
, vol.13
, pp. 199-205
-
-
Cotter, S.E.1
Surana, N.K.2
St Geme III, J.W.3
-
32
-
-
33745743311
-
Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter
-
Meng G, Surana NK, St Geme JW 3rd, Waksman G, (2006) Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. EMBO J 25: 2297-304.
-
(2006)
EMBO J
, vol.25
, pp. 2297-2304
-
-
Meng, G.1
Surana, N.K.2
St Geme III, J.W.3
Waksman, G.4
-
33
-
-
23344450318
-
Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection
-
Larocque RC, Harris JB, Dziejman M, Li X, Khan AI, et al. (2005) Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun 73: 4488-93.
-
(2005)
Infect Immun
, vol.73
, pp. 4488-4493
-
-
Larocque, R.C.1
Harris, J.B.2
Dziejman, M.3
Li, X.4
Khan, A.I.5
-
34
-
-
46949102189
-
Cyclic-di-GMP regulates extracellular polysaccharide production, biofilm formation, and rugose colony development by Vibrio vulnificus
-
Nakhamchik A, Wilde C, Rowe-Magnus DA, (2008) Cyclic-di-GMP regulates extracellular polysaccharide production, biofilm formation, and rugose colony development by Vibrio vulnificus. Appl Environ Microbiol 74: 4199-209.
-
(2008)
Appl Environ Microbiol
, vol.74
, pp. 4199-4209
-
-
Nakhamchik, A.1
Wilde, C.2
Rowe-Magnus, D.A.3
-
35
-
-
33646575898
-
Transcriptome and phenotypic responses of Vibrio cholerae to increased cyclic di-GMP level
-
Beyhan S, Tischler AD, Camilli A, Yildiz FH, (2006) Transcriptome and phenotypic responses of Vibrio cholerae to increased cyclic di-GMP level. J Bacteriol 188: 3600-13.
-
(2006)
J Bacteriol
, vol.188
, pp. 3600-3613
-
-
Beyhan, S.1
Tischler, A.D.2
Camilli, A.3
Yildiz, F.H.4
-
36
-
-
34548658907
-
Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni
-
Barnes IH, Bagnall MC, Browning DD, Thompson SA, Manning G, et al. (2007) Gamma-glutamyl transpeptidase has a role in the persistent colonization of the avian gut by Campylobacter jejuni. Microb Pathog 43: 198-207.
-
(2007)
Microb Pathog
, vol.43
, pp. 198-207
-
-
Barnes, I.H.1
Bagnall, M.C.2
Browning, D.D.3
Thompson, S.A.4
Manning, G.5
-
37
-
-
0032982703
-
Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice
-
Chevalier C, Thiberge JM, Ferrero RL, Labigne A, (1999) Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice. Mol Microbiol 31: 1359-72.
-
(1999)
Mol Microbiol
, vol.31
, pp. 1359-1372
-
-
Chevalier, C.1
Thiberge, J.M.2
Ferrero, R.L.3
Labigne, A.4
-
38
-
-
14244254898
-
Cyclic diguanylate is a ubiquitous signalling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
-
Ryjenkov DA, Tarutina M, Moskvin OV, Gomelsky M, (2005) Cyclic diguanylate is a ubiquitous signalling molecule in bacteria: insights into biochemistry of the GGDEF protein domain. J Bacteriol 187: 1792-8.
-
(2005)
J Bacteriol
, vol.187
, pp. 1792-1798
-
-
Ryjenkov, D.A.1
Tarutina, M.2
Moskvin, O.V.3
Gomelsky, M.4
-
39
-
-
17144462135
-
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
-
Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, et al. (2000) DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406: 477-83.
-
(2000)
Nature
, vol.406
, pp. 477-483
-
-
Heidelberg, J.F.1
Eisen, J.A.2
Nelson, W.C.3
Clayton, R.A.4
Gwinn, M.L.5
-
40
-
-
0032169654
-
The great escape: structure and function of the autotransporter proteins
-
Henderson IR, Navarro-Garcia F, Nataro JP, (1998) The great escape: structure and function of the autotransporter proteins. Trends Microbiol 6: 370-8.
-
(1998)
Trends Microbiol
, vol.6
, pp. 370-378
-
-
Henderson, I.R.1
Navarro-Garcia, F.2
Nataro, J.P.3
-
41
-
-
0030693901
-
Structural determinants of processing and secretion of the Haemophilus influenzae hap protein
-
Hendrixson DR, de la Morena ML, Stathopoulos C, St Geme JW 3rd, (1997) Structural determinants of processing and secretion of the Haemophilus influenzae hap protein. Mol Microbiol 26: 505-18.
-
(1997)
Mol Microbiol
, vol.26
, pp. 505-518
-
-
Hendrixson, D.R.1
de la Morena, M.L.2
Stathopoulos, C.3
St Geme III, J.W.4
-
42
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
-
Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-402.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schäffer, A.A.3
Zhang, J.4
Zhang, Z.5
-
43
-
-
58149200939
-
DOOR: a database for prokaryotic operons
-
Mao F, Dam P, Chou J, Olman V, Xu Y, (2009) DOOR: a database for prokaryotic operons. Nucleic Acids Res 37: D459-63.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 459-463
-
-
Mao, F.1
Dam, P.2
Chou, J.3
Olman, V.4
Xu, Y.5
-
44
-
-
36749061828
-
Template-based modeling and free modeling by I-TASSER in CASP7
-
Zhang Y, (2007) Template-based modeling and free modeling by I-TASSER in CASP7. Proteins 69: 108-17.
-
(2007)
Proteins
, vol.69
, pp. 108-117
-
-
Zhang, Y.1
-
45
-
-
38849092210
-
A note on difficult structure alignment problems
-
Sippl MJ, Wiederstein M, (2008) A note on difficult structure alignment problems. Bioinformatics 24: 426-7.
-
(2008)
Bioinformatics
, vol.24
, pp. 426-427
-
-
Sippl, M.J.1
Wiederstein, M.2
-
47
-
-
0034874253
-
A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence
-
Zhai Y, Saier MH Jr, (2001) A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence. J Mol Microbiol Biotechnol 3: 501-2.
-
(2001)
J Mol Microbiol Biotechnol
, vol.3
, pp. 501-502
-
-
Zhai, Y.1
Saier Jr., M.H.2
-
48
-
-
3242883431
-
PRED-TMBB: a web server for predicting the topology of beta-barrel outer membrane proteins
-
Bagos PG, Liakopoulos TD, Spyropoulos IC, Hamodrakas SJ, (2004) PRED-TMBB: a web server for predicting the topology of beta-barrel outer membrane proteins. Nucleic Acids Res 32: W400-4.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 400-404
-
-
Bagos, P.G.1
Liakopoulos, T.D.2
Spyropoulos, I.C.3
Hamodrakas, S.J.4
-
49
-
-
0031757669
-
Multiple sequence alignment with Clustal X
-
Jeanmougin F, Thompson JD, Gouy M, Higgins DG, Gibson TJ, (1998) Multiple sequence alignment with Clustal X. Trends Biochem Sci 23: 403-5.
-
(1998)
Trends Biochem Sci
, vol.23
, pp. 403-405
-
-
Jeanmougin, F.1
Thompson, J.D.2
Gouy, M.3
Higgins, D.G.4
Gibson, T.J.5
-
50
-
-
14644430471
-
ProbCons: Probabilistic consistency-based multiple sequence alignment
-
Do CB, Mahabhashyam MS, Brudno M, Batzoglou S, (2005) ProbCons: Probabilistic consistency-based multiple sequence alignment. Genome Res 15: 330-40.
-
(2005)
Genome Res
, vol.15
, pp. 330-340
-
-
Do, C.B.1
Mahabhashyam, M.S.2
Brudno, M.3
Batzoglou, S.4
-
51
-
-
33747856166
-
The MPI Bioinformatics Toolkit for protein sequence analysis
-
Biegert A, Mayer C, Remmert M, Söding J, Lupas AN, (2006) The MPI Bioinformatics Toolkit for protein sequence analysis. Nucleic Acids Res 34: W335-9.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 335-339
-
-
Biegert, A.1
Mayer, C.2
Remmert, M.3
Söding, J.4
Lupas, A.N.5
-
52
-
-
34547781750
-
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0
-
Tamura K, Dudley J, Nei M, Kumar S, (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-9.
-
(2007)
Mol Biol Evol
, vol.24
, pp. 1596-1599
-
-
Tamura, K.1
Dudley, J.2
Nei, M.3
Kumar, S.4
|