-
1
-
-
42549143615
-
Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa
-
DOI 10.1136/gut.2007.130922
-
Di Sabatino A, Pickard KM, Rampton D, et al. Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut 2008;57:605-612. (Pubitemid 351579972)
-
(2008)
Gut
, vol.57
, Issue.5
, pp. 605-612
-
-
Di, S.A.1
Pickard, K.M.2
Rampton, D.3
Kruidenier, L.4
Rovedatti, L.5
Leakey, N.A.B.6
Corazza, G.R.7
Monteleone, G.8
MacDonald, T.T.9
-
2
-
-
40549113336
-
Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants
-
DOI 10.1172/JCI32140
-
Jarry A, Bossard C, Bou-Hanna C, et al. Mucosal IL-10 and TGFbeta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants. J Clin Invest 2008;118:1132-1142. (Pubitemid 351364620)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.3
, pp. 1132-1142
-
-
Jarry, A.1
Bossard, C.2
Bou-Hanna, C.3
Masson, D.4
Espaze, E.5
Denis, M.G.6
Laboisse, C.L.7
-
3
-
-
33847381116
-
The fundamental basis of inflammatory bowel disease
-
DOI 10.1172/JCI30587
-
Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest 2007;117:514-521. (Pubitemid 46348505)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.3
, pp. 514-521
-
-
Strober, W.1
Fuss, I.2
Mannon, P.3
-
4
-
-
27744485015
-
Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease
-
DOI 10.1053/j.gastro.2005.09.005, PII S0016508505017890
-
Monteleone G, Del Vecchio Blanco G, Monteleone I, et al. Posttranscriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. Gastroenterology 2005;129:1420-1429. (Pubitemid 41597384)
-
(2005)
Gastroenterology
, vol.129
, Issue.5
, pp. 1420-1429
-
-
Monteleone, G.1
Del, V.B.G.2
Monteleone, I.3
Fina, D.4
Caruso, R.5
Gioia, V.6
Ballerini, S.7
Federici, G.8
Bernardini, S.9
Pallone, F.10
MacDonald, T.T.11
-
5
-
-
65549131489
-
Defective IL-10 production in severe phenotypes of Crohn's disease
-
Correa I, Veny M, Esteller M, et al. Defective IL-10 production in severe phenotypes of Crohn's disease. J Leukoc Biol 2009;85:896-903.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 896-903
-
-
Correa, I.1
Veny, M.2
Esteller, M.3
-
6
-
-
65249115914
-
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
-
Noguchi E, Homma Y, Kang X, et al. A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol 2009;10:471-479.
-
(2009)
Nat Immunol
, vol.10
, pp. 471-479
-
-
Noguchi, E.1
Homma, Y.2
Kang, X.3
-
7
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009;361:2033-2045.
-
(2009)
N Engl J Med
, vol.361
, pp. 2033-2045
-
-
Glocker, E.O.1
Kotlarz, D.2
Boztug, K.3
-
8
-
-
0037313578
-
Interleukin-12 and the regulation of innate resistance and adaptive immunity
-
DOI 10.1038/nri1001
-
Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3:133-146. (Pubitemid 37328691)
-
(2003)
Nature Reviews Immunology
, vol.3
, Issue.2
, pp. 133-146
-
-
Trinchieri, G.1
-
9
-
-
2542457495
-
Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
-
DOI 10.1016/j.cell.2004.05.004, PII S0092867404004908
-
Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004;117:561-574. (Pubitemid 38692523)
-
(2004)
Cell
, vol.117
, Issue.5
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
11
-
-
0030995575
-
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
-
DOI 10.1016/S0016-5085(97)70128-8
-
Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997;112:1169-1178. (Pubitemid 27157528)
-
(1997)
Gastroenterology
, vol.112
, Issue.4
, pp. 1169-1178
-
-
Monteleone, G.1
Biancone, L.2
Marasco, R.3
Morrone, G.4
Marasco, O.5
Luzza, F.6
Pallone, F.7
-
12
-
-
0033152023
-
IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Expression and localization in intestinal mucosal cells
-
Pizarro TT, Michie MH, Bentz M, et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 1999;162:6829-6835. (Pubitemid 29309411)
-
(1999)
Journal of Immunology
, vol.162
, Issue.11
, pp. 6829-6835
-
-
Pizarro, T.T.1
Michie, M.H.2
Bentz, M.3
Woraratanadharm, J.4
Smith Jr., M.F.5
Foley, E.6
Moskaluk, C.A.7
Bickston, S.J.8
Cominelli, F.9
-
13
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
-
DOI 10.1097/01.MIB.0000194183.92671.b6
-
Fuss IJ, Becker C, Yang Z, et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 2006;12:9-15. (Pubitemid 43032445)
-
(2006)
Inflammatory Bowel Diseases
, vol.12
, Issue.1
, pp. 9-15
-
-
Fuss, I.J.1
Becker, C.2
Yang, Z.3
Groden, C.4
Hornung, R.L.5
Heller, F.6
Neurath, M.F.7
Strober, W.8
Mannon, P.J.9
-
14
-
-
30344486965
-
Human colonic myocytes are involved in postischemic inflammation through ADAM17-dependent TNFalpha production
-
DOI 10.1038/sj.bjp.0706449, PII 0706449
-
Jarry A, Bach-Ngohou K, Masson D, et al. Human colonic myocytes are involved in postischemic inflammation through ADAM17 dependent TNFalpha production. Br J Pharmacol 2006;147:64-72. (Pubitemid 43069097)
-
(2006)
British Journal of Pharmacology
, vol.147
, Issue.1
, pp. 64-72
-
-
Jarry, A.1
Bach-Ngohou, K.2
Masson, D.3
Dejoie, T.4
Lehur, P.-A.5
Mosnier, J.-F.6
Denis, M.G.7
Laboisse, C.L.8
-
15
-
-
0036842274
-
Flow cytometric detection of intracellular IL-12 release: In vitro effect of widely used immunosuppressants
-
DOI 10.1016/S1567-5769(02)00208-4, PII S1567576902002084
-
Tsiavou A, Degiannis D, Hatziagelaki E, et al. Flow cytometric detection of intracellular IL-12 release: in vitro effect of widely used immunosuppressants. Int Immunopharmacol 2002;2:1713-1720. (Pubitemid 35284609)
-
(2002)
International Immunopharmacology
, vol.2
, Issue.12
, pp. 1713-1720
-
-
Tsiavou, A.1
Degiannis, D.2
Hatziagelaki, E.3
Koniavitou, K.4
Raptis, S.5
-
16
-
-
0037255218
-
- dendritic cell populations in the colonic mucosa of patients with Crohn's disease
-
DOI 10.1002/immu.200390017
-
te Velde AA, van Kooyk Y, Braat H, et al. Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. Eur J Immunol 2003;33:143-151. (Pubitemid 36157652)
-
(2003)
European Journal of Immunology
, vol.33
, Issue.1
, pp. 143-151
-
-
Te, V.A.A.1
Van Kooyk, Y.2
Braat, H.3
Hommes, D.W.4
Dellemjin, T.A.M.5
Slors, J.F.M.6
Van Deventer, S.J.H.7
Vyth-Dreese, F.A.8
-
17
-
-
0032983336
-
Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
-
DOI 10.1016/S1074-7613(00)80013-8
-
Novick D, Kim SH, Fantuzzi G, et al. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity 1999;10:127-136. (Pubitemid 29077390)
-
(1999)
Immunity
, vol.10
, Issue.1
, pp. 127-136
-
-
Novick, D.1
Kim, S.-H.2
Fantuzzi, G.3
Reznikov, L.L.4
Dinarello, C.A.5
Rubinstein, M.6
-
18
-
-
0027531528
-
1 null mutation in mice causes excessive inflammatory response and early death
-
DOI 10.1073/pnas.90.2.770
-
Kulkarni AB, Huh CG, Becker D, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 1993;90:770-774. (Pubitemid 23028947)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.2
, pp. 770-774
-
-
Kulkarni, A.B.1
Huh, C.-G.2
Becker, D.3
Geiser, A.4
Lyght, M.5
Flanders, K.C.6
Roberts, A.B.7
Sporn, M.B.8
Ward, J.M.9
Karlsson, S.10
-
19
-
-
0034924028
-
Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
-
DOI 10.1136/gut.49.2.190
-
Hahm KB, Im YH, Parks TW, et al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001;49:190-198. (Pubitemid 32675110)
-
(2001)
Gut
, vol.49
, Issue.2
, pp. 190-198
-
-
Hahm, K.-B.1
Im, Y.-H.2
Parks, T.W.3
Park, S.-H.4
Markowitz, S.5
Jung, H.-Y.6
Green, J.7
Kim, S.-J.8
-
21
-
-
0031253731
-
TGF-beta Production Regulates the Development of the 2,4,6- Trinitrophenol-Conjugated Keyhole Limpet Hemocyanin-Induced Colonic Inflammation in IL-2-Deficient Mice
-
Ludviksson BR, Ehrhardt RO, Strober W. TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. J Immunol 1997;159:3622-3628. (Pubitemid 127482122)
-
(1997)
Journal of Immunology
, vol.159
, Issue.7
, pp. 3622-3628
-
-
Ludviksson, B.R.1
Ehrhardt, R.O.2
Strober, W.3
-
22
-
-
0037080032
-
The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis
-
Fuss IJ, Boirivant M, Lacy B, et al. The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis. J Immunol 2002;168:900-908. (Pubitemid 34049594)
-
(2002)
Journal of Immunology
, vol.168
, Issue.2
, pp. 900-908
-
-
Fuss, I.J.1
Boirivant, M.2
Lacy, B.3
Strober, W.4
-
23
-
-
0034600789
-
Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid:TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation
-
DOI 10.1084/jem.192.1.41
-
Kitani A, Fuss IJ, Nakamura K, et al. Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1- mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation. J Exp Med 2000;192:41-52. (Pubitemid 30470805)
-
(2000)
Journal of Experimental Medicine
, vol.192
, Issue.1
, pp. 41-52
-
-
Kitani, A.1
Fuss, I.J.2
Nakamura, K.3
Schwartz, O.M.4
Usui, T.5
Strober, W.6
-
24
-
-
3943094621
-
Lymphocytes endowed with colon-selective homing and engineered to produce TGF-beta1 prevent the development of dinitrobenzene sulphonic acid colitis
-
DOI 10.1097/00042737-200312000-00002
-
Castagliuolo I, Brun P, Tormen D, et al. Lymphocytes endowed with colon-selective homing and engineered to produce TGF-beta1 prevent the development of dinitrobenzene sulphonic acid colitis. Eur J Gastroenterol Hepatol 2003;15:1257-1265. (Pubitemid 39049667)
-
(2003)
European Journal of Gastroenterology and Hepatology
, vol.15
, Issue.12
, pp. 1257-1265
-
-
Castagliuolo, I.1
Brun, P.2
Tormen, D.3
Palu, G.4
-
25
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-1290.
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
-
26
-
-
0032698471
-
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
-
Fantuzzi G, Reed DA, Dinarello CA. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor. J Clin Invest 1999;104:761-767. (Pubitemid 29536361)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.6
, pp. 761-767
-
-
Fantuzzi, G.1
Reed, D.A.2
Dinarello, C.A.3
-
27
-
-
0034668049
-
Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection
-
Bliss SK, Butcher BA, Denkers EY. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J Immunol 2000;165:4515-4521.
-
(2000)
J Immunol
, vol.165
, pp. 4515-4521
-
-
Bliss, S.K.1
Butcher, B.A.2
Denkers, E.Y.3
-
28
-
-
0034698826
-
Preformed membraneassociated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
-
Quinones M, Ahuja SK, Melby PC, et al. Preformed membraneassociated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite. J Exp Med 2000;192:507-516.
-
(2000)
J Exp Med
, vol.192
, pp. 507-516
-
-
Quinones, M.1
Ahuja, S.K.2
Melby, P.C.3
-
29
-
-
0032817625
-
Interleukin 1 and interleukin 1 beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer
-
Jarry A, Vallette G, Cassagnau E, et al. Interleukin 1 and interleukin 1beta converting enzyme (caspase 1) expression in the human colonic epithelial barrier. Caspase 1 downregulation in colon cancer. Gut 1999;45:246-251. (Pubitemid 29333774)
-
(1999)
Gut
, vol.45
, Issue.2
, pp. 246-251
-
-
Jarry, A.1
Vallette, G.2
Cassagnau, E.3
Moreau, A.4
Bou-Hanna, C.5
Lemarre, P.6
Letessier, E.7
Le, N.J.-C.8
Galmiche, J.-P.9
Laboisse, C.L.10
-
30
-
-
0031921472
-
Expression of interleukin 1beta and interleukin 1beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease
-
McAlindon ME, Hawkey CJ, Mahida YR. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut 1998; 42:214-219. (Pubitemid 28212176)
-
(1998)
Gut
, vol.42
, Issue.2
, pp. 214-219
-
-
McAlindon, M.E.1
Hawkey, C.J.2
Mahida, Y.R.3
-
31
-
-
0032521933
-
+ T lymphocytes
-
Barbulescu K, Becker C, Schlaak JF, et al. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFNgamma promoter in primary CD4+ T lymphocytes. J Immunol 1998;160:3642-3647. (Pubitemid 28176063)
-
(1998)
Journal of Immunology
, vol.160
, Issue.8
, pp. 3642-3647
-
-
Barbulescu, K.1
Becker, C.2
Schlaak, J.F.3
Schmitt, E.4
Meyer, Z.B.K.-H.5
Neurath, M.F.6
-
32
-
-
0141886175
-
IFN-gamma-independent effects of IL-12 during intestinal nematode infection
-
Helmby H, Grencis RK. IFN-gamma-independent effects of IL-12 during intestinal nematode infection. J Immunol 2003;171:3691-3696. (Pubitemid 37254573)
-
(2003)
Journal of Immunology
, vol.171
, Issue.7
, pp. 3691-3696
-
-
Helmby, H.1
Grencis, R.K.2
-
33
-
-
0028670487
-
Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major
-
Wang ZE, Zheng, Corry DB, et al. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci U S A 1994;91:12932-12936.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 12932-12936
-
-
Wang, Z.E.1
Zheng2
Corry, D.B.3
|