Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells

Neurochemical Research

Volumn 36, Issue 11, 2011, Pages 2083-2090

  Yi, Hyoseok ^a,b   Lee, Seong Jin ^a   Lee, Jiyeong ^a   Myung, Chang Seon ^b   Park, Woo Kyu ^a   Lim, Hee Jong ^a   Lee, Ge Hyeong ^a   Kong, Jae Yang ^a,c   Cho, Heeyeong ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

amyloid; secretase (BACE1); Alzheimer's disease; Lysophospholipids; Sphingosylphosphorylcholine

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLCHOLINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSYLPHOSPHORYLCHOLINE;

ANIMAL CELL; ARTICLE; BACE1 GENE; CATALYSIS; CELL CULTURE; CELL NUCLEUS; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME INHIBITION; GENE; GENE EXPRESSION REGULATION; IC 50; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; RAT; TRANSCRIPTION REGULATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; DOWN-REGULATION; HUMANS; LYSOPHOSPHOLIPIDS; NF-KAPPA B; PC12 CELLS; PHOSPHORYLCHOLINE; RATS; SPHINGOSINE;

EID: 80055010831     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0532-0     Document Type: Article

References (47)

1. C Haass MG Schlossmacher AY Hung, et al. 1992 Amyloid beta-peptide is produced by cultured cells during normal metabolism Nature 359 322 325 1383826 10.1038/359322a0 1:CAS:528:DyaK38XmtV2msro%3D
2. FM LaFerla KN Green S Oddo 2007 Intracellular amyloid-beta in Alzheimer's disease Nat Rev Neurosci 8 499 509 17551515 10.1038/nrn2168 1:CAS:528:DC%2BD2sXmslWjsr8%3D (Pubitemid 46985362)
3. C De Jonghe C Esselens S Kumar-Singh, et al. 2001 Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability Hum Mol Genet 10 1665 1671 11487570 10.1093/hmg/10.16.1665 (Pubitemid 32776296)
4. A Herreman L Serneels W Annaert, et al. 2000 Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells Nat Cell Biol 2 461 462 10878813 10.1038/35017105 1:CAS:528:DC%2BD3cXkvFCqt70%3D
5. DJ Selkoe 1998 The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease Trends Cell Biol 8 447 453 9854312 10.1016/S0962-8924(98)01363-4 1:CAS:528:DyaK1MXmsV2m (Pubitemid 28529718)
6. R Vassar BD Bennett S Babu-Khan, et al. 1999 Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE Science 286 735 741 10531052 10.1126/science.286.5440.735 1:CAS:528:DyaK1MXntFWit74%3D (Pubitemid 29505878)
7. CM Smith M Swash AN Exton-Smith, et al. 1978 Choline therapy in Alzheimer's disease Lancet 2 318 79110 10.1016/S0140-6736(78)91721-X 1:STN:280:DyaE1c3it1eisg%3D%3D (Pubitemid 9001847)
8. MG Schlossmacher BL Ostaszewski LI Hecker, et al. 1992 Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes Neurobiol Aging 13 421 434 1625772 10.1016/0197-4580(92)90117-G 1:CAS:528:DyaK38XlsVyntLk%3D
9. BD Bennett S Babu-Khan R Loeloff, et al. 2000 Expression analysis of BACE2 in brain and peripheral tissues J Biol Chem 275 20647 20651 10749877 10.1074/jbc.M002688200 1:CAS:528:DC%2BD3cXkvVyhsbs%3D (Pubitemid 30457651)
10. M Farzan CE Schnitzler N Vasilieva, et al. 2000 BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein Proc Natl Acad Sci USA 97 9712 9717 10931940 10.1073/pnas.160115697 1:CAS:528:DC%2BD3cXmtVentL8%3D (Pubitemid 30650841)
11. C Lange-Dohna U Zeitschel F Gaunitz, et al. 2003 Cloning and expression of the rat BACE1 promoter J Neurosci Res 73 73 80 12815710 10.1002/jnr.10639 1:CAS:528:DC%2BD3sXltlSqt7s%3D (Pubitemid 36791371)
12. KZ Bourne DC Ferrari C Lange-Dohna, et al. 2007 Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides J Neurosci Res 85 1194 1204 17385716 10.1002/jnr.21252 1:CAS:528:DC%2BD2sXlsV2rs7s%3D (Pubitemid 46724363)
13. X He Y Huang B Li, et al. 2010 Deregulation of sphingolipid metabolism in Alzheimer's disease Neurobiol Aging 31 398 408 18547682 10.1016/j. neurobiolaging.2008.05.010 1:CAS:528:DC%2BC3cXntVWruw%3D%3D
14. A Jana K Pahan 2004 Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease J Biol Chem 279 51451 51459 15452132 10.1074/jbc.M404635200 1:CAS:528:DC%2BD2cXhtVaqs73M (Pubitemid 40017893)
15. XL Qi J Xiu KR Shan, et al. 2005 Oxidative stress induced by beta-amyloid peptide(1-42) is involved in the altered composition of cellular membrane lipids and the decreased expression of nicotinic receptors in human SH-SY5Y neuroblastoma cells Neurochem Int 46 613 621 15863239 10.1016/j.neuint.2005.02. 007 1:CAS:528:DC%2BD2MXjs1Cnurw%3D (Pubitemid 40614864)
16. CQ Duong SM Bared A Abu-Khader, et al. 2004 Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages Biochim Biophys Acta 1682 112 119 15158762 1:CAS:528:DC%2BD2cXktF2rurs%3D (Pubitemid 38670541)
17. D Meyer zu Heringdorf HM Himmel KH Jakobs 2002 Sphingosylphosphorylcholine-biological functions and mechanisms of action Biochim Biophys Acta 1582 178 189 12069827 1:CAS:528:DC%2BD38XksF2htL8%3D
18. GF Nixon FA Mathieson I Hunter 2008 The multi-functional role of sphingosylphosphorylcholine Prog Lipid Res 47 62 75 18042469 10.1016/j.plipres.2007.11.001 1:CAS:528:DC%2BD2sXhsVSmurbK (Pubitemid 350216623)
19. G Imokawa 2009 A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide J Dermatol Sci 55 1 9 19443184 10.1016/j.jdermsci.2009.04.006 1:CAS:528:DC%2BD1MXms12jtLw%3D
20. HJ Kim H Kim ES Han, et al. 2008 Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632 Eur J Pharmacol 583 92 96 18289521 10.1016/j.ejphar.2008.01.005 1:CAS:528:DC%2BD1cXivVejs7k%3D
21. G Boguslawski D Lyons KA Harvey, et al. 2000 Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis Biochem Biophys Res Commun 272 603 609 10833459 10.1006/bbrc.2000.2822 1:CAS:528:DC%2BD3cXjs12ns7g%3D (Pubitemid 30444663)
22. G Boguslawski JR Grogg Z Welch, et al. 2002 Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response Exp Cell Res 274 264 274 11900487 10.1006/excr.2002.5472 1:CAS:528:DC%2BD38XitVaisro%3D
23. ES Jeon YJ Kang HY Song, et al. 2005 Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways Cell Signal 17 777 787 15722202 10.1016/j.cellsig.2004.11.004 1:CAS:528:DC%2BD2MXhslWlur4%3D (Pubitemid 40250178)
24. M Tolle A Pawlak M Schuchardt, et al. 2008 HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production Arterioscler Thromb Vasc Biol 28 1542 1548 18483405 10.1161/ATVBAHA.107.161042
25. C Xin S Ren W Eberhardt, et al. 2007 Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation J Lipid Res 48 1985 1996 17592175 10.1194/jlr.M700077-JLR200 1:CAS:528:DC%2BD2sXpslOju70%3D (Pubitemid 47360618)
26. O Murch M Abdelrahman M Collino, et al. 2008 Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat Crit Care Med 36 550 559 18216604 10.1097/01.CCM.0B013E3181620D2F 1:CAS:528:DC%2BD1cXptlejuw%3D%3D (Pubitemid 351158632)
27. N Konno A Nakamura Y Ikeno, et al. 2007 Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells Biochem Biophys Res Commun 364 163 168 17935698 10.1016/j.bbrc.2007.09.121 1:CAS:528:DC%2BD2sXht1aktbrF (Pubitemid 47599459)
28. AK Ghosh N Kumaragurubaran L Hong, et al. 2007 Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands J Med Chem 50 2399 2407 17432843 10.1021/jm061338s 1:CAS:528:DC%2BD2sXktFCqsLY%3D (Pubitemid 46799251)
29. R Lin X Chen W Li, et al. 2008 Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin Neurosci Lett 440 344 347 18583042 10.1016/j.neulet.2008.05.070 1:CAS:528:DC%2BD1cXnvVOgtbg%3D
30. X Zhu W Zhou Y Cui, et al. 2009 Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells Biochem Biophys Res Commun 384 110 113 19393223 10.1016/j.bbrc.2009.04.080 1:CAS:528:DC%2BD1MXmtFShsLs%3D
31. JA Hillion K Takahashi D Maric, et al. 2005 Development of an ischemic tolerance model in a PC12 cell line J Cereb Blood Flow Metab 25 154 162 15647748 10.1038/sj.jcbfm.9600003 1:CAS:528:DC%2BD2MXitFOisrY%3D (Pubitemid 40171198)
32. U Reimann-Philipp R Ovase PH Weigel, et al. 2001 Mechanisms of cell death in primary cortical neurons and PC12 cells J Neurosci Res 64 654 660 11398190 10.1002/jnr.1119 1:CAS:528:DC%2BD3MXksVOks7o%3D (Pubitemid 32520688)
33. DS Auld TJ Kornecook S Bastianetto, et al. 2002 Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies Prog Neurobiol 68 209 245 12450488 10.1016/S0301-0082(02)00079-5 1:CAS:528:DC%2BD38XovFeiurk%3D (Pubitemid 35346805)
34. M Asai C Hattori B Szabo, et al. 2003 Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase Biochem Biophys Res Commun 301 231 235 12535668 10.1016/S0006-291X(02)02999-6 1:CAS:528:DC%2BD3sXjtFCitQ%3D%3D (Pubitemid 36268873)
35. F Fahrenholz S Gilbert E Kojro, et al. 2000 Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure Ann N Y Acad Sci 920 215 222 11193153 10.1111/j.1749-6632.2000.tb06925.x 1:CAS:528:DC%2BD3MXotlaisg%3D%3D (Pubitemid 32056572)
36. MA Christensen W Zhou H Qing, et al. 2004 Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1 Mol Cell Biol 24 865 874 14701757 10.1128/MCB.24.2.865-874.2004 1:CAS:528: DC%2BD2cXktVyrsw%3D%3D (Pubitemid 38057936)
37. T Tanaka K Isoe-Wada H Yamamori, et al. 2006 Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease Acta Neurol Taiwan 15 68 71 16599295
38. ML Bolognesi M Bartolini F Mancini, et al. 2010 Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities ChemMedChem 5 1215 1220 20486153 10.1002/cmdc.201000086 1:CAS:528:DC%2BC3cXptl2jurc%3D
39. P Camps X Formosa C Galdeano, et al. 2010 Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates Chem Biol Interact 187 411 415 20167211 10.1016/j.cbi.2010.02. 013 1:CAS:528:DC%2BC3cXps1Wnsr0%3D
40. HA Jung SE Jin RJ Choi, et al. 2010 Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1 Life Sci 87 420 430 20736023 10.1016/j.lfs.2010.08.005 1:CAS:528:DC%2BC3cXht1SqsrbL
41. HA Jung EJ Lee JS Kim, et al. 2009 Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata Arch Pharm Res 32 1399 1408 19898803 10.1007/s12272-009-2009-0 1:CAS:528:DC%2BD1MXhtlOrtLzK
42. HA Jung BS Min T Yokozawa, et al. 2009 Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids Biol Pharm Bull 32 1433 1438 19652386 10.1248/bpb.32.1433 1:CAS:528:DC%2BD1MXhtFCjsLbO
43. HA Jung T Yokozawa BW Kim, et al. 2010 Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases Am J Chin Med 38 415 429 20387235 10.1142/S0192415X10007944 1:CAS:528:DC%2BC3cXlvVWiu74%3D
44. L Piazzi A Cavalli F Colizzi, et al. 2008 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds Bioorg Med Chem Lett 18 423 426 17998161 10.1016/j.bmcl.2007.09.100 1:CAS:528:DC%2BD1cXis1WgtA%3D%3D
45. ME Lin DR Herr J Chun 2010 Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance Prostaglandins Other Lipid Mediat 91 130 138 20331961 10.1016/j.prostaglandins.2009.02.002 1:CAS:528: DC%2BC3cXjslSiu7k%3D
46. K Nakanaga K Hama J Aoki 2010 Autotaxin-an LPA producing enzyme with diverse functions J Biochem 148 13 24 20495010 10.1093/jb/mvq052 1:CAS:528:DC%2BC3cXotlChsLg%3D
47. EJ Mufson SE Counts SE Perez, et al. 2008 Cholinergic system during the progression of Alzheimer's disease: therapeutic implications Expert Rev Neurother 8 1703 1718 18986241 10.1586/14737175.8.11.1703 1:CAS:528: DC%2BD1cXhtlentLvP