Chloroquine phosphate potentiates indomethacin and HCl/ethanol-induced gastric mucosa injury in rats

International Journal of Pharmacology

Volumn 4, Issue 6, 2008, Pages 482-486

  Ajeigbe, Kazeem Olasunkanmi ^a   Nwobodo, E O ^b   Oyesola, T O ^a   Ofusori, D A ^a   Olaleye, S B ^c  

^a IGBINEDION UNIVERSITY   (Nigeria)

^b NNAMDI AZIKIWE UNIVERSITY   (Nigeria)

^c UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Catalase; Chloroquine phosphate; Oxidative stress; Thiobarbituric acid reactive; Ulcer

Indexed keywords

ALCOHOL; CATALASE; CHLORIDE; CHLOROQUINE; INDOMETACIN; PROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLORIMETRY; CONTROLLED STUDY; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; RAT; STOMACH ACID SECRETION; STOMACH JUICE; STOMACH MUCOSA INJURY; STOMACH MUCUS; STOMACH PH; TISSUE HOMOGENATE;

EID: 65849296554     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.482.486     Document Type: Article

References (30)

1. Abiose, A.K., M. Grossman, O. Tangphao, B.B. Hoffman and T.F. Blaschke, 1997. Chloroquine-induced venodilation in human hand veins. Clin. Pharmacol. Ther., 61 677-683.
2. Ahmed, M.H. and M.M. Osman, 2007. Why does chloroquine impair renal function? Chloroquine may modulate the renal tubular response to vasopressin either directly by inhibiting cyclic AMP generation, or indirectly via nitric oxide. Med. Hypotheses, 68: 140-143.
3. Ajayi, A.A., A. Oluokun, O. Sofowora, A. Akinleye and A.T. Ajayi, 1989. Epidemiology of antimalaria induced pruritus in Africans. Eur. J. Clin. Pharmacol., 37: 539-540.
4. Anadan, R., R.D. Rekha, N. Saravanan and T. Devaki, 1999. Protective effects of Picrorrhiza kurroa against HC1/ethanol induced ulceration in rats. Fitoterapia, 70: 498-503.
5. Christopher, J.S., Z. Yan, M. Carol, M. Koboldt and S.Z. Ben et al., 1998. Pharmacological analysis of cyclo-oxygenase 1 in inflammation. Proc. Natl. Acad Sci. USA., 95: 13313-13318.
6. Corne, S.J., S.M. Morrissey and R.J. Woods, 1974. A method for the quantitative estimation of gastric barrier mucus. J. Physiol., 242: 116-117.
7. Desai, J.K., R.K. Goal and N.S. Parmar, 1997. Pathogenesis of peptic ulcer disease and current trends in therapy. Indian J. Physiol. Pharmacol., 41: 3-15.
8. El-Sayed, N.K., L.R. Abdel-Khalek and K.M. Gaafar, 1998. Profiles of serum proteins and free amino acids associated with chloroquine retinopathy. Acta Ophthalmol. Scand., 76: 422-430.
9. Etimita, Y.O., S.A. Bisong, A.B. Antai, C.O. Nku and E.E. Osim, 2005. Preliminary studies on effect of Chloroquine phosphate on gastric acid secretion in rats. Nigeria J. Physiol. Sci., 20: 69-73.
10. Gaafar, K.M.L.R. Abdel-Khalek and N.K. El-Sayed, 1995. Lipidemic effect as a manifestation of chloroquine retinotoxicity. Arzneimittelforschung, 45: 1231-1235.
11. Gustafsson, L.I., O. Walker, G. Alvan, B. Beermann and F. Esterverz et al., 1983. Disposition of chloroquine in man after single intravenous and oral dose. Br. J. Clin. Pharmacol., 15: 471-479.
12. Ibironke, G.F., S.B. Olaleye, O. Balogun and D.A. Aremu, 1997. Effects of diets containing seeds of Garcinia kola (Heckel) on gastric acidity and experimental ulceration in rats. Phytotherapy Res., 11: 312-313.
13. Kapui, Z., K. Boer, I. Rozsa, G.Y. Blasko and I. Hermecz, 1993. Investigations of indomethacin-induced gastric ulcer in rats. Arzneium-Forsch/Drug Res., 43: 767-771.
14. Lowry, O.H., N.J. Rosebrough, A.C. Larr and R.I. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
15. Ma, L., W.P. Wang, J.Y. Chow, S.T. Yuen and C.H. Cho, 2000. Reduction of EDF is associated with the delay of ulcer healing by cigarette smoking. Am. J. Physiol. Gastrointest. Liver Physiol., 278: G10-G17.
16. Mahon, G.J., H.R. Anderson and T.A. Gardiner, 2004. Chloroqume causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy. Curr. Eye Res., 28: 277-284.
17. Masuda, E., S. Kawano, K. Nagano, S. Tsuji and Y. Takei et al., 1995. Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats. Gastroenterology, 108: 58-64.
18. Mawdsley, J.E. and S. Rampton, 2006. The role of psychological stress in inflammatory bowel disease. Neuroimmunomodulation, 13: 327-336.
19. Olaleye, S.B., O.A. Adaramoye, P.P. Erigbali and O.S. Adeniyi, 2007. Lead increase oxidative stress in the gastric mucosa of HC1/Ethanol exposed rats. World J. Gastroenterol., 13: 5121-5126.
20. Olliaro, P.L. and W.R.J. Taylor, 2003. Antimalarial compounds: From bench to bedside. J. Exp. Biol., 206: 3753-3759.
21. Onigbogi, O., A.A. Ajayi and O.E. Ukponwan, 2000. Mechanism of chloroquine induced body-scratching behaviour in rats, evidence of involvement of endogenous opioid peptides. Pharmacol. Biochem. Behav., 65: 333-337.
22. Rao, V.S., F.A. Santos, T.T. Sobrierra, M.F. Souza and C.L. Melo et al., 1997. Investigations on the gastroprotective and antidiarrhoeal properties of Ternatin, a tetramethoxy flavones from Egletes viscose. Planta Medica, 63: 146-149.
23. Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan, 2004. Gastroprotective and antisecretary effect of Nigella sativa and its extracts in indomethacin treated rats. Pak. J. Biol. Sci., 7: 995-1000.
24. Rostom, A., G. Wells, P. Tugwell, V. Welch, C. Dube and J. McGowon, 2000. Prevention of chronic NSAID induced upper gastrointestinal toxicity. Cochrane Database Syst. Rev.
25. Schmassmann, A., 1998. Mechanisms of ulcer healing and effects of nonsteroidal anti-inflammatory drugs. Am. J. Med., 104: 43S-51S.
26. Sinha, A.K., 1972. Colorimetric assay of catalase. Anal. Biochem., 47: 389-394.
27. Tanaka, T., Y. Morioka and U. Gebert, 1993. Effect of a noval Xanthenes derivative on experimental ulcers in rats. Arzneim-Forsch/Drug Res., 43: 558-562.
28. Walls, R., K.S. Kumar and P. Hochstein, 1976. Aging human erythrocytes, Differential sensitivity of young and old erythrocytes to hemolysis induced by peroxide in the presence of thyroxine. Arch. Biochem. Biophys., 174: 463-468.
29. White, N.J., 2004. Antimalaria drug resistance. J. Clin. Investigat., 113: 1084-1092.
30. Yamaguchi, N. and T. Kakizoe, 2001. Synergistic interaction between Helicobacter pylori and gastric cancer. Lancet Oncol., 2: 88-94.