A thiopurine drug inhibits west nile virus production in cell culture, but not in mice

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Lim, Pei Yin ^a,b   Keating, Julie A ^d   Hoover, Spencer ^d   Striker, Rob ^c,d   Bernard, Kristen A ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WADSWORTH CENTER   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOPURINE; 6 METHYLTHIOINOSINE; ANTIVIRUS AGENT;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENGUE VIRUS 2; DISEASE EXACERBATION; DRUG BIOAVAILABILITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; FEMALE; FLAVIVIRUS INFECTION; LOW DRUG DOSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBSERVATIONAL STUDY; PERIPHERAL NERVOUS SYSTEM; VIROGENESIS; VIRUS INHIBITION; VIRUS LOAD; WEIGHT REDUCTION; WEST NILE FLAVIVIRUS; YELLOW FEVER FLAVIVIRUS; ANIMAL; CELL CULTURE; CERCOPITHECUS; DRUG EFFECT; HAMSTER; PHYSIOLOGY; VERO CELL; VIRUS REPLICATION;

BOVINE VIRAL DIARRHEA VIRUS 1; DENGUE VIRUS; FLAVIVIRIDAE; FLAVIVIRUS; HEPATITIS C VIRUS; MUS; WEST NILE VIRUS; YELLOW FEVER VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CRICETINAE; METHYLTHIOINOSINE; MICE; VERO CELLS; VIRUS REPLICATION; WEST NILE VIRUS;

EID: 80055048925     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026697     Document Type: Article

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