메뉴 건너뛰기




Volumn 11, Issue 3, 2011, Pages 215-225

Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat

Author keywords

Apoptosis; Doxorubicin; Heart; Hesperetin; Oxidative stress

Indexed keywords

CASPASE 3; DOXORUBICIN; GLUTATHIONE; HESPERETIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38;

EID: 80054898863     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-011-9114-2     Document Type: Article
Times cited : (95)

References (50)
  • 1
    • 0033197850 scopus 로고    scopus 로고
    • Testicular cytotoxicity of DA-125, a new anthracycline anticancer agent, in rats
    • Kim, J. C., Kim, K. H., & Chung, M. K. (1999). Testicular cytotoxicity of DA-125, a new anthracycline anticancer agent, in rats. Reproductive Toxicology, 13, 391-397.
    • (1999) Reproductive Toxicology , vol.13 , pp. 391-397
    • Kim, J.C.1    Kim, K.H.2    Chung, M.K.3
  • 4
    • 58149343451 scopus 로고    scopus 로고
    • Heat shock protein 20 interacting with phosphory-lated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity
    • Fan, G. C., Zhou, X., Wang, X., Song, G., Qian, J., Nicolaou, P., et al. (2008). Heat shock protein 20 interacting with phosphory-lated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation Research, 103, 1270-1279.
    • (2008) Circulation Research , vol.103 , pp. 1270-1279
    • Fan, G.C.1    Zhou, X.2    Wang, X.3    Song, G.4    Qian, J.5    Nicolaou, P.6
  • 5
    • 45849094744 scopus 로고    scopus 로고
    • The effect of chronic doxorubicin treatment on mitogen-activated protein kinases and heat stress proteins in rat hearts
    • Simoncikova, P., Ravingerova, T., & Barancik, M. (2008). The effect of chronic doxorubicin treatment on mitogen-activated protein kinases and heat stress proteins in rat hearts. Physiological Research, 57(Suppl 2), S97-S102.
    • (2008) Physiological Research , vol.57 , Issue.SUPPL. 2
    • Simoncikova, P.1    Ravingerova, T.2    Barancik, M.3
  • 6
    • 73449117216 scopus 로고    scopus 로고
    • Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro
    • Liu, Z., Song, X. D., Xin, Y., Wang, X. J., Yu, H., Bai, Y. Y., et al. (2009). Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro. Chinese Medical Journal, 122, 2652-2656.
    • (2009) Chinese Medical Journal , vol.122 , pp. 2652-2656
    • Liu, Z.1    Song, X.D.2    Xin, Y.3    Wang, X.J.4    Yu, H.5    Bai, Y.Y.6
  • 7
    • 62649160560 scopus 로고    scopus 로고
    • Doxorubicin inactivates myocardial cytochrome c oxidase in rats: Cardioprotection by Mito-Q
    • Chandran, K., Aggarwal, D., Migrino, R. Q., Joseph, J., McAllister, D., Konorev, E. A., et al. (2009). Doxorubicin inactivates myocardial cytochrome c oxidase in rats: Cardioprotection by Mito-Q. Biophysical Journal, 96, 1388-1398.
    • (2009) Biophysical Journal , vol.96 , pp. 1388-1398
    • Chandran, K.1    Aggarwal, D.2    Migrino, R.Q.3    Joseph, J.4    McAllister, D.5    Konorev, E.A.6
  • 8
    • 36749096845 scopus 로고    scopus 로고
    • Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling
    • DOI 10.1158/1078-0432.CCR-07-1579
    • Li, L., Pan, Q., Han, W., Liu, Z., Li, L., & Hu, X. (2007). Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling. Clinical Cancer Research, 13, 6753-6760. (Pubitemid 350206813)
    • (2007) Clinical Cancer Research , vol.13 , Issue.22 , pp. 6753-6760
    • Li, N.1    Pan, Q.2    Han, W.3    Liu, Z.4    Hu, X.5
  • 9
    • 84961877370 scopus 로고    scopus 로고
    • Different dosage schedules for reducing cardio-toxicity in cancer patients receiving anthracycline chemotherapy
    • Van Dalen, E. C., van der Pal, H. J., Caron, H. N., & Kremer, L. C. (2009). Different dosage schedules for reducing cardio-toxicity in cancer patients receiving anthracycline chemotherapy. Cochrane Database of Systematic Reviews, 4, CD00 5008.
    • (2009) Cochrane Database of Systematic Reviews , vol.4
    • Van Dalen, E.C.1    Van Der Pal, H.J.2    Caron, H.N.3    Kremer, L.C.4
  • 13
    • 4043153467 scopus 로고    scopus 로고
    • Antiallergic activity of hesperidin is activated by intestinal microflora
    • Lee, N. K., Choi, S. H., Park, S. H., Park, E. K., & Kim, D. H. (2004). Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology, 71, 174-180.
    • (2004) Pharmacology , vol.71 , pp. 174-180
    • Lee, N.K.1    Choi, S.H.2    Park, S.H.3    Park, E.K.4    Kim, D.H.5
  • 14
    • 0037327340 scopus 로고    scopus 로고
    • Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two dose of orange juice
    • DOI 10.1038/sj.ejcn.1601547
    • Manach, C., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C., & Remesy, C. (2003). Bioavailability in humans of the flava-nones hesperidin and narirutin after the ingestion of two doses of orange juice. European Journal of Clinical Nutrition, 57, 235-242. (Pubitemid 36240474)
    • (2003) European Journal of Clinical Nutrition , vol.57 , Issue.2 , pp. 235-242
    • Manach, C.1    Morand, C.2    Gil-Izquierdo, A.3    Bouteloup-Demange, C.4    Remesy, C.5
  • 15
    • 0029897621 scopus 로고    scopus 로고
    • Biological effects of hesperidin, a Citrus flavonoid. (note III): Antihypertensive and diuretic activity in rat
    • Galati, E. M., Trovato, A., Kirjavainen, S., Forestieri, A. M., Rossitto, A., & Monforte, M. T. (1996). Biological effects of hesperidin, a Citrus flavonoid. (Note III): Antihypertensive and diuretic activity in rat. Farmaco, 51, 219-221. (Pubitemid 26162092)
    • (1996) Farmaco , vol.51 , Issue.3 , pp. 219-221
    • Galati, E.M.1    Trovato, A.2    Kirjavainen, S.3    Forestieri, A.M.4    Rossitto, A.5    Monforte, M.T.6
  • 16
    • 0035667114 scopus 로고    scopus 로고
    • Chemistry and pharmacology of the Citrus bioflavonoid hesperidin
    • DOI 10.1002/ptr.1074
    • Garg, A., Garg, S., Zaneveld, L. J., & Singla, A. K. (2001). Chemistry and pharmacology of the Citrus bioflavonoid hesper-idin. Phytotherapy Research, 15, 655-669. (Pubitemid 34016792)
    • (2001) Phytotherapy Research , vol.15 , Issue.8 , pp. 655-669
    • Garg, A.1    Garg, S.2    Zaneveld, L.J.D.3    Singla, A.K.4
  • 17
    • 52949110924 scopus 로고    scopus 로고
    • Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: A dose-dependent study
    • Aranganathan, S., Selvam, J. P., & Nalini, N. (2008). Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: A dose-dependent study. Journal of Pharmacy and Pharmacology, 60, 1385-1392.
    • (2008) Journal of Pharmacy and Pharmacology , vol.60 , pp. 1385-1392
    • Aranganathan, S.1    Selvam, J.P.2    Nalini, N.3
  • 18
    • 56749179749 scopus 로고    scopus 로고
    • Neuroprotective effects of chronic hesperetin administration in mice
    • Choi, E. J., & Ahn, W. S. (2008). Neuroprotective effects of chronic hesperetin administration in mice. Archives of Pharmacal Research, 31, 1457-1462.
    • (2008) Archives of Pharmacal Research , vol.31 , pp. 1457-1462
    • Choi, E.J.1    Ahn, W.S.2
  • 19
    • 33644760296 scopus 로고    scopus 로고
    • Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro
    • DOI 10.1211/jpp.58.3.0012
    • Dimpfel, W. (2006). Different anticonvulsive effects of hesperi-din and its aglycone hesperetin on electrical activity in the rat hippocampus in vitro. Journal of Pharmacy and Pharmacology, 58, 375-379. (Pubitemid 43344581)
    • (2006) Journal of Pharmacy and Pharmacology , vol.58 , Issue.3 , pp. 375-379
    • Dimpfel, W.1
  • 21
    • 0031870664 scopus 로고    scopus 로고
    • Protective effects of lemon flavonoids on oxidative stress in diabetic rats
    • DOI 10.1007/s11745-998-0258-y
    • Miyake, Y., Yamamoto, K., Tsujihara, N., & Osawa, T. (1998). Protective effects of lemon flavonoids on oxidative stress in diabetic Rats. Lipids, 33, 689-695. (Pubitemid 28328798)
    • (1998) Lipids , vol.33 , Issue.7 , pp. 689-695
    • Miyake, Y.1    Yamamoto, K.2    Tsujihara, N.3    Osawa, T.4
  • 23
    • 0033836675 scopus 로고    scopus 로고
    • Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection
    • DOI 10.1006/phrs.1999.0585
    • Nagi, M. N., & Mansour, M. A. (2000). Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacological Research, 41, 283-289. (Pubitemid 30663132)
    • (2000) Pharmacological Research , vol.41 , Issue.3 , pp. 283-289
    • Nagi, M.N.1    Mansour, M.A.2
  • 24
    • 64649106046 scopus 로고    scopus 로고
    • Hesperetin exerts dose dependent chemopreventive effect against 1, 2-dimethyl hydrazine induced rat colon carcinogenesis
    • Aranganathan, S., Selvam, J. P., & Nalini, N. (2009). Hesperetin exerts dose dependent chemopreventive effect against 1, 2-dimethyl hydrazine induced rat colon carcinogenesis. Investi-gational New Drugs, 27, 203-213.
    • (2009) Investi-gational New Drugs , vol.27 , pp. 203-213
    • Aranganathan, S.1    Selvam, J.P.2    Nalini, N.3
  • 25
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • DOI 10.1016/0003-2697(79)90738-3
    • Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95, 351-358. (Pubitemid 9194347)
    • (1979) Analytical Biochemistry , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 26
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • Moron, M. S., Depierre, J. W., & Mannervik, B. (1979). Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et Biophysica Acta, 582, 67-78. (Pubitemid 9065588)
    • (1979) Biochimica et Biophysica Acta , vol.582 , Issue.1 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 28
    • 36849078901 scopus 로고    scopus 로고
    • Intervention of d-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat
    • DOI 10.1016/j.taap.2007.09.006, PII S0041008X07004139
    • Vikram, A., Tripathi, D. N., Ramarao, P., & Jena, G. B. (2008). Intervention of D-glucose ameliorates the toxicity of streptozo-tocin in accessory sex organs of rat. Toxicology and Applied Pharmacology, 226, 84-93. (Pubitemid 350235584)
    • (2008) Toxicology and Applied Pharmacology , vol.226 , Issue.1 , pp. 84-93
    • Vikram, A.1    Tripathi, D.N.2    Ramarao, P.3    Jena, G.B.4
  • 29
    • 0030002162 scopus 로고    scopus 로고
    • Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay
    • DOI 10.1016/S0165-1218(96)90041-5
    • Kasamatsu, T., Kohda, K., & Kawazoe, Y. (1996). Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay. Mutation Research, 369, 1-6. (Pubitemid 26242791)
    • (1996) Mutation Research - Genetic Toxicology , vol.369 , Issue.1 , pp. 1-6
    • Kasamatsu, T.1    Kohda, K.2    Kawazoe, Y.3
  • 30
    • 0032604577 scopus 로고    scopus 로고
    • The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair
    • Speit, G., & Hartmann, A. (1999). The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Methods in Molecular Biology, 113, 203-212.
    • (1999) Methods in Molecular Biology , vol.113 , pp. 203-212
    • Speit, G.1    Hartmann, A.2
  • 31
    • 0034630349 scopus 로고    scopus 로고
    • A simple method for accurate estimation of apoptotic cells
    • DOI 10.1006/excr.2000.4810
    • Singh, N. P. (2000). A simple method for accurate estimation of apoptotic cells. Experimental Cell Research, 256, 328-337. (Pubitemid 30211196)
    • (2000) Experimental Cell Research , vol.256 , Issue.1 , pp. 328-337
    • Singh, N.P.1
  • 32
    • 34447573788 scopus 로고    scopus 로고
    • Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats
    • DOI 10.1038/sj.bjp.0707294, PII 0707294
    • Lebrecht, D., Geist, A., Ketelsen, U. P., Haberstroh, J., Setzer, B., & Walker, U. A. (2007). Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. British Journal of Psychiatry, 151, 771-778. (Pubitemid 47075325)
    • (2007) British Journal of Pharmacology , vol.151 , Issue.6 , pp. 771-778
    • Lebrecht, D.1    Geist, A.2    Ketelsen, U.-P.3    Haberstroh, J.4    Setzer, B.5    Walker, U.A.6
  • 33
    • 66949171305 scopus 로고    scopus 로고
    • Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron
    • Simunek, T., Sterba, M., Popelova, O., Adamcova, M., Hrdina, R., & Gersl, V. (2009). Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron. Pharmacological Reports, 61, 154-171.
    • (2009) Pharmacological Reports , vol.61 , pp. 154-171
    • Simunek, T.1    Sterba, M.2    Popelova, O.3    Adamcova, M.4    Hrdina, R.5    Gersl, V.6
  • 34
    • 65649092956 scopus 로고    scopus 로고
    • Hydrogen sulfide regulates cardiac function and structure in adriamycin-induced cardiomyopathy
    • Su, Y. W., Liang, C., Jin, H. F., Tang, X. Y., Han, W., Chai, L. J., et al. (2009). Hydrogen sulfide regulates cardiac function and structure in adriamycin-induced cardiomyopathy. Circulation Journal, 73, 741-749.
    • (2009) Circulation Journal , vol.73 , pp. 741-749
    • Su, Y.W.1    Liang, C.2    Jin, H.F.3    Tang, X.Y.4    Han, W.5    Chai, L.J.6
  • 35
    • 49349104151 scopus 로고    scopus 로고
    • Protective effects of telmisartan against acute doxorubi-cin-induced cardiotoxicity in rats
    • Iqbal, M., Dubey, K., Anwer, T., Ashish, A., & Pillai, K. K. (2008). Protective effects of telmisartan against acute doxorubi-cin-induced cardiotoxicity in rats. Pharmacological Reports, 60, 382-390.
    • (2008) Pharmacological Reports , vol.60 , pp. 382-390
    • Iqbal, M.1    Dubey, K.2    Anwer, T.3    Ashish, A.4    Pillai, K.K.5
  • 37
    • 78651429337 scopus 로고    scopus 로고
    • L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes
    • Chao, H. H., Liu, J. C., Hong, H. J., Lin, J. W., Chen, C. H., & Cheng, T. H. (2011). L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes. International Journal of Cardiology, 146, 145-152.
    • (2011) International Journal of Cardiology , vol.146 , pp. 145-152
    • Chao, H.H.1    Liu, J.C.2    Hong, H.J.3    Lin, J.W.4    Chen, C.H.5    Cheng, T.H.6
  • 38
    • 0033163393 scopus 로고    scopus 로고
    • Is NF-kappaB the sensor of oxidative stress?
    • Li, N., & Karin, M. (1999). Is NF-kappaB the sensor of oxidative stress? The Faseb Journal, 13, 1137-1143.
    • (1999) The Faseb Journal , vol.13 , pp. 1137-1143
    • Li, N.1    Karin, M.2
  • 39
    • 0036845841 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: The role of hydrogen peroxide
    • DOI 10.1042/BJ20020752
    • Wang, S., Kotamraju, S., Konorev, E., Kalivendi, S., Joseph, J., & Kalyanaraman, B. (2002). Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: The role of hydrogen peroxide. Biochemical Journal, 367, 729-740. (Pubitemid 35305712)
    • (2002) Biochemical Journal , vol.367 , Issue.3 , pp. 729-740
    • Wang, S.1    Kotamraju, S.2    Konorev, E.3    Kalivendi, S.4    Joseph, J.5    Kalyanaraman, B.6
  • 40
    • 57049095435 scopus 로고    scopus 로고
    • ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes
    • Liu, J., Mao, W., Ding, B., & Liang, C. S. (2008). ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. American Journal of Physiology, 295, H1956-H1965.
    • (2008) American Journal of Physiology , vol.295
    • Liu, J.1    Mao, W.2    Ding, B.3    Liang, C.S.4
  • 42
    • 33748291395 scopus 로고    scopus 로고
    • Modulation of the age-related nuclear factor-κB (NF-κB) pathway by hesperetin
    • DOI 10.1111/j.1474-9726.2006.00233.x
    • Kim, J. Y., Jung, K. J., Choi, J. S., & Chung, H. Y. (2006). Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin. Aging Cell, 5, 401-411. (Pubitemid 44322536)
    • (2006) Aging Cell , vol.5 , Issue.5 , pp. 401-411
    • Kim, J.Y.1    Jung, K.J.2    Choi, J.S.3    Chung, H.Y.4
  • 43
    • 67349167673 scopus 로고    scopus 로고
    • Morphological alterations induced by doxorubicin on H9c2 myoblasts: Nuclear, mitochondrial, and cytoskeletal targets
    • Sardao, V. A., Oliveira, P. J., Holy, J., Oliveira, C. R., & Wallace, K. B. (2009). Morphological alterations induced by doxorubicin on H9c2 myoblasts: Nuclear, mitochondrial, and cytoskeletal targets. Cell Biology and Toxicology, 25, 227-243.
    • (2009) Cell Biology and Toxicology , vol.25 , pp. 227-243
    • Sardao, V.A.1    Oliveira, P.J.2    Holy, J.3    Oliveira, C.R.4    Wallace, K.B.5
  • 44
    • 70449339747 scopus 로고    scopus 로고
    • Protective effect of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo
    • Zhang, S. H., Wang, W. Q., & Wang, J. L. (2009). Protective effect of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo. Acta Pharmacologica Sinica, 30, 1479-1487.
    • (2009) Acta Pharmacologica Sinica , vol.30 , pp. 1479-1487
    • Zhang, S.H.1    Wang, W.Q.2    Wang, J.L.3
  • 45
    • 80051842687 scopus 로고    scopus 로고
    • Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells
    • Hwang, S. L., & Yen, G. C. (2008). Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. Journal of Agricultural and Food Chemistry, 56, 859-864.
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , pp. 859-864
    • Hwang, S.L.1    Yen, G.C.2
  • 46
    • 78651354623 scopus 로고    scopus 로고
    • Anti-/pro-apoptotic effects of hesperetin against 7, 12-dimetylbenz(a) anthracene-induced alteration in animals
    • Choi, E. J., & Kim, G. H. (2011). Anti-/pro-apoptotic effects of hesperetin against 7, 12-dimetylbenz(a)anthracene-induced alteration in animals. Oncology Reports, 25, 545-550.
    • (2011) Oncology Reports , vol.25 , pp. 545-550
    • Choi, E.J.1    Kim, G.H.2
  • 48
    • 33847156848 scopus 로고    scopus 로고
    • The tumor-growth inhibitory activity of flavanone and 2-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs
    • Hsiao, Y. C., Hsieh, Y. S., Kuo, W. H., Chiou, H. L., Yang, S. F., Chiang, W. L., et al. (2007). The tumor-growth inhibitory activity of flavanone and 2-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. Journal of Biomedical Science, 14, 107-119.
    • (2007) Journal of Biomedical Science , vol.14 , pp. 107-119
    • Hsiao, Y.C.1    Hsieh, Y.S.2    Kuo, W.H.3    Chiou, H.L.4    Yang, S.F.5    Chiang, W.L.6
  • 49
    • 35148840445 scopus 로고    scopus 로고
    • Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: Involvement of CDK4 and p21
    • Choi, E. J. (2007). Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: Involvement of CDK4 and p21. Nutrition and Cancer, 59, 115-119. (Pubitemid 47549789)
    • (2007) Nutrition and Cancer , vol.59 , Issue.1 , pp. 115-119
    • Choi, E.J.1
  • 50
    • 79957679248 scopus 로고    scopus 로고
    • Inhibitory effect of flavonoids on mutant H-Rasp protein
    • Masoodi, T. A., & Alhamdanz, A. H. (2010). Inhibitory effect of flavonoids on mutant H-Rasp protein. Bioinformation, 5, 11-15.
    • (2010) Bioinformation , vol.5 , pp. 11-15
    • Masoodi, T.A.1    Alhamdanz, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.