Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski

Journal of Cellular Physiology

Volumn 227, Issue 1, 2012, Pages 278-287

  Marcelain, Katherine ^a   Armisen, Ricardo ^a   Aguirre, Adam ^a   Ueki, Nobuhide ^b   Toro, Jessica ^a   Colmenares, Clemencia ^c   Hayman, Michael J ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b STONY BROOK UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COREPRESSOR PROTEIN; SKI PROTEIN; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL POLARITY; CHROMATIN; CHROMOSOMAL INSTABILITY; CHROMOSOME REARRANGEMENT; CHROMOSOME SEGREGATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENOMIC INSTABILITY; IN VIVO STUDY; METAPHASE; MICRONUCLEUS; MITOSIS; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TIME LAPSE IMAGING;

ANIMALS; CELL SEPARATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOMAL INSTABILITY; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; MITOSIS; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION, GENETIC;

AVES;

EID: 80054882111     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22733     Document Type: Article

References (47)

1. Akiyoshi S, Inoue H, Hanai J, Kusanagi K, Nemoto N, Miyazono K, Kawabata M. 1999. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem 274:35269-35277.
2. Azuma H, Ehata S, Miyazaki H, Watabe T, Maruyama O, Imamura T, Sakamoto T, Kiyama S, Kiyama Y, Ubai T, Inamoto T, Takahara S, Itoh Y, Otsuki Y, Katsuoka Y, Miyazono K, Horie S. 2005. Effect of Smad7 expression on metastasis of mouse mammary carcinoma JygMC(A) cells. J Natl Cancer Inst 97:1734-1746.
3. Bharadwaj R, Yu H. 2004. The spindle checkpoint, aneuploidy, and cancer. Oncogene 23:2016-2027.
4. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. 2004. Cell death by mitotic catastrophe: A molecular definition. Oncogene 23:2825-2837.
5. Cimini D, Mattiuzzo M, Torosantucci L, Degrassi F. 2003. Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Mol Biol Cell 14:3821-3833.
6. Colmenares C, Heilstedt HA, Shaffer LG, Schwartz S, Berk M, Murray JC, Stavnezer E. 2002. Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice. Nat Genet 30:106-109.
7. Colmenares C, Sutrave P, Hughes SH, Stavnezer E. 1991. Activation of the c-ski oncogene by overexpression. J Virol 65:4929-4935.
8. Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavnezer E, Campisi J, Fisher DE, Ben-Ze'ev A, Medrano EE. 2003. SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res 63:6626-6634.
9. Dahl R, Kieslinger M, Beug H, Hayman MJ. 1998. Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling. Proc Natl Acad Sci USA 95:11187-11192.
10. Deheuninck J, Luo K. 2009. Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res 19:47-57.
11. Dowling M, Voong KR, Kim M, Keutmann MK, Harris E, Kao GD. 2005. Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. Cancer Biol Ther 4:197-206.
12. Draviam VM, Xie S, Sorger PK. 2004. Chromosome segregation and genomic stability. Curr Opin Genet Dev 14:120-125.
13. Eot-Houllier G, Fulcrand G, Watanabe Y, Magnaghi-Jaulin L, Jaulin C. 2008. Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion. Genes Dev 22:2639-2644.
14. Geigl JB, Obenauf AC, Schwarzbraun T, Speicher MR. 2008. Defining 'chromosomal instability'. Trends Genet 24:64-69.
15. Gisselsson D, Hakanson U, Stoller P, Marti D, Jin Y, Rosengren AH, Stewenius Y, Kahl F, Panagopoulos I. 2008. When the genome plays dice: Circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses. PLoS One 3:e1871.
16. Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM. 2003. The small molecule hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161:281-294.
17. Ishii S, Kurasawa Y, Wong J, Yu-Lee LY. 2008. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc Natl Acad Sci USA 105:4179-4184.
18. Johnson VL, Scott MI, Holt SV, Hussein D, Taylor SS. 2004. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci 117:1577-1589.
19. Kimata Y, Matsuyama A, Nagao K, Furuya K, Obuse C, Yoshida M, Yanagida M. 2008. Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. J Cell Sci 121:1107-1118.
20. King RW. 2008. When 2+2=5: The origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta 1786:4-14.
21. Kops GJ, Weaver BA, Cleveland DW. 2005. On the road to cancer: Aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5:773-785.
22. Larsen J, Beug H, Hayman MJ. 1992. The v-ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation. Oncogene 7:1903-1911.
23. Le Scolan E, Zhu Q, Wang L, Bandyopadhyay A, Javelaud D, Mauviel A, Sun L, Luo K. 2008. Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res 68:3277-3285.
24. Li Y, Turck CM, Teumer JK, Stavnezer E. 1986. Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene. J Virol 57:1065-1072.
25. Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ. 2003. Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat Cell Biol 5:341-345.
26. Luo K, Stroschein SL, Wang W, Chen D, Martens E, Zhou S, Zhou Q. 1999. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev 13:2196-2206.
27. Macdonald M, Wan Y, Wang W, Roberts E, Cheung TH, Erickson R, Knuesel MT, Liu X. 2004. Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34. Oncogene 23:5643-5653.
28. Marcelain K, Hayman MJ. 2005. The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosis. Oncogene 24:4321-4329.
29. Musacchio A, Salmon ED. 2007. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8:379-393.
30. Nomura T, Khan MM, Kaul SC, Dong HD, Wadhwa R, Colmenares C, Kohno I, Ishii S. 1999. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev 13:412-423.
31. Pan D, Zhu Q, Luo K. 2009. SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J 28:3500-3513.
32. Poser I, Rothhammer T, Dooley S, Weiskirchen R, Bosserhoff AK. 2005. Characterization of Sno expression in malignant melanoma. Int J Oncol 26:1411-1417.
33. Rajagopalan H, Lengauer C. 2004. Aneuploidy and cancer. Nature 432:338-341.
34. Sen S. 2000. Aneuploidy and cancer. Curr Opin Oncol 12:82-88.
35. Shinagawa T, Nomura T, Colmenares C, Ohira M, Nakagawara A, Ishii S. 2001. Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice. Oncogene 20:8100-8108.
36. Stavnezer E, Barkas AE, Brennan LA, Brodeur D, Li Y. 1986. Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinations. J Virol 57:1073-1083.
37. Sun Y, Liu X, Eaton EN, Lane WS, Lodish HF, Weinberg RA. 1999. Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell 4:499-509.
38. Tabata T, Kokura K, Ten Dijke P, Ishii S. 2009. Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5. Genes Cells 14:17-28.
39. Taddei A, Maison C, Roche D, Almouzni G. 2001. Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. Nat Cell Biol 3:114-120.
40. Ueki N, Zhang L, Hayman MJ. 2008. Ski can negatively regulates macrophage differentiation through its interaction with PU.1. Oncogene 27:300-307.
41. Vakifahmetoglu H, Olsson M, Zhivotovsky B. 2008. Death through a tragedy: Mitotic catastrophe. Cell Death Differ 15:1153-1162.
42. Weaver BA, Bonday ZQ, Putkey FR, Kops GJ, Silk AD, Cleveland DW. 2003. Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol 162:551-563.
43. Weaver BA, Cleveland DW. 2005. Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 8:7-12.
44. Xu W, Angelis K, Danielpour D, Haddad MM, Bischof O, Campisi J, Stavnezer E, Medrano EE. 2000. Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor. Proc Natl Acad Sci USA 97:5924-5929.
45. Zhang H, Stavnezer E. 2009. Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. J Biol Chem 284:2867-2879.
46. Zhao HL, Ueki N, Marcelain K, Hayman MJ. 2009. The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun 383:119-124.
47. Zhu Q, Krakowski AR, Dunham EE, Wang L, Bandyopadhyay A, Berdeaux R, Martin GS, Sun L, Luo K. 2007. Dual role of SnoN in mammalian tumorigenesis. Mol Cell Biol 27:324-339.