Keeping the rhythm - Pro-arrhythmic investigations in isolated Göttingen minipig hearts

Journal of Pharmacological and Toxicological Methods

Volumn 64, Issue 2, 2011, Pages 134-144

  Laursen, Morten ^a,b   Grunnet, Morten ^b,c   Olesen, Søren Peter ^b,c   Jespersen, Thomas ^b   Mow, Tomas ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NEUROSEARCH A S   (Denmark)

Author keywords

Action potential; Arrhythmia; Cardiac; ECG; G ttingen Minipig; Torsades de Pointes

Indexed keywords

ISOPRENALINE;

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DISEASE RESISTANCE; DOG; ELECTROSTIMULATION; EXCITATION CONTRACTION COUPLING; FEMALE; HEART ARRHYTHMIA; HEART MUSCLE POTENTIAL; HEART PACING; HEART REPOLARIZATION; ISOLATED HEART; MINIPIG; NONHUMAN; QT INTERVAL;

ADRENERGIC BETA-AGONISTS; ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIOVENTRICULAR BLOCK; DISEASE MODELS, ANIMAL; DOGS; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; FEMALE; ISOPROTERENOL; SPECIES SPECIFICITY; SWINE; SWINE, MINIATURE;

ANIMALIA; CANIS FAMILIARIS;

EID: 80054848219     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2011.05.001     Document Type: Article

References (42)

1. Abi-Gerges N., Philp K., Pollard C., Wakefield I., Hammond T.G., Valentin J.P. Sex differences in ventricular repolarization: From cardiac electrophysiology to Torsades de Pointes. Fundamental and Clinical Pharmacology 2004, 18:139-151.
2. Bednar M.M., Harrigan E.P., Anziano R.J., Camm A.J., Ruskin J.N. The QT interval. Progress in Cardiovascular Diseases 2001, 43:1-45.
3. Belardinelli L., Shryock J.C., Song Y., Wang D., Srinivas M. Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. The Federation of American Societies for Experimental Biology Journal 1995, 9:359-365.
4. Bode G., Clausing P., Gervais F., Loegsted J., Luft, Nogues V., et al. The utility of the minipig as an animal model in regulatory toxicology. Journal of Pharmacological and Toxicological Methods 2011, 62:196-220.
5. Burashikov A., Antzelevitch C. Late-phase 3 EAD. A unique mechanism contributing to initiation of atrial fibrillation. Pacing and Clinical Electrophysiology 2006, 29:290-295.
6. Eckardt L., Haverkamp W., Mertens H., Johna R., Clague J.R., Borggrefe M., et al. Drug-related torsades de pointes in the isolated rabbit heart: Comparison of clofilium, d, l-sotalol, and erythromycin. Journal of Cardiovascular Pharmacology 1998, 32:425-434.
7. Franz M.R., Swerdlow C.D., Liem L.B., Schaefer J. Cycle length dependence of human action potential duration in vivo. Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies. The Journal of Clinical Investigation 1988, 82:972-979.
8. Gallacher D.J., Van de W.A., van der L.H., Hermans A.N., Lu H.R., Towart R., et al. In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome. Cardiovascular Research 2007, 76:247-256.
9. Garrey W.E. The nature of fibrillatory contraction of the heart. Its relation to tissue mass and form. American Journal of Physiology 1914, 33:397-414.
10. Glukhov A.V., Fedorov V.V., Lou Q., Ravikumar V.K., Kalish P.W., Schuessler R.B., et al. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circulation Research 2010, 19;106:981-991.
11. Hondeghem L.M., Carlsson L., Duker G. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation 2001, 103:2004-2013.
12. Hondeghem L.M., Dumotier B., Traebert M. Oscillations of cardiac wave length and proarrhythmia. Naunyn-Schmiedeberg's Archives of Pharmacology 2010, 382:367-376.
13. Hondeghem L.M., Hofmann P. Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: Importance of triangulation, reverse use dependence, and instability. Journal of Cardiovascular Pharmacology 2003, 41:14-24.
14. Hondeghem L.M., Lu H.R., van Rossem K., De Clerck F. Detection of proarrhythmia in the female rabbit heart: Blinded validation. Journal of Cardiovascular Electrophysiology 2003, 14:287-294.
15. ICH. (2005). ICH harmonised tripartite guideline S7B. The non-clinical evaluation of the potential for delayed repolarization (QT interval prolongation) by human pharmaceuticals. European Medicines Agency Step 5, http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html.
16. Johnson D.M., Heijman J., Pollard C.E., Valentin J.P., Crijns H.J.G.M., bi-Gerges N., et al. IKs restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation. Journal of Molecular and Cellular Cardiology 2010, 48:122-130.
17. Jost N., Virag L., Bitay M., Takacs J., Lengyel C., Biliczki P., et al. Restricting excessive cardiac action potential and QT prolongation: A vital role for IKs in human ventricular muscle. Circulation 2005, 112:1392-1399.
18. Jurkiewicz N.K., Sanguinetti M.C. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circulation Research 1993, 72:75-83.
19. Langendorff O. Untersuchungen am überlebenden Säugetierherzen. Pflügers Archiv 1895, 61:291-332.
20. Laursen M., Olesen S.P., Grunnet M., Mow T., Jespersen T. Characterization of cardiac repolarization in the Gottingen minipig. Journal of Pharmacological and Toxicological Methods 2011, 63:186-195.
21. Lu H.R., Vlaminckx E., Van De Water A., Gallacher D.J. Both [beta]-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of IKs channel blockers in vitro. Journal of Pharmacological and Toxicological Methods 2005, 51:81-90.
22. Meester B.J., Shankley N.P., Welsh N.J., Wood J., Meijler F.L., Black J.W. Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig. British Journal of Pharmacology 1998, 124:685-692.
23. Morita H., Wu J., Zipes D.P. The QT syndromes: Long and short. Lancet 2008, 372:750-763.
24. Pascale P., Schlaepfer J., Oddo M., Schaller M.D., Vogt P., Fromer M. Ventricular arrhythmia in coronary artery disease: Limits of a risk stratification strategy based on the ejection fraction alone and impact of infarct localization. Europace 2009, 11:1639-1646.
25. Roden D.M. Drug-induced prolongation of the QT interval. The New England Journal of Medicine 2004, 350:1013-1022.
26. Seed W.A., Noble M.I., Oldershaw P., Wanless R.B., Drake-Holland A.J., Redwood D., et al. Relation of human cardiac action potential duration to the interval between beats: Implications for the validity of rate corrected QT interval (QTc). British Heart Journal 1987, 57:32-37.
27. Stevens J.L., Baker T.K. The future of drug safety testing: expanding the view and narrowing the focus. Drug Discovery Today 2009, 14:162-167.
28. Swindle M.M., Smith A.C. Comparative anatomy and physiology of the pig. Scandinavian Journal of Laboratory Animal Science 1998, 25:1-10.
29. Thomas G., Gerlach U., Antzelevitch C. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. Journal of Cardiovascular Pharmacology 2003, 41:140-147.
30. Thomsen M.B., Oros A., Schoenmakers M., van Opstal J.M., Maas J.N., Beekman J.D.M., et al. Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovascular Research 2007, 73:521-530.
31. Thomsen M.B., Verduyn S.C., Stengl M., Beekman J.D., de P.G., van O.J., et al. Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 2004, 19;110:2453-2459.
32. Towart R., Linders J.T.M., Hermans A.N., Rohrbacher J., van der Linde H.J., Ercken M., et al. Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?. Journal of Pharmacological and Toxicological Methods 2007, 60:1-10.
33. Valentin J.P., Hoffmann P., De Clerck F., Hammond T.G., Hondeghem L. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. Journal of Pharmacological and Toxicological Methods 2004, 49:171-181.
34. Van de Water A., Verheyen J., Xhonneux R., Reneman R.S. An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. Journal of Pharmacological Methods 1989, 22:207-217.
35. van der Linde H.J., Somers Y., Van Deuren B., Teisman A., Gallacher D.J. The electro-mechanical window in the fentanyl/etomidate-anaesthetised Göttingen minipig (compared to FEAB dogs) 2010, Safety Pharmacology Society, Annual Meeting Boston, Poster.
36. van der Linde H.J., Van Deuren B., Somers Y., Loenders B., Towart R., Gallacher D.J. The electro-mechanical window: A risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias. British Journal of Pharmacology 2010, 161:1444-1454.
37. Van Deuren B., Van Ammel K., Somers Y., Cools F., Straetemans R., van der Linde H.J., et al. The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in cardiovascular safety research. Journal of Pharmacological and Toxicological Methods 2009, 60:11-23.
38. Wu L., Belardinelli L., Zablocki J.A., Palle V., Shryock J.C. A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts. American Journal of Physiology - Heart and Circulatory Physiology 2001, 280:H334-H343.
39. Wu M.H., Su M.J., Sun S.S.M. Electrophysiological profile after inward rectifier K channel blockade by barium in isolated rabbit hearts. Altered repolarization and unmasked decremental conduction property. Europace 1999, 1:85-95.
40. Yan G.X., Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998, 98:1928-1936.
41. Yap Y.G., Camm A.J. Drug induced QT prolongation and torsades de pointes. Heart 2003, 89:1363-1372.
42. Zeng J., Rudy Y. Early afterdepolarizations in cardiac myocytes: Mechanism and rate dependence. Biophysical Journal 1995, 68:949-964.