Aminomethyltetrazoles as potential inhibitors of the c-aminobutyric acid transporters mGAT1-mGAT4: Synthesis and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6492-6504

  Schaffert, Eva S ^a   Höfner, Georg ^a   Wanner, Klaus T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bioisosteric replacement; GABA uptake; Tetrazole; Ugi reaction

Indexed keywords

(1 BENZYL 1H TETRAZOL 5 YLMETHYL) (4,4 DIPHENYLBUTYL)AMINE; (1 CYCLOHEXYL 1H TETRAZOL 5 YLMETHYL) (2,2 DIPHENYLETHYL)AMINE; (3 CARBAZOL 9 YLPROPYL) (1H TETRAZOL 5 YLMETHYL)AMINE; (3 CARBAZOL 9 YLPROPYL) 1 [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]AMINE; (3,3 DIPHENYLALLYL) (1H TETRAZOL 5 YLMETHYL)AMINE; (3,3 DIPHENYLALLYL) [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]AMINE; (3,3 DIPHENYLPROPYL) (1H TETRAZOL 5 YLMETHYL)AMINE; (3,3 DIPHENYLPROPYL) BIS [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]AMINE; (3,3 DIPHENYLPROPYL) [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]AMINE; (4,4 DIPHENYLBUT 3 EN 1 YL) (1H TETRAZOL 5 YLMETHYL)AMINE; (4,4 DIPHENYLBUT 3 EN 1 YL) [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]AMINE; (4,4 DIPHENYLBUTYL) (1H TETRAZOL 5 YLMETHYL)AMINE; (4,4 DIPHENYLBUTYL) [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]AMINE; 1 (1H TETRAZOL 5 YLMETHYL)PIPERAZINE; 1 [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]PIPERAZINE; 1,5 DISUBSTITUTED AMINOMETHYLTETRAZOLE DERIVATIVE; 1H TETRAZOL 5 YLMETHYLAMINE; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID CARRIER 1; 4 AMINOBUTYRIC ACID CARRIER 2; 4 AMINOBUTYRIC ACID CARRIER 3; 4 AMINOBUTYRIC ACID CARRIER 4; 4 [1 (1,1,3,3 TETRAMETHYLBUTYL) 1H TETRAZOL 5 YLMETHYL]PIPERAZINE 1 CARBOXYLIC ACID TERT BUTYLESTER; 5 MONOSUBSTITUTED AMINOMETHYLTETRAZOLE DERIVATIVE; AMINOMETHYLTETRAZOLE DERIVATIVE; BENZHYDRYL (1 BENZYL 1H TETRAZOL 5 YLMETHYL)AMINE; GLYCINE DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

MURINAE;

EID: 80054953616     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.039     Document Type: Article

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