Inhibition of parainfluenza virus type 3 and newcastle disease virus hemagglutinin-neuraminidase receptor binding: Effect of receptor avidity and steric hindrance at the inhibitor binding sites

Journal of Virology

Volumn 78, Issue 24, 2004, Pages 13911-13919

  Porotto, Matteo ^a   Murrell, Matthew ^a   Greengard, Olga ^a   Lawrence, Michael C ^b   McKimm Breschkin, Jennifer L ^b   Moscona, Anne ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HN PROTEIN; SIALIDASE INHIBITOR; ZANAMIVIR;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CATALYSIS; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MUTATION; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PARAINFLUENZA VIRUS 3; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR SENSITIVITY; STEREOSPECIFICITY; STRUCTURE ANALYSIS; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; GUANIDINES; HN PROTEIN; HUMANS; MODELS, MOLECULAR; MUTATION; NEURAMINIDASE; NEWCASTLE DISEASE VIRUS; PARAINFLUENZA VIRUS 3, HUMAN; PYRANS; RECEPTORS, VIRUS; SIALIC ACIDS; ZANAMIVIR;

EID: 10044296412     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.24.13911-13919.2004     Document Type: Article

References (25)

1. Herman, H. M., J. Westbrook, Z. Feng, G. Gilliland, T. N. Bhat, H. Weissig, I. N. Shindyalov, and P. E. Bourne. 2000. The Protein Data Bank. Nucleic Acids Res. 28:235-242.
2. Blick, T., T. Tiong, A. Sahasrabudhe, J. Varghese, P. Colman, G. Hart, R. Bethell, and J. McKimm-Breschkin. 1995. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Virology 214:475-484.
3. Connaris, H., T. Takimoto, R. Russell, S. Crennell, I. Moustafa, A. Portner, and G. Taylor. 2002. Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: identification of key amino acids involved in cell binding, catalysis, and fusion. J. Virol. 76:1816-1824.
4. Crennell, S., T. Takimoto, A. Portner, and G. Taylor. 2000. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat. Struct. Biol. 7:1068-1074.
5. Dunbrack, R. 2002. Rotamer libraries in the 21st century. Curr. Opin. Struct. Biol. 12:431-440.
6. Greengard, O., N. Poltoratskaia, E. Leikina, J. Zimmerberg, and A. Moscona. 2000. The anti-influenza virus agent 4-GU-DANA (zanamivir) inhibits cell fusion mediated by human parainfluenza virus and influenza virus HA. J. Virol. 74:11108-11114.
7. Kleywegt, G., and T. Jones. 1994. A super position. CCP4/ESF-EACBM News. Protein Crystallogr. 31:9-14.
8. Kraulis, P. 1991. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24:946-950.
9. Lamb, R., and D. Kolakofsky. 1996. Paramyxoviridae: the viruses and their replication, p. 577-604. In B. Fields, D. Knipe, and P. Howley (ed.), Fields virology. Lippincott-Raven, Philadelphia, Pa.
10. Lawrence, M. C., N. A. Borg, V. A. Streltsov, P. A. Pilling, V. C. Epa, J. N. Varghese, J. L. McKimm-Breschkin, and P. M. Colman. 2004. Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III. J. Mol. Biol. 335:1343-1357.
11. Levin Perlman, S., M. Jordan, R. Brossmer, O. Greengard, and A. Moscona. 1999. The use of a quantitative fusion assay to evaluate HN-receptor interaction for human parainfluenza virus type 3. Virology 265:57-65.
12. McKimm-Breschkin. 2000. Resistance of influenza viruses to neuraminidase inhibitors-a review. Antiviral Res. 47:1-17.
13. Meindl, P., G. Bodo, P. Palese, J. Schulman, and H. Tuppy. 1974. Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-AT- acetyl-neuraminic acid. Virology 58:457-463.
14. Merritt, E., and D. Bacon. 1997. Raster3D: photorealistic molecular graphics. Methods Enzymol. 277:505-524.
15. Moscona, A., and R. W. Peluso. 1993. Relative affinity of the human parainfluenza virus 3 hemagglutinin-neuraminidase for sialic acid correlates with virus-induced fusion activity. J. Virol. 67:6463-6468.
16. Murrell, M., O. Greengard, M. Porotto, N. Poltoratskaia, and A. Moscona. 2001. A single amino acid alteration in the human parainfluenza virus type 3 HN confers resistance to both binding inhibition and neuraminidase inhibition by the antiviral agent 4-GU-DANA (zanamivir). J. Virol. 75:6310-6320.
17. Murrell, M., M. Porotto, T. Weber, O. Greengard, and A. Moscona. 2003. Mutations in human parainfluenza virus type 3 HN causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (zanamivir). J. Virol. 77:309-317.
18. Palese, P., and R. W. Compans. 1976. Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action. J. Gen. Virol. 33:159-163.
19. Palese, P., J. L. Schulman, G. Bodo, and P. Meindl. 1974. Inhibition of influenza and parainfluenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacelylneuraminic cid (FANA). Virology 59:490-498.
20. Park, M. S., M. L. Shaw, J. Munoz-Jordan, J. F. Cros, T. Nakaya, N. Bouvier, P. Palese, A. Garcia-Sastre, and C. F. Basler. 2003. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. J. Virol. 77:1501-1511.
21. Plemper, R. K., A. S. Lakdawala, K. M. Gernert, J. P. Snyder, and R. W. Compans. 2003. Structural features of paramyxovirus F protein required for fusion initiation. Biochemistry 42:6645-6655.
22. Porotto, M., O. Greengard, N. Poltoratskaia, M.-A. Horga, and A. Moscona. 2001. Human parainfluenza virus type 3 HN-receptor interaction: the effect of 4-GU-DANA on a neuraminidase-deficient variant. J. Virol. 76:7481-7488.
23. Porotto, M., M. Murrell, O. Greengard, and A. Moscona. 2003. Triggering of human parainfluenza virus 3 fusion protein (F) by the hemagglutinin- neuraminidase (HN): an HN mutation diminishing the rate of F activation and fusion. J. Virol. 77:3647-3654.
24. von Itzstein, M., W.-Y. Wu, G. Kok, M. Pegg, J. Dyason, B. Jin, T. Phan, M. Smythe, H. White, S. Oliver, P. Colman, J. Varghese, D. Ryan, J. Woods, R. Bethell, V. Hotham, J. Cameron, and C. Penn. 1993. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363:418-423.
25. Zaitsev, V., M. von Itzstein, D. Groves, M. Kiefel, T. Takimoto, A. Portner, and G. Taylor. 2004. Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion. J. Virol. 78:3733-3741.