Electrophysiological profile after inward rectifier K channel blockade by barium in isolated rabbit hearts. Altered repolarization and unmasked decremental conduction property

Europace

Volumn 1, Issue 2, 1999, Pages 85-95

  Wu, M H ^a   Su, M J ^a   Sun, S S M ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Barium; Decremental cardiac conduction; Inward rectifier K current; Isolated rabbit heart electrophysiology; K channel

Indexed keywords

BARIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL; ARTICLE; ELECTROCARDIOGRAPHY; HEART FUNCTION TEST; HEART MUSCLE CONDUCTION SYSTEM; PHYSIOLOGY; PURKINJE CELL; RABBIT;

ANIMALS; BARIUM; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART CONDUCTION SYSTEM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PURKINJE CELLS; RABBITS;

EID: 0033108054     PISSN: 10995129     EISSN: None     Source Type: Journal    
DOI: 10.1053/eupc.1998.0022     Document Type: Article

References (30)

1. Grant AO. On the mechanism of action of antiarrhythmic agents. Am Heart J. 123:1992;1130-1136.
2. Singh BN, Sarma JS, Zhang ZH, Takanaka C. Controlling cardiac arrhythmias by lengthening repolarization: rationale from experimental findings and clinical considerations. Ann NY Acad Sci. 644:1992;187-209.
3. Lynch JJ, Sanguinetti MC, Kimura S, Bassett AL. Therapeutic potential of modulating potassium currents in the diseased myocardium. FASEB J. 6:1992;2952-2960.
4. +current acting as pure class III antiarrhythmic agents. J Cardiovasc Pharmacol. 2:1992;S106-13.
5. K1blockade is a potentially useful antiarrhythmic mechanism. Cardiovasc Res. 28:1994;421.
6. K1blockade: a new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit and primate. Circulation. 87:1993;1979-1989.
7. +channels and control of ventricular repolarization in the heart. Fundament Clin Pharmacol. 7:1993;19-28.
8. K1blockade is unlikely to be a useful antiarrhythmic mechanism. Cardiovasc Res. 28:1994;420.
9. K1blockade proarrhythmic or antiarrhythmic? Cardiovasc Res. 28:1994;1120-1121.
10. Francesco D, Ferroni A, Visentin S. Barium-induced blockade of the inward rectifier in calf Purkinje fibers. Flugers Archiv. 402:1984;446-453.
11. Chen F, Wetzel GT, Friedman WF, Klitzner TS. Single-channel according of inwardly rectifying potassium currents in developing myocardium. J Mol Cell Cardiol. 23:1991;259-267.
12. Mitra R, Morad M. A uniform enzymatic method for associ-ation of myocytes from hearts and stomachs of vertebrates. Am J Physiol. 249:1985;H1056-60.
13. Wu MH, Su MJ, Lue HC. Age-related quinidine effects on ionic currents of rabbit cardiac myocytes. J Mol Cell Cardiol. 26:1994;1167-1177.
14. Wu MH, Su MJ, Lee SS, Young ML. The electrophysiological effects of antiarrhythmic potential of a secoaporphine, N-Allylsecoboldine. Br J Pharmacol. 113:1994;221-227.
15. Josephson ME, Seides SF. Clinical cardiac electrophysiology. Technique and interpretations. Philadelphia: Lea & Febiger. 1993;41-65.
16. Giles WR, Imaizumi Y. Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol. 405:1998;123-145.
17. Vassalle M, Yu H, Cohen IS. The pacemaker current in cardiac Purkinje myocytes. J Gen Physiol. 106:1995;559-578.
18. Vandenberg, CA, 1991, Cardiac inward rectifier potassium channel. In: Spooner PM, Brown AM, Catterall WA, Kaczorowski J, Strauss HC, eds. Ion channels in the cardiovascular system. New, York, Futura Publishing Co. 1991, 145, 68.
19. Arnsdorf MF. Cardiac excitability and antiarrhythmia drugs: a different perspective. J Clin Pharmacol. 29:1989;395-404.
20. Colatsky TJ, Follmer CH, Starmer CF. Channel specificity in antiarrhythmic drug action. Circulation. 82:1990;2235-2242.
21. Janse MJ, Wit AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev. 69:1989;1049-1069.
22. Roza O, Berman LB. The pathophysiology of barium: hypokalemic and cardiovascular effects. J Pharmacol Exp Ther. 177:1971;1153-1162.
23. Shankle R, Keane JR. Acute paralysis from inhaled barium carbonate. Arch Neurol. 45:1988;579-590.
24. Hirano, Y, Hiraoka, M, 1998, Barium-induced automaticity in isolated ventricular myocytes from guinea-pig hearts, J Physiol, 1989, 395, 455, 72.
25. Delmar M, Jalife J. Low Ba-induced pacemaker current in well-polarized cat papillary muscle. Am J Physiol. 252:1987;H325-33.
26. 2+in guinea pig ventricular muscles. Am J Physiol. 251:1986;H24-33.
27. 2+induced automaticity in guinea pig cardiac myocytes. Cardiovasc Res. 25:1991;421-430.
28. Franz MR, Birgheer K, Costard-Jackle A, Miller DC, Lichtlen PR. Human ventricular repolarization and T wave genesis. Prog Cardiovas Dis. 33:1991;369-384.
29. Billette J. Atrioventricular nodal activation during periodic premature stimulation of the atrium. Am J Physiol. 152:1987;H163-77.
30. Scheinman MM. Atrioventricular nodal conduction and refractoriness. Pace. 16:1993;592-598.