Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1483-1498

  Hack, Silke ^a   Wörlein, Babette ^a   Höfner, Georg ^a   Pabel, Jörg ^a   Wanner, Klaus T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antiepileptic; GABA uptake inhibitor; Imidazole; mGAT3

Indexed keywords

1 [2 [TRIS(4 METHOXYPHENYL)METHYL]ETHYL] 3 PIPERIDINECARBOXYLIC ACID; 1 TERTBUTYL 6 ETHYL 4,5,6,7 TETRAHYDRO 1H BENZIMIDAZOL 1,5 DICARBOXYLATE; 1 TERTBUTYL 6 ETHYL 4,5,6,7 TETRAHYDRO 1H BENZIMIDAZOL 1,6 DICARBOXYLATE; 1 TRIPHENYLMETHYL 1H IMIDAZOL 2 CARBALDEHYDE; 1H IMIDAZOL 1 YLACETIC ACID; 2 (1H IMIDAZOL 2 YL)ACETIC ACID; 2 [3 (4 METHYL 2,6,7 TRIOXA BICYCLO[2.2.2]OCTAN 1 YL) PROPYL] 1 TRIPHENYLMETHYL 1H IMIDAZOLE; 3 (1 TRIPHENYLMETHYL 1H IMIDAZOL 2 YL) ACRYLIC ACID ETHYL ESTER; 3 (1 TRIPHENYLMETHYL 1H IMIDAZOL 2 YL)ACRYLIC ACID ETHYL ESTER; 3 (1H IMIDAZOL 2 YL)ACETIC ACID; 3 (1H IMIDAZOL 2 YL)ACRYLIC ACID; 4 (1H IMIDAZOL 2 YL)ACETIC ACID; 4 AMINOBUTYRIC ACID CARRIER; 4,5,6,7 TETRAHYDRO 1H BENZIMIDAZOL 4 CARBOXYLIC ACID; 4,5,6,7 TETRAHYDRO 1H BENZIMIDAZOL 5 CARBOXYLIC ACID; 4,5,6,7 TETRAHYDRO 1H BENZIMIDAZOL 5 CARBOXYLIC ACID ETHYL ESTER; 5 (1 TRIPHENYLMETHYL 1H IMIDAZOL 2 YL)PENT 2 ENOIC ACID ETHYL ESTER; 5 (1H IMIDAZOL 1 YL)PENTANOIC ACID; 5 (1H IMIDAZOL 2 YL)ACETIC ACID; 5 (1H IMIDAZOL 2 YL)PENT 2 ENOIC ACID; 5 (1H IMIDAZOL 4 YL)PENT 2 ENOIC ACID; 5 (1H IMIDAZOL 4 YL)PENTANOIC ACID; 6 (1H IMIDAZOL 1 YL)HEXANOIC ACID; 7 (1H IMIDAZOL 1 YL)HEPTANOIC ACID; 8 (1H IMIDAZOL 1 YL)OCTANOIC ACID; ALKANOIC ACID; EF 1502; IMIDAZOLE DERIVATIVE; NNC 052045; PROTEIN MGAT3; SNAP 5294; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

CELL LINE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GABA UPTAKE INHIBITORS; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 79953217627     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.042     Document Type: Article

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