4,5,6-Trisubstituted piperidinones as conformationally restricted ceramide analogues: Synthesis and evaluation as inhibitors of sphingosine and ceramide kinases and as NKT cell-stimulatory antigens

Chemistry and Biodiversity

Volumn 6, Issue 10, 2009, Pages 1688-1715

  Mathew, Thresen ^a   Cavallari, Marco ^b   Billich, Andreas ^c   Bornancin, Frederic ^c   Nussbaumer, Peter ^c   De Libero, Gennaro ^b   Vasella, Andrea ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c Novartis Institutes for BioMedical Research Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

3 (BUT 2 ENYL) 5 HYDROXY 6 (HYDROXYMETHYL) 4 (TRIDEC 1 ENYL)PIPERIDIN 2 ONE; 3 BUTYL 5 HYDROXY 6 (HYDROXYMETHYL) 4 (TRIDECYL)PIPERIDIN 2 ONE; 5 HYDROXY 6 (HYDROXYMETHYL) 3 PROPYL 4 (TRIDECYL)PIPERIDIN 2 ONE; 5 HYDROXY 6 (HYDROXYMETHYL) 4 (TRIDEC 1 ENYL)PIPERIDIN 2 ONE; 5 HYDROXY 6 (HYDROXYMETHYL) 4 (TRIDECYL)PIPERIDIN 2 ONE; 6 (AMINOMETHYL) 5 HYDROXY 4 (TRIDEC 1 ENYL)PIPERIDIN 2 ONE; 6 (AMINOMETHYL) 5 HYDROXY 4 (TRIDECYL)PIPERIDIN 2 ONE; CD1D ANTIGEN; CERAMIDE DERIVATIVE; CERAMIDE KINASE; ENZYME INHIBITOR; PIPERIDONE DERIVATIVE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; CYTOKINE RELEASE; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NATURAL KILLER T CELL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANTIGENS, CD1D; CERAMIDES; CYTOKINES; ENZYME INHIBITORS; HUMANS; LIPID METABOLISM; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NATURAL KILLER T-CELLS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PIPERIDINES; RECEPTORS, ANTIGEN, T-CELL;

EID: 70350289199     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200900045     Document Type: Article

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