Design, synthesis, and characterization of the antitumor activity of novel ceramide analogues

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3994-4000

  Macchia, M ^a   Barontini, S ^a   Bertini, S ^a   Di Bussolo, V ^a   Fogli, S ^a   Giovannetti, E ^a   Grossi, E ^b   Minutolo, F ^a   Danesi, R ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Medical Department   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CERAMIDE DERIVATIVE; CYCLOPHOSPHAMIDE; CYTOCHROME C; DNA FRAGMENT; PYRIMIDINE DERIVATIVE; THIOURACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL DIVISION; CERAMIDES; CYTOCHROME C GROUP; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; FEMALE; HUMANS; IMMUNOBLOTTING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, NUDE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOURACIL; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; URACIL;

EID: 0035829464     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010947r     Document Type: Article

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