Pain/depression dyad: A key to a better understanding and treatment of functional somatic syndromes

American Journal of Medicine

Volumn 123, Issue 8, 2010, Pages 675-682

  Goldenberg, Don L ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chronic pain; Depression; Fibromyalgia; Functional somatic syndromes; Irritable bowel syndrome

Indexed keywords

ANTIDEPRESSANT AGENT;

CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL FEATURE; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; FIBROMYALGIA; HUMAN; IMMUNE RESPONSE; IRRITABLE COLON; MAJOR DEPRESSION; NEUROENDOCRINE DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STRESS;

COMORBIDITY; DEPRESSION; FIBROMYALGIA; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKINS; IRRITABLE BOWEL SYNDROME; PAIN;

EID: 77955510375     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2010.01.014     Document Type: Review

References (83)

1. L.A. Aaron, and D. Buchwald A review of the evidence for overlap among unexplained clinical conditions Ann Intern Med 134 2001 868 881
2. F. Wolfe, H.A. Smythe, and M.B. Yunus The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee Arthritis Rheum 33 1990 160 172
3. G.F. Longstreth, W.G. Thompson, and W.D. Chey Functional bowel disorders Gastroenterology 130 2006 480 491
4. K. Kato, P.F. Sullivan, B. Evengard, and N.L. Pedersen Chronic widespread pain and its comorbidities: a population-based study Arch Intern Med 166 2006 1649 1654
5. P.O. Vandvik, S. Lydersen, and P.G. Farup Prevalence, comorbidity and impact of irritable bowel syndrome in Norway Scand J Gastroenterol 41 2006 650 656
6. J.A. Cole, K.J. Rothman, and H.J. Cabral Migraine, fibromyalgia and depression among people with IBS: a prevalence study BMC Gastroenterol 6 2006 26
7. P.T. Weir, G.A. Harlan, and F.L. Nkoy The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes J Clin Rheumatol 12 2006 124 128
8. W.E. Whitehead, O. Palsson, and K.R. Jones Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications Gastroenterology 122 2002 1140 1156
9. A. Riedl, M. Schmidtmann, and A. Stengel Somatic comorbidities of irritable bowel syndrome: a systematic analysis J Psychosom Res 64 2008 573 582
10. J.E. Kurland, W.J. Coyle, A. Winkler, and E. Zable Prevalence of irritable bowel syndrome and depression in fibromyalgia Dig Dis Sci 51 2006 454 460
11. C. Almansa, E. Rey, and R.G. Sanchez Prevalence of functional gastrointestinal disorders in patients with fibromyalgia and the role of psychologic distress Clin Gastroenterol Hepatol 7 2009 438 445
12. L.M. Arnold, J.I. Hudson, and P.E. Keck Comorbidity of fibromyalgia and psychiatric disorders J Clin Psychiatry 67 2006 1219 1225
13. M.K. Wojczynski, K.E. North, N.L. Pedersen, and P.F. Sullivan Irritable bowel syndrome: a co-twin analysis Am J Gastroenterol 102 2007 2220 2229
14. M.J. Bair, J. Wu, and T.M. Damush Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients Psychosom Med 70 2008 890 897
15. B.I. Nicholl, G.J. Macfarlane, and K.A. Davies Premorbid psychosocial factors are associated with poor health-related quality of life in subjects with new onset of chronic widespread painresults from the EPIFUND study Pain 141 2009 119 126
16. M. Mussell, K. Kroenke, and R.L. Spitzer Gastrointestinal symptoms in primary care: prevalence and association with depression and anxiety J Psychosom Res 64 2008 605 612
17. B.I. Nicholl, S. Halder, and G.J. Macfarlane Psychosocial risk markers for new onset irritable bowel syndromeresults of a large prospective population-based study Pain 137 2008 147 155
18. J.S. Kalantar, G.R. Locke 3rd, and A.R. Zinsmeister Familial aggregation of irritable bowel syndrome: a prospective study Gut 52 2003 1703 1707
19. M.-B. Bengtson, T. Ronning, M.H. Vatn, and J.R. Harris Irritable bowel syndrome in twins: genes and environment Gut 55 2006 1754 1759
20. K.S. Kendler, M. Gatz, C.O. Gardner, and N.L. Pedersen A Swedish national twin study of lifetime major depression Am J Psychiatry 163 2006 109 114
21. D. Buskila, and P. Sarzi-Puttini Biology and therapy of fibromyalgia Genetic aspects of fibromyalgia syndrome Arthritis Res Ther 8 2006 218
22. G. Vargas-Alarcon, J.M. Fragoso, and D. Cruz-Robles Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains Arthritis Rheum 60 2009 2169 2173
23. C. Hotoleanu, R. Popp, and A.P. Trifa Genetic determination of irritable bowel syndrome World J Gastroenterol 14 2008 6636 6640
24. M. Camilleri, C.N. Andrews, and A.E. Bharucha Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome Gastroenterology 132 2007 17 25
25. Y.W. Yu, S.J. Tsai, and T.J. Chen Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders Mol Psychiatry 7 2002 1115 1119
26. T. Traks, K. Koido, and T. Eller Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder BMC Med Genetics 9 2008 111
27. N. Uceyler, R. Valenza, and M. Stock Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain Arthritis Rheum 54 2006 2656 2664
28. H. Wang, M. Buchner, and M.T. Moser The role of IL-8 in patients with fibromyalgia: a prospective longitudinal study of 6 months Clin J Pain 25 2009 1 4
29. J.A. Macedo, J. Hesse, and J.D. Turner Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils J Neuroimmunolgy 188 2007 159 166
30. T. Liebregts, B. Adam, and C. Bredack Immune activation in patients with irritable bowel syndrome Gastroenterology 132 2007 913 920
31. R. Dantzer Cytokine, sickness behavior, and depression Immunol Allergy Clinics N Am 29 2009 247 264
32. K. Schrocksnadel, B. Wirleitner, C. Winkler, and D. Fuchs Monitoring tryptophan metabolism in chronic immune activation Clin Chem Acta 364 2006 82 90
33. L. Capuron, A. Ravaud, and A.H. Miller Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy Brain Behav Immunol 18 2004 205 213
34. Y.K. Kim, K.S. Na, and K.H. Shin Cytokine imbalance in the pathophysiology of major depressive disorder Prog Neuropsychopharmacol Biol Psychiatry 31 2007 1044 1053
35. S. Alesci, P.E. Martinez, and S. Kelkar Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, a loss of physiological complexity in its secretion: clinical implications J Clin Endocrinol Metab 90 2005 2522 2530
36. Y. Ovaskainen, H. Koponen, and J. Jokelainen Depressive symptomatology is associated with decreased interleukin-1 beta and increased interleukin-1 receptor antagonist levels in males Psychiatry Res 167 2009 73 79
37. R. Staud, J.G. Craggs, and W.M. Perlstein Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls Eur J Pain 12 2008 1078 1089
38. R. Staud, M.E. Robinson, C.J. Vierck, and D.D. Price Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients Pain 101 2003 167 174
39. K.B. Jensen, E. Kosek, and F. Petzke Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain Pain 144 2009 95 100
40. J.B. De Souza, S. Potvin, and P. Goffaux The deficit of pain inhibition in fibromyalgia is more pronounced in patients with comorbid depressive symptoms Clin J Pain 25 2009 123 127
41. I. Russell, M.D. Orr, and B. Littman Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome Arthritis Rheum 37 1994 1593 1601
42. C. Laske, E. Stransky, and G.W. Eschweiler Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants J Psychiatr Res 41 2007 600 605
43. P.B. Wood, P. Schweinhardt, and E. Jaeger Fibromyalgia patients show an abnormal dopamine response to pain Eur J Neurosci 25 2007 3576 3582
44. T. Giesecke, R.H. Gracely, and D.A. Williams The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort Arthritis Rheum 52 2005 1577 1584
45. D.B. Cook, G. Lange, and D.S. Ciccone Functional imaging of pain in patients with primary fibromyalgia J Rheumatol 31 2004 364 378
46. R.E. Harris, D.J. Clauw, and D.J. Scott Decreased central mu-opioid receptor availability in fibromyalgia J Neurosci 27 2007 1000 1006
47. R.E. Harris, P.C. Sundgren, and Y. Pang Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia Arthritis Rheum 58 2008 903 907
48. K.B. Jensen, E. Kosek, and F. Petzke Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain Pain 144 2009 95 100
49. X.L. Zuo, Y.Q. Li, and L. Shi Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome J Gastroenterol 41 2006 311 317
50. C.H. Wilder-Smith, and J. Robert-Yap Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome World J Gastroenterol 13 2007 3699 3704
51. P. Iovino, F. Tremolaterra, and D. Consalvo Perception of electrocutaneous stimuli in irritable bowel syndrome Am J Gastroenterol 101 2006 596 603
52. D.D. Price, Q. Zhou, and B. Moshiree Peripheral and central contributions to hyperalgesia in irritable bowel syndrome J Pain 7 2006 529 535
53. C.D. King, F. Wong, and T. Currie Deficiency in endogenous modulation of prolonged heat pain in patients with irritable bowel syndrome and temporomandibular disorder Pain 143 2009 172 178
54. C.L. Kwan, N.E. Diamant, and G. Pope Abnormal forebrain activity in functional bowel disorder patients with chronic pain Neurology 65 2005 1268 1277
55. K.J. Bar, G. Wagner, and M. Koschke Increased prefrontal activation during pain perception in major depression Biol Psychiatry 62 2007 1281 1287
56. G. Wagner, M. Koschke, and T. Leuf Reduced heat pain thresholds after sad-mood induction are associated with changes in thalamic activity Neuropsychologia 47 2009 980 987
57. G. Hasler, J.W. van der Veen, and T. Tumonis Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy Arch Gen Psychiatry 64 2007 193 200
58. F. Karege, G. Vaudan, and M. Schwald Neurotropin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs Brain Res Mol Brain Res 136 2005 29 37
59. S.E. Kennedy, R.A. Koeppe, E.A. Young, and J.K. Zubieta Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women Arch Gen Psychiatry 63 2006 705 713
60. I.A. Strigo, A.N. Simmons, and S.C. Matthews Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain Arch Gen Psychiatry 65 2008 1275 1284
61. S. Grimm, P. Boesiger, and J. Beck Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects Neuropsychopharmacology 34 2009 932 943
62. A. Kuchinad, P. Schweinhardt, and D.A. Seminowicz Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci 27 2007 4004 4007
63. M. Burgmer, M. Gaubitz, and C. Konrad Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia Psychosom Med 71 2009 566 573
64. P. Videbech, and B. Ravnkilde Hippocampal volume and depression: a meta-analysis of MRI studies Am J Psychiatry 161 2004 1957 1966
65. T. Frodl, N. Koutsouleris, and R. Bottlender Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression Mol Psychiatry 13 2008 1093 1101
66. K. Zou, X. Huang, and T. Li Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study J Psych Neurosci 33 2008 525 530
67. J.P. Hamilton, M. Siemer, and I.H. Gotlib Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies Mol Psychiatry 13 2008 993 1000
68. J. McBeth, A.J. Silman, and A. Gupta Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal axis in the onset of chronic widespread musculoskeletal pain Arthritis Rheum 56 2007 360 371
69. K. Wingenfeld, C. Heim, and I. Schmidt HPA axis reactivity and lymphocyte glucocorticoid sensitivity in fibromyalgia syndrome and chronic pelvic pain Psychosom Med 70 2008 65 72
70. K. Wingenfeld, D. Wagner, and I. Schmidt The low-dose dexamethasone suppression test in fibromyalgia J Psychosom Res 62 2007 85 91
71. T.G. Dinan, E.M.M. Quigley, and S.M.M. Ahmed Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 130 2006 304 311
72. T. Deak, K.A. Bordner, and N.K. McElderry Stress-induced increases in hypothalamic IL-1: a systematic comparison of multiple stressor paradigms Brain Res Bull 64 2005 541 556
73. Z. Merali, L. Du, and P. Hrdina Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA (A) receptor subunits in frontal cortical brain regions J Neurosci 24 2004 1478 1485
74. D.L. Goldenberg, C. Burckhardt, and L. Crofford Management of fibromyalgia syndrome JAMA 292 2004 2388 2395
75. D.L. Goldenberg Pharmacological treatment of fibromyalgia and other chronic musculoskeletal pain Best Pract Res Clin Rheumatol 21 2007 499 511
76. N. Uceyler, W. Hauser, and C. Sommer A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome Arthritis Rheum 59 2009 1278 1298
77. D.A. Drossman, B.B. Toner, and W.E. Whitehead Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders Gastreoenterology 125 2003 19 31
78. J.M. Lackner, J. Jaccard, and S.S. Krasner Self-administered cognitive behavior therapy for moderate to severe irritable bowel syndrome: clinical efficacy, tolerability, feasibility Clin Gastroenterol Hepatol 6 2008 899 906
79. A.C. Ford, N.J. Talley, and P.S. Schoenfeld Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis Gut 58 2009 367 378
80. J. Hudson, and H. Pope Does childhood sexual abuse cause fibromyalgia? Arthritis Rheum 38 1995 161 163
81. D. Drossman Irritable bowel syndrome and sexual/physical abuse history Eur J Gastroenterol Hepatol 9 1997 327 330 (Pubitemid 27187328)
82. M. Pich, M. Arsenault, and P. Poitras Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome Pain 148 2010 49 58 Epub 2009 Nov 3
83. T. Giesecke, D.A. Williams, and R.E. Harris Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors Arthritis Rheum 48 2003 2916 2922