Antiulcer effects of alpha lipoic acid on gastric acid secretion and mucosal defense factors in rats

Asian Journal of Biochemistry

Volumn 6, Issue 6, 2011, Pages 426-438

  Abd El Kader, M A ^a   Ali, M M ^a   El Sammad, N M ^a   El Shaer, M A ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antioxidants; Bipid peroxidation; Mucus; Ulcer

Indexed keywords

ANIMALIA; RATTUS;

EID: 80055091801     PISSN: 18159923     EISSN: None     Source Type: Journal    
DOI: 10.3923/ajb.2011.426.438     Document Type: Article

References (48)

1. Aebi, H, 1984. Catalase in vitro. Methods Enzymol, 105: 121-126.
2. Ajeigbe, K.O, E.O. Nwobodo, T.O. Oyesola, D.A. Ofuson and S.B. Olaleye, 2008. Chloroqume phosphate potentiates indomethacin and HCl/Ethanol-induced gastric mucosa injury in rats. Int. J. Pharmacol., 4: 482-486.
3. Al-Attar, A.M., 2011. Protective effect of Avicennia alba leaves extract on gastric mucosal damage induced by ethanol. Res. J. Med. Plant, 5: 477-490.
4. Alsaif, M.A., 2004. Inhibition of gastric mucosal damage by boric acid pretreatment in rats. J. Medical Sci, 4: 102-109.
5. Bandyopadhyay, D., K. Biswas, U. Bandyopadhyay, R.J. Reiter and R.K. Banerjee, 2000. Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical. J. Pineal Res, 29: 143-151.
6. Basivireddy, J, M. Jacob, P. Ramamoorthy, A.B. Pulimood and K.A. Balasubramanian, 2003. Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. Biochem. Pharmacol, 65: 683-695.
7. Bayir, Y, F. Odabasoglu, A. Cakir, A. Asian, H. Svleyman, M. Hahci and C. Kazaz, 2006. The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid. Phytomedicine, 13: 584-590.
8. Biewenga, G.P, G.R.M.M. Haenen and A. Bast, 1997. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol, 29: 315-331.
9. Bihci, M, C. Ozturk, H. Dursun, F. Albayrak and M.B. Saglam et al, 2009. Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters. Dig. Dis. Sci, 54: 1868-1875.
10. Bilska, A. and L. Wlodek, 2005. Lipoic acid-the drug of the future. Pharmacol. Rep, 57: 570-577.
11. Chng, H.T, L.S. New, A.H. Neo, C.W. Goh, E.R. Browne and E.C.Y. Chan, 2009. Distribution study of orally administered lipoic acid in rat brain tissues. Brain Res, 1251: 80-86.
12. Cicchillo, R.M, D.F. I wig, A.D. Jones, N.M. Nesbitt and C. Baleanu-Gogonea et al, 2004. Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid. Biochemistry, 43: 6378-6386.
13. Copeman, M, J. Matuz, A.J. Leonard, J.P. Pearson, P.W. Dettmar and A. Allen, 1994. The g astro duodenal mucus barrier and its role in protection against luminal pepsins: The effect of 16, 16 dimethyl prostaglandin E2, carbolpolyacrylate, sucrafate and bismuth salicylate. J. Gastroenterol. Hepatol, 9: 55-59.
14. Corne, S.J, S.M. Morrissey and R.J. Woods, 1974. A method for the quantitative estimation of gastric barrier mucus. J. Physiol, 242: 116-117.
15. Demircan, B, G. Celik, H. Suleyman and F. Akay, 2005. Effects of indomethacin, celecoxib and meloxican on glutathione, malondialdehyde4 and myeloperoxidase in rat gastric tissue. Pain Clin., 17: 383-388.
16. Dengiz, O.G., F. Odabasoglu, Z. Halici, H. Suleyman, E. Cadirci and Y. Bayir, 2007. Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. Arch. Pharm. Res., 30: 1426-1434.
17. Draper, H.H. and M. Hadley, 1990. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol., 186: 421-431.
18. Durak, I., O. Canbolat, M. Kavutcu, H.S. Ozturk and Z. Yurtaslani, 1996. Activities of total, cytoplasmic and mitochondrial superoxide dismutase enzyme in sera and pleural fluids from patients with lung cancer. J. Clin. Lab. Anal., 10: 17-20.
19. El-Missiry, A.M., H.I. El-Sayed and LA. Othman, 2001. Protection by metal complexes with SOD-mimetic activity against oxidative gastric injury induced by indometacin and ethanol in rats. Ann. Clin. Biochem., 38: 694-700.
20. Ellman, G.L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82: 70-77.
21. George, S., A. Sathiamoorthy and S.S. Sathimoorthy, 1999. Effect of alpha tocopherol on gastric ulcers induced by pylorus ligation in rats. Indian J. Pharmacol., 31: 431-433.
22. Gill, N.S., J. Bajwa, P. Sharma, K. Dhiman and S. Sood et al., 2011. Evaluation of antioxidant and antiulcer activity of traditionally consumed Cucumis melo seeds. J. Pharmacol. Toxicol, 6: 82-89.
23. Goel, R.K. and S.K. Bhattacharya, 1991. Gastroduodenal mucosal defense and protective agents. Indian J. Exp. Biol, 29: 701-714.
24. Grant, H.W, K.R. Palmer, R.W. Kelley, N.H. Wislon and J.J. Misewicz, 1988. Dietary hnoleic acid, gastric acid and prostaglandin secretion. Gastroenterology, 94: 955-959.
25. Guidobono, F, F. Pagani, C. Ticozzi, V. Sibilia, A. Pecile and C. Netti, 1997. Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats. Br. J. Pharmacol, 120: 581-586.
26. Gul, M, F.Z. Kutay, S. Temocin and O. Hanninen, 2000. Cellular and clinical implications of glutathione. Indian J. Exp. Biol, 38: 625-634.
27. Huang, J.Q, S. Sridhar and R.H. Hunt, 2002. Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic-ulcer disease: A meta-analysis. Lancet, 359: 14-22.
28. Jiang, G.L, W.B. Im, Y. Donde and L.A. Wheeler, 2009. EP4 agonist alleviates indomethacin induced and promotes chronic gastric ulcer healing. World J. Gastroenterol, 15: 5149-5156.
29. Leonard, A, M.T. Droy-Lefaix and A. Allen, 1994. Pepsin hydrolysis of the adherent mucus barrier and subsequent gastric mucosal damage in rat: Effect of diosmectite and 16, 16-dimethyl prostaglandin E2. Gastroenterol. Clin. Biol, 18: 609-616.
30. Maritim, A.C, R.A. Sanders and J.B. Watkins, 2003. Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J. Nutr. Biochem, 14: 288-294.
31. Marnett, L.J. and C.L. Wilcox, 1977. Stimulation of prostaglandin biosynthesis by lipoic acid. Biochem. Biophys. Acta, 487: 222-230.
32. Naito, Y, T. Yoshikawa, N. Yoshida and M. Kondo, 1998. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Dig. Dis. Sci, 43: 30S-34S.
33. Odabasoglu, F, Z. Halici, A. Cakir, M. Halici and H. Aygun et al., 2008. Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats. Eur. J. Pharmacol, 591: 300-306.
34. Ogle, C.W., C.H. Cho, M.C. Tong and M.W.L. Koo, 1985. The influence of verapamil on the gastric effects of stress in rats. Eur. J. Pharmacol, 112: 399-404.
35. Olaleye, S.B. and K.O. Ajeigbe, 2009. Attenuation of experimental gastric ulceration by sulfadoxine-pyrimethamine in albino rats. J. Med. Sci, 9: 87-92.
36. Oluwole, F.S. and M.T. Saka, 2007. Effect of thyroid hormone on gastric mucus secretion around indomethacin induced gastric ulcers in rats. J. Medical Sci, 7: 678-681.
37. Packer, L, E.H. Witt and H.J. Tritschler, 1995. Alpha-lipoic acid as a biological antioxidant. Free Radic. Biol. Med, 19: 227-250.
38. Repetto, M.G. and S.F. Llesuy, 2002. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz. J. Med. Biol. Res, 35: 523-534.
39. Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan, 2004. Gastroprotective and anti-secretory effect of Nigella sativa seed and its extracts in indomethacin-treated rats. Pak. J. Biol. Sci, 7: 995-1000.
40. Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan, 2005. Protective effects of Polygonum viviparum L. root and its extracts against lipid-peroxidation induced by indomethacin in rats. Int. J. Pharmacol, 1: 324-328.
41. Ross, M.H, E.J. Reith and L.J. Romrell, 1989. Histology A Text and Atlas. Williams andWilkms, Baltimore, USA.
42. Shay, P.K, R.F. Moreau, E.J. Smith and T.M. Hagen, 2008. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo. Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life, 60: 362-367.
43. Smith, W.L. and L.J. Marnett, 1991. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochim. Biophys. Acta, 1083: 1-17.
44. Song, K.H, W.J. Lee, J.M. Koh, H.S. Kim and J.Y. Youn et al., 2004. Alpha-lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem. Biophys. Res. Commun, 326: 197-202.
45. Suh, J.H, R. Moreau, S.H. Heath and T.M. Hagen, 2005. Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Redox. Rep, 10: 52-60.
46. Suh, J.H, H. Wang, R.M. Liu, J. Liu and T.M. Hagen, 2004. (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch. Biochem. Biophys, 423: 126-135.
47. Takeuchi, K, A. Tanaka, Y. Hayashi and A. Yokota, 2005. COX inhibition and NSAID-mduced gastric damage-roles in various pathogenic events. Curr. Top. Med. Chem, 5: 475-486.
48. Winiarska, K, D. Malinska, K. Szymanski, M. Dudziak and J. Bryla, 2008. Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetes rabbits. Biochimie, 90: 450-459.