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Volumn 141, Issue 5, 2011, Pages 1566-1571.e1

Genetic profiling in inflammatory bowel disease: From association to bedside

Author keywords

[No Author keywords available]

Indexed keywords

ATG16L1 PROTEIN; BIOLOGICAL MARKER; CASPASE RECRUITMENT DOMAIN PROTEIN 15; HISTONE DEACETYLASE 1; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 23 RECEPTOR; JANUS KINASE 2; MICRORNA; PROTEIN; STAT3 PROTEIN; TLE1 PROTEIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH INHIBITOR;

EID: 80054852494     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.09.018     Document Type: Article
Times cited : (19)

References (46)
  • 1
    • 79959652551 scopus 로고    scopus 로고
    • Assessment of thiopurine s-methyltransferase activity in patients prescribed thiopurines: A systematic review
    • Booth RA, Ansari MT, Loit E, et al. Assessment of thiopurine s-methyltransferase activity in patients prescribed thiopurines: a systematic review. Ann Intern Med 2011;154:814-823.
    • (2011) Ann Intern Med , vol.154 , pp. 814-823
    • Booth, R.A.1    Ansari, M.T.2    Loit, E.3
  • 2
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med 2010;363:301-304.
    • (2010) N Engl J Med , vol.363 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 5
    • 79954994711 scopus 로고    scopus 로고
    • Levels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease
    • Jürgens M, Mahachie JM, Cleynen I, et al. Levels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease. Clin Gastroenterol Hepatol 2011;9:421-427.e1.
    • (2011) Clin Gastroenterol Hepatol , vol.9
    • Jürgens, M.1    Mahachie, J.M.2    Cleynen, I.3
  • 6
    • 79955555545 scopus 로고    scopus 로고
    • The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease
    • Lewis JD. The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 2011;140:1817-1826.e2.
    • (2011) Gastroenterology , vol.140
    • Lewis, J.D.1
  • 7
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DPB, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.B.2    Barrett, J.C.3
  • 8
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA, Boucher G, Lees CW, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011;43:246-252.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3
  • 9
    • 70649113728 scopus 로고    scopus 로고
    • Common variants at five new loci associated with early-onset inflammatory bowel disease
    • Imielinski M, Baldassano RN, Griffiths A, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 2009;41:1335-1340.
    • (2009) Nat Genet , vol.41 , pp. 1335-1340
    • Imielinski, M.1    Baldassano, R.N.2    Griffiths, A.3
  • 10
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • Villani AC, Lemire M, Fortin G, et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009;41:71-76.
    • (2009) Nat Genet , vol.41 , pp. 71-76
    • Villani, A.C.1    Lemire, M.2    Fortin, G.3
  • 11
    • 80051494421 scopus 로고    scopus 로고
    • The GTPase RAC1 is associated with ulcerative colitis
    • Muise AM, Walters TD, Xu W, et al. The GTPase RAC1 is associated with ulcerative colitis. Gastroenterology 2011;141:633-641.
    • (2011) Gastroenterology , vol.141 , pp. 633-641
    • Muise, A.M.1    Walters, T.D.2    Xu, W.3
  • 12
    • 79952929840 scopus 로고    scopus 로고
    • Gene-environment interactions in chronic inflammatory disease
    • Renz H, von Mutius E, Brandtzaeg P, et al. Gene-environment interactions in chronic inflammatory disease. Nat Immunol 2011;12:273-277.
    • (2011) Nat Immunol , vol.12 , pp. 273-277
    • Renz, H.1    Von Mutius, E.2    Brandtzaeg, P.3
  • 13
    • 79851502150 scopus 로고    scopus 로고
    • Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
    • Gojobori T, Rossin EJ, Lage K, et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet 2011;7:e1001273.
    • (2011) PLoS Genet , vol.7
    • Gojobori, T.1    Rossin, E.J.2    Lage, K.3
  • 15
    • 79953771887 scopus 로고    scopus 로고
    • The prognostic power of the NOD2 genotype for complicated Crohn's disease: A metaanalysis
    • Adler J, Rangwalla SC, Dwamena BA, et al. The prognostic power of the NOD2 genotype for complicated Crohn's disease: a metaanalysis. Am J Gastroenterol 2011;106:699-712.
    • (2011) Am J Gastroenterol , vol.106 , pp. 699-712
    • Adler, J.1    Rangwalla, S.C.2    Dwamena, B.A.3
  • 16
    • 36249002287 scopus 로고    scopus 로고
    • An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases
    • Dideberg V, Kristjansdottir G, Milani L, et al. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Hum Mol Genet 2007;16:3008-3016.
    • (2007) Hum Mol Genet , vol.16 , pp. 3008-3016
    • Dideberg, V.1    Kristjansdottir, G.2    Milani, L.3
  • 17
    • 70049094025 scopus 로고    scopus 로고
    • NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis
    • Pandey AK, Yang Y, Jiang Z, et al. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog 2009;5:e1000500.
    • (2009) PLoS Pathog , vol.5
    • Pandey, A.K.1    Yang, Y.2    Jiang, Z.3
  • 18
    • 79951671510 scopus 로고    scopus 로고
    • IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
    • Krausgruber T, Blazek K, Smallie T, et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 2011;12:231-238.
    • (2011) Nat Immunol , vol.12 , pp. 231-238
    • Krausgruber, T.1    Blazek, K.2    Smallie, T.3
  • 19
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: Common pathways with other diseases
    • Feb 7 Epub ahead of print
    • Lees CW, Barrett JC, Parkes M, et al. New IBD genetics: common pathways with other diseases. Gut 2011 Feb 7 [Epub ahead of print].
    • (2011) Gut
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3
  • 20
    • 79955566359 scopus 로고    scopus 로고
    • Recent insights into the genetics of inflammatory bowel disease
    • Cho JH, Brant SR. Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 2011;140:1704-1712.e2.
    • (2011) Gastroenterology , vol.140
    • Cho, J.H.1    Brant, S.R.2
  • 21
    • 78651227093 scopus 로고    scopus 로고
    • Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
    • Melum E, Franke A, Schramm C, et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet 2011;43:17-19.
    • (2011) Nat Genet , vol.43 , pp. 17-19
    • Melum, E.1    Franke, A.2    Schramm, C.3
  • 22
    • 79957502386 scopus 로고    scopus 로고
    • Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL and CARD9
    • Janse M, Lamberts LE, Franke L, et al. Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL and CARD9. Hepatology 2011:53:1977-1985.
    • (2011) Hepatology , vol.53 , pp. 1977-1985
    • Janse, M.1    Lamberts, L.E.2    Franke, L.3
  • 23
    • 80051544183 scopus 로고    scopus 로고
    • Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype, but do not predict it. Results from the IBDchip European project
    • Figueroa C, Cleynen I, Franke A, et al. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype, but do not predict it. Results from the IBDchip European project. Gastroenterology 2010;138:S-678.
    • (2010) Gastroenterology , vol.138
    • Figueroa, C.1    Cleynen, I.2    Franke, A.3
  • 24
    • 69249152654 scopus 로고    scopus 로고
    • Genetic risk profiling and prediction of disease course in Crohn's disease patients
    • Henckaerts L, Van Steen K, Verstreken I, et al. Genetic risk profiling and prediction of disease course in Crohn's disease patients. Clin Gastroenterol Hepatol 2009;7:972-980.e2.
    • (2009) Clin Gastroenterol Hepatol , vol.7
    • Henckaerts, L.1    Van Steen, K.2    Verstreken, I.3
  • 25
    • 84857016140 scopus 로고    scopus 로고
    • A combination of genetic, clinical and immune markers predict the need for surgery in Crohn's disease
    • Dubinsky M, Kugathasan S, Kwon S, et al. A combination of genetic, clinical and immune markers predict the need for surgery in Crohn's disease. Gastroenterology 2011;140:S-153.
    • (2011) Gastroenterology , vol.140
    • Dubinsky, M.1    Kugathasan, S.2    Kwon, S.3
  • 26
    • 80855128813 scopus 로고    scopus 로고
    • Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior
    • Mar 9 Epub ahead of print
    • Lichtenstein GR, Targan SR, Dubinsky MC, et al. Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior. Inflammatory Bowel Diseases 2011 Mar 9 [Epub ahead of print].
    • (2011) Inflammatory Bowel Diseases
    • Lichtenstein, G.R.1    Targan, S.R.2    Dubinsky, M.C.3
  • 27
    • 79952131166 scopus 로고    scopus 로고
    • The long and winding road from correlation to causation
    • Georges M. The long and winding road from correlation to causation. Nat Genet 2011;43:180-181.
    • (2011) Nat Genet , vol.43 , pp. 180-181
    • Georges, M.1
  • 28
    • 80054867812 scopus 로고    scopus 로고
    • Analysis of protein-protein and gene-gene interactions implicates TLE1 as a critical modifier of NOD2 effect in Crohn's disease
    • Nimmo ER, Phillips AM, Stevens C, et al. Analysis of protein-protein and gene-gene interactions implicates TLE1 as a critical modifier of NOD2 effect in Crohn's disease. Gastroenterology 2011;141:972-981.
    • (2011) Gastroenterology , vol.141 , pp. 972-981
    • Nimmo, E.R.1    Phillips, A.M.2    Stevens, C.3
  • 29
    • 79952134938 scopus 로고    scopus 로고
    • A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
    • Brest P, Lapaquette P, Souidi M, et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet 2011;43:242-245.
    • (2011) Nat Genet , vol.43 , pp. 242-245
    • Brest, P.1    Lapaquette, P.2    Souidi, M.3
  • 30
    • 0037075551 scopus 로고    scopus 로고
    • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    • Kobayashi K, Inohara N, Hernandez LD, et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002;416:194-199.
    • (2002) Nature , vol.416 , pp. 194-199
    • Kobayashi, K.1    Inohara, N.2    Hernandez, L.D.3
  • 31
    • 33646941554 scopus 로고    scopus 로고
    • Role for erbin in bacterial activation of Nod2
    • Kufer TA, Kremmer E, Banks DJ, et al. Role for erbin in bacterial activation of Nod2. Infect Immun 2006;74:3115-3124.
    • (2006) Infect Immun , vol.74 , pp. 3115-3124
    • Kufer, T.A.1    Kremmer, E.2    Banks, D.J.3
  • 32
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010;11:55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 33
    • 20444486755 scopus 로고    scopus 로고
    • GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells
    • Barnich N, Hisamatsu T, Aguirre JE, et al. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 2005;280:19021-19026.
    • (2005) J Biol Chem , vol.280 , pp. 19021-19026
    • Barnich, N.1    Hisamatsu, T.2    Aguirre, J.E.3
  • 34
    • 8444248180 scopus 로고    scopus 로고
    • Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response
    • Damiano JS, Newman RM, Reed JC. Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response. J Immunol 2004;173:6338-6345.
    • (2004) J Immunol , vol.173 , pp. 6338-6345
    • Damiano, J.S.1    Newman, R.M.2    Reed, J.C.3
  • 35
    • 80051550866 scopus 로고    scopus 로고
    • Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
    • Plantinga TS, Crisan TO, Oosting M, et al. Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 2011;60:1229-1235.
    • (2011) Gut , vol.60 , pp. 1229-1235
    • Plantinga, T.S.1    Crisan, T.O.2    Oosting, M.3
  • 36
    • 33846469538 scopus 로고    scopus 로고
    • The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    • Hsu YM. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 2007;8:198-205.
    • (2007) Nat Immunol , vol.8 , pp. 198-205
    • Hsu, Y.M.1
  • 37
    • 79957962932 scopus 로고    scopus 로고
    • Non-apoptotic role of BID in inflammation and innate immunity
    • Yeretssian G, Correa RG, Doiron K, et al. Non-apoptotic role of BID in inflammation and innate immunity. Nature 2011;474:96-99.
    • (2011) Nature , vol.474 , pp. 96-99
    • Yeretssian, G.1    Correa, R.G.2    Doiron, K.3
  • 38
    • 78651225855 scopus 로고    scopus 로고
    • Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
    • Momozawa Y, Mni M, Nakamura K, et al. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet 2011;43:43-47.
    • (2011) Nat Genet , vol.43 , pp. 43-47
    • Momozawa, Y.1    Mni, M.2    Nakamura, K.3
  • 39
    • 61549115034 scopus 로고    scopus 로고
    • Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn disease
    • Wang K, Zhang H, Kugathasan S, et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn disease. Am J Human Genet 2009;84:399-405.
    • (2009) Am J Human Genet , vol.84 , pp. 399-405
    • Wang, K.1    Zhang, H.2    Kugathasan, S.3
  • 40
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010;16:90-97.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 41
    • 78650099360 scopus 로고    scopus 로고
    • Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    • Frank DN, Robertson CE, Hamm CM, et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 2011;17:179-184.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 179-184
    • Frank, D.N.1    Robertson, C.E.2    Hamm, C.M.3
  • 42
    • 79955554300 scopus 로고    scopus 로고
    • The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases
    • Chassaing B, Darfeuille-Michaud A. The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 2011;140:1720-1728.e3.
    • (2011) Gastroenterology , vol.140
    • Chassaing, B.1    Darfeuille-Michaud, A.2
  • 43
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009;361:2033-2045.
    • (2009) N Engl J Med , vol.361 , pp. 2033-2045
    • Glocker, E.O.1    Kotlarz, D.2    Boztug, K.3
  • 44
    • 79961023788 scopus 로고    scopus 로고
    • Defective IL10 Signaling defining a subgroup of patients with inflammatory bowel disease
    • Begue B, Verdier J, Rieux-Laucat F, et al. Defective IL10 Signaling defining a subgroup of patients with inflammatory bowel disease. Am J Gastroenterol 2011;106:1544-1555.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1544-1555
    • Begue, B.1    Verdier, J.2    Rieux-Laucat, F.3
  • 45
    • 77958003426 scopus 로고    scopus 로고
    • Infant colitis: It's in the genes
    • Glocker EO, Frede N, Perro M, et al. Infant colitis: it's in the genes. Lancet 2010;376:1272.
    • (2010) Lancet , vol.376 , pp. 1272
    • Glocker, E.O.1    Frede, N.2    Perro, M.3
  • 46
    • 65249115914 scopus 로고    scopus 로고
    • A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
    • Noguchi E, Homma Y, Kang X, et al. A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol 2009;10:471-479.
    • (2009) Nat Immunol , vol.10 , pp. 471-479
    • Noguchi, E.1    Homma, Y.2    Kang, X.3


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