Phosphoramidate protides of the anticancer agent fudr successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7247-7258

  McGuigan, Christopher ^a   Murziani, Paola ^a   Slusarczyk, Magdalena ^a   Gonczy, Blanka ^a   Vande Voorde, Johan ^b   Liekens, Sandra ^b   Balzarini, Jan ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYL(BENZYLALANINYL)PHOSPHOROCHLORIDATE; 2' DEOXYNUCLEOSIDE; 5 FLUORO 2' DEOXYURIDINE 5' O [(ALANINYL)]PHOSPHATE AMMONIUM SALT; 5 FLUORO 2' DEOXYURIDINE 5' O [1 NAPHTHYL(BENZYLALANINYL)]PHOSPHATE; ANTINEOPLASTIC AGENT; FLUOROURACIL; PRODRUG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; DRUG DELIVERY SYSTEM; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FLOXURIDINE; HUMANS; MYCOPLASMA HYORHINIS; ORGANOPHOSPHORUS COMPOUNDS; PRODRUGS; PYRIMIDINE PHOSPHORYLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054931912     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200815w     Document Type: Article

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