Anti-inflammatory therapies in cancer cachexia

European Journal of Pharmacology

Volumn 668, Issue SUPPL. 1, 2011, Pages

  Argilés, Josep M ^a   Busquets, Sílvia ^a   López Soriano, Francisco J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Cachexia; Inflammation; Muscle wasting

Indexed keywords

BRANCHED CHAIN AMINO ACID; CILIARY NEUROTROPHIC FACTOR; DOCETAXEL; ETANERCEPT; GAMMA INTERFERON; GLUTAMINE; ICOSAPENTAENOIC ACID; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 15; INTERLEUKIN 6; OMEGA 3 FATTY ACID; PLACEBO; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ADVANCED CANCER; ANOREXIA; CACHEXIA; CLINICAL FEATURE; CONFERENCE PAPER; CYTOKINE RESPONSE; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE COURSE; DRUG SAFETY; FATIGUE; HUMAN; IMMUNOMODULATION; INFLAMMATION; MUSCLE ATROPHY; MUSCLE METABOLISM; NEOPLASM; NONHUMAN; NUTRITIONAL SUPPORT; PANCREAS CANCER; PARENTERAL NUTRITION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; WASTING SYNDROME;

EID: 80054990795     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.07.007     Document Type: Conference Paper

References (61)

1. S.D. Anker, and A.J. Coats How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH Int. J. Cardiol. 86 2002 123 130 (Pubitemid 35284800)
2. M. Anti, G. Marra, F. Armelao, G.M. Bartoli, R. Ficarelli, A. Percesepe, I. De Vitis, G. Maria, L. Sofo, and G.L. Rapaccini Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer Gastroenterology 103 1992 883 891
3. J.M. Argiles, S. Busquets, and F.J. Lopez-Soriano The pivotal role of cytokines in muscle wasting during cancer Int. J. Biochem. Cell Biol. 37 2005 1609 1619 (Pubitemid 40719640)
4. J.M. Argiles, F.J. Lopez-Soriano, and S. Busquets Mechanisms to explain wasting of muscle and fat in cancer cachexia Curr. Opin. Support. Palliat. Care 1 2007 293 298
5. J.M. Argiles, S. Busquets, M. Toledo, and F.J. Lopez-Soriano The role of cytokines in cancer cachexia Curr. Opin. Support. Palliat. Care 3 2009 263 268
6. J.M. Argiles, F.J. Lopez-Soriano, and S. Busquets Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity Drug Discov. Today 14 2009 208 213
7. I. Bayram, F. Erbey, N. Celik, J.L. Nelson, and A. Tanyeli The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy-related weight loss in children Pediatr. Blood Cancer 52 2009 571 574
8. S. Busquets, M.T. Figueras, S. Meijsing, N. Carbo, L.S. Quinn, V. Almendro, J.M. Argiles, and F.J. Lopez-Soriano Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect Int. J. Mol. Med. 16 2005 471 476
9. C. Cangiano, A. Laviano, M.M. Meguid, M. Mulieri, L. Conversano, I. Preziosa, and F. Rossi-Fanelli Effects of administration of oral branched-chain amino acids on anorexia and caloric intake in cancer patients J. Natl. Cancer Inst. 88 1996 550 552 (Pubitemid 126613359)
10. N. Carbo, J. Lopez-Soriano, P. Costelli, B. Alvarez, S. Busquets, F.M. Baccino, L.S. Quinn, F.J. Lopez-Soriano, and J.M. Argiles Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control Biochim. Biophys. Acta 1526 2001 17 24 (Pubitemid 32245767)
11. M.K. Chen, R.M. Salloum, T.R. Austgen, J.B. Bland, K.I. Bland, E.M. Copeland III, and W.W. Souba Tumor regulation of hepatic glutamine metabolism JPEN J Parenter Enteral Nutr 15 1991 159 164
12. S.J. Clarke, C. Gebbie, C. Sweeney, N. And Olszewski, and J. Smith A phase I, pharmacokinetic (PK) and preliminary efficacy assesssment of ALD518, a humanized anti-interleukin (IL)6 antibody, in patients with advanced cancer J. Cachexia, Sarc. Muscle 1 2010 98 101
13. C. Constantinou, C.C. Fontes de Oliveira, D. Mintzopoulos, S. Busquets, J. He, M. Kesarwani, M. Mindrinos, L.G. Rahme, J.M. Argiles, and A.A. Tzika Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia Int. J. Mol. Med. 27 2011 15 24
14. P. Costelli, M. Llovera, N. Carbo, C. Garcia-Martinez, F.J. Lopez-Sorianoq, and J.M. Argiles Interleukin-1 receptor antagonist (IL-1ra) is unable to reverse cachexia in rats bearing an ascites hepatoma (Yoshida AH-130) Cancer Lett. 95 1995 33 38
15. A. Dewey, C. Baughan, T. Dean, B. Higgins, and I. Johnson Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia Cochrane Database Syst. Rev. 2007 CD004597
16. W. Droge, A. Gross, V. Hack, R. Kinscherf, M. Schykowski, M. Bockstette, S. Mihm, and D. Galter Role of cysteine and glutathione in HIV infection and cancer cachexia: therapeutic intervention with N-acetylcysteine Adv. Pharmacol. 38 1997 581 600
17. R.D. Evans, J.M. Argiles, and D.H. Williamson Metabolic effects of tumour necrosis factor-alpha (cachectin) and interleukin-1 Clin. Sci. (Lond.) 77 1989 357 364 (Pubitemid 19237076)
18. W.J. Evans, J.E. Morley, J. Argiles, C. Bales, V. Baracos, D. Guttridge, A. Jatoi, K. Kalantar-Zadeh, H. Lochs, G. Mantovani, D. Marks, W.E. Mitch, M. Muscaritoli, A. Najand, P. Ponikowski, F. Rossi Fanelli, M. Schambelan, A. Schols, M. Schuster, D. Thomas, R. Wolfe, and S.D. Anker Cachexia: a new definition Clin. Nutr. 27 2008 793 799
19. J. Faber, P. Vos, D. Kegler, K. van Norren, J.M. Argiles, A. Laviano, J. Garssen, and A. van Helvoort Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia Br. J. Cancer 99 2008 2029 2036
20. K.C. Fearon, M.F. Von Meyenfeldt, A.G. Moses, R. Van Geenen, A. Roy, D.J. Gouma, A. Giacosa, A. Van Gossum, J. Bauer, M.D. Barber, N.K. Aaronson, A.C. Voss, and M.J. Tisdale Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial Gut 52 2003 1479 1486 (Pubitemid 37176729)
21. K.C. Fearon, M.D. Barber, A.G. Moses, S.H. Ahmedzai, G.S. Taylor, M.J. Tisdale, and G.D. Murray Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia J. Clin. Oncol. 24 2006 3401 3407 (Pubitemid 46638896)
22. J.D. Fernstrom Dietary effects on brain serotonin synthesis: relationship to appetite regulation Am. J. Clin. Nutr. 42 1985 1072 1082 (Pubitemid 16148061)
23. M. Figueras, S. Busquets, N. Carbo, E. Barreiro, V. Almendro, J.M. Argiles, and F.J. Lopez-Soriano Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats FEBS Lett. 569 2004 201 206 (Pubitemid 38844618)
24. K. Fujimoto-Ouchi, S. Tamura, K. Mori, Y. Tanaka, and H. Ishitsuka Establishment and characterization of cachexia-inducing and -non-inducing clones of murine colon 26 carcinoma Int. J. Cancer 61 1995 522 528
25. J.N. Gordon, T.M. Trebble, R.D. Ellis, H.D. Duncan, T. Johns, and P.M. Goggin Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial Gut 54 2005 540 545 (Pubitemid 40403032)
26. Y. Han, S. Weinman, I. Boldogh, R.K. Walker, and A.R. Brasier Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation J. Biol. Chem. 274 1999 787 794
27. J.T. Henderson, B.J. Mullen, and J.C. Roder Physiological effects of CNTF-induced wasting Cytokine 8 1996 784 793 (Pubitemid 27023297)
28. D.C. Hunter, M. Weintraub, G.L. Blackburn, and B.R. Bistrian Branched chain amino acids as the protein component of parenteral nutrition in cancer cachexia Br. J. Surg. 76 1989 149 153 (Pubitemid 19057011)
29. V.S. Klimberg, E. Nwokedi, L.F. Hutchins, A.A. Pappas, N.P. Lang, J.R. Broadwater, R.C. Read, and K.C. Westbrook Glutamine facilitates chemotherapy while reducing toxicity JPEN J Parenter Enteral Nutr 16 1992 83S 87S
30. R. Krause, J.H. James, V. Ziparo, and J.E. Fischer Brain tryptophan and the neoplastic anorexia-cachexia syndrome Cancer 44 1979 1003 1008 (Pubitemid 10242234)
31. K. Kuroda, J. Nakashima, K. Kanao, E. Kikuchi, A. Miyajima, Y. Horiguchi, K. Nakagawa, M. Oya, T. Ohigashi, and M. Murai Interleukin 6 is associated with cachexia in patients with prostate cancer Urology 69 2007 113 117 (Pubitemid 46161697)
32. M. Lainscak, G.S. Filippatos, M. Gheorghiade, G.C. Fonarow, and S.D. Anker Cachexia: common, deadly, with an urgent need for precise definition and new therapies Am. J. Cardiol. 101 2008 8E 10E
33. A. Laviano, T. Renvyle, and Z.J. Yang From laboratory to bedside: new strategies in the treatment of malnutrition in cancer patients Nutrition 12 1996 112 122 (Pubitemid 26166066)
34. G. Mantovani, A. Maccio, L. Mura, E. Massa, M.C. Mudu, C. Mulas, M.R. Lusso, C. Madeddu, and A. Dessi Serum levels of leptin and proinflammatory cytokines in patients with advanced-stage cancer at different sites J. Mol. Med. 78 2000 554 561 (Pubitemid 32039615)
35. G. Mantovani, A. Maccio, C. Madeddu, G. Gramignano, M.R. Lusso, R. Serpe, E. Massa, G. Astara, and L. Deiana A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress Cancer Epidemiol. Biomarkers Prev. 15 2006 1030 1034 (Pubitemid 43823535)
36. G. Mantovani, A. Maccio, C. Madeddu, R. Serpe, E. Massa, M. Dessi, F. Panzone, and P. Contu Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia Oncologist 15 2010 200 211
37. P. Matthys, H. Heremans, G. Opdenakker, and A. Billiau Anti-interferon-gamma antibody treatment, growth of Lewis lung tumours in mice and tumour-associated cachexia Eur. J. Cancer 27 1991 182 187
38. M.M. Meguid, M. Muscaritoli, J.L. Beverly, Z.J. Yang, C. Cangiano, and F. Rossi-Fanelli The early cancer anorexia paradigm: changes in plasma free tryptophan and feeding indexes JPEN J Parenter Enteral Nutr 16 1992 56S 59S
39. M.R. Mehra, C.J. Lavie, H.O. Ventura, and R.V. Milani Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure J. Heart Lung Transplant. 25 2006 834 838 (Pubitemid 43963369)
40. J.P. Monk, G. Phillips, R. Waite, J. Kuhn, L.J. Schaaf, G.A. Otterson, D. Guttridge, C. Rhoades, M. Shah, T. Criswell, M.A. Caligiuri, and M.A. Villalona-Calero Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients J. Clin. Oncol. 24 2006 1852 1859 (Pubitemid 46638983)
41. E.A. Nunes, D. Kuczera, G.A. Brito, S.J. Bonatto, R.K. Yamazaki, R.A. Tanhoffer, R.C. Mund, M. Kryczyk, and L.C. Fernandes Beta-hydroxy-beta- methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression Nutr. Res. 28 2008 487 493 (Pubitemid 351802290)
42. E. Pasini, R. Aquilani, F.S. Dioguardi, G. D'Antona, M. Gheorghiade, and H. Taegtmeyer Hypercatabolic syndrome: molecular basis and effects of nutritional supplements with amino acids Am. J. Cardiol. 101 2008 11E 15E
43. L.S. Quinn, K.L. Haugk, and K.H. Grabstein Interleukin-15: a novel anabolic cytokine for skeletal muscle Endocrinology 136 1995 3669 3672
44. J.A. Read, P.J. Beale, D.H. Volker, N. Smith, A. Childs, and S.J. Clarke Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial Support. Care Cancer 15 2007 301 307 (Pubitemid 46295216)
45. M.B. Reid, and Y.P. Li Tumor necrosis factor-alpha and muscle wasting: a cellular perspective Respir. Res. 2 2001 269 272 (Pubitemid 34189649)
46. S. Rivera, J. Azcon-Bieto, F.J. Lopez-Soriano, M. Miralpeix, and J.M. Argiles Amino acid metabolism in tumour-bearing mice Biochem. J. 249 1988 443 449 (Pubitemid 18030938)
47. D.P. Rose, and J.M. Connolly Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice J. Natl. Cancer Inst. 85 1993 1743 1747 (Pubitemid 23320844)
48. E.P. Sampaio, E.N. Sarno, R. Galilly, Z.A. Cohn, and G. Kaplan Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes J. Exp. Med. 173 1991 699 703
49. E.P. Sampaio, G. Kaplan, A. Miranda, J.A. Nery, C.P. Miguel, S.M. Viana, and E.N. Sarno The influence of thalidomide on the clinical and immunologic manifestation of erythema nodosum leprosum J. Infect. Dis. 168 1993 408 414 (Pubitemid 23210619)
50. W.W. Souba Glutamine and cancer Ann. Surg. 218 1993 715 728 (Pubitemid 24005815)
51. B.T. Steffen, S.J. Lees, and F.W. Booth Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia J. Appl. Physiol. 105 2008 1950 1958
52. G. Strassmann, M. Fong, J.S. Kenney, and C.O. Jacob Evidence for the involvement of interleukin 6 in experimental cancer cachexia J. Clin. Invest. 89 1992 1681 1684
53. J.A. Tayek, B.R. Bistrian, D.J. Hehir, R. Martin, L.L. Moldawer, and G.L. Blackburn Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial Cancer 58 1986 147 157 (Pubitemid 16093118)
54. M.J. Tisdale Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein Prostaglandins Leukot. Essent. Fatty Acids 48 1993 105 109 (Pubitemid 23011121)
55. B.S. van der Meij, J.A. Langius, E.F. Smit, M.D. Spreeuwenberg, B.M. von Blomberg, A.C. Heijboer, M.A. Paul, and P.A. van Leeuwen Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment J. Nutr. 140 2010 1774 1780
56. K. van Norren, D. Kegler, J.M. Argiles, Y. Luiking, M. Gorselink, A. Laviano, K. Arts, J. Faber, H. Jansen, E.M. van der Beek, and A. van Helvoort Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice Br. J. Cancer 100 2009 713 722
57. M.C. Wang, and N.E. Forsberg Effects of ciliary neurotrophic factor (CNTF) on protein turnover in cultured muscle cells Cytokine 12 2000 41 48 (Pubitemid 30042680)
58. B. Wiedenmann, P. Malfertheiner, H. Friess, P. Ritch, J. Arseneau, G. Mantovani, F. Caprioni, E. Van Cutsem, D. Richel, M. DeWitte, M. Qi, D. Robinson Jr., B. Zhong, C. De Boer, J.D. Lu, U. Prabhakar, R. Corringham, and D. Von Hoff A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia J. Support. Oncol. 6 2008 18 25 (Pubitemid 351227865)
59. N. Yamamoto, I. Kawamura, F. Nishigaki, S. Tsujimoto, Y. Naoe, M. Inami, L. Elizabeth, T. Manda, and K. Shimomura Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice Anticancer Res. 18 1998 139 144 (Pubitemid 28174697)
60. M.H. Zaki, J.A. Nemeth, and M. Trikha CNTO 328, a monoclonal antibody to IL-6, inhibits human tumor-induced cachexia in nude mice Int. J. Cancer 111 2004 592 595 (Pubitemid 39045327)
61. T.R. Ziegler, L.S. Young, K. Benfell, M. Scheltinga, K. Hortos, R. Bye, F.D. Morrow, D.O. Jacobs, R.J. Smith, and J.H. Antin Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study Ann. Intern. Med. 116 1992 821 828 (Pubitemid 23034759)