Synthesis and in vitro cytotoxicity evaluation of some fluorinated hexahydropyrimidine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 989-992

  Agbaje, Oluropo C ^a   Fadeyi, Olugbeminiyi O ^a   Fadeyi, S Adamson ^a   Myles, Lewis E ^a   Okoro, Cosmas O ^a  

^a TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Colon cancer; Hexahydropyrimidine; In vitro cytotoxicity; Polyphosphate ester; Stereogenic; Synthesis; Tetrahydropyrimidine; Trifluoromethyl

Indexed keywords

CYTOTOXIC AGENT; FLUORINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MEMBRANE PERMEABILITY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HALOGENATION; HUMANS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

CITRUS MACROPHYLLA;

EID: 78751644502     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.022     Document Type: Article

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