Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase

Nature Structural Biology

Volumn 7, Issue 11, 2000, Pages 1068-1074

  Crennell, Susan ^a   Takimoto, Toru ^b   Portner, Allen ^b   Taylor, Garry ^a,c  

^a University of Bath   (United Kingdom)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; HEMAGGLUTININ; MEMBRANE ANTIGEN; SIALIDASE; VIRUS ENZYME;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; HYDROLYSIS; MUTAGENESIS; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PARAMYXOVIRUS; PRIORITY JOURNAL; RECEPTOR BINDING; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HN PROTEIN; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LACTOSE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; N-ACETYLNEURAMINIC ACID; NEWCASTLE DISEASE VIRUS; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, VIRUS; SEQUENCE ALIGNMENT; SIALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033762350     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/81002     Document Type: Article

References (46)

1. The role of viral glycoproteins in adsorption, penetration and pathogenicity of viruses
2. Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and sendai virus important for membrane fusion
3. Localization of a domain on the paramyxovirus attachment protein required for the promotion of cellular fusion by its homologous fusion protein spike
4. The attachment function of the Newcastle-disease virus hemagglutinin-neuraminidase protein can be separated from fusion promotion by mutation
5. Functional interaction of paramyxovirus glycoproteins: Identification of a domain in sendai virus HN which promotes cell fusion
6. A single amino-acid change enhances the fusion promotion activity of human parainfluenza virus type-1 hemagglutinin-neuraminidase glycoprotein
7. Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type-2 important for promoting ceil fusion
8. Crystal structures of influenza-virus hemagglutinin in complex with high-affinity receptor analogs
9. Rational design of potent sialidase-based inhibitors of influenza virus replication
10. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
11. Protein-protein interactions within paramyxoviruses identified by native disulfide binding or reversible chemical cross-linking
12. Structure, function, and intracellular processing of paramyxovirus membrane proteins
13. Reducing agent-sensitive dimerization of the hemagglutinin-neuraminidase giycoprotein of Newcastle-disease virus correlates with the presence of cysteine at residue 123
14. The role of the individual cysteine residues in the formation of the mature, antigenic HN protein of Newcastle disease virus
15. Crystallization of Newcastle disease virus hemagglutinin-neuraminidase giycoprotein
16. Sialidases: Structures, biological significance and therapeutic potential
17. Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase
18. Sequence and structure alignment of paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin
19. Determination of the disulfide bond arrangement of Newcastle disease virus hemagglutinin neuraminidase: Correlation with a beta-sheet propeller structural fold predicted for paramyxoviridae attachment proteins
20. The role of individual oligosaccharide chains in the activities of the HN glycoprotein of Newcastle-disease virus
21. Influenza-B virus neuraminidase can synthesize its own inhibitor
22. Molecular modeling studies on ligand-binding to sialidase from influenza-virus and the mechanism of catalysis
23. Ionic dependence of the sialidase activity of hemagglutinin-neuraminidase glycoprotein in Newcastle-disease virus membrane
24. Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza-virus
25. The structure of the complex between influenza-virus neuraminidase and sialic-acid, the viral receptor
26. Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases
27. Site-directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin-neuraminidase glycoprotein: Effects on antigenic structure and function
28. A single amino-acid substitution in the hemagglutinin-neuraminidase of Newcastle-disease virus results in a protein-deficient in both functions
29. Mutations in the Newcastle disease virus hemagglutinin-neuraminidase protein that interfere with its ability to interact with the homologous F protein in the promotion of fusion
30. Identification of biological activities of paramyxovirus giycoproteins. Activation of cell fusion, hemolysis, and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus
31. Inhibition of the neuraminidase of paramyxoviruses by halide-ions: A possible means of modulating the two activities of the HN protein
32. Localization of functional sites on the hemagglutinin neuraminidase glycoprotein of sendai virus by sequence-analysis of antigenic and temperature-sensitive mutants
33. Structure of the influenza-virus hemagglutinin complexed with its receptor, sialic-acid
34. Mapping of three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle-disease virus
35. Functional and neutralization profile of seven overlapping antigenic sites on the HN giycoprotein of Newcastle-disease virus: Monoclonal antibodies to some sites prevent viral attachment
36. Identification of amino-acid residues important to the neuraminidase activity of the HN glycoprotein of Newcastle-disease virus
37. On the inhibition mechanism of the sialidase activity from Newcastle disease virus
38. Modulation of the neuraminidase activity of HN protein from Newcastle disease virus by substrate binding and conformational change: Kinetic and thermal denaturation studies
39. Cooperative neuraminidase activity in a paramyxovirus
40. Mutations in the Newcastle disease virus hemagglutinin-neuraminidase protein that interfere with its ability to interact with the homologous F protein in the promotion of fusion
41. CCP4 suite: Programs for protein crystallography
42. Improved methods for the building of protein models in electron density maps and the location of errors in these models
43. Crystallography and NMR system: A new software suite for macromolecular structure determination
44. Processing of X-ray diffraction data collected in oscillation mode