Long-term recovery after bone marrow stromal cell treatment of traumatic brain injury in rats

Journal of Neurosurgery

Volumn 104, Issue 2, 2006, Pages 272-277

  Mahmood, Asim ^a,b   Lu, Dunyue ^a   Qu, Changsheng ^a   Goussev, Anton ^a   Chopp, Michael ^a  

^a HENRY FORD HEALTH SCIENCES CENTER   (United States)

^b HENRY FORD HOSPITAL   (United States)

Author keywords

Bone marrow stromal cell; Growth factor; Rat; Traumatic brain injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; PHOSPHATE BUFFERED SALINE;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BRAIN TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CONVALESCENCE; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RATING SCALE; SPECIES COMPARISON; STAINING; STROMA CELL; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN INJURIES; CELL PROLIFERATION; FEMALE; IMMUNOHISTOCHEMISTRY; RATS; RATS, WISTAR; STROMAL CELLS; TREATMENT OUTCOME;

EID: 33644509245     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/jns.2006.104.2.272     Document Type: Article

References (35)

1. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al: Administration of methylprednisolone for 24 to 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277:1597-1604, 1997
2. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al: Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow-up. Results of the Third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 89:699-706, 1998
3. Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, et al: Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18:257-267, 1997
4. Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, et al: Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res 69:687-691, 2002
5. Dekosky ST, Goss JR, Miller PD, Styren SD, Kochanek PM, Marion D: Upregulation of nerve growth factor following cortical trauma. Exp Neurol 130:173-177, 1994
6. Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL: A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods 39:253-262, 1991
7. Dixon CE, Flinn P, Bao J, Veyna R, Hayes RL: Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats. Exp Neurol 146:479-490, 1997
8. Hicks RR, Boggs A, Leider D, Kraemer P, Brown R, Scheff SW, et al: Effects of exercise following lateral fluid percussion brain injury in rats. Restor Neurol Neurosci 12:41-47, 1998
9. Hicks RR, Numan S, Dhillon HS, Prasad MR, Seroogy KB: Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma. Brain Res Mol Brain Res 48:401-406, 1997
10. Hicks RR, Zhang L, Atkinson A, Stevenon M, Veneracion M, Seroogy KB: Environmental enrichment attenuates cognitive deficits, but does not alter neurotrophin gene expression in the hippocampus following lateral fluid percussion brain injury. Neuroscience 112:631-637, 2002
11. Hicks RR, Zhang L, Dhillon HS, Prasad MR, Seroogy KB: Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma. Brain Res Mol Brain Res 59:264-268, 1998
12. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, et al: Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7:430-436, 2001
13. Lee J, Duan W, Mattson MP: Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367-1375, 2002
14. Li Y, Chen J, Chen XJ, Wang L, Gautam SC, Xu YX, et al: Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 59:514-523, 2002
15. Liau LM, Bergsherder M, Becker DP: Pathology and pathophysiology of head injury, in Youmans JR (ed): Neurological Surgery, ed 4. Philadelphia: WB Saunders, 1996 pp 1549-1594
16. Lu D, Li Y, Mahmood A, Wang L, Rafiq T, Chopp M: Neural and marrow-derived stromal cell sphere transplantation in a rat model of traumatic brain injury. J Neurosurg 97:935-940, 2002
17. Lu D, Mahmood A, Chopp M: Biological transplantation and neurotrophic induced neuroplasticity after traumatic brain injury. J Head Trauma Rehabil 18:357-376, 2003
18. Lu D, Mahmood A, Wang L, Li Y, Lu M, Chopp M: Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 12:559-563, 2001
19. Mahmood A, Lu D, Chopp M: Intravenous administration of marrow stromal cells (BMSCs) increases the expression of growth factors in rat brain after traumatic brain injury. J Neurotrauma 21:33-39, 2004
20. Mahmood A, Lu D, Li Y, Chen JL, Chopp M: Intracranial bone marrow transplantation after traumatic brain injury improves functional outcome in adult rats. J Neurosurg 94:589-595, 2001
21. Mahmood A, Lu D, Lu M, Chopp M: Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery 53:697-703, 2003
22. Mahmood A, Lu D, Wang L, Chopp M: Intracerebral transplantation of marrow stromal cells cultured with neurotrophic factors promotes functional recovery in adult rats subjected to traumatic brain injury. J Neurotrauma 19:1609-1617, 2002
23. Mahmood A, Lu D, Wang L, Li Y, Lu M, Chopp M: Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells. Neurosurgery 49:1196-1204, 2001
24. Memberg SP, Hall AK: Proliferation, differentiation, and survival of rat sensory neuron precursors in vitro require specific trophic factors. Mol Cell Neurosci 6:323-335, 1995
25. Newman MP, Feron F, Mackay-Sim A: Growth factor regulation of neurogenesis in adult olfactory epithelium. Neuroscience 99:343-350, 2000
26. Pencea V, Bingaman KD, Wiegand SJ, Luskin MB: Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci 21:6706-6717, 2001
27. Poo MM: Neurotrophins as synaptic modulators. Nat Rev Neurosci 2:24-32, 2001
28. Posmantur R, Kampfl A, Simon R, Liu SJ, Zhao X, Clifton GL, et al: A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 77:875-888, 1997
29. Raghavendra Rao VL, Dhodda VK, Song G, Bowen KK, Dempsey RJ: Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis. J Neurosci Res 71:208-219, 2003
30. Rutherford LC, Nelson SB, Turrigiano GG: BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses. Neuron 21:521-530, 1998
31. Seil FJ, Drake-Baumann R: TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis. J Neurosci 20:5367-5373, 2000
32. Shohami E, Novikov M, Bass R: Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res 674:55-62, 1995
33. Snider WD, Lichtman JW: Are neurotrophins synaptotrophins? Mol Cell Neurosci 7:433-442, 1996
34. Vicario-Abejon C, Collin C, McKay RD, Segal M: Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. J Neurosci 18:7256-7271, 1998
35. Zhao LR, Duan WM, Reyes M, Keene CD, Verfaillie CM, Low WC: Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp Neurol 174:11-20, 2002