Interactions of the circadian CLOCK system and the HPA axis

Trends in Endocrinology and Metabolism

Volumn 21, Issue 5, 2010, Pages 277-286

  Nader, Nancy ^a   Chrousos, George P ^b   Kino, Tomoshige ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CRYPTOCHROME 1; CRYPTOCHROME 2; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PER1 PROTEIN; PER2 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BMAL1; STAT5 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR CLOCK; TUMOR NECROSIS FACTOR ALPHA;

CIRCADIAN RHYTHM; DIABETES MELLITUS; DYSLIPIDEMIA; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOPATHOLOGY; INSULIN RESISTANCE; LIGHT DARK CYCLE; METABOLIC SYNDROME X; NONHUMAN; OBESITY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION REGULATION;

ANIMALS; BIOLOGICAL CLOCKS; BLOOD GLUCOSE; CIRCADIAN RHYTHM; CUSHING SYNDROME; DIABETES MELLITUS, TYPE 2; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; STRESS, PHYSIOLOGICAL;

EID: 77952474442     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2009.12.011     Document Type: Review

References (64)

1. Takahashi J.S., et al. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat. Rev. Genet. 2008, 9:764-775.
2. Ko C.H., Takahashi J.S. Molecular components of the mammalian circadian clock. Hum. Mol. Genet. 2006, 15(Spec. No. 2):R271-R277.
3. Hastings M., et al. Circadian clocks: regulators of endocrine and metabolic rhythms. J. Endocrinol. 2007, 195:187-198.
4. Chrousos G.P. Stress and disorders of the stress system. Nat. Rev. Endocrinol. 2009, 5:374-381.
5. Chrousos G.P., Kino T. Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 2007, 10:213-219.
6. Kalsbeek A., et al. SCN outputs and the hypothalamic balance of life. J. Biol. Rhythms 2006, 21:458-469.
7. Cermakian N., Sassone-Corsi P. Multilevel regulation of the circadian clock. Nat. Rev. Mol. Cell Biol. 2000, 1:59-67.
8. Kondratov R.V., et al. Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES. Cell Cycle 2006, 5:890-895.
9. Kiyohara Y.B., et al. The BMAL1 C terminus regulates the circadian transcription feedback loop. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:10074-10079.
10. Ripperger J.A., Schibler U. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat. Genet. 2006, 38:369-374.
11. Meijer J.H., Schwartz W.J. In search of the pathways for light-induced pacemaker resetting in the suprachiasmatic nucleus. J. Biol. Rhythms 2003, 18:235-249.
12. Oster H., et al. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Cell Metab. 2006, 4:163-173.
13. Kraves S., Weitz C.J. A role for cardiotrophin-like cytokine in the circadian control of mammalian locomotor activity. Nat. Neurosci. 2006, 9:212-219.
14. Mori K., et al. Neuromedin S: discovery and functions. Results Probl. Cell Differ. 2008, 46:201-212.
15. Yoo S.H., et al. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:5339-5346.
16. Damiola F., et al. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 2000, 14:2950-2961.
17. Fuller P.M., et al. Differential rescue of light- and food-entrainable circadian rhythms. Science 2008, 320:1074-1077.
18. Bao A.M., et al. The stress system in depression and neurodegeneration: focus on the human hypothalamus. Brain Res. Rev. 2008, 57:531-553.
19. Kino T., Chrousos G.P. Glucocorticoid effect on gene expression. Handbook on Stress and the Brain 2005, 295-312. Elsevier BV. T. Steckler (Ed.).
20. Chrousos G.P., Kino T. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci. STKE 2005, 2005:pe48.
21. Kino T., Chrousos G.P. Glucocorticoid and mineralocorticoid receptors and associated diseases. Essays Biochem. 2004, 40:137-155.
22. Chrousos G.P. Glucocorticoid therapy. Endocrinology and Metabolism 2001, 609-632. McGraw-Hill. 4th edn. P. Felig, L.A. Frohman (Eds.).
23. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 1995, 332:1351-1362.
24. Ishida A., et al. Light activates the adrenal gland: timing of gene expression and glucocorticoid release. Cell Metab. 2005, 2:297-307.
25. Ulrich-Lai Y.M., et al. Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R1128-R1135.
26. Dallmann R., et al. Impaired daily glucocorticoid rhythm in Per1 (Brd) mice. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 2006, 192:769-775.
27. Yang S., et al. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology 2009, 150:2153-2160.
28. Balsalobre A., et al. Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 2000, 289:2344-2347.
29. Fukuoka Y., et al. Glucocorticoid administration increases hPer1 mRNA levels in human peripheral blood mononuclear cells in vitro or in vivo. J. Biol. Rhythms 2005, 20:550-553.
30. Segall L.A., et al. Glucocorticoid rhythms control the rhythm of expression of the clock protein, Period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats. Neuroscience 2006, 140:753-757.
31. Oishi K., et al. Genome-wide expression analysis reveals 100 adrenal gland-dependent circadian genes in the mouse liver. DNA Res. 2005, 12:191-202.
32. Burioka N., et al. Circadian rhythms in the CNS and peripheral clock disorders: function of clock genes: influence of medication for bronchial asthma on circadian gene. J. Pharmacol. Sci. 2007, 103:144-149.
33. Yamamoto T., et al. Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element. J. Biol. Chem. 2005, 280:42036-42043.
34. So A.Y., et al. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:17582-17587.
35. Segall L.A., et al. Brain glucocorticoid receptors are necessary for the rhythmic expression of the clock protein, PERIOD2, in the central extended amygdala in mice. Neurosci. Lett. 2009, 457:58-60.
36. Nader N., et al. Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 2009, 23:1572-1583.
37. Doi M., et al. Circadian regulator CLOCK is a histone acetyltransferase. Cell 2006, 125:497-508.
38. Yang X., et al. Nuclear receptor expression links the circadian clock to metabolism. Cell 2006, 126:801-810.
39. Staels B. When the Clock stops ticking, metabolic syndrome explodes. Nat. Med. 2006, 12:54-55.
40. Panda S., et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 2002, 109:307-320.
41. Storch K.F., et al. Extensive and divergent circadian gene expression in liver and heart. Nature 2002, 417:78-83.
42. Duez H., Staels B. Rev-erbα gives a time cue to metabolism. FEBS Lett. 2008, 582:19-25.
43. Yin L., et al. Rev-erbα, a heme sensor that coordinates metabolic and circadian pathways. Science 2007, 318:1786-1789.
44. Rudic R.D., et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004, 2:e377.
45. Turek F.W., et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 2005, 308:1043-1045.
46. Oishi K. Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders. Clin. Exp. Hypertens. 2009, 31:208-219.
47. Oishi K., et al. CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression. J. Thromb. Haemost. 2006, 4:1774-1780.
48. Oishi K., et al. PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice. J. Mol. Cell. Cardiol. 2009, 46:545-552.
49. Fujino Y., et al. A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers. Am. J. Epidemiol. 2006, 164:128-135.
50. Sookoian S., et al. Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation. J. Intern. Med. 2007, 261:285-292.
51. Sookoian S., et al. Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am. J. Clin. Nutr. 2008, 87:1606-1615.
52. Scott E.M., et al. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int. J. Obes. (Lond.) 2008, 32:658-662.
53. Gomez-Abellan P., et al. Clock genes are implicated in the human metabolic syndrome. Int. J. Obes. (Lond.) 2008, 32:121-128.
54. Friedman T.C., et al. Carbohydrate and lipid metabolism in endogenous hypercortisolism: shared features with metabolic syndrome X and NIDDM. Endocr. J. 1996, 43:645-655.
55. Ekstrand K., et al. Cardiovascular risk factors in commercial flight aircrew officers compared with those in the general population. Angiology 1996, 47:1089-1094.
56. Scheer F.A., et al. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:4453-4458.
57. Liu J., et al. The circadian clock Period 2 gene regulates γ interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Infect. Immun. 2006, 74:4750-4756.
58. Arjona A., Sarkar D.K. Are circadian rhythms the code of hypothalamic-immune communication? Insights from natural killer cells. Neurochem. Res. 2008, 33:708-718.
59. Rhen T., Cidlowski J.A. Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N. Engl. J. Med. 2005, 353:1711-1723.
60. Pilorz V., et al. Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes Per1 and Per2. Physiol. Behav. 2009, 96:57-63.
61. Reddy A.B., et al. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology 2007, 45:1478-1488.
62. Segall L.A., et al. Timed restricted feeding restores the rhythms of expression of the clock protein, Period2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in adrenalectomized rats. Neuroscience 2008, 157:52-56.
63. Woon P.Y., et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:14412-14417.
64. Chrousos G.P. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int. J. Obes. Relat. Metab. Disord. 2000, 24:S50-S55.