N1-Alkylated 3,4-dihydropyrimidine-2(1H)-ones: Convenient one-pot selective synthesis and evaluation of their calcium channel blocking activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 1997-2001

  Singh, Kamaljit ^a   Arora, Divya ^a   Poremsky, Elizabeth ^b   Lowery, Jazmyne ^b   Moreland, Robert S ^b  

^a GURU NANAK DEV UNIVERSITY   (India)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Biginelli dihydropyrimidinones; N Alkylation; Phase transfer catalysis; Regioselective; Tetrabutylammonium hydrogen sulfate; Vascular smooth muscle

Indexed keywords

BASE; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; SODIUM HYDROXIDE; SOLVENT; TETRABUTYLAMMONIUM;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CATALYST; DRUG ACTIVITY; DRUG SYNTHESIS; NONHUMAN;

ALKYLATION; CALCIUM CHANNEL BLOCKERS; CATALYSIS; HUMANS; PYRIMIDINONES;

EID: 62549122911     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.10.002     Document Type: Article

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