P-thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB

Biochemistry

Volumn 50, Issue 43, 2011, Pages 9340-9351

  Chen, Shengxi ^a   Zhang, Yi ^b   Hecht, Sidney M ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOND ENERGIES; DIVALENT METAL ION; DNA CLEAVAGE; DNA TOPOISOMERASE; DUPLEX DNA; ENZYME ACTIVE SITES; IN-VITRO; MODIFIED ENZYMES; OH GROUP; PLASMID DNA; RELAXATION ACTIVITIES; SMALL SIZE; SUPERCOILED; TARGET SITES; TOPOISOMERASES; WILD TYPES; WILD-TYPE ENZYMES;

AMINO ACIDS; CATALYSIS; CATALYSTS; ENZYMES; MANGANESE; MANGANESE COMPOUNDS; METAL IONS;

DNA;

DNA TOPOISOMERASE; HYDROXYL GROUP; MAGNESIUM ION; MANGANESE; MODIFIED VACCINIA TOPOISOMERASE 1B; P THIOPHENYLALANINE; PHENYLALANINE DERIVATIVE; PLASMID DNA; THIOL GROUP; TRANSFER RNA; TYROSINE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; DNA CLEAVAGE; DNA SUPERCOILING; ENERGY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MODIFICATION; IN VITRO STUDY; KINETICS; NONHUMAN; PRIORITY JOURNAL; RNA TRANSLATION; VACCINIA VIRUS; WILD TYPE;

DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; MAGNESIUM; MANGANESE; MUTATION; PHENYLALANINE; PLASMIDS; PROTEIN BIOSYNTHESIS; RNA, TRANSFER; SULFHYDRYL COMPOUNDS; VACCINIA VIRUS;

EID: 80054980571     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201291p     Document Type: Article

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