1,3-dihydro-2H-indol-2-ones derivatives: Design, Synthesis, in vitro antibacterial, antifungal and antitubercular study

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5573-5579

  Akhaja, Tarunkumar Nanjibhai ^a   Raval, Jignesh Priyakant ^a  

^a Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences   (India)

Author keywords

1,3 dihydro 2H indol 2 ones; Antimicrobial activity; Biginelli reaction; CaCl 2 catalyst; in vitro antituberculer activity; MCRs (Multicomponent Reactions)

Indexed keywords

1,3 DIHYDRO 2H INDOL 2 ONE DERIVATIVE; 3 [[5 (6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 5 NITRO 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [[5 (6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [[5 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [[5 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 5 NITRO 1,3 DIHYDRO 2H INDOL 2 ONE; 5 BROMO 3 [[5 (6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 BROMO 3 [[5 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 CHLORO 3 [[5 (6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 CHLORO 3 [[5 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 FLUORO 3 [[5 (6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 FLUORO 3 [[5 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 IODO 3 [[5 (6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 5 IODO 3 [[5 (6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; ANTIFUNGAL AGENT; CALCIUM CHLORIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; ASPERGILLUS CLAVATUS; ASPERGILLUS NIGER; BACILLUS SUBTILIS; BIGINELLI REACTION; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG PURITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TEST; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

ANTIFUNGAL AGENTS; ANTITUBERCULAR AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; FUNGI; INDOLES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS;

EID: 80054909846     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.023     Document Type: Article

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