-
1
-
-
0038387389
-
Hit and lead generation: Beyond high-throughput screening
-
DOI 10.1038/nrd1086
-
K.H. Bleicher, H.-J. Bohm, K. Muller, and A.I. Alanine Hit and lead generation: beyond high-throughput screening Nat Rev Drug Discov 2 5 2003 369 378 (Pubitemid 37361707)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.5
, pp. 369-378
-
-
Bleicher, K.H.1
Bohm, H.-J.2
Muller, K.3
Alanine, A.I.4
-
2
-
-
39049189914
-
Anticancer drug discovery and pharmaceutical chemistry: A history
-
M. Braña, and A. Sánchez-Migallón Anticancer drug discovery and pharmaceutical chemistry: a history Clin Transl Oncol 8 10 2006 717 728
-
(2006)
Clin Transl Oncol
, vol.8
, Issue.10
, pp. 717-728
-
-
Braña, M.1
Sánchez-Migallón, A.2
-
3
-
-
0037464449
-
L following diverse apoptogenic stimuli
-
DOI 10.1016/S0014-5793(03)00299-0
-
G. Brumatti, R. Weinlich, C.F. Chehab, M. Yon, and G.P. Amarante-Mendes Comparison of the anti-apoptotic effects of Bcr-Abl, Bcl-2 and Bcl-x(L) following diverse apoptogenic stimuli FEBS Lett 541 1-3 2003 57 63 (Pubitemid 36428917)
-
(2003)
FEBS Letters
, vol.541
, Issue.1-3
, pp. 57-63
-
-
Brumatti, G.1
Weinlich, R.2
Chehab, C.F.3
Yon, M.4
Amarante-Mendes, G.P.5
-
4
-
-
77951810135
-
Design, synthesis and in Vitro evaluation on glucosamine-6P synthase of aromatic analogs of 2-Aminohexitols-6P
-
D.F. Dias, C. Roux, P. Durand, B. Iorga, M.A. Badet-Denisot, and B. Badet Design, synthesis and In Vitro evaluation on glucosamine-6P synthase of aromatic analogs of 2-Aminohexitols-6P J Braz Chem Soc 21 2009 680 685
-
(2009)
J Braz Chem Soc
, vol.21
, pp. 680-685
-
-
Dias, D.F.1
Roux, C.2
Durand, P.3
Iorga, B.4
Badet-Denisot, M.A.5
Badet, B.6
-
5
-
-
28544443984
-
Promoting apoptosis as a strategy for cancer drug discovery
-
DOI 10.1038/nrc1736
-
S.W. Fesik Promoting apoptosis as a strategy for cancer drug discovery Nat Rev Cancer 5 11 2005 876 885 (Pubitemid 41746032)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.11
, pp. 876-885
-
-
Fesik, S.W.1
-
6
-
-
22744437978
-
Apoptosis-based therapies and drug targets
-
DOI 10.1038/sj.cdd.4401556
-
U. Fischer, and K. Schulze-Osthoff Apoptosis-based therapies and drug targets Cell Death Differ 12 Suppl 1 2005 942 961 (Pubitemid 41030608)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.SUPPL. 1
, pp. 942-961
-
-
Fischer, U.1
Schulze-Osthoff, K.2
-
7
-
-
30344462674
-
Modulating apoptosis as a target for effective therapy
-
DOI 10.1016/j.molimm.2005.07.013, PII S0161589005002804
-
A. Fleischer, A. Ghadiri, F. Dessauge, M. Duhamel, M.P. Rebollo, and F. Alvarez-Franco Modulating apoptosis as a target for effective therapy Mol Immunol 43 8 2006 1065 1079 (Pubitemid 43063161)
-
(2006)
Molecular Immunology
, vol.43
, Issue.8
, pp. 1065-1079
-
-
Fleischer, A.1
Ghadiri, A.2
Dessauge, F.3
Duhamel, M.4
Rebollo, M.P.5
Alvarez-Franco, F.6
Rebollo, A.7
-
8
-
-
33845282544
-
The synthesis and configurational stability of differentially protected. beta.-hydroxy-.alpha.-amino aldehydes
-
P. Garner, and J.M. Park The synthesis and configurational stability of differentially protected. beta.-hydroxy-.alpha.-amino aldehydes J Org Chem 52 12 1987 2361 2364
-
(1987)
J Org Chem
, vol.52
, Issue.12
, pp. 2361-2364
-
-
Garner, P.1
Park, J.M.2
-
9
-
-
0020532781
-
Immune responses during human schistosomiasis mansoni. X. Production and standardization of an antigen-induced mitogenic activity by peripheral blood mononuclear cells from treated, but not active cases of schistosomiasis
-
G. Gazzinelli, N. Katz, R.S. Rocha, and D.G. Colley Immune responses during human Schistosomiasis mansoni. X. Production and standardization of an antigen-induced mitogenic activity by peripheral blood mononuclear cells from treated, but not active cases of schistosomiasis J Immunol 130 6 1983 2891 2895 (Pubitemid 13107726)
-
(1983)
Journal of Immunology
, vol.130
, Issue.6
, pp. 2891-2895
-
-
Gazzinelli, G.1
Katz, N.2
Rocha, R.S.3
Colley, D.G.4
-
10
-
-
68049143304
-
Apoptosis and cancer: Mutations within caspase genes
-
S. Ghavami, M. Hashemi, S.R. Ande, B. Yeganeh, W. Xiao, and M. Eshraghi Apoptosis and cancer: mutations within caspase genes J Med Genet 46 2009 497 510
-
(2009)
J Med Genet
, vol.46
, pp. 497-510
-
-
Ghavami, S.1
Hashemi, M.2
Ande, S.R.3
Yeganeh, B.4
Xiao, W.5
Eshraghi, M.6
-
11
-
-
0035060354
-
Is cisplatin-induced cell death always produced by apoptosis?
-
V.M. Gonzalez, M.A. Fuertes, C. Alonso, and J.M. Perez Is cisplatin-induced cell death always produced by apoptosis? Mol Pharmacol 59 4 2001 657 663 (Pubitemid 32273993)
-
(2001)
Molecular Pharmacology
, vol.59
, Issue.4
, pp. 657-663
-
-
Gonzalez, V.M.1
Fuertes, M.A.2
Alonso, C.3
Perez, J.M.4
-
12
-
-
0034641918
-
The biochemistry of apoptosis
-
M.O. Hengartner The biochemistry of apoptosis Nature 407 6805 2000 770 776
-
(2000)
Nature
, vol.407
, Issue.6805
, pp. 770-776
-
-
Hengartner, M.O.1
-
13
-
-
0026698173
-
Apoptosis induced by anticancer drugs
-
J.A. Hickman Apoptosis induced by anticancer drugs Cancer Metastasis Rev 11 2 1992 121 139
-
(1992)
Cancer Metastasis Rev
, vol.11
, Issue.2
, pp. 121-139
-
-
Hickman, J.A.1
-
14
-
-
35449007304
-
Apoptosis: Potential therapeutic targets for new drug discovery
-
DOI 10.2174/092986707781745569
-
S. Jana, and J. Paliwal Apoptosis: potential therapeutic targets for new drug discovery Curr Med Chem 14 22 2007 2369 2379 (Pubitemid 47618045)
-
(2007)
Current Medicinal Chemistry
, vol.14
, Issue.22
, pp. 2369-2379
-
-
Jana, S.1
Paliwal, J.2
-
15
-
-
0142073728
-
L/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry
-
DOI 10.1093/emboj/cdg533
-
Y.M. Janumyan, C.G. Sansam, A. Chattopadhyay, N. Cheng, E.L. Soucie, and L.Z. Penn Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry EMBO J 22 20 2003 5459 5470 (Pubitemid 37279955)
-
(2003)
EMBO Journal
, vol.22
, Issue.20
, pp. 5459-5470
-
-
Janumyan, Y.M.1
Sansam, C.G.2
Chattopadhyay, A.3
Cheng, N.4
Soucie, E.L.5
Penn, L.Z.6
Andrews, D.7
Knudson, C.M.8
Yang, E.9
-
16
-
-
0037053298
-
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c
-
DOI 10.1074/jbc.M110629200
-
N.O. Karpinich, M. Tafani, R.J. Rothman, M.A. Russo, and J.L. Farber The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c J Biol Chem 277 19 2002 16547 16552 (Pubitemid 34967670)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.19
, pp. 16547-16552
-
-
Karpinich, N.O.1
Tafani, M.2
Rothman, R.J.3
Russo, M.A.4
Farber, J.L.5
-
17
-
-
33745809902
-
Hit discovery and hit-to-lead approaches
-
DOI 10.1016/j.drudis.2006.06.016, PII S1359644606002285
-
G.M. Keseru, and G.M. Makara Hit discovery and hit-to-lead approaches Drug Discov Today 11 15-16 2006 741 748 (Pubitemid 44038630)
-
(2006)
Drug Discovery Today
, vol.11
, Issue.15-16
, pp. 741-748
-
-
Keseru, G.M.1
Makara, G.M.2
-
18
-
-
32044472287
-
Effects of dexamethasone and aminophylline on survival of Jurkat and HL-60 cells
-
Y. Kizawa, M. Furuya, K. Saito, T. Masuko, and T. Kusama Effects of dexamethasone and aminophylline on survival of Jurkat and HL-60 cells Biol Pharm Bull 29 2 2006 281 285 (Pubitemid 43200897)
-
(2006)
Biological and Pharmaceutical Bulletin
, vol.29
, Issue.2
, pp. 281-285
-
-
Kizawa, Y.1
Furuya, M.2
Saito, K.3
Masuko, T.4
Kusama, T.5
-
19
-
-
0022515738
-
Increased expression of p53 protein in human leukemia cells
-
H.P. Koeffler, C. Miller, M.A. Nicolson, J. Ranyard, and R.A. Bosselman Increased expression of p53 protein in human leukemia cells Proc Natl Acad Sci 83 11 1986 4035 4039 (Pubitemid 16062417)
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, Issue.11
, pp. 4035-4039
-
-
Koeffler, H.P.1
Miller, C.2
Nicolson, M.A.3
-
20
-
-
0037085048
-
Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel
-
DOI 10.1016/S0006-2952(01)00895-4, PII S0006295201008954
-
G.M. Kolfschoten, T.M. Hulscher, M.C.A. Duyndam, H.M. Pinedo, and E. Boven Variation in the kinetics of caspase-3 activation, Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian cancer cell lines as a response to docetaxel Biochem Pharmacol 63 4 2002 733 743 (Pubitemid 34457705)
-
(2002)
Biochemical Pharmacology
, vol.63
, Issue.4
, pp. 733-743
-
-
Kolfschoten, G.M.1
Hulscher, T.M.2
Duyndam, M.C.A.3
Pinedo, H.M.4
Boven, E.5
-
21
-
-
70349433676
-
Hit finding: Towards [']smarter' approaches
-
T. Langer, R. Hoffmann, S. Bryant, and B. Lesur Hit finding: towards [']smarter' approaches Curr Opin Pharmacol 9 5 2009 589 593
-
(2009)
Curr Opin Pharmacol
, vol.9
, Issue.5
, pp. 589-593
-
-
Langer, T.1
Hoffmann, R.2
Bryant, S.3
Lesur, B.4
-
22
-
-
33750341631
-
Cell-based assays for profiling activity and safety properties of cancer drugs
-
DOI 10.1016/j.vascn.2006.02.014, PII S1056871906000323
-
W. Li, M.S. Lam, A. Birkeland, A. Riffel, L. Montana, and M.E. Sullivan Cell-based assays for profiling activity and safety properties of cancer drugs J Pharmacol Toxicol Methods 54 3 2006 313 319 (Pubitemid 44636258)
-
(2006)
Journal of Pharmacological and Toxicological Methods
, vol.54
, Issue.3
, pp. 313-319
-
-
Li, W.1
Lam, M.S.2
Birkeland, A.3
Riffel, A.4
Montana, L.5
Sullivan, M.E.6
Post, J.M.7
-
23
-
-
20144387787
-
Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-γ ligands induces apoptosis on human myeloid leukemia cells in vitro
-
DOI 10.1093/annonc/mdi077
-
3 ligands induces apoptosis on human myeloid leukemia cells in vitro Ann Oncol 16 2005 455 459 (Pubitemid 40458324)
-
(2005)
Annals of Oncology
, vol.16
, Issue.3
, pp. 455-459
-
-
Liu, J.J.1
Huang, R.W.2
Lin, D.J.3
Peng, J.4
Wu, X.Y.5
Lin, Q.6
Pan, X.L.7
Song, Y.Q.8
Zhang, M.H.9
Hou, M.10
Chen, F.11
-
24
-
-
0033927677
-
Apoptosis and cancer chemotherapy
-
G. Makin, and J.A. Hickman Apoptosis and cancer chemotherapy Cell Tissue Res 301 1 2000 143 152 (Pubitemid 30459861)
-
(2000)
Cell and Tissue Research
, vol.301
, Issue.1
, pp. 143-152
-
-
Makin, G.1
Hickman, J.A.2
-
25
-
-
0028800947
-
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
-
S.J. Martin, C.P. Reutelingsperger, A.J. McGahon, J.A. Rader, R.C. van Schie, and D.M. LaFace Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl J Exp Med 182 5 1995 1545 1556
-
(1995)
J Exp Med
, vol.182
, Issue.5
, pp. 1545-1556
-
-
Martin, S.J.1
Reutelingsperger, C.P.2
McGahon, A.J.3
Rader, J.A.4
Van Schie, R.C.5
Laface, D.M.6
-
26
-
-
0027980535
-
A straightforward synthesis of N-BOC-L-serinal and N-BOC-L-threoninal acetonides
-
P. Meffre, P. Durand, E. Branquet, and F.C.L. Goffic A straightforward synthesis of N-Boc-l-serinal and N-Boc-l-threoninal acetonides Synth Commun 24 1994 2147 2152 (Pubitemid 24244611)
-
(1994)
Synthetic Communications
, vol.24
, Issue.15
, pp. 2147-2152
-
-
Meffre, P.1
Durand, P.2
Branquet, E.3
Le Goffic, F.4
-
27
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1-2 1983 55 63 (Pubitemid 14203433)
-
(1983)
Journal of Immunological Methods
, vol.65
, Issue.1-2
, pp. 55-63
-
-
Mosmann, T.1
-
28
-
-
0034630317
-
Apoptotic DNA fragmentation
-
DOI 10.1006/excr.2000.4834
-
S. Nagata Apoptotic DNA fragmentation Exp Cell Res 256 1 2000 12 18 (Pubitemid 30211161)
-
(2000)
Experimental Cell Research
, vol.256
, Issue.1
, pp. 12-18
-
-
Nagata, S.1
-
29
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
I. Nicoletti, G. Migliorati, M.C. Pagliacci, F. Grignani, and C. Riccardi A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry J Immunol Methods 139 2 1991 271 279
-
(1991)
J Immunol Methods
, vol.139
, Issue.2
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
30
-
-
1242293657
-
Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata
-
DOI 10.1016/j.canlet.2003.09.034
-
S.Y. Park, H.C. Yang, J.Y. Moon, N.H. Lee, S.J. Kim, and J.H. Kang Induction of the apoptosis of HL-60 promyelocytic leukemia cells by Eurya emarginata Cancer Lett 205 1 2004 31 38 (Pubitemid 38230136)
-
(2004)
Cancer Letters
, vol.205
, Issue.1
, pp. 31-38
-
-
Park, S.Y.1
Yang, H.C.2
Moon, J.Y.3
Lee, N.H.4
Kim, S.J.5
Kang, J.H.6
Lee, Y.K.7
Park, D.B.8
Yoo, E.S.9
Kang, H.K.10
-
31
-
-
0344496880
-
Synthesis of 3-Aminochroman Derivatives by Radical Cyclization
-
DOI 10.1021/ol0353215
-
G. Pave, S. Usse-Versluys, M.C. Viaud-Massuard, and G. Guillaumet Synthesis of 3-aminochroman derivatives by radical cyclization Org Lett 5 23 2003 4253 4256 (Pubitemid 37490603)
-
(2003)
Organic Letters
, vol.5
, Issue.23
, pp. 4253-4256
-
-
Pave, G.1
Usse-Versluys, S.2
Viaud-Massuard, M.-C.3
Guillaumet, G.4
-
32
-
-
77955553932
-
Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: Cytotoxicity against human leukemia cell lines
-
D.C. Reis, M.C.X. Pinto, E.M. Souza-Fagundes, S.M.S.V. Wardell, J.L. Wardell, and H. Beraldo Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: cytotoxicity against human leukemia cell lines Eur J Med Chem 45 9 2010 3904 3910
-
(2010)
Eur J Med Chem
, vol.45
, Issue.9
, pp. 3904-3910
-
-
Reis, D.C.1
Pinto, M.C.X.2
Souza-Fagundes, E.M.3
Wardell, S.M.S.V.4
Wardell, J.L.5
Beraldo, H.6
-
33
-
-
53649101495
-
High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2)
-
W.E. Severson, M. McDowell, S. Ananthan, D.-H. Chung, L. Rasmussen, and M.I. Sosa High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2) J Biomol Screen 13 2008 879 887
-
(2008)
J Biomol Screen
, vol.13
, pp. 879-887
-
-
Severson, W.E.1
McDowell, M.2
Ananthan, S.3
Chung, D.-H.4
Rasmussen, L.5
Sosa, M.I.6
-
34
-
-
0030886788
-
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: Effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of bath caspases and serine proteases
-
T. Shimizu, and Y. Pommier Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases Leukemia 11 8 1997 1238 1244 (Pubitemid 27387299)
-
(1997)
Leukemia
, vol.11
, Issue.8
, pp. 1238-1244
-
-
Shimizu, T.1
Pommier, Y.2
-
35
-
-
0032078217
-
Caspases: Key mediators of apoptosis
-
N.A. Thornberry Caspases: key mediators of apoptosis Chem Biol 5 5 1998 R97 R103 (Pubitemid 28259737)
-
(1998)
Chemistry and Biology
, vol.5
, Issue.5
-
-
Thornberry, N.A.1
-
36
-
-
0037341502
-
Mechanisms of staurosporine induced apoptosis in a human corneal endothelial cell line
-
DOI 10.1136/bjo.87.3.346
-
G. Thuret, C. Chiquet, S. Herrag, J.M. Dumollard, D. Boudard, and J. Bednarz Mechanisms of staurosporine induced apoptosis in a human corneal endothelial cell line Br J Ophthalmol 87 3 2003 346 352 (Pubitemid 36307913)
-
(2003)
British Journal of Ophthalmology
, vol.87
, Issue.3
, pp. 346-352
-
-
Thuret, G.1
Chiquet, C.2
Herrag, S.3
Dumollard, J.-M.4
Boudard, D.5
Bednarz, J.6
Campos, L.7
Gain, P.8
-
37
-
-
0034929314
-
Editorial: The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition
-
C.J.F. Van Noorden The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition Acta Histochem 103 3 2001 241 251 (Pubitemid 32624783)
-
(2001)
Acta Histochemica
, vol.103
, Issue.3
, pp. 241-251
-
-
Van Noorden, C.J.F.1
-
38
-
-
0033258120
-
Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
-
M.G. Vander Heiden, and C.B. Thompson Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? Nat Cell Biol 1 8 1999 E209 E216 (Pubitemid 129503663)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.8
-
-
Vander Heiden, M.G.1
Thompson, C.B.2
-
39
-
-
23744496416
-
Pathways to caspase activation
-
DOI 10.1016/j.cellbi.2005.04.001, PII S1065699505000867
-
Z.-B. Wang, Y.-Q. Liu, and Y.-F. Cui Pathways to caspase activation Cell Biol Int 29 7 2005 489 496 (Pubitemid 41138210)
-
(2005)
Cell Biology International
, vol.29
, Issue.7
, pp. 489-496
-
-
Wang, Z.-B.1
Liu, Y.-Q.2
Cui, Y.-F.3
-
40
-
-
22244464818
-
L, but not Bcl-2, until displaced by BH3-only proteins
-
DOI 10.1101/gad.1304105
-
S.N. Willis, L. Chen, G. Dewson, A. Wei, E. Naik, and J.I. Fletcher Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins Genes Dev 19 11 2005 1294 1305 (Pubitemid 41003019)
-
(2005)
Genes and Development
, vol.19
, Issue.11
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.S.8
-
41
-
-
3042801604
-
Morphological features of cell death
-
U. Ziegler, and P. Groscurth Morphological features of cell death News Physiol Sci 19 2004 124 128
-
(2004)
News Physiol Sci
, vol.19
, pp. 124-128
-
-
Ziegler, U.1
Groscurth, P.2
|