Impaired hepatocellular regeneration in murine sepsis is dependent on regulatory protein levels

Shock

Volumn 36, Issue 5, 2011, Pages 471-477

  Abcejo, Arnoley ^a   Andrejko, Kenneth M ^a   Ochroch, E Andrew ^a   Raj, Nichelle R ^a   Deutschman, Clifford S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

cdk 4; cyclin D1; dihydrofolate reductase; DNA polymerase ; E2F; PCNA; Retinoblastoma protein; thymidine kinase

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 5; CYCLINE; DIHYDROFOLATE REDUCTASE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE DELTA; MESSENGER RNA; RETINOBLASTOMA PROTEIN; THYMIDINE KINASE; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CECUM; CELL COUNT; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DNA BINDING; DNA REPLICATION; GENETIC TRANSCRIPTION; INTESTINE INJURY; LIGATION; LIVER CELL; LIVER REGENERATION; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SEPSIS; SHAM PROCEDURE; STAINING; STEADY STATE;

ANIMALS; BLOTTING, NORTHERN; CELL PROLIFERATION; CYCLIN D1; DNA-DIRECTED DNA POLYMERASE; HEPATOCYTES; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; RETINOBLASTOMA PROTEIN; SEPSIS; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDINE KINASE;

EID: 80054959782     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31822d60ff     Document Type: Article

References (38)

1. Angus DC, Linde-Zwerbel WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care. Crit Care Med 29:1303-1310, 2001. (Pubitemid 32641789)
2. Kohl BA, Deutschman CS: The inflammatory response in organ injury. In: Newman MF, Fleisher LA, Fink MP, (eds.): Perioperative Management. Philadelphia, PA: Saunders/Elsevier, pp 19-28, 2008.
3. Rubulotta F, Marshall JC, Ramsay G, Nelson D, Levy M, Williams M: Predisposition, insult/infection, response, and organ dysfunction: a new model for staging severe sepsis. Crit Care Med 37:1329-1335, 2009.
4. Andrejko KM, Deutschman CS: Altered hepatic gene expression in fecal peritonitis: changes in transcription of gluconeogenic, beta-oxidative, and ureagenic genes. Shock 7:164-169, 1997. (Pubitemid 127654263)
5. Deutschman CS, Cereda M, Ochroch EA, Raj NR: Sepsis-induced cholestasis, steatosis, hepatocellular injury, and impaired hepatocellular regeneration are enhanced in interleukin-6Y/Y mice. Crit Care Med 34:2613-2620, 2006. (Pubitemid 44413061)
6. Weiss YG, Bellin L, Kim PK, Andrejko KM, Haaxma CA, Raj N, Furth EE, Deutschman CS: Compensatory hepatic regeneration after mild, but not fulminant, intraperitoneal sepsis in rats. Am J Physiol Gastrointest Liver Physiol 280:G968YG973, 2001.
7. Diehl AM: Roles of CCAAT/Enhancer binding proteins in regulation of liver regenerative growth. J Biol Chem 273:30843-30846, 1998. (Pubitemid 28533081)
8. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE: Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T-and B-cellYdeficient mice. Crit Care Med 25:1298-1307, 1997. (Pubitemid 27347292)
9. Kohli V, Madden JF, Bentley RC, Clavien PA: Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. Gastroenterology 116:168-178, 1999. (Pubitemid 29013506)
10. Kovalovitch K, DeAngelis RA, Li W, Furth EE, Ciliberto G, Taub R: Increased toxin-induced liver injury and fibrosis in interleukin-6Ydeficient mice. Hepatology 31:49-59, 2000.
11. Shi J, Aisaki K, Ikawa Y, Wake K: Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride. Am J Pathol 153:515-525, 1998. (Pubitemid 28373662)
12. Yamada Y, Webber EM, Kirillova I, Peschon JJ, Fausto N: Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor. Hepatology 28:959-970, 1998. (Pubitemid 28450256)
13. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Taub R: Liver failure and defective hepatocyte regeneration in interleukin-6 deficient mice. Science 274:1379-1383, 1996. (Pubitemid 26391463)
14. Michalopoulos GK: Liver regeneration. J Cell Physiol 213:286-300, 2007. (Pubitemid 47509705)
15. Blomen VA, Boonstra J: Cell fate determination during G1 phase progression. Cell Mol Life Sci 64:3084-3104, 2007. (Pubitemid 351152236)
16. Swiss VA, Casaccia P: Cell-context specific role of E2F/Rb pathway in development and disease. Glia 58:377-380, 2010.
17. Abcejo AS, Andrejko KM, Raj NR, Deutschman CS: Failed interleukin-6 signal transduction in murine sepsis: attenuation of hepatic glycoprotein 130 phosphorylation. Crit Care Med 37:1729-1734, 2009.
18. Andrejko KM, Raj NR, Kim PK, Deutschman CS: IL-6 modulates sepsisinduced decreases in transcription of hepatic organic anion and bile acid transporters. Shock 29:490-496, 2008. (Pubitemid 351416803)
19. Andrejko KM, Chen J, Deutschman CS: Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. Am J Phys 275:G1423YG1429, 1998.
20. Stoimenov I, Helleday T: PCNA on the crossroad of cancer. Biochem Soc Trans 37:605-613, 2009.
21. Blain SW: Switching cyclin DYCdk4 kinase activity on and off. Cell Cycle 1:892-898, 2008. (Pubitemid 351573783)
22. Boonstra J: Identification of a restriction point at the M/G1 transition during the ongoing cell cycle. Adv Enzyme Regul 47:208-221, 2007. (Pubitemid 47302060)
23. Michalopoulos GK: Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 176:2-13, 2010.
24. Yamada Y, Fausto N: Deficient liver regeneration after carbon tetracholide injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am J Pathol 152:1577-1589, 1998. (Pubitemid 28275015)
25. Olthoff KM: Hepatic regeneration in living donor transplantation. Liver Transplant 9:S35YS41, 2003. (Pubitemid 37304445)
26. Debonera F, Aldeguer X, Shen X, Gelman AE, Gao F, Que X, Greenbaum LE, Furth EE, Taub R, Olthoff KM: Activation of interleukin-6/STAT3 and liver regeneration following transplantation. J Surg Res 96:289-295, 2001. (Pubitemid 34969446)
27. Rutherford A, Chung RT: Acute liver failure: mechanisms of hepatocyte liver injury and regeneration. Semin Liver Dis 28:167-174, 2008. (Pubitemid 351632956)
28. Tsim NC, Frampton AE, Habib NA, Jiao LR: Surgical treatment for liver cancer. World J Gastroenterol 16:927-933, 2010.
29. Leu JI, Crissey MS, Craig LE, Taub R: Impaired hepatocyte DNA synthesic response posthepatectomy in insulin-like growth factor binding protein 1Ydeficient mice with defects in C/EBPâ and mitogen-activated protein kinase/extracellular signal-reduced kinase regulation. Mol Cell Biol 23:1251-1259, 2003. (Pubitemid 36177035)
30. Yamada Y, Kirillova I, Peschon JJ, Fausto N: Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type 1 tumor necrosis factor receptor. Proc Nat Acad Sci USA 94:1441-1446, 1997. (Pubitemid 27087870)
31. Campbell JS, Pritchard L, Schaper F, Schmitz J, Stephanson-Famy A, Rosenfeld ME, Argast GM, Heinrich PC, Fausto N: Expression of suppressors of cytokine signaling during liver regeneration. J Clin Invest 107:1285-1292, 2001. (Pubitemid 32494545)
32. Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE: Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res 66:2544-2552, 2006.
33. Hotchkiss RS, Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6:813-822, 2006. (Pubitemid 44631650)
34. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GW, Buchman TG, Karl IE: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27:1230-1251, 1999. (Pubitemid 29379358)
35. Levy RJ, Deutschman CS: Cytochrome C oxidase dysfunction in sepsis. Crit Care Med 35:S468YS475, 2007. (Pubitemid 47312181)
36. Bharadwaj U, Li M, Chen C, Yao Q: Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol Cancer Res 6:1755-1765, 2008.
37. Bromberg Z, Raj NR, Goloubinoff P, Deutschman CS, Weiss YG: Enhanced expression of Hsp70 limits cell division in a sepsis-induced model of ARDS. Crit Care Med 36:246-255, 2008.
38. Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne GP, Bahr M, McDunn JE, Karl IE et al.: TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol 176:5471-5477, 2006.