3,4-Disubstituted oxazolidin-2-ones as constrained ceramide analogs with anticancer activities

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6174-6181

  Singh, Alok ^a   Ha, Hyun Joon ^a   Park, Jungchan ^a   Kim, Jun Hee ^b   Lee, Won Koo ^b  

^a Hankuk University of Foreign Studies   (South Korea)

^b Sogang University   (South Korea)

Author keywords

antileukemic; apoptosis; ceramide; oxazolidin 2 one; sphingoid

Indexed keywords

1 [1 (1 PHENYLETHYL)AZIRIDIN 2 YL]HEXADEC 2 YN 1 OL; 1 [1 (1 PHENYLETHYL)AZIRIDIN 2 YL]HEXADEC 2 YN 1 ONE; 2 (1 PHENYLETHYLAMINO) 3 (TERT BUTYLDIMETHYLSILYLOXY)OCTADEC 4 ENYL ACETATE; 3 (CYCLOPENTANECARBONYL) 4 (1 HYDROXY 4 PHENYLBUT 2 ENYL)OXAZOLIDIN 2 ONE; 3 (CYCLOPENTANECARBONYL) 4 (1 HYDROXYBUT 2 ENYL)OXAZOLIDIN 2 ONE; 3 (CYCLOPENTANECARBONYL) 4 (1 HYDROXYHEPT 2 ENYL)OXAZOLIDIN 2 ONE; 3 (CYCLOPENTANECARBONYL) 4 (1 HYDROXYNON 2 ENYL)OXAZOLIDIN 2 ONE; 3 (CYCLOPENTANECARBONYL) 4 (1 HYDROXYTRIDEC 2 ENYL)OXAZOLIDIN 2 ONE; 3 (CYCLOPENTANECARBONYL) 4 (1 HYDROXYUNDEC 2 ENYL)OXAZOLIDIN 2 ONE; 3 (CYCLOPENTANECARBONYL) 4 (3 CYCLOPENTYL 1 HYDROXYALLYL 2 ENYL)OXAZOLIDIN 2 ONE; 3 (FURAN 2 CARBONYL) 4 (1 HYDROXYHEXADEC 2 ENYL)OXAZOLIDIN 2 ONE; 3 ACETYL 4 (1 HYDROXYHEXADEC 2 ENYL)OXAZOLIDIN 2 ONE; 3 PHENYL 4 (1 HYDROXYHEXADEC 2 ENYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (1 NAPHTHOYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (2 TOLYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (4 NITROPHENYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (CINNAMYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (CYCLOPENTYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (ISOBUTYRYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (PHENYLACETYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 (PIVALOYL)OXAZOLIDIN 2 ONE; 4 (1 HYDROXYHEXADEC 2 ENYL) 3 PROPIONYLOXAZOLIDIN 2 ONE; 4 (1 TERT BUTYLDIMETHYLSILYLOXYHEXADEC 2 ENYL)OXAZOLIDIN 2 ONE; ANTINEOPLASTIC AGENT; CERAMIDE 1 PHOSPHATE; CERAMIDE DERIVATIVE; GLUCOSYLTRANSFERASE; OXAZOLIDIN 2 ONE DERIVATIVE; SPHINGOMYELIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DESILYLATION; DNA FRAGMENTATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPID METABOLISM; PROTEIN CONFORMATION;

SPHINGOIDEA;

EID: 80054938798     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.022     Document Type: Article

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