Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3809-3812

  Fang, K C ^a   Chen, Y L ^a   Sheu, J Y ^a   Wang, T C ^b   Tzeng, C C ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b TAJEN INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 6 FLUORO 4 OXO 7 [4 [2 HYDROXYIMINO 2 (4 PHENYL)ETHYL] 1 PIPERAZINYL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 [4 [(2,3,4,5 TETRAHYDRO 4 METHYLENE 2 PHENYL 5 OXOFURAN 2 YL)METHYL]PIPERAZINYL] 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 [4 [2 (4 CHLOROPHENYL) 2 HYDROXYIMINOETHYL] 1 PIPERAZINYL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 [4 [[2,3,4,5 TETRAHYDRO 2 (4 METHOXYPHENYL) 4 METHYLENE 2 PHENYL 5 OXOFURAN 2 YL]METHYL]PIPERAZINYL] 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; NORFLOXACIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; DRUG RESISTANCE, MICROBIAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROBIAL SENSITIVITY TESTS; NORFLOXACIN; PIPERAZINES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034609780     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000153x     Document Type: Article

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