Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a) anthracene-induced alteration in animals

Oncology Reports

Volumn 25, Issue 2, 2011, Pages 545-550

  Choi, Eun Jeong ^a   Kim, Gun Hee ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Anti apoptosis; Antioxidant; DMBA; Hesperetin; In vivo; Pro apoptosis

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CYCLINE; HESPERETIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; BREAST CARCINOMA; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GENE EXPRESSION; LIVER; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR CELL; TUMOR VOLUME;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; DRUG EVALUATION, PRECLINICAL; FEMALE; HESPERIDIN; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED ICR; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 78651354623     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2010.1105     Document Type: Article

References (46)

1. Musarrat J, Arezina-Wilson J and Wani AA: Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer 32A: 1209-1214, 1996. (Pubitemid 26231805)
2. Hollman PC and Katan MB: Health effects and bioavailability of dietary flavonols. Free Radic Res 3: S75-S80, 1999. (Pubitemid 30060593)
3. Jung KJ, Wallig MA and Singletary KW: Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 233: 279-288, 2006.
4. Garg A, Garg S, Zaneveld LJ and Singla AK: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res 15: 655-669, 2001. (Pubitemid 34016792)
5. Gil-Izquierdo A, Gil MI, Ferreres F and Tomás-Barberán FA: In vitro availability of flavonoids and other phenolics in orange juice. J Agric Food Chem 49: 1035-1041, 2001.
6. Choi EJ: Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21. Nutr Cancer 59: 115-119, 2007. (Pubitemid 47549789)
7. Huggins C, Grand LC and Brillantes FP: Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Nature 189: 204-207, 1961.
8. Maltzman TH, Christou M, Gould MN and Jefcoate CR: Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. Carcinogenesis 12: 2081-2087, 1991.
9. Harvey RG, Dai Q, Ran C and Penning TM: Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis. J Org Chem 69: 2024-2032, 2004. (Pubitemid 38366668)
10. Izzotti A, Camoirano A, Cartiglia C, Grubbs CJ. Lubet RA, Kelloff GJ and De Flora S: Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12- dimethylbenz(a)anthracene, and selective effects of chemopreventive agents. Cancer Res 59: 4285-4290, 1999. (Pubitemid 29418744)
11. Anbuselvam C, Vijayavel K and Balasubramanian MP: Protective effect of Operculina turpethum against 7,12-dimethyl benz(a)anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chem Biol Interact 168: 229-236, 2007. (Pubitemid 46976883)
12. Prasad S, Kalra N and Shukla Y: Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice. Mol Nutr Food Res 51: 352-359, 2007. (Pubitemid 47083670)
13. Barrett JC: Mechanisms of multistep carcinogenesis and carcinogen risk assessment. Environ Health Perspect 100: 9-20, 1993. (Pubitemid 23197088)
14. Manna S, Chakraborty T, Damodaran S, Samanta K, Rana B and Chatterjee M: Protective role of fish oil (Maxepa) on early events of rat mammary carcinogenesis by modulation of DNA-protein crosslinks, cell proliferation and p53 expression. Cancer Cell Int 7: 6, 2007. (Pubitemid 46831463)
15. Sallinen PK, Haapasalo HK, Visakorpi T, Helén PT, Rantala IS, Isola JJ and Helin HJ: Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples. J Pathol 174: 275-282, 1994.
16. Ehrmann J Jr, Kolár Z, Vojtesek B, Kala M, Komenda S and Oulton A: Prognostic factors in astrocytomas: relationship of p53, MDM-2, BCL-2 and PCNA immunohistochemical expression to tumor grade and overall patient survival. Neoplasma 44: 299-304, 1997. (Pubitemid 28237835)
17. Manjanatha M, Shelton S, Bishop M, Lyn-Cook L and Aidoo A: Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a] anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue transgenic rats. Carcinogenesis 27: 1970-1979, 2006.
18. Kumaraguruparan R, Seshagiri PB, Hara Y and Nagini S: Chemoprevention of rat mammary carcinogenesis by black tea polyphenols: modulation of xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation, apoptosis, and angiogenesis. Mol Carcinog 46: 797-806, 2007. (Pubitemid 47438730)
19. Agarwal ML, Agarwal A, Taylor WR and Stark GR: p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 92: 8493-8497, 1995.
20. Park M, Chae HD, Yun J, Jung M, Kim YS, Kim SH, Han MH and Shin DY: Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Cancer Res 60: 542-545, 2000. (Pubitemid 30094547)
21. Lepik D, Jaks V, Kadaja L, Varv S and Maimets T: Electroporation and carrier DNA cause p53 activation, cell cycle arrest, and apoptosis. Anal Biochem 318: 52-59, 2003. (Pubitemid 36637014)
22. Oakes SA, Lin SS and Bassik MC: The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr Mol Med 6: 99-109, 2006.
23. van Delft MF and Huang DC: How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 16: 203-213, 2006. (Pubitemid 43247978)
24. Lucken-Ardjomande S and Martinou JC: Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. CR Biol 328: 616-631, 2005. (Pubitemid 40903696)
25. Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6: 99-104, 1999.
26. Abu-Qare AW and Abou-Donia MB: Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2′- deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene. J Toxicol Environ Health B Crit Rev 4: 313-332, 2001.
27. Galati G and O'Brien PJ: Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 37: 287-303, 2004. (Pubitemid 38833996)
28. Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N and Moore MA: Cancer prevention by natural compounds. Drug Metab Pharmacokinet 19: 245-263, 2004.
29. Kandaswami C, Lee LT, Lee PP, Hwang JJ, Ke FC, Huang YT and Lee MT: The antitumor activities of flavonoids. In Vivo 19: 895-909, 2005.
30. Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S and Grubbs C: Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. J Nutr 134: S3445-S3452, 2004. (Pubitemid 39587588)
31. Samy RP, Gopalakrishnakone P and Ignacimuthu S: Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a) anthracene-induced mammary tumors in rats. Chem Biol Interact 164: 1-14, 2006. (Pubitemid 44709707)
32. Frenkel K: The role of active oxygen species in biological damage and the effect of some chemopreventive agents. In: Protease Inhibitors as Cancer Chemopreventive Agents. Troll W and Kennedy AR (ed). Plenum Press, New York, pp227-249, 1993.
33. Kang DH: Oxidative stress, DNA damage, and breast cancer. AACN Clin Issues 13: 540-549, 2002.
34. Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160: 1-40, 2006. (Pubitemid 43227479)
35. Sigounas G, Hooker JL, Li W, Anagnostou A and Steiner M: S-allylmercaptocysteine, a stable thioallyl compound, induces apoptosis in erythroleukemia cell lines. Nutr Cancer 28: 153-159, 1997. (Pubitemid 27396203)
36. Fu X, Latendresse JR, Muskhelishvili L, Blaydes BS and Delclos KB: Dietary modulation of 7,12-dimethylbenz[a] anthracene (DMBA)-induced adrenal toxicity in female Sprague-Dawley rats. Food Chem Toxicol 43: 765-774, 2005. (Pubitemid 40381180)
37. Zheng Q, Hirose Y, Yoshimi N, Murakami A, Koshimizu K, Ohigashi H, Sakata K, Matsumoto Y, Sayama Y and Mori H: Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. J Cancer Res Clin Oncol 128: 539-546, 2002. (Pubitemid 35244929)
38. Leung HW, Kuo CL, Yang WH, Lin CH and Lee HZ: Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol 534: 12-18, 2006.
39. Hsu CL and Yen GC: Induction of cell apoptosis in 3T3-L1 preadipocytes by flavonoids is associated with their antioxidant activity. Mol Nutr Food Res 50: 1072-1079, 2006.
40. Jeong YJ, Choi YJ, Kwon HM, Kang SW, Park HS, Lee M and Kang YH: Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids. Br J Nutr 93: 581-591, 2005. (Pubitemid 43906341)
41. Agostini M, Di Marco B, Nocentini G and Delfino DV: Oxidative stress and apoptosis in immune diseases. Int J Immunopathol Pharmacol 15: 157-164, 2002. (Pubitemid 35285193)
42. Tsuta K, Shikata N, Kominami S and Tsubura A: Mechanisms of adrenal damage induced by 7,12-dimethylbenz (alpha) anthrancene in female Sprague-Dawley rats. Exp Mol Pathol 70: 162-172, 2001. (Pubitemid 34412215)
43. Jaeschke H and Lemasters JJ: Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology 125: 1246-1257, 2003. (Pubitemid 37193469)
44. Raffray M and Cohen GM: Apoptosis and necrosis in toxicology: a continuum or distinct modes of cell death? Pharmacol Ther 75: 153-177, 1997.
45. Kim JY and Park JH: ROS-dependent caspase-9 activation in hypoxic cell death. FEBS Lett 549: 94-98, 2003. (Pubitemid 36959851)
46. Choi EJ, Kim GD, Chee KM and Kim GH: Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells. Nutrition 22: 947-951, 2006.