Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters

Digestive Diseases and Sciences

Volumn 54, Issue 9, 2009, Pages 1868-1875

  Bilici, Mehmet ^a   Ozturk, Cengiz ^b   Dursun, Hakan ^a   Albayrak, Fatih ^a   Saglam, Mustafa Bahadir ^a   Uyanik, Abdullah ^a   Gulaboglu, Mine ^c   Tekin, Salim Basol ^a  

^a ATATURK UNIVERSITY   (Turkey)

^b Erzurum Numune Hastanesi   (Turkey)

^c ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Antioxidants; Indomethacin; Mirtazapine; Rat; Ulcer

Indexed keywords

CATALASE; FAMOTIDINE; GLUTATHIONE; INDOMETACIN; MALONALDEHYDE; MIRTAZAPINE; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; ANTIULCER AGENT; DRUG DERIVATIVE; MIANSERIN; NONSTEROID ANTIINFLAMMATORY AGENT; OXIDOREDUCTASE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STOMACH PROTECTION; STOMACH ULCER; TREATMENT RESPONSE; ANIMAL; CHEMICALLY INDUCED DISORDER; ENZYMOLOGY; METABOLISM; OXIDATIVE STRESS; STOMACH; WISTAR RAT;

EID: 68249161278     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0560-z     Document Type: Article

References (57)

1. WA Hooderwerf PJ Pasricha 2006
2. Feldman F, Friedman LS, Sleisenger MH. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. Philadelphia: WB Saunders Co.; 2002:615.
3. M Guldahl 1977 The effect of trimipramine (Surmontil r) on masked depression in patients with duodenal ulcer. A double-blind study Scand J Gastroenterol Suppl 43 27 31
4. KW Olden 2005 The use of antidepressants in functional gastrointestinal disorders: new uses for old drugs CNS Spectr 10 891 896
5. DE Hernandez BG Xue 1989 Imipramine prevents stress gastric glandular lesions in rats Neurosci Lett 103 209 212 10.1016/0304-3940(89)90577-6 (Pubitemid 19201254)
6. A Tobe Y Yoshida M Egawa 1983 The influence of 2-(4-methylaminobutoxy) diphenylmethane hydrochloride (MCI-2016) on gastric ulcer and gastric acid secretion Arzneimittelforschung 33 397 400
7. WP Paré E Redei 1993 Depressive behavior and stress ulcer in Wistar Kyoto rats J Physiol (Paris) 87 229 238 10.1016/0928-4257(93)90010-Q (Pubitemid 23316861)
8. JN Nobrega NI Wiener 1983 Effects of catecholamine agonist and antagonist drugs on acute stomach ulceration induced by medial hypothalamic lesions in rats Pharmacol Biochem Behav 19 831 838 10.1016/0091-3057(83)90089-8 (Pubitemid 14248690)
9. J Hano J Bugajski C Wantuch 1978 The effect of drugs interfering with biogenic amines metabolism on gastric secretion and reserpine-ulcers development in rats Pol J Pharmacol Pharm 30 501 511
10. TE Ruud GS Hoff M Tonder O Holter 1982 Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study J Clin Psychiatry 43 56 60
11. RK Shrivastava H Siegal R Lawlor BK Shah G Dayican 1985 Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine Clin Ther 7 319 326
12. U Becker P Faurschou J Jensen PB Pedersen PJ Ranløv 1983 Efficacy of trimipramine and cimetidine in the treatment of duodenal ulcer Scand J Gastroenterol 18 137 143
13. M Jainu CS Devi 2006 Gastroprotective action of Cissus quadrangularis extract against NSAID-induced gastric ulcer: role of proinflammatory cytokines and oxidative damage Chem Biol Interact 161 262 270 10.1016/j.cbi.2006.04.011 (Pubitemid 44080158)
14. A Shirwaikar HN Ram P Mohapatra 2006 Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation Indian J Exp Biol 44 474 480
15. D Bilici H Suleyman ZN Banoglu A Kiziltunc B Avci A Ciftcioglu S Bilici 2002 Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect Dig Dis Sci 47 856 861 10.1023/A:1014764705864 (Pubitemid 34286884)
16. GO Dengiz F Odabasoglu Z Halici H Suleyman E Cadirci Y Bayir 2007 Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats Arch Pharm Res 30 1426 1434
17. F Guidobono F Pagani C Ticozzi V Sibilia A Pecile C Netti 1997 Protection by amylin of gastric erosions induced by indomethacin or ethanol in rats Br J Pharmacol 120 581 586 10.1038/sj.bjp.0700941 (Pubitemid 27089404)
18. J Sedlak RH Lindsay 1968 Estimation of total, protein-bound, and nonprotein sulfhydryls groups in tissue with Ellman's reagent Anal Biochem 25 192 205 10.1016/0003-2697(68)90092-4
19. H Aebi 1984 Catalase Methods Enzymol 105 121 126 10.1016/S0076-6879(84) 05016-3
20. Y Sun WO Larry L Ying 1988 A simple method for clinical assay of superoxide dismutase Clin Chem 34 3 497 500
21. PP Bradley DA Priebat RD Christensen G Rothstein 1982 Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker J Invest Dermatol 78 206 209 10.1111/1523-1747.ep12506462
22. H Ohkawa N Ohishi K Yagi 1979 Assay for lipid peroxide in animal tissues by thiobarbutiric acid reaction Anal Biochem 95 351 358 10.1016/0003-2697(79) 90738-3 (Pubitemid 9194347)
23. H Suleyman F Akcay K Altinkaynak 2002 The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats Pharmacol Res 45 155 158 10.1006/phrs.2001.0933 (Pubitemid 35425655)
24. H Kataoka Y Horie R Koyama S Nakatsugi M Furukawa 2000 Interaction between NSAIDs and steroid in rat stomach: safety of nimesulide as a preferential COX-2 inhibitor in the stomach Dig Dis Sci 45 1366 1375 10.1023/A:1005560104847 (Pubitemid 30639068)
25. A Benelli A DePol R PoggIolI E CavazzutI R Arletti R Bertolini V Vergoni 2000 l-sulpiride, at antidepressant dosage, prevents conditioned-fear stress-induced gastric lesions in rats Pharmacol Res 42 157 160 10.1006/phrs.2000.0668 (Pubitemid 30658944)
26. T Sen CA Abdulsalam S Pal S Sen S Karmakar KS Saravanan AK ChaudhurI 2002 Effect of amitriptyline on gastric ulserasyon Blackwell Science Fundam Clin Pharmacol 16 311 315 10.1046/j.1472-8206.2002.00092.x (Pubitemid 35205342)
27. N Stollman CD Metz 2005 Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients J Crit Care 20 35 45 10.1016/j.jcrc.2004.10.003 (Pubitemid 40602222)
28. TH De Boer F Nefkens A Van Heivoirt 1994 The α2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo Eur J Pharmacol 253 R5 6 10.1016/0014-2999(94)90778-1
29. TH De Boer G Maura M Raiteri CJ de Vos J Wieringa RM Pinder 1988 Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin. Org 3770 and its enantiomers Neuropharmacology 7 399 408 10.1016/0028-3908(88)90149-9 (Pubitemid 18143829)
30. N Haddjeri P Blier C de Montigny 1997 Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission Naunyn Schmiedebergs Arch Pharmacol 355 20 29 10.1007/PL00004913 (Pubitemid 27008448)
31. H Suleyman Z Halici E Cadirci A Hacimuftuoglu S Keles F Gocer 2007 Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats Naunyn Schmiedebergs Arch Pharmacol 375 189 198 10.1007/s00210-007-0151-0 (Pubitemid 46525449)
32. P Del Soldato 1986 Gastric lesion-preventing or -potentiating activity of clonidine in rats Jpn J Pharmacol 41 257 259 10.1254/jjp.41.257
33. JF DiJoseph JR Eash GN Mir 2002 Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity Pharmacol Exp Ther 241 97 102
34. J Kunchandy S Khanna SK Kulkarni 1985 Effect of alpha2 agonists clonidine, guanfacine and B HT 920 on gastric acid secretion and ulcers in rats Arch Int Pharmacodyn Ther 275 123 138
35. K Fulop Z Zadori AZ Ronai K Gyires 2005 Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence Eur J Pharmacol 528 150 157 10.1016/j.ejphar.2005.10.025 (Pubitemid 41773666)
36. K Gyires K Mullner S Furst AZ Ronai 2000 Alpha-2 adrenergic and opioid receptor-mediated gastroprotection J Physiol (Paris) 94 117 121 10.1016/S0928-4257(00)00151-0 (Pubitemid 30202863)
37. JD Lewis BL Strom AR Localio DC Metz JT Farrar RM Weinrieb L Nessel C Brensinger SE Kimmel 2008 Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity Pharmacoepidemiol Drug Saf 17 328 335 10.1002/pds.1546 (Pubitemid 351566348)
38. de Abajo FJ, Rodríguez LA, Montero D. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study. BMJ. 1999;319:1106-1109.
39. A Frazer 1994 Antidepressant drugs Depression 2 1 19 10.1002/depr. 3050020102
40. MV Rudorfer HK Manji WZ Potter 1994 Comparative tolerability profiles of the newer versus older antidepressants Drug Saf 10 18 46
41. Dubovsky SL. Beyond the serotonin reuptakeinhibitors: rationales for the development of new serotonergic agents. J Clin Psychiatry. 1994;55(Suppl):34-44.
42. MY Agargun S Ebrinc 1998 Mirtazapin: bir gözden geçirme Klinik Psikofarmakoloji Bulteni 8 59 68 In Turkish
43. Y Naito T Yoshikawa N Yoshida M Kondo 1998 Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury Dig Dis Sci 43 30S 4S
44. Y Naito T Yoshikawa T Kaneko S Iinuma S Nishimura S Takahashi M Kondo 1993 Role of oxygen radicals in indomethacin-induced gastric mucosal microvascular injury in rats J Clin Gastroenterol 17 1 99 103 10.1097/00004836-199312001-00018
45. M Hirota M Inoue Y Ando K Hirayama Y Morino K Sakamoto K Mori M Akagi 1989 Inhibition of stress-induced gastric injury in the rat by glutathione Gastroenterology 97 853 859
46. A Robert D Eberle N Kaplowitz 1984 Role of glutathione in gastric mucosal cytoprotection Am J Physiol 247 G296 304
47. MW Walker MT Kinter RJ Roberts DR Spitz 1995 Nitric oxide-induced cytotoxicity: involvement of cellular resistance to oxidative stress and the role of glutathione in protection Pediatr Res 37 41 49 10.1203/00006450- 199501000-00010
48. J Basivireddy M Jacob P Ramamoorthy AB Pulimood KA Balasubramanian 2003 Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes Biochem Pharmacol 65 683 695 10.1016/S0006-2952(02)01616-7 (Pubitemid 36144256)
49. KH Cheeseman TF Slater 1993 An introduction to free radical biochemistry Br Med Bull 49 481 493
50. F Odabasoglu OI Kufrevioglu 2001 Effects of the treating with pesticides and plant hormones on catalase, peroxidase, and polyphenol oxidase activities in spinach (Spinacia oleraceae L.) Bull Pure Appl Sci 20 79 88
51. B Djahanguiri 1969 The production of acute gastric ulceration by indomethacin in the rat Scand J Gastroenterol 4 265 267
52. BJ Whittle 2004 Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors Eur J Pharmacol 500 427 439 10.1016/j.ejphar.2004.07.042 (Pubitemid 39304025)
53. C Bombardier 2002 An evidence-based evaluation of the gastrointestinal safety of coxibs Am J Cardiol 89 3D 9D 10.1016/S0002-9149(02)02231-2
54. F Karmeli E Okon D Rachmilewitz 1996 Sulphydryl blocker induced gastric damage is ameliorated by scavenging of free radicals Gut 38 826 831 10.1136/gut.38.6.826
55. S Borovic A Meinitzer I Loncaric S Sabolovic R Wildburger M Tillian P Martinac I Stipancic N Zarkovic 2000 Monitoring influence of surgical stress on formation of hydroxyl radicals in tumor bearing rats by measuring salicylic acid metabolites Electron J Int Fed Clin Chem Lab Med 12 1 4
56. DU Talas A Nayci G Polat S Atis U Comelekoglu OT Bagdatoglu C Bagdatoglu 2002 The effects of dexamethasone on lipid peroxidation and nitric oxide levels on the healing of tracheal anastomoses: an experimental study in rats Pharmacol Res 46 265 271 10.1016/S1043-6618(02)00130-5 (Pubitemid 35300766)
57. B Demircan G Celik H Suleyman F Akcay 2005 Effect of indomethacin, celecoxib and meloxicam on glutathione; malondialdehyde and myeloperoxidase in rat gastric tissue Pain Clin 17 383 388 10.1163/156856905774482797 (Pubitemid 41809479)