Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: Effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of bath caspases and serine proteases

Leukemia

Volumn 11, Issue 8, 1997, Pages 1238-1244

  Shimizu, T ^a,b   Pommier, Y ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SHIZUOKA CITY SHIMIZU HOSPITAL   (Japan)

Author keywords

Apoptosis; Camptothecin; Caspase; HL60; Serine protease; Topoisomerase I

Indexed keywords

CAMPTOTHECIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DNA FRAGMENT; ENDONUCLEASE; ISOCOUMARIN DERIVATIVE; LAMIN B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; PROTEINASE INHIBITOR; SERINE PROTEINASE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

APOPTOSIS; ARTICLE; CELL FREE SYSTEM; CELL NUCLEUS; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOSOL; DNA CLEAVAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0030886788     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400734     Document Type: Article

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