Human models in acute and chronic stress: Assessing determinants of individual hypothalamuspituitaryadrenal axis activity and reactivity

Stress

Volumn 13, Issue 1, 2010, Pages 1-14

  Kudielka, Brigitte M ^a,c   Wüst, Stefan ^b,c  

^a JACOBS UNIVERSITY BREMEN   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c UNIVERSITY OF TRIER   (Germany)

Author keywords

Cortisol; Cortisol awakening response (CAR); HPA axis; Human; Stress; Trier social stress test (TSST)

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE;

ACUTE STRESS; ADRENERGIC SYSTEM; ALCOHOL CONSUMPTION; CHRONIC STRESS; COFFEE; DIETARY INTAKE; FUNCTION TEST; HORMONE RESPONSE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOCUS CERULEUS; MENTAL STRESS; PERSONAL EXPERIENCE; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; REVIEW; SALIVA LEVEL; SMOKING; SOCIAL STRESS; TRIER SOCIAL STRESS TEST;

ACUTE DISEASE; CHRONIC DISEASE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; SOCIAL BEHAVIOR; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL;

EID: 75749111698     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.3109/10253890902874913     Document Type: Review

References (226)

1. Adam EK. 2006. Transactions among adolescent trait and state emotion and diurnal and momentary cortisol activity in naturalistic settings. Psychoneuroendocrinology 31:664-679.
2. Adam EK, Hawkley LC, Kudielka BM, Cacioppo JT. 2006. Day-today dynamics of experience-cortisol associations in a population-based sample of older adults. Proc Natl Acad Sci USA 103:17058-17063.
3. Al'Absi M, Lovallo WR, McKey B, Sung BH, Whitsett TL, Wilson MF. 1998. Hypothalamic-pituitary-adrenocortical responses to psychological stress and caffeine in men at high and low risk for hypertension. Psychosom Med 60:521-527.
4. Al'Absi M, Amunrud T, Wittmers LE. 2002. Psychophysiological effects of nicotine abstinence and behavioral challenges in habitual smokers. Pharmacol Biochem Behav 72:707-716
5. al'Absi M, Wittmers LE, Erickson J, Hatsukami D, Crouse B. 2003. Attenuated adrenocortical and blood pressure responses to psychological stress in ad libitum and abstinent smokers. Pharmacol Biochem Behav 74:401-410.
6. Alderling M, Theorell T, de la Torre B, Lundberg I. 2006. The demand control model and circadian saliva cortisol variations in a Swedish population based sample (The PART study). BMC Public Health 6:288.
7. Altemus M, Redwine LS, Leong YM, Frye CA, Porges SW, Carter CS. 2001. Responses to laboratory psychosocial stress in postpartum women. Psychosom Med 63:814-821. (Pubitemid 32911011)
8. Backhaus J, Junghanns K, Hohagen F. 2004. Sleep disturbances are correlated with decreased morning awakening salivary cortisol. Psychoneuroendocrinology 29:1184-1191.
9. Badrick E, Kirschbaum C, Kumari M. 2007. The relationship between smoking status and cortisol secretion. J Clin Endocrinol Metab 92:819-824.
10. Bartels M, de Geus EJ, Kirschbaum C, Sluyter F, Boomsma DI. 2003a. Heritability of daytime cortisol levels in children. Behav Genet 33:421-433.
11. Bartels M, Van den Berg M, Sluyter F, Boomsma DI, de Geus EJ. 2003b. Heritability of cortisol levels: Review and simultaneous analysis of twin studies. Psychoneuroendocrinol-ogy 28:121-137.
12. Bellingrath S, Kudielka BM. 2008. Effort-reward-imbalance and overcommitment are associated with hypothalamus-pituitary-adrenal (HPA) axis responses to acute psychosocial stress in healthy working schoolteachers. Psychoneuroendocrinology 33:1335-1343.
13. Bellingrath S, Weigl T, Kudielka BM. 2008. Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance. Biol Psychol 78:104-113.
14. Bhagwagar Z, Hafizi S, Cowen PJ. 2003. Increase in concentration of waking salivary cortisol in recovered patients with depression. Am J Psychiatry 160:1890-1891.
15. Bhagwagar Z, Hafizi S, Cowen PJ. 2005. Increased salivary cortisol after waking in depression. Psychopharmacology (Berl) 182: 54-57.
16. Bhattacharyya MR, Molloy GJ, Steptoe A. 2008. Depression is associated with flatter cortisol rhythms in patients with coronary artery disease. J Psychosom Res 65:107-113.
17. Böhmelt AH, Nater UM, Franke S, Hellhammer DH, Ehlert U. 2005. Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosom Med 67:288-294.
18. Born J, Hansen K, Marshall L, Molle M, Fehm HL. 1999. Timing the end of nocturnal sleep. Nature 397:29-30.
19. Bornstein SR, Engeland WC, Ehrhart-Bornstein M, Herman JP. 2008. Dissociation of ACTH and glucocorticoids. Trends Endocrinol Metab 19:175-180.
20. Bower JE, Ganz PA, Aziz N. 2005. Altered cortisol response to psychologic stress in breast cancer survivors with persistent fatigue. Psychosom Med 67:277-280.
21. Brenner K, Liu A, Laplante DP, Lupien S, Pruessner JC, Ciampi A, Joober R, King S. 2009. Cortisol response to a psychosocial stressor in schizophrenia: Blunted, delayed, or normal? Psychoneuroendocrinology 34:859-868.
22. Broderick JE, Arnold D, Kudielka BM, Kirschbaum C. 2004. Salivary cortisol sampling compliance: Comparison of patients and healthy volunteers. Psychoneuroendocrinology 29: 636-650.
23. Brody S, Preut R, Schommer K, Schümeyer TH. 2002. A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology (Berl) 159:319-324.
24. Bruehl H, Wolf OT, Convit A. 2009. A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus. Psychoneuroendocrinology 34: 815-821.
25. Buchanan TW, Kern S, Allen JS, Tranel D, Kirschbaum C. 2004. Circadian regulation of cortisol after hippocampal damage in humans. Biol Psychiatry 56:651-656.
26. Burke HM, Davis MC, Otte C, Mohr DC. 2005. Depression and cortisol responses to psychological stress: A meta-analysis. Psychoneuroendocrinology 30:846-856.
27. Buske-Kirschbaum A, Hellhammer DH. 2003. Endocrine and immune responses to stress in chronic inflammatory skin disorders. Ann N Y Acad Sci 992:231-240.
28. Buske-Kirschbaum A, Jobst S, Psych D, Wustmans A, Kirschbaum C, Rauh W, Hellhammer D. 1997. Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis. Psychosom Med 59:419-426.
29. Buske-Kirschbaum A, Geiben A, Hellhammer D. 2001. Psycho-biological aspects of atopic dermatitis: An overview. Psychother Psychosom 70:6-16.
30. Buske-Kirschbaum A, Geiben A, Hollig H, Morschhauser E, Hellhammer D. 2002. Altered responsiveness of the hypothala-mus-pituitary-adrenal axis and the sympathetic adreno-medullary system to stress in patients with atopic dermatitis. J Clin Endocrinol Metab 87:4245-4251.
31. Buske-Kirschbaum A, von Auer K, Krieger S, Weis S, Rauh W, Hellhammer D. 2003. Blunted cortisol responses to psychosocial stress in asthmatic children: A general feature of atopic disease? Psychosom Med 65:806-810.
32. Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF, Mello MF, et al. 2007. Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol Psychiatry 62: 1080-1087.
33. Chrousos GP, Gold PW. 1992. The concepts of stress and stress system disorders. Overview of physical and behavioral homeo-stasis. JAMA 267:1244-1252.
34. Clow A, Thorn L, Evans P, Hucklebridge F. 2004. The awakening cortisol response: Methodological issues and significance. Stress 7:29-37.
35. Condren RM, O'Neill A, Ryan MC, Barrett P, Thakore JH. 2002. HPA axis response to a psychological stressor in generalised social phobia. Psychoneuroendocrinology 27:693-703.
36. Davidson JR, Moldofsky H, Lue FA. 1991. Growth hormone and cortisol secretion in relation to sleep and wakefulness. J Psychiatry Neurosci 16:96-102.
37. de Kloet CS, Vermetten E, Heijnen CJ, Geuze E, Lentjes EG, Westenberg HG. 2007. Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology 32:215-226.
38. De Vente W, Olff M, Van Amsterdam JG, Kamphuis JH, Emmelkamp PM. 2003. Physiological differences between burnout patients and healthy controls: Blood pressure, heart rate, and cortisol responses. Occup Environ Med 60(Suppl 1): i54-i61.
39. de Vugt ME, Nicolson NA, Aalten P,LousbergR, Jolle J, Verhey FR. 2005. Behavioral problems in dementia patients and salivary cortisol patterns in caregivers. J Neuropsychiatry Clin Neurosci 17:201-207.
40. Dedovic K, Renwick R, Mahani NK, Engert V, Lupien SJ, Pruessner JC. 2005. The Montreal imaging stress task: Using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain. J Psychiatry Neurosci 30:319-325.
41. Deinzer R, Kirschbaum C, Gresele C, Hellhammer DH. 1997. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61:507-511.
42. DeRijk RH, Wüst S, Meijer OC, Zennaro MC, Federenko IS, Hellhammer DH, et al. 2006. A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab 91:5083-5089.
43. Deshauer D, Duffy A, Alda M, Grof E, Albuquerque J, Grof P. 2003. The cortisol awakening response in bipolar illness: A pilot study. Can J Psychiatry 48:462-466.
44. Deshauer D, Duffy A, Meaney M, Sharma S, Grof P. 2006. Salivary cortisol secretion in remitted bipolar patients and offspring of bipolar parents. Bipolar Disord 8:345-349.
45. Dettenborn L, Rosenloecher F, Kirschbaum C. 2007. No effects of repeated forced wakings during three consecutive nights on morning cortisol awakening responses (CAR): A preliminary study. Psychoneuroendocrinology 32:915-921.
46. Dickerson SS, Kemeny ME. 2004. Acute stressors and cortisol responses: A theoretical integration and synthesis of laboratory research. Psychol Bull 130:355-391.
47. Ditzen B, Schmidt S, Strauss B, Nater UM, Ehlert U, Heinrichs M. 2008. Adult attachment and social support interact to reduce psychological but not cortisol responses to stress. J Psychosom Res 64:479-486.
48. Dockray S, Bhattacharyya MR, Molloy GJ, Steptoe A. 2008. The cortisol awakening response in relation to objective and subjective measures of waking in the morning. Psychoneuro-endocrinology 33:77-82.
49. Dorn LD, Campo JC, Thato S, Dahl RE, Lewin D, Chandra R, Di Lorenzo C. 2003. Psychological comorbidity and stress reactivity in children and adolescents with recurrent abdominal pain and anxiety disorders. J Am Acad Child Adolesc Psychiatry 42:66-75.
50. Ebrecht M, Hextall J, Kirtley LG, Taylor A, Dyson M, Weinman J. 2004. Perceived stress and cortisol levels predict speed of wound healing in healthy male adults. Psychoneuroendocrinology 29:798-809.
51. EdwardsS,Clow A, EvansP, Hucklebridge F. 2001a. Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity. Life Sci 68:2093-2103.
52. Edwards S, Evans P, Hucklebridge F, Clow A. 2001b. Association between time of awakening and diurnal cortisol secretory activity. Psychoneuroendocrinology 26:613-622.
53. Edwards S, Hucklebridge F, Clow A, Evans P. 2003. Components of the diurnal cortisol cycle in relation to upper respiratory symptoms and perceived stress. Psychosom Med 65:320-327.
54. Ellenbogen MA, Hodgins S, Walker CD. 2004. High levels of cortisol among adolescent offspring of parents with bipolar disorder: A pilot study. Psychoneuroendocrinology 29:99-106.
55. Entringer S, Kumsta R, Hellhammer DH, Wadhwa PD, Wüst S. 2009. Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults. Horm Behav 55:292-298.
56. Federenko I, Wüst S, Hellhammer DH, Dechoux R, Kumsta R, Kirschbaum C. 2004a. Free cortisol awakening responses are influenced by awakening time. Psychoneuroendocrinology 29: 174-184.
57. Federenko IS, Nagamine M, Hellhammer DH, Wadhwa PD, Wüst S. 2004b. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent. J Clin Endocrinol Metab 89:6244-6250.
58. Federenko IS, Wolf JM, Wüst S, Schlotz W, Hellhammer J, Kudielka BM, et al. 2006. Parity does not alter baseline or stimulated activity of the hypothalamus-pituitary-adrenal axis in women. Dev Psychobiol 48:703-711.
59. FriesE,Hesse J, HellhammerJ, Hellhammer DH. 2005.A new view on hypocortisolism. Psychoneuroendocrinology 30:1010-1016.
60. Fries E, Hellhammer DH, Hellhammer J. 2006. Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier social stress test by the benzodiazepine alprazolam. Psychoneuro-endocrinology 31:1278-1288.
61. Fries E, Dettenborn L, Kirschbaum C. 2009. The cortisol awakening response (CAR): Facts and future directions. Int J Psychophysiol 72:67-73.
62. Gaab J, Huster D, Peisen R, Engert V, Heitz V, Schad T, et al. 2002. Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation. Psychosom Med 64:951-962.
63. Gaab J, Blattler N, Menzi T, Pabst B, Stoyer S, Ehlert U. 2003. Randomized controlled evaluation of the effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects. Psychoneuroendocrinology 28: 767-779.
64. Geiss A, Varadi E, Steinbach K, Bauer HW, Anton F. 1997. Psychoneuroimmunological correlates of persisting sciatic pain in patients who underwent discectomy. Neurosci Lett 237: 65-68.
65. Gerra G, Zaimovic A, Zambelli U, Timpano M, Reali N, Bernasconi S, Brambilla F. 2000. Neuroendocrine responses to psychological stress in adolescents with anxiety disorder. Neuropsychobiology 42:82-92.
66. Gonzalez-Bono E, Rohleder N, Hellhammer DH, Salvador A, Kirschbaum C. 2002. Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress. Horm Behav 41:328-333.
67. Greaves-Lord K, Ferdinand RF, Oldehinkel AJ, Sondeijker FE, Ormel J, Verhulst FC. 2007. Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatr Scand 116:137-144.
68. Gröschl M, Rauh M. 2006. Influence of commercial collection devices for saliva on the reliability of salivary steroids analysis. Steroids 71:1097-1100.
69. Grossi G, Perski A, Ekstedt M, Johansson T, Lindström M, Holm K. 2005. The morning salivary cortisol response in burnout. J Psychosom Res 59:103-111.
70. Gunnar MR, Talge NM, Herrera A. 2009. Stressor paradigms in developmental studies: What does and does not work to produce mean increases in salivary cortisol. Psychoneuroendocrinology 34:953-967.
71. Hammerfald K, Eberle C, Grau M, Kinsperger A, Zimmermann A, Ehlert U, Gaab J. 2006. Persistent effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects-a randomized controlled trial. Psychoneuro-endocrinology 31:333-339. (Pubitemid 43261652)
72. Harris A, Ursin H, Murison R, Eriksen HR. 2007. Coffee, stress and cortisol in nursing staff. Psychoneuroendocrinology 32: 322-330.
73. Heim C, Ehlert U, Hellhammer DH. 2000a. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25:1-35.
74. Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, et al. 2000b. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Jama 284:592-597.
75. Heim C, Newport DJ, Wagner D, Wilcox MM, Miller AH, Nemeroff CB. 2002. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: A multiple regression analysis. Depress Anxiety 15:117-125.
76. Heinrichs M, Meinlschmidt G, Neumann I, Wagner S, Kirschbaum C, Ehlert U, Hellhammer DH. 2001. Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women. J Clin Endocrinol Metab 86:4798-4804.
77. Heinrichs M, Neumann I, Ehlert U. 2002. Lactation and stress: Protective effects of breast-feeding in humans. Stress 5: 195-203.
78. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. 2003. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54:1389-1398.
79. Hellhammer DH, Buchtal J, Gutberlet I, Kirschbaum C. 1997. Social hierarchy and adrenocortical stress reactivity in men. Psychoneuroendocrinology 22:643-650.
80. Hellhammer J, Fries E, Schweisthal OW, Schlotz W, Stone AA, Hagemann D. 2007. Several daily measurements are necessary to reliably assess the cortisol rise after awakening: State-and trait components. Psychoneuroendocrinology 32:80-86.
81. Hellhammer DH, Wüst S, Kudielka BM. 2009. Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology 34: 163-171.
82. Holsboer F. 1989. Psychiatric implications of altered limbic-hypothalamic-pituitary-adrenocortical activity. Eur Arch Psychiatry Neurol Sci 238:302-322.
83. Huber TJ, Issa K, Schik G, Wolf OT. 2006. The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression. Psychoneuroendocrinology 31:900-904.
84. Hucklebridge F, Clow A, Rahman H, Evans P. 2000. The cortisol response to normal and nocturnal awakening. J Psychophysiol 14:24-28.
85. Hucklebridge F, Mellins J, Evans P, Clow A. 2002. The awakening cortisol response: No evidence for an influence of body posture. Life Sci 71:639-646.
86. Hucklebridge F, Hussain T, Evans P, Clow A. 2005. The diurnal patterns of the adrenal steroids cortisol and dehydroepiandro-sterone (DHEA) in relation to awakening. Psychoneuroendocri-nology 30:51-57.
87. Huizink AC, Mulder EJ, Buitelaar JK. 2004. Prenatal stress and risk for psychopathology: Specific effects or induction of general susceptibility? Psychol Bull 130:115-142.
88. Hurwitz Eller N, Netterstrom B, Hansen AM. 2001. Cortisol in urine and saliva: Relations to the intima media thickness, IMT. Atherosclerosis 159:175-185.
89. Hurwitz Eller N, Netterstrom B, Hansen AM. 2006. Psychosocial factors at home and at work and levels of salivary cortisol. Biol Psychol 73:280-287.
90. Jessop DS, Turner-Cobb JM. 2008. Measurement and meaning of salivary cortisol: A focus on health and disease in children. Stress 11:1-14.
91. Jones DA, Rollman GB, Brooke RI. 1997. The cortisol response to psychological stress in temporomandibular dysfunction. Pain 72:171-182.
92. Jones A, Godfrey KM, Wood P, Osmond C, Goulden P, Phillips DI. 2006. Fetal growth and the adrenocortical response to psychological stress. J Clin Endocrinol Metab 91:1868-1871.
93. Kajantie E, Phillips DI. 2006. The effects of sex and hormonal status on the physiological response to acute psychosocial stress. Psychoneuroendocrinology 31:151-178.
94. Kallen VL, Tulen JH, Utens EM, Treffers PD, De Jong FH, Ferdinand RF. 2008. Associations between HPA axis functioning and level of anxiety in children and adolescents with an anxiety disorder. Depress Anxiety 25:131-141.
95. Khalfa S, Bella SD, Roy M, Peretz I, Lupien SJ. 2003. Effects of relaxing music on salivary cortisol level after psychological stress. Ann N Y Acad Sci 999:374-376.
96. Kirschbaum C, Bartussek D, Strasburger CJ. 1992a. Cortisol responses to psychological stress and correlations with personality traits. Personal Indiv Differ 13:1353-1357.
97. Kirschbaum C, Wüst S, Hellhammer D. 1992b. Consistent sex differences in cortisol responses to psychological stress. Psychosom Med 54:648-657.
98. Kirschbaum C, Pirke KM, Hellhammer DH. 1993a. The 'Trier social stress test'-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28: 76-81.
99. Kirschbaum C, Strasburger CJ, Langkrar J. 1993b. Attenuated cortisol response to psychological stress but not to CRH or ergometry in young habitual smokers. Pharmacol Biochem Behav 44:527-531.
100. Kirschbaum C, Scherer G, Strasburger CJ. 1994. Pituitary and adrenal hormone responses to pharmacological, physical, and psychological stimulation in habitual smokers and nonsmokers. Clin Investig 72:804-810.
101. Kirschbaum C, Klauer T, Filipp SH, Hellhammer DH. 1995a. Sex-specific effects of social support on cortisol and subjective responses to acute psychological stress. Psychosom Med 57:23-31.
102. Kirschbaum C, Prüssner JC, Stone AA, Federenko I, Gaab J, Lintz D, et al. 1995b. Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men. Psychosom Med 57:468-474.
103. Kirschbaum C, Platte P, Pirke KM, Hellhammer D. 1996a. Adrenocortical activation following stressful exercise: Further evidence for attenuated free cortisol responses in women using oral contraceptives. Stress Med 12:137-143.
104. Kirschbaum C, Schommer N, Federenko I, Gaab J, Neumann O, Oellers M, et al. 1996b. Short-term estradiol treatment enhances pituitary-adrenal axis and sympathetic responses to psycho-social stress in healthy young men. J Clin Endocrinol Metab 81:3639-3643.
105. Kirschbaum C, Gonzalez Bono E, Rohleder N, Gessner C, Pirke KM, Salvador A, Hellhammer DH. 1997. Effects of fasting and glucose load on free cortisol responses to stress and nicotine. J Clin Endocrinol Metab 82:1101-1105.
106. Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. 1999. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothala-mus-pituitary-adrenal axis. Psychosom Med 61:154-162.
107. Kudielka BM, Kern S. 2004. Cortisol day profiles in victims of mobbing (bullying at the work place): Preliminary results of a first psychobiological field study. J Psychosom Res 56:149-150.
108. Kudielka BM, Kirschbaum C. 2003. Awakening cortisol responses are influenced by health status and awakening time but not by menstrual cycle phase. Psychoneuroendocrinology 28:35-47.
109. Kudielka BM, Kirschbaum C. 2005. Sex differences in HPA axis responses to stress: A review. Biol Psychol 69:113-132.
110. Kudielka BM, Wüst S. 2008. The cortisol awakening response (CAR): A useful tool for ambulant assessment of hypothalamus-pituitary-adrenal (HPA) axis activity. In: Léglise A-L, editor. Progress in circadian rhythm research. New York: Nova Science Publishers, Inc. p 223-234.
111. Kudielka BM, Hellhammer J, Hellhammer DH, Wolf OT, Pirke KM, Varadi E, et al. 1998. Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandros-terone treatment. J Clin Endocrinol Metab 83:1756-1761.
112. Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Kirschbaum C. 1999. Psychological and endocrine responses to psychosocial stress and dexamethasone/corticotropin-releas-ing hormone in healthy postmenopausal women and young controls: The impact of age and a two-week estradiol treatment. Neuroendocrinology 70:422-430.
113. Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Schürmeyer T, Kirschbaum C. 2000. Psychosocial stress and HPA functioning: No evidence for a reduced resilience in healthy elderly men. Stress 3:229-240.
114. Kudielka BM, Broderick JE, Kirschbaum C. 2003. Compliance with saliva sampling protocols: Electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects. Psychosom Med 65:313-319.
115. Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C. 2004a. Differential heart rate reactivity and recovery after psychosocial stress (TSST) in healthy children, younger adults, and elderly adults: The impact of age and gender. Int J Behav Med 11:116-121. (Pubitemid 39093269)
116. Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C. 2004b. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: Impact of age and gender. Psychoneuroendocri- nology 29:83-98. (Pubitemid 37303960)
117. Kudielka BM, Schommer NC, Hellhammer DH, Kirschbaum C. 2004c. Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans at different times of day. Psychoneuroendocrinology 29:983-992.
118. Kudielka BM, Bellingrath S, Hellhammer DH. 2006a. Cortisol in burnout and vital exhaustion: An overview. Appl Psychol Work Rehabil Med 28:34-42.
119. Kudielka BM, Federenko IS, Hellhammer DH, Wüst S. 2006b. Morningness and eveningness: The free cortisol rise after awakening in 'early birds' and 'night owls'. Biol Psychol 72: 141-146.
120. Kudielka BM, von Känel R, Preckel D, Zgraggen L, Mischler K, Fischer JE. 2006c. Exhaustion is associated with reduced habituation of free cortisol responses to repeated acute psychosocial stress. Biol Psychol 72:147-153.
121. Kudielka BM, Bellingrath S, Hellhammer DH. 2007a. Further support for higher salivary cortisol levels in 'morning' compared to 'evening' persons. J Psychosom Res 62:595-596.
122. Kudielka BM, Buchtal J, Uhde A, Wüst S. 2007b. Circadian cortisol profiles and psychological self-reports in shift workers with and without recent change in the shift rotation system. Biol Psychol 74:92-103.
123. Kudielka BM, Fischer JE, Metzenthin P, Helfricht S, Preckel D, von Känel R. 2007c. No effect of 5-day treatment with acetylsalicylic acid (aspirin) or the beta-blocker propranolol (inderal) on free cortisol responses to acute psychosocial stress: A randomized double-blind, placebo-controlled study. Neurop-sychobiology 56:159-166.
124. Kudielka BM, Hawkley LC, Adam EK, Cacioppo JT. 2007d. Compliance with ambulatory saliva sampling in the chicago health, aging, and social relations study and associations with social support. Ann Behav Med 34:209-216.
125. Kudielka BM, Hellhammer DH, Kirschbaum C. 2007e. Ten years of research with the Trier social stress test (TSST)-revisited. In: Harmon-Jones E, Winkielman P, editors. Social neuro-science: Integrating biological and psychological explanations of social behavior. New York: The Guilford Press. p 56-83
126. Chapter 54. Kudielka BM, Wüst S, Kirschbaum C, Hellhammer DH, et al. 2007f. Trier social stress test. In: Fink G, Chrousos G, Craig I, de Kloet ER, Feuerstein G, McEwen BS, editors. Encyclopedia of stress. Vol.3. 2nd revised ed., Oxford: Academic Press. p 776-781.
127. Kudielka BM, Hellhammer DH, Wüst S. 2009. Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology 34:2-18.
128. Kuehner C, Holzhauer S, Huffziger S. 2007. Decreased cortisol response to awakening is associated with cognitive vulnerability to depression in a nonclinical sample of young adults. Psychoneuroendocrinology 32:199-209.
129. Kumsta R, Entringer S, Hellhammer DH, Wüst S. 2007a. Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels. Psychoneuroendocrino-logy 32:1153-1157.
130. Kumsta R, Entringer S, Koper JW, van Rossum EF, Hellhammer DH, Wüst S. 2007b. Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol Psychiatry 62:863-869.
131. Kunz-Ebrecht SR, Kirschbaum C, Marmot M, Steptoe A. 2004a. Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall II cohort. Psychoneuroendocrinology 29:516-528.
132. Kunz-Ebrecht SR, Kirschbaum C, Steptoe A. 2004b. Work stress, socioeconomic status and neuroendocrine activation over the working day. Soc Sci Med 58:1523-1530.
133. Kupper N, de Geus EJ, van den Berg M, Kirschbaum C, Boomsma DI, Willemsen G. 2005. Familial influences on basal salivary cortisol in an adult population. Psychoneuroendo-crinology 30:857-868.
134. Lackschewitz H, Huther G, Kroner-Herwig B. 2008. Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrino-logy 33:612-624.
135. Lai JC, Evans PD, Ng SH, Chong AM, Siu OT, Chan CL, et al. 2005. Optimism, positive affectivity, and salivary cortisol. Br J Health Psychol 10:467-484.
136. Lane JD, Adcock RA, Williams RB, Kuhn CM. 1990. Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption. Psychosom Med 52:320-336.
137. Langelaan S, Bakker AB, Schaufeli WB, van Rhenen W, van Doornen LJ. 2006. Do burned-out and work-engaged employees differ in the functioning of the hypothalamic-pituitary-adrenal axis? Scand J Work Environ Health 32:339-348.
138. Lieb K, Rexhausen JE, Kahl KG, Schweiger U, Philipsen A, Hellhammer DH, Bohus M. 2004. Increased diurnal salivary cortisol in women with borderline personality disorder. J Psychiatr Res 38:559-565.
139. Lovallo WR, Dickensheets SL, Myers DA, Thomas TL, Nixon SJ. 2000. Blunted stress cortisol response in abstinent alcoholic and polysubstance-abusing men. Alcohol Clin Exp Res 24:651-658.
140. Lovallo WR, Farag NH, Vincent AS, Thomas TL, Wilson MF. 2006. Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacol Biochem Behav 83:441-447.
141. Maheu FS, Joober R, Lupien SJ. 2005. Declarative memory after stress in humans: Differential involvement of the beta-adrenergic and corticosteroid systems. J Clin Endocrinol Metab 90: 1697-1704.
142. Makatsori A, Duncko R, Moncek F, Loder I, Katina S, Jezova D. 2004. Modulation of neuroendocrine response and non-verbal behavior during psychosocial stress in healthy volunteers by the glutamate release-inhibiting drug lamotrigine. Neuroendocrinol-ogy 79:34-42.
143. Martel FL, Hayward C, Lyons DM, Sanborn K, Varady S, Schatzberg AF. 1999. Salivary cortisol levels in socially phobic adolescent girls. Depress Anxiety 10:25-27.
144. Mason JW. 1968. A review of psychoendocrine research on the pituitary-adrenal cortical system. Psychosom Med 30: 576-607.
145. Matchock RL, Dorn LD, Susman EJ. 2007. Diurnal and seasonal cortisol, testosterone, and DHEA rhythms in boys and girls during puberty. Chronobiol Int 24:969-990.
146. McEwen BS. 1998. Protective and damaging effects of stress mediators. N Engl J Med 338:171-179.
147. McRae AL, Saladin ME, Brady KT, Upadhyaya H, Back SE, Timmerman MA. 2006. Stress reactivity: Biological and subjective responses to the cold pressor and Trier social stressors. Hum Psychopharmacol 21:377-385.
148. Meinlschmidt G, Heim C. 2005. Decreased cortisol awakening response after early loss experience. Psychoneuroendocrinology 30:568-576.
149. Mischler K, Fischer JE, Zgraggen L, Kudielka BM, Preckel D, von Känel R. 2005. The effect of repeated acute mental stress on habituation and recovery responses in hemoconcentration and blood cells in healthy men. Life Sci 77:1166-1179.
150. Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ. 2006a. Immune and endocrine function in burnout syndrome. Psychosom Med 68:879-886.
151. Mommersteeg PM, Heijnen CJ, Verbraak MJ, van Doornen LJ. 2006b. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 31:216-225.
152. Mommersteeg PM, Keijsers GP, Heijnen CJ, Verbraak MJ, van Doornen LJ. 2006c. Cortisol deviations in people with burnout before and after psychotherapy: A pilot study. Health Psychol 25:243-248.
153. Munro CA, Oswald LM, Weerts EM, McCaul ME, Wand GS. 2005. Hormone responses to social stress in abstinent alcohol-dependent subjects and social drinkers with no history of alcohol dependence. Alcohol Clin Exp Res 29:1133-1138.
154. Nater UM, Maloney E, Boneva RS, Gurbaxani BM, Lin JM, Jones JF, et al. 2008. Attenuated morning salivary cortisol concentrations in a population-based study of persons with chronic fatigue syndrome and well controls. J Clin Endocrinol Metab 93:703-709.
155. Neylan TC, Brunet A, Pole N, Best SR, Metzler TJ, Yehuda R, Marmar CR. 2005. PTSD symptoms predict waking salivary cortisol levels in police officers. Psychoneuroendocrinology 30:373-381.
156. Oskis A, Loveday C, Hucklebridge F, Thorn L, Clow A. 2009. Diurnal patterns of salivary cortisol across the adolescent period in healthy females. Psychoneuroendocrinology 34:307-316.
157. Pierrehumbert B, Torrisi R, Glatz N, Dimitrova N, Heinrichs M, Halfon O. 2009. The influence of attachment on perceived stress and cortisol response to acute stress in women sexually abused in childhood or adolescence. Psychoneuroendocrinology 34:924-938.
158. Polk DE, Cohen S, Doyle WJ, Skoner DP, Kirschbaum C. 2005. State and trait affect as predictors of salivary cortisol in healthy adults. Psychoneuroendocrinology 30:261-272.
159. Portella MJ, Harmer CJ, Flint J, Cowen P, Goodwin GM. 2005. Enhanced early morning salivary cortisol in neuroticism. Am J Psychiatry 162:807-809.
160. Pruessner JC, Gaab J, Hellhammer DH, Lintz D, Schommer N, Kirschbaum C. 1997a. Increasing correlations between personality traits and cortisol stress responses obtained by data aggregation. Psychoneuroendocrinology 22:615-625.
161. Pruessner JC, Wolf OT, Hellhammer DH, Buske-Kirschbaum A, von Auer K,
162. Pruessner JC, Hellhammer DH, Kirschbaum C. 1999. Burnout, perceived stress, and cortisol responses to awakening. Psycho-som Med 61:197-204.
163. Pruessner M, Hellhammer DH, Pruessner JC, Lupien SJ. 2003. Self-reported depressive symptoms and stress levels in healthy young men: Associations with the cortisol response to awakening. Psychosom Med 65:92-99.
164. Raison CL, Miller AH. 2003. When not enough is too much: The role of insufficient glucocorticoid signaling in the pathophysio-logy of stress-related disorders. Am J Psychiatry 160: 1554-1565.
165. Roberts AD, Wessely S, Chalder T, Papadopoulos A, Cleare AJ. 2004. Salivary cortisol response to awakening in chronic fatigue syndrome. Br J Psychiatry 184:136-141.
166. Roelofs K, van Peer J, Berretty E, Jong P, Spinhoven P, Elzinga BM. 2009. Hypothalamus-pituitary-adrenal axis hyperresponsive-ness is associated with increased social avoidance behavior in social phobia. Biol Psychiatry 65:336-343.
167. Rohleder N, Kirschbaum C. 2006. The hypothalamic-pituitary-adrenal (HPA) axis in habitual smokers. Int J Psychophysiol 59:236-243.
168. Rohleder N, Kirschbaum C. 2007. Effects of nutrition on neuro-endocrine stress responses. Curr Opin Clin Nutr Metab Care 10:504-510.
169. Rohleder N, Kudielka BM, Hellhammer DH, Wolf JM, Kirschbaum C. 2002. Age and sex steroid-related changes in glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress. J Neuroimmunol 126:69-77.
170. Rohleder N, Joksimovic L, Wolf JM, Kirschbaum C. 2004. Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biol Psychiatry 55:745-751.
171. Rohleder N, Beulen SE, Chen E, Wolf JM, Kirschbaum C. 2007. Stress on the dance floor: The cortisol stress response to social-evaluative threat in competitive ballroom dancers. Pers Soc Psychol Bull 33:69-84.
172. Rosmalen JG, Oldehinkel AJ, Ormel J, de Winter AF, Buitelaar JK, Verhulst FC. 2005. Determinants of salivary cortisol levels in 10-12 year old children; A population-based study of individual differences. Psychoneuroendocrinology 30:483-495.
173. Scheer FA, Buijs RM. 1999. Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab 84:3395-3398.
174. Schlotz W, Hellhammer J, Schulz P, Stone AA. 2004. Perceived work overload and chronic worrying predict weekend-weekday differences in the cortisol awakening response. Psychosom Med 66:207-214.
175. Schmidt-Reinwald A, Pruessner JC, Hellhammer DH, Federenko I, Rohleder N, Schürmeyer TH, Kirschbaum C. 1999. The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci 64:1653-1660.
176. Schommer NC, Hellhammer DH, Kirschbaum C. 2003. Dissociation between reactivity of the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medullary system to repeated psychosocial stress. Psychosom Med 65:450-460.
177. Schulz P, Kirschbaum C, Pruessner JC, Hellhammer DH. 1998. Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload. Stress Med 14:91-97.
178. Simeon D, Knutelska M, Smith L, Baker BR, Hollander E. 2007a. A preliminary study of cortisol and norepinephrine reactivity to psychosocial stress in borderline personality disorder with high and low dissociation. Psychiatry Res 149:177-184.
179. Simeon D, Knutelska M, Yehuda R, Putnam F, Schmeidler J, Smith LM. 2007b. Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biol Psychiatry 61:966-973.
180. Söderström M, Ekstedt M, Akerstedt T. 2006. Weekday and weekend patterns of diurnal cortisol, activation and fatigue among people scoring high for burnout. Scand J Work Environ Health Suppl 2:35-40.
181. Sonnenschein M, Mommersteeg PM, Houtveen JH, Sorbi MJ, Schaufeli WB, van Doornen LJ. 2007. Exhaustion and endocrine functioning in clinical burnout: An in-depth study using the experience sampling method. Biol Psychol 75: 176-184.
182. Sorocco KH, Lovallo WR, Vincent AS, Collins FL. 2006. Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism. Int J Psychophysiol 59:210-217.
183. Stalder T, Hucklebridge F, Evans P, Clow A. 2008. Use of a single case study design to examine state variation in the cortisol awakening response: Relationship with time of awakening. Psychoneuroendocrinology 34:607-614.
184. Steptoe A, Ussher M. 2006. Smoking, cortisol and nicotine. Int J Psychophysiol 59:228-235.
185. Steptoe A, Kunz-Ebrecht S, Owen N, Feldman PJ, Willemsen G, Kirschbaum C, Marmot M. 2003. Socioeconomic status and stress-related biological responses over the working day. Psychosom Med 65:461-470.
186. Steptoe A, Kunz-Ebrecht SR, Brydon L, Wardle J. 2004a. Central adiposity and cortisol responses to waking in middle-aged men and women. Int J Obes Relat Metab Disord 28:1168-1173.
187. Steptoe A, Owen N, Kunz-Ebrecht SR, Brydon L. 2004b. Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women. Psychoneuroendocrinology 29:593-611.
188. Steptoe A, Wright CE, O'Donnell K, Brydon L, Wardle J. 2006. Parental adiposity and cortisol awakening responses in young men and women. Psychoneuroendocrinology 31:1117-1126.
189. Steptoe A, Gibson EL, Hamer M, Wardle J. 2007. Neuroendocrine and cardiovascular correlates of positive affect measured by ecological momentary assessment and by questionnaire. Psychoneuroendocrinology 32:56-64.
190. Stetler C, Miller GE. 2005. Blunted cortisol response to awakening in mild to moderate depression: Regulatory influences of sleep patterns and social contacts. J Abnorm Psychol 114: 697-705.
191. Stratakis CA, Chrousos GP. 1995. Neuroendocrinology and pathophysiology of the stress system. In: Chrousos GP, McCarty R, Pacâk K, Cizza G, Sternberg E, Gold PW, Kvetnanský R, editors. Annals of the New York academy of sciences. Stress: Basic mechanisms and clinical implications. Vol.771. New York: The New York Academy of Sciences. p 1-18.
192. Strazdins L, Meyerkort S, Brent V, D'Souza RM, Broom DH, Kyd JM. 2005. Impact of saliva collection methods on sIgA and cortisol assays and acceptability to participants. J Immunol Methods 307:167-171.
193. Stroud LR, Tanofsky-Kraff M, Wilfley DE, Salovey P. 2000. The Yale interpersonal stressor (YIPS): Affective, physiological, and behavioral responses to a novel interpersonal rejection paradigm. Ann Behav Med 22:204-213
194. ter Wolbeek M, van Doornen LJ, Coffeng LE, Kavelaars A, Heijnen CJ. 2007. Cortisol and severe fatigue: A longitudinal study in adolescent girls. Psychoneuroendocrinology 32:171-182.
195. Therrien F, Drapeau V, Lalonde J, Lupien SJ, Beaulieu S, Tremblay A, Richard D. 2007. Awakening cortisol response in lean, obese, and reduced obese individuals: Effect of gender and fat distribution. Obesity (Silver Spring) 15:377-385.
196. Thorn L, Hucklebridge F, Esgate A, Evans P, Clow A. 2004. The effect of dawn simulation on the cortisol response to awakening in healthy participants. Psychoneuroendocrinology 29: 925-930.
197. Thorn L, Hucklebridge F, Evans P, Clow A. 2006. Suspected non-adherence and weekend versus week day differences in the awakening cortisol response. Psychoneuroendocrinology 31:1009-1018.
198. Tsigos C, Chrousos GP. 1994. Physiology of the hypothalamic-pituitary- adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinol Metab Clin North Am 23:451-466.
199. Tsigos C, Chrousos GP. 2002. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 53: 865-871.
200. Tu MT, Lupien SJ, Walker CD. 2006. Multiparity reveals the blunting effect of breastfeeding on physiological reactivity to psychological stress. J Neuroendocrinol 18:494-503.
201. Uhart M, Chong RY, Oswald L, Lin PI, Wand GS. 2006a. Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity. Psychoneuroendocrinology 31:642-652.
202. Uhart M, Oswald L, McCaul ME, Chong R, Wand GS. 2006b. Hormonal responses to psychological stress and family history of alcoholism. Neuropsychopharmacology 31:2255-2263.
203. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, Chrousos GP. 2004. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 89:2119-2126.
204. Vocks S, Ockenfels M, Jürgensen R, Mussgay L, Ruddel H. 2004. Blood pressure reactivity can be reduced by a cognitive behavioral stress management program. Int J Behav Med 11: 63-70.
205. von Känel R, Preckel D, Zgraggen L, Mischler K, Kudielka BM, Haeberli A, Fischer JE. 2004. The effect of natural habituation on coagulation responses to acute mental stress and recovery in men. Thromb Haemost 92:1327-1335.
206. Von Känel R, Kudielka BM, Preckel D, Hanebuth D, Fischer JE. 2006. Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men. Brain Behav Immun 20:40-48.
207. Wallerius S, Rosmond R, Ljung T, Holm G, Björntorp P. 2003. Rise in morning saliva cortisol is associated with abdominal obesity in men: A preliminary report. J Endocrinol Invest 26:616-619.
208. Wessa M, Rohleder N, Kirschbaum C, Flor H. 2006. Altered cortisol awakening response in posttraumatic stress disorder. Psychoneuroendocrinology 31:209-215.
209. Whitehead DL, Perkins-Porras L, Strike PC, Magid K, Steptoe A. 2007. Cortisol awakening response is elevated in acute coronary syndrome patients with type-D personality. J Psychosom Res 62: 419-425.
210. Wiesli P, Schmid C, Kerwer O, Nigg-Koch C, Klaghofer R, Seifert B, et al. 2005. Acute psychological stress affects glucose concentrations in patients with type 1 diabetes following food intake but not in the fasting state. Diabetes Care 28:1910-1915.
211. Wilhelm I, Born J, Kudielka BM, Schlotz W, Wüst S. 2007. Is the cortisol awakening rise a response to awakening? Psychoneuro-endocrinology 32:358-366.
212. Williams RA, Hagerty BM, Brooks G. 2004. Trier social stress test: A method for use in nursing research. Nurs Res 53:277-280.
213. Williams E, Magid K, Steptoe A. 2005. The impact of time of waking and concurrent subjective stress on the cortisol response to awakening. Psychoneuroendocrinology 30:139-148.
214. Wingenfeld K, Heim C, Schmidt I, Wagner D, Meinlschmidt G, Hellhammer DH. 2008. HPA axis reactivity and lymphocyte glucocorticoid sensitivity in fibromyalgia syndrome and chronic pelvic pain. Psychosom Med 70:65-72.
215. Wirtz PH, von Känel R, Emini L, Ruedisueli K, Groessbauer S, Maercker A, Ehlert U. 2007. Evidence for altered hypothala-mus-pituitary-adrenal axis functioning in systemic hypertension: Blunted cortisol response to awakening and lower negative feedback sensitivity. Psychoneuroendocrinology 32:430-436.
216. Wolf OT, Fujiwara E, Luwinski G, Kirschbaum C, Markowitsch HJ. 2005. No morning cortisol response in patients with severe global amnesia. Psychoneuroendocrinology 30:101-105.
217. Wright CE, Steptoe A. 2005. Subjective socioeconomic position, gender and cortisol responses to waking in an elderly population. Psychoneuroendocrinology 30:582-590.
218. Wüst S, Federenko I, Hellhammer DH, Kirschbaum C. 2000a. Genetic factors, perceived chronic stress, and the free cortisol response to awakening. Psychoneuroendocrinology 25: 707-720.
219. Wüst S, Wolf J, Hellhammer DH, Federenko I, Schommer N, Kirschbaum C. 2000b. The cortisol awakening response-normal values and confounds. Noise Health 2:79-88.
220. Wüst S, Federenko IS, van Rossum EF, Koper JW, Kumsta R, Entringer S, Hellhammer DH. 2004a. A psychobiological perspective on genetic determinants of hypothalamus-pitu-itary-adrenal axis activity. Ann N Y Acad Sci 1032:52-62.
221. Wüst S, Van Rossum EF, Federenko IS, Koper JW, Kumsta R, Hellhammer DH. 2004b. Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab 89:565-573.
222. Wüst S, Entringer S, Federenko IS, Schlotz W, Hellhammer DH. 2005a. Birth weight is associated with salivary cortisol responses to psychosocial stress in adult life. Psychoneuroendocrinology 30:591-598.
223. WüstS,Federenko IS, van Rossum EF, Koper JW, Hellhammer DH. 2005b. Habituation of cortisol responses to repeated psychoso-cial stress-further characterization and impact of genetic factors. Psychoneuroendocrinology 30:199-211.
224. Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. 2000. Hormonal evidence for altered responsiveness to social stress in major depression. Neuropsychopharmacology 23: 411-418.
225. Young EA, Abelson JL, Cameron OG. 2004. Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol Psychiatry 56:113-120.
226. Zimmermann U, Spring K, Kunz-Ebrecht SR, Uhr M, Wittchen HU, Holsboer F. 2004. Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. Neuropsychophar- macology 29:1156-1165. (Pubitemid 38670052)