Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5636-5640

  Zohdi, Hussein F ^a   Rateb, Nora M ^a   Elnagdy, Sherif M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Green chemistry; Grinding; Hexahydropyrimidine; Multicomponent reactions; Solid state synthesis; Trifluoromethyl

Indexed keywords

ETHYL 4 (TRIFLUOROMETHYL) 6 (4 FLUOROPHENYL)HEXAHYDRO 4 HYDROXY 2 OXOYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL) 6 (4 FLUOROPHENYL)HEXAHYDRO 4 HYDROXY 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL) 6 (FURAN 2 YL)HEXAHYDRO 4 HYDROXY 2 OXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL) 6 (FURAN 2 YL)HEXAHYDRO 4 HYDROXY 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 OXO 6 (THIOPHEN 2 YL)PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 OXO 6 4 TOLYLPHENYLPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 OXO 6 PHENYLPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 THIOXO 6 4 TOLYL PYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (4 HYDROXYPHENYL) 2 OXOYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (4 HYDROXYPHENYL) 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (4 METHOXYPHENYL) 2 OXOYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (4 METHOXYPHENYL) 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (4 NITROPHENYL) 2 OXOYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (4 NITROPHENYL) 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 (THIOPHEN 2 YL) 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 6 PHENYL 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 (4 CHLOROPHENYL) 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 OXOYRIMIDINE 5 CARBOXYLATE; ETHYL 6 (4 CHLOROPHENYL) 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 4 (DIMETHYLAMINOPHENYL) 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 OXOYRIMIDINE 5 CARBOXYLATE; ETHYL 6 [4 (DIMETHYLAMINO)PHENYL] 4 (TRIFLUOROMETHYL)HEXAHYDRO 4 HYDROXY 2 THIOXOPYRIMIDINE 5 CARBOXYLATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS THURINGIENSIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; GRINDING; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE;

ANTI-INFECTIVE AGENTS; BACILLUS THURINGIENSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; ESCHERICHIA COLI; GREEN CHEMISTRY TECHNOLOGY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIMIDINES;

EID: 80054918944     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.036     Document Type: Article

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