The role of structure activity relationship studies in the search for new GABA uptake inhibitors

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 12, 2008, Pages 1214-1223

  Kulig, Katarzyna ^a   Szwaczkiewicz, Marta ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Aminobutyric acid; GABA; GABA transporter; GABA uptake antagonist; GAT

Indexed keywords

1 (4,4 DIPHENYL 3 BUTENYL)NIPECOTIC ACID; 1 [2 [4,4' BIS(TRIFLUOROMETHYL)BENZHYDRYLOXY]ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 2 FLUORO 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID DERIVATIVE; 4 AMINOBUTYRIC ACID UPTAKE INHIBITOR; 4,5,6,7 TETRAHYDROISOXAZOLO[4,5 C]PYRIDIN 3 OL; DERAMCICLANE FUMARATE; EF 1502; GABOXADOL; GUAVACINE; MUSCIMOL; NATURAL PRODUCT; NEUROTRANSMITTER; NEUROTRANSMITTER UPTAKE INHIBITOR; NIPECOTIC ACID; PYRIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; TIAGABINE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ANXIETY; CENTRAL NERVOUS SYSTEM; EPILEPSY; GABAERGIC TRANSMISSION; MAMMAL; NEUROLOGIC DISEASE; NONHUMAN; PAIN; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GABA ANTAGONISTS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; NEUROTRANSMITTER AGENTS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57149124120     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708786141070     Document Type: Review

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