The therapeutic potential of neural stem cells in traumatic brain injuries

Current Signal Transduction Therapy

Volumn 6, Issue 3, 2011, Pages 327-336

  Kabatas, Serdar ^a   Cansever, Tufan ^a   Civelek, Erdinc ^a   Yilmaz, Cem ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Angiogenesis; Functional recovery; Neurogenesis; Stem cell; Traumatic brain injury; Treatment

Indexed keywords

3,3 BIS(2 AMINOETHYL) 1 HYDROXY 2 OXOTRIAZENE; ATORVASTATIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; STROMAL CELL DERIVED FACTOR 1;

ANGIOGENESIS; ARTICLE; CELL REGENERATION; CELL TYPE; CONVALESCENCE; GLASGOW OUTCOME SCALE; HUMAN; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TRAUMATIC BRAIN INJURY;

EID: 80054952589     PISSN: 15743624     EISSN: None     Source Type: Journal    
DOI: 10.2174/157436211797483976     Document Type: Article

References (111)

1. Goldstein M Traumatic brain injury: a silent epidemic. Ann Neurol 1990; 27: 327. (Pubitemid 20122385)
2. Sosin DM, Sniezek JE, Waxweiler RJ. Trends in death associated with traumatic brain injury, 1979 through 1992. Success and failure. JAMA 1995; 273: 1778-80.
3. Thurman DJ, C Alverson, KA Dunn, J Guerrero, JE Sniezek. Traumatic brain injury in the United States: a public health perspective. J Head Trauma Rehabil 1999; 14: 602-15. (Pubitemid 30027268)
4. Bittigau P, Sifringer M, Felderhoff-Mueser U, Hansen HH, Ikonomidou C. Neuropathological and biochemical features of traumatic injury in the developing brain. Neurotox Res 2003; 5: 475-90. Review.
5. Losiniecki A, Shutter L. Management of traumatic brain injury. Curr Treat Options Neurol 2010: 12: 142-54.
6. Rosso SM, Landweer EJ, Houterman M, Donker Kaat L, van Duijn CM, van Swieten JC. Medical and environmental risk factors for sporadic frontotemporal dementia: a retrospective case-control study. J Neurol Neurosurg Psychiatry 2003; 74: 1574-6.
7. Adelson PD, Robichaud P, Hamilton RL, Kochanek PM. A model of diffuse traumatic brain injury in the immature rat. J Neurosurg. 1996; 85: 877-84. (Pubitemid 26362153)
8. Koskiniemi M, Tykka T, Nybo T, Jarho L. Long-term outcome after severe brain injury in preschoolers is worse than expected. Arch Pediatr Adolesc Med 1995; 149: 249-54.
9. Mahoney WJ, D'Souza BJ, Haller A, Rogers MC, Epstein MH, Freeman JM. Long-term outcome of children with severe head trauma and prolonged coma. Pediatrics 1983; 71: 756-62. (Pubitemid 13081707)
10. Kraus JF, Fife D, Conroy C. Pediatric brain injuries: the nature, clinical course and early outcomes in a defined United States population. Pediatrics 1987; 79: 501-7. (Pubitemid 17051408)
11. James HE. Pediatric head injury: what is unique and different. Acta Neurochir Suppl (Wien) 1999; 73: 85-8.
12. BarlowKM, Minns RA. Annual incidence of shaken impact syndrome in young children. Lancet 2000; 356: 1571-2.
13. Bonnier C, Nassogne MC, Evrard P. Outcome and prognosis of whiplash shaken infant syndrome: late consequences after a symptom free interval. Dev Med Child Neurol 1995; 37: 943-56.
14. Duhaime AC, Christian CW, Moss E, Seidl T. Long-term outcome in infants with the shaking impact syndrome. Pediatr Neurosurg 1996; 24: 292-8. (Pubitemid 26403147)
15. Jaspan T, Narorough G, Punt JAG, Lowe J. Cerebral contusional tears as marker of child abuse -detection by cranial sonography. Pediatr Radiol 1992; 22: 237-45.
16. Shaver EG, Duhaime AC, Curtis M, Gennarelli LM, Barret R. Experimental acute subdural hematoma in infant piglets. Pediatr Neurosurg 1996; 25: 123-9. (Pubitemid 27168239)
17. Morganti-Kossmann MC, Satgunaseelan L, Bye N, Kossmann T. Modulation of immune response by head injury. Injury 2007; 38: 1392-400. (Pubitemid 350192405)
18. Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 1965; 3: 319-35.
19. Altman J. Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol 1969; 4: 433-57.
20. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992; 5052: 1707-10.
21. Lois C, Alvarez-Buylla A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc Natl Acad Sci USA 1993; 5: 2074-7.
22. Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al. Neurogenesis in the adult human hippocampus. Nat Med 1998; 11, 1313-7. (Pubitemid 28512114)
23. Sanai N, Tramontin AD, Quinones-Hinojosa A, et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 2004; 6976: 740-4. (Pubitemid 38294593)
24. Curtis MA, Kam M, Nannmark U, et al. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science 2007; 5816: 1243-9. (Pubitemid 46364256)
25. Vandenbosch R, Borgs L, Beukelaers P, et al . Adult neurogenesis and the diseased brain. Curr Med Chem 2009; 16: 652-66.
26. Morshead CM, Reynolds BA, Craig CG, et al. Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron, 1994, 5, 1071-82. (Pubitemid 24372126)
27. Gritti A, Parati EA, Cova L, et al. Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J Neurosci 1996; 3: 1091-1100.
28. Morshead CM, Craig CG, vander KD. In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain. Development 1998; 12: 2251-61. (Pubitemid 28336386)
29. Maslov AY, Barone TA, Plunkett RJ, Pruitt SC. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci 2004; 7:1726-33. (Pubitemid 38240970)
30. Hattiangady B, Shetty AK. Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus. Neurobiol Aging 2008; 1: 129-47. (Pubitemid 350102711)
31. Seki T, Arai Y. Age-related production of new granule cells in the adult dentate gyrus. Neuroreport 1995; 18: 2479-82. (Pubitemid 26031190)
32. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 1996; 6: 2027-33. (Pubitemid 26144015)
33. Enwere E, Shingo T, Gregg C, Fujikawa H, Ohta S, Weiss S. Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J Neurosci 2004; 38: 8354-65. (Pubitemid 39280814)
34. Molofsky AV, Slutsky SG, Joseph NM, et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 2006; 7110: 448-52. (Pubitemid 44477280)
35. Kippin TE, Martens, D.J, van der Kooy D. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev 2005, 6, 756-67. (Pubitemid 40395086)
36. Sii-Felice K, Etienne O, Hoffschir F, et al. Fanconi DNA repair pathway is required for survival and long-term maintenance of neural progenitors. EMBO J 2008, 5, 770-81. (Pubitemid 351506678)
37. Jablonska B, Aguirre A, Vandenbosch R, et al. Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone. J Cell Biol 2007, 6, 1231-45. (Pubitemid 350277741)
38. Gould E, Reeves AJ, Fallah M, Tanapat P, Gross CG, Fuchs E. Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci USA 1999, 9, 5263-7. (Pubitemid 29214571)
39. Kornack DR, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc Natl Acad Sci USA 1999; 10: 5768-73. (Pubitemid 29234693)
40. Del Bigio MR. Proliferative status of cells in adult human dentate gyrus. Microsc Res Tech 1999; 6: 353-8. (Pubitemid 29321050)
41. Bhardwaj RD, Curtis MA, Spalding KL, et al. Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci USA 2006; 33: 12564-8. (Pubitemid 44267298)
42. Boekhoorn K, Joels M, Lucassen PJ. Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus. Neurobiol Dis 2006; 1: 1-14. (Pubitemid 44416208)
43. Macas J, Nern C, Plate KH, Momma S. Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain. J Neurosci 2006; 50: 13114-9. (Pubitemid 44954629)
44. Gould E, Reeves AJ, Graziano MS, Gross CG. Neurogenesisin the neocortex of adult primates. Science 1999; 5439: 548-52.
45. Gould E, Vail N, Wagers M, Gross CG. Adult-generatedhippocampal and neocortical neurons in macaques have a transientexistence. Proc Natl Acad Sci USA 2001; 19: 10910-7. (Pubitemid 32878718)
46. Kornack DR, Rakic P. Cell proliferation without neurogenesis in adult primate neocortex. Science 2001; 5549: 2127-30. (Pubitemid 33150663)
47. Koketsu D, Mikami A, Miyamoto Y, Hisatsune T. Nonrenewal of neurons in the cerebral neocortex of adult macaque monkeys. J Neurosci 2003; 3: 937-42. (Pubitemid 36206184)
48. Bernier PJ, Bedard A, Vinet J, Levesque M, Parent A. Newly generated neurons in the amygdala and adjoining cortex of adult primates. Proc Natl Acad Sci USA 2002; 17: 11464-9. (Pubitemid 34920948)
49. Rietze R, Poulin P, Weiss S. Mitotically active cells that generate neurons and astrocytes are present in multiple regions of the adult mouse hippocampus. J Comp Neurol 2000; 3: 397-408. (Pubitemid 30670441)
50. Bauer S, Hay M, Amilhon B, Jean A, Moyse E. In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem. Neuroscience 2005; 1: 75-90. (Pubitemid 39550416)
51. Zhao M, Momma S, Delfani K, et al. Evidence for neurogenesis in the adult mammalian substantia nigra. Proc Natl Acad Sci USA 2003; 13: 7925-30. (Pubitemid 36760071)
52. Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature 2000; 6807: 963-70.
53. Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH. The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci 2002; 15, 6639-49. (Pubitemid 35386420)
54. Frielingsdorf H, Schwarz K, Brundin P, Mohapel P. No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proc Natl Acad Sci USA 2004; 27: 10177-82. (Pubitemid 38891215)
55. Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999; 19: 8487-97. (Pubitemid 30226767)
56. Kondo T, Raff M. Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev 2004; 23, 2963-72. (Pubitemid 39602314)
57. Reynolds R, Hardy R. Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo. J Neurosci Res 1997; 5: 455-70. (Pubitemid 27106542)
58. Shihabuddin LS, Ray J, Gage FH. FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord. Exp Neurol 1997; 2: 577-86. (Pubitemid 28068850)
59. Shihabuddin LS, Horner PJ, Ray J, Gage FH. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci 2000; 23, 8727-35.
60. Belachew S, Chittajallu R, Aguirre AA, Yuan et al. Postnatal NG2 proteoglycan expressing progenitor cells are intrinsically multipotent and generate functional neurons. J Cell Biol 2003; 1: 169-86. (Pubitemid 36459089)
61. Dawson MR, Polito A, Levine JM, Reynolds R. NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 2003; 2: 476-88. (Pubitemid 37311310)
62. Lichtenwalner RJ, Parent JM. Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab 2006; 1: 1-20. (Pubitemid 41818065)
63. Buffo A, Rite I, Tripathi P, et al. Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci USA 2008; 105: 3581-6. (Pubitemid 351723595)
64. Farin A, Liu CY, Langmoen IA, Apuzzo ML. The biological restoration of central nervous system architecture and function: part 2-emergence of the realization of adult neurogenesis. Neurosurgery 2009; 64: 581-600.
65. Boockvar JA, Schouten J, Royo N, et al. Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells. Neurosurgery 2005; 56: 163-71. (Pubitemid 40054003)
66. Chen X, Katakowski M, Li Y, et al. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: Growth factor production. J Neurosci Res 2002; 69: 687-91. (Pubitemid 34966882)
67. Gao J, Prough DS, McAdoo DJ, et al. Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Exp Neurol 2006; 201: 281-92. (Pubitemid 44344239)
68. Harting MT, Baumgartner JE, Worth LL, et al. Cell therapies for traumatic brain. Neurosurg Focus 2008; 24: E18.
69. Lu D, Li Y, Wang L, Chen J, Mahmood A, Chopp M. Intraarterial administration of marrow stromal cells in a rat model of traumatic brain injury. J Neurotrauma 2001; 18: 813-9. (Pubitemid 32769777)
70. Lu D, Mahmood A, Qu C, Hong X, Kaplan D, Chopp M. Collagen scaffolds populated with human marrow stromal cells reduce lesion volume and improve functional outcome after traumatic brain injury. Neurosurgery 2007; 61: 596-603.
71. Lu D, Mahmood A, Zhang R, Copp M. Upregulation of neurogenesis and reduction in functional deficits following administration of DEtA/ NONOate, a nitric oxide donor, after traumatic brain injury in rats. J Neurosurg 2003; 99: 351-61. (Pubitemid 36900130)
72. Lu D, Sanberg PR, Mahmood A, et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant 2002; 11: 275-81. (Pubitemid 34665828)
73. Mahmood A, Lu D, Lu M, Chopp M. Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery 2003; 53:697-703. (Pubitemid 37055948)
74. Mahmood A, Lu D, Qu C, Goussev A, Chopp M. Human marrow stromal cell treatment provides long-lasting benefit after traumatic brain injury in rats. Neurosurgery 2005; 57: 1026-31.
75. Muir JK, Raghupathi R, Saatman KE, et al. Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain. J Neurotrauma 1999; 16: 403-14. (Pubitemid 29264792)
76. Riess P, Molcanyi M, Bentz K, et al. Embryonic stem cell transplantation after experimental traumatic brain injury dramatically improves neurological outcome, but may cause tumors. J Neurotrauma 2007; 24: 216-25. (Pubitemid 46214427)
77. Shear DA, Tate MC, Archer DR, et al. Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury. Brain Res 2004; 1026: 11-22. (Pubitemid 39336412)
78. Shindo T, Matsumoto Y, Wang Q, Kawai N, Tamiya T, Nagao S. Differences in the neuronal stem cells survival, neuronal differentiation and neurological improvement after transplantation of neural stem cells between mild and severe experimental traumatic brain injury. J Med Invest 2006; 53: 42-51.
79. Tate MC, Shear DA, Hoffman SW, Stein DG, Archer DR, LaPlaca MC. Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain. Cell Transplant 2002; 11: 28395.
80. Carroll JE, Borlongan CV Adult stem cell therapy for acute brain injury in children. CNS Neurol Disord Drug Targets. 2008; 7: 361-9. Review
81. Hattori K, Heissig B, Rafii S. The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. Leuk Lymphoma. 2003; 44: 575-82. (Pubitemid 36304814)
82. Miller JT, Bartley JH, Wimborne HJ, et al. The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury. BMC Neurosci. 2005; 6:63.
83. Lazarini F, Tham TN, Casanova P, Arenzana-Seisdedos F, Dubois-Dalcq M. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia. 2003; 42:139-48. Review. (Pubitemid 36565118)
84. Stumm RK, Zhou C, Ara T, et al. CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci 2003; 23: 5123-30. (Pubitemid 36793240)
85. Hill WD, Hess DC, Martin-Studdard A, et al. Neuropathol. Expert. Neurol 2004; 63: 84.
86. Tolar J, O'shaughnessy MJ, Panoskaltsis-Mortari A, et al. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood 2006; 107: 4182-8. (Pubitemid 43726831)
87. Mahmood A, Lu D, Qu C, Goussev A, Chopp M. Treatment of traumatic brain injury with a combination therapy of marrow stromal cells and atorvastatinin rats. Neurosurgery 2007; 60: 546-54.
88. Borlongan CV, Hadman M, Sanberg CD, Sanberg PR. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 2004; 35: 2385-9. (Pubitemid 39311268)
89. Xiao J, Nan Z, Motooka Y, Low WC. Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev 2005; 14: 722-33. (Pubitemid 43201906)
90. Nan Z, Grande A, Sanberg CD, Sanberg PR, Low WC. Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury. Ann N Y Acad Sci 2005; 1049: 84-96. (Pubitemid 40967577)
91. Bakshi A, Shimizu S, Keck CA, et al. Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. Eur J Neurosci 2006; 23: 2119-34.
92. Gernert M, Thompson KW, Löscher W, Tobin AJ. Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats. Exp Neurol 2002; 176:183-192. (Pubitemid 34762118)
93. Seri B, Garcia-Verdugo JM, McEwen BS, varez-Buylla A. Astrocytes give rise to new neurons in the adult mammalian hippocampus. J. Neurosci 2001, 18, 7153-60. (Pubitemid 32846963)
94. Ong J, Plane JM, Parent JM, Silverstein FS. Hypoxic-ischemic injury stimulates subventricular zone proliferation and neurogenesis in the neonatal rat. Pediatr Res 2005 ;58:600-6 (Pubitemid 41254531)
95. Brazel CY, Rosti RT 3rd, Boyce S, Rothstein RP, Levison SW. Perinatal hypoxia/ischemia damages and depletes progenitors from the mouse subventricular zone. Dev Neurosci 2004 ;26:266-74 (Pubitemid 40867981)
96. Zaidi AU, Bessert DA, Ong JE, et al. New oligodendrocytes are generated after neonatal hypoxic-ischemic brain injury in rodents. Glia 2004; 46:380-90. (Pubitemid 38679196)
97. Hagan M, Wennersten A, Meijer X, Holmin S, Wahlberg L, Mathiesen T. Neuroprotection by human neural progenitor cells after experimental contusion in rats. Neurosci Lett 2003; 351: 149-52. (Pubitemid 37410326)
98. Englund U, Fricker-Gates RA, Lundberg C, Björklund A, Wictorin K. Transplantation of human neural progenitor cells into the neonatal rat brain: Extensive migration and differentiation with longdistance axonal projections. Exp Neurol 2002; 173: 1-21. (Pubitemid 34081722)
99. Englund U, Björklund A, Wictorin K, Lindvall O, Kokaia M. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc Natl Acad Sci USA 2002; 99: 17089-94. (Pubitemid 36034103)
100. Al Nimer F, Wennersten A, Holmin S, Meijer X, Wahlberg L, Mathiesen T. MHC expression after human neural stem cell transplantation to brain contused rats. Neuroreport 2004; 15: 1871-5. (Pubitemid 39180603)
101. Sinson G, Voddi M, McIntosh TK. Combined fetal neural transplantation and nerve growth factor infusion: Effects on neurological outcome following fluid-percussion brain injury in the rat. J Neurosurg 1996; 84: 655-62. (Pubitemid 26104235)
102. Borlongan CV, Evans A, Yu G, Hess DC. Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats. Brain Res. 2005; 1048:116-22. (Pubitemid 40800265)
103. Hattiangady B, Rao MS, Zaman V, Shetty AK. Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: Effects of combined neurotrophic supplementation and caspase inhibition. Neuroscience 2006; 139: 1369-83.
104. Mahmood A, Lu D, Qu C, Goussev A, Chopp M. Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats. J Neurosurg 2006; 104: 272-7.
105. Singh Roy N, Nakano T, Xuing L, Kang J, Nedergaard M, Goldman SA. Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 2005; 196: 224-34. (Pubitemid 41607810)
106. Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell 2008 132:645-60. (Pubitemid 351253687)
107. Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage FH. In vivo fate analysis reveals the multipotent and self-Renewal capacities of Sox2(+) neural stem cells in the adult hippocampus. Cell Stem Cell 2007; 5, 515-28. (Pubitemid 350056408)
108. Leuner B, Gould E, Shors TJ. Is there a link between adult neurogenesis and learning? Hippocampus 2006, 3, 216-24.
109. Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV. GFAPexpressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat. Neurosci 2004, 11, 1233-41. (Pubitemid 39426243)
110. Parras CM, Galli R, Britz O, et al. Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J 2004, 22, 4495-505. (Pubitemid 39601974)
111. Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF. Pharmacology of traumatic brain injury: where is the "golden bullet"? Mol Med 2008; 14:731-40. Epub 2008. Review.