Predictive modeling of the hypothalamic-pituitary-adrenal (HPA) axis response to acute and chronic stress

Endocrine Journal

Volumn 58, Issue 10, 2011, Pages 889-904

  Marković, Vladimir M ^a   Čupić, Željko ^b   Vukojević, Vladana ^c   Kolar Anić, Ljiljana ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Circadian and ultradian rhythmicity; Cortisol; HPA axis; Predictive modeling; Stress

Indexed keywords

ACUTE STRESS; ARTICLE; CHRONIC STRESS; CIRCADIAN RHYTHM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; OSCILLATION; PREDICTION; ULTRADIAN RHYTHM;

ACTIVITY CYCLES; ACUTE DISEASE; ADRENAL CORTEX HORMONES; ANIMALS; CHRONIC DISEASE; CIRCADIAN RHYTHM; COMPUTER SIMULATION; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMIC HORMONES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MODELS, BIOLOGICAL; PITUITARY HORMONES; PITUITARY-ADRENAL SYSTEM; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL;

EID: 80055071240     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ11-0037     Document Type: Article

References (60)

1. Goldbetter A (1996), Biochemical Oscillations and Cellular Rhythms. Cambridge University Press, Cambridge.
2. Koukkari WL, Sothern RB, Introducing biological rhythms. Springer Science Business Media Inc., New York.
3. Lightman SL, Windle RJ, Ma XM, Harbuz MS, Shanks NM, Julian MD, Wood SA, Kershaw YM, Ingram CD (2002) Hypothalamic-pituitary-adrenal function. Arch Physiol Biochem 110: 90-93.
4. Miller WL, Chrousos GP (2001) The Adrenal Cortex. In Felig P, Frohman L (eds) Endocrinology & Metabolism. McGraw-Hill, New York: 387-524.
5. Tsigos C, Chrousos GP (2002) Hypothalamic-pituitaryadrenal axis, neuroendocrine factors and stress. J Psychosom Res 53: 865-871.
6. Hartmann A, Veldhuis JD, Deuschle M, Standhardt H, Heuser I (1997) Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol Aging 18: 285-289.
7. Nader N, Chrousos GP, Kino T (2010) Interactions of the circadian CLOCK system and the HPA axis. Trends Endocrinol Metab 21: 277-286.
8. Swaab DF, Bao AM, Lucassen PJ (2005) The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev 4: 141-194.
9. Conway-Campbell BL, McKenna MA, Wiles CC, Atkinson HC, De Kloet ER, Lightman SL (2007) Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone. Endocrinology 148: 5470-5477.
10. Lightman SL, Wiles CC, Atkinson HC, Henley DE, Russell GM, Leendertz JA, McKenna MA, Spiga F, Wood SA, Conway-Campbell BL (2008) The significance of glucocorticoid pulsatility. Eur J Pharmacol 583: 255-262.
11. Russell GM, Henley DE, Leendertz J, Douthwaite JA, Wood SA, Stevens A, Woltersdorf WW, Peeters BW, Ruigt GS, White A, Veldhuis JD, Lightman SL (2010) Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males. J Neurosci 30: 6106-6115.
12. Stavreva DA, Wiench M, John S, Conway-Campbell BL, McKenna MA, Pooley JR, Johnson TA, Voss TC, Lightman SL, Hager GL. (2009). Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol 11: 1093-1102.
13. Windle RJ, Wood SA, Shanks N, Lightman SL, Ingram CD (1998) Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress. Endocrinology 139: 443-450.
14. Windle RJ, Wood SA, Lightman SL, Ingram CD (1998) The pulsatile characteristics of hypothalamo-pituitaryadrenal activity in female Lewis and Fischer 344 rats and its relationship to differential stress responses. Endocrinology 139: 4044-4052.
15. Windle RJ, Wood SA, Kershaw YM, Lightman SL, Ingram CD, Harbuz MS (2001) Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness. J Neuroendocrinol 13: 905-911.
16. Bairagi N, Chatterjee S, Chattopadhyay J (2008) Variability in the secretion of corticotropin-releasing hormone, adrenocorticotropic hormone and cortisol and understandability of the hypothalamic-pituitary-adrenal axis dynamics-a mathematical study based on clinical evidence. Math Med Biol 25: 37-63.
17. Jelić S, Čupić Ž, Kolar-Anić Lj (2005) Mathematical modelling of the hypothalamic-pituitary-adrenal system activity. Math Biosci 197: 173-187.
18. Jelić S, Čupić Ž, Kolar-Anić Lj (2008) Modelling of the hypothalamic-pituitary-adrenal system activity based on the stoichiometric analysis. In Romano E, De Luca S (eds) New research on neurosecretory systems. Nova Science Publishers Inc., New York: 225-245.
19. Jelić S, Čupić Ž, Kolar-Anić Lj, Vukojević V (2009) Predictive modeling of the hypothalamic-pituitary-adrenal (HPA) function. Dynamic system theory approach by stochiometric network analysis and quenching of small amplitude oscillations. Int J Nonolin Sci Num 10: 1451-1472.
20. Keenan DM, Licinio J, Veldhuis JD (2001) A feedbackcontrolled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis. Proc Natl Acad Sci USA 98: 4028-4033.
21. Keenan DM, Veldhuis JD (2003) Cortisol feedback state governs adrenocorticotropin secretory-burst shape, frequency, and mass in a dual-waveform construct: time of day-dependent regulation. Am J Physiol Regul Integr Comp Physiol 285: R950-R961.
22. Keenan DM, Roelfsema F, Veldhuis, JD (2004) Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human. Am J Physiol Endocrinol Metab 287: E652-E661.
23. Keenan DM, Chattopadhyay S, Veldhuis JD (2005) Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood. J Theor Biol 236: 242-255.
24. Lenbury Y, Pornsawad P (2005) A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans, Math Med Biol 22: 15-33.
25. Marković V, Jelić S, Vukojević V, Kolar-Anić Lj (2010) Modelling the hypothalamic-pituitary-adrenal (HPA) axis response to external perturbations with cortisol. Physical Chemistry 2010. Society of Physical Chemists of Serbia, Belgrade: 212-214.
26. Veldhuis JD, Keenan DM, Pincus SM (2008) Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 29: 823-864.
27. Walker JJ, Terry JR, Lightman SL (2010) Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis. Proc R Soc B 277: 1627-1633.
28. McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87: 873-904.
29. Kudielka BM, Hellhammer DH, Wüst S (2009) Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology 34: 2-18.
30. Kudielka BM, Wüst S (2010) Human models in acute and chronic stress: assessing determinants of individual hypothalamus-pituitary-adrenal axis activity and reactivity, Stress 13: 1-14.
31. VanItallie TB (2002) Stress: a risk factor for serious illness. Metabolism 51: 40-45.
32. Chrousos GP (2001) Glucocorticoid Therapy. In Felig P, Frohman LA (eds) Endocrinology & Metabolism. McGraw-Hill, New York: 609-632.
33. Holsboer F (2000) The stress hormone system is back on the map. Curr Psychiatry Rep 2: 454-456.
34. Kellendonk C, Gass P, Kretz O, Schutz G, Tronche F (2002) Corticosteroid receptors in the brain: gene targeting studies. Brain Res Bull 57: 73-83.
35. Makino S, Hashimoto K, Gold PW (2002) Multiple feedback mechanisms activating corticotropinreleasing hormone system in the brain during stress. Pharmacol Biochem Behav 73: 147-158.
36. Schulkin J, Gold PW, McEwen BS (1998) Induction of corticotrophin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology 23: 219-243.
37. Benson SW (1960) The Foundations of Chemical Kinetics. McGraw-Hill Book Company, New York: 1960.
38. Yeremin EN (1979) The foundations of Chemical Kinetics. Mir Publishers, Moscow: 1979.
39. Gear CW (1971) Numerical initial value problems in ordinary differential equations. Prentice-Hall Inc., Englewood Cliffs, New Jersey.
40. Engler D, Pham T, Liu JP, Fullerton MJ, Clarke IJ, Funder JW (1990) Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. II. Evidence for in vivo ultradian hypersecretion of proopiomelanocortin, peptides by the isolated anterior and intermediate pituitary. Endocrinology 127: 1956-1966.
41. Dhabhar FS (2002) Stress-induced augmentation of immune function-the role of stress hormones, leukocyte trafficking, and cytokines. Brain Behav Immun 16: 785-798.
42. Sorrells SF, Caso JR, Munhoz CD, Sapolsky RM (2009) The stressed CNS: when glucocorticoids aggravate inflammation. Neuron 64: 33-39.
43. Miller GE, Chen E, Zhou ES (2007) If it goes up, must it come down? Chronic stress and the hypothalamicpituitary-adrenocortical axis in humans. Psychol Bull 133: 25-45.
44. De Kloet ER, Joëls M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6: 463-475.
45. Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23: 477-501.
46. Joëls M., Tallie BZ (2009) The neuro-symphony of stress. Nat Rev Neurosci 10: 459-466.
47. McEwen BS (2008) Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 583: 174-185.
48. Blaustein JD (2007) Behavioral Neurochemistry and Neuroendocrinology. In Lajtha A (ed) Handbook of Neurochemistry and Molecular Neurobiology. Springer, New York.
49. Vgontzas AN, Bixler EO, Lin HM, Prolo P, Mastorakos G, Vela-Bueno A, Kales A and Chrousos GP (2001) Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications. J Clin Endocrinol Metab 86: 3787-3794.
50. Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions, Endocr Rev 21: 55-89.
51. Martin LB (2009) Stress and immunity in wild vertebrates: timing is everything. Gen Comp Endocrinol 163: 70-76.
52. Reinberg A, Smolensky MH, D'Alonzo GE, McGovern JP (2003) Chronobiology and asthma. III. Timing corticotherapy to biological rhythms to optimize treatment goals. J Asthma 25: 219-248.
53. Chakera AJ, Vaidya B (2010) Addison disease in adults: diagnosis and management. Am. J Med 123: 409-413.
54. Løvås K, Husebye ES (2008) Replacement therapy for Addison's disease: recent developments. Expert Opin Investig Drugs 17: 497-509.
55. Reisch N, Arlt W (2009) Fine tuning for quality of life: 21st century approach to treatment of Addison's disease. Endocrinol Metab Clin North Am 38: 407-418.
56. Fauci AS (1978) Alternate-day corticosteroid therapy. Am J Med, 64: 729-731.
57. Seth A, Aggarwal A (2004) Monitoring adverse reactions to steroid therapy in children. Indian Pediatr 41: 349-357.
58. Perrot D, Bonneton A, Dechaud H, Motin J, Pugeat M (1993) Hypercortisolism in septic shock is not suppressible by dexamethasone infusion. Crit Care Med 21: 396-401.
59. Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK (1993) Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration: a new test to distinguish Cushing's syndrome from pseudo-Cushing's states. JAMA 269: 2232-2238.
60. Newell-Price J, Trainer P, Besser M, Grossman A (1998) The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev 19: 647-672.