Premature activation of the paramyxovirus fusion protein before target cell attachment with corruption of the viral fusion machinery

Journal of Biological Chemistry

Volumn 286, Issue 44, 2011, Pages 37945-37954

  Farzan, Shohreh F ^a   Palermo, Laura M ^a   Yokoyama, Christine C ^a   Orefice, Gianmarco ^a   Fornabaio, Micaela ^b   Sarkar, Aurijit ^b   Kellogg, Glen E ^b   Greengard, Olga ^a,c   Porotto, Matteo ^a   Moscona, Anne ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL AGENTS; CELLULAR MEMBRANES; CONFORMATIONAL CHANGE; ENVELOPE GLYCOPROTEINS; FUSION PROCESS; FUSION PROTEINS; HOST CELLS; NEURAMINIDASE; NEW STRATEGY; RECEPTOR BINDING; SMALL MOLECULES; TARGET CELLS;

CELL MEMBRANES; CYTOLOGY; MACHINERY;

VIRUSES;

4 [BIS(4 HYDROXY 2 METHYL 6 OXO 1,6 DIHYDROPIRIDIMIN 5 YL)METHYL]BENZOIC ACID; 4 HYDROXY N[4 HYDROXY 3 (1H 1,2,4 TRIAZOL 3 YLMETHYL)PHENYL]BENZENESULFONAMIDE; ANTIVIRUS AGENT; CSC 11; CSC 5; CSC 7; HN PROTEIN; N [4 HYDROXY 3 (1H 1,2,4 TRIAZOL 3 YLMETHYL)PHENYL]THIOPHENE 2 SULFONAMIDE; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; ZANAMIVIR;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; HOST CELL; HUMAN; HUMAN CELL; MEMBRANE FUSION; NONHUMAN; PARAMYXOVIRUS; PRIORITY JOURNAL; RECEPTOR BINDING; TARGET CELL; VIRION; VIRUS ACTIVATION; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS INFECTION;

ADSORPTION; ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HN PROTEIN; HUMANS; MEMBRANE FUSION; MODELS, CHEMICAL; NEURAMINIDASE; PROTEIN CONFORMATION; VIRAL FUSION PROTEINS; VIRAL PROTEINS;

HUMAN PARAINFLUENZA VIRUS 3; PARAMYXOVIRIDAE;

EID: 80055078313     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.256248     Document Type: Article

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