Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig

British Journal of Pharmacology

Volumn 124, Issue 4, 1998, Pages 685-692

  Meester, B J ^a   Shankley, N P ^a   Welsh, N J ^a   Wood, J ^b   Meijler, F L ^c   Black, J W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Alcuin College   (United Kingdom)

^c ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Adenosine receptor; Atrioventricular node; Sinoatrial node

Indexed keywords

2 ANILINOADENOSINE; 2 CHLOROADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; 9 METHYL 6 N (2 NORBORNYL)ADENINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; CYCLOHEXYLADENOSINE;

ANIMAL TISSUE; ARTICLE; GUINEA PIG; HEART ATRIOVENTRICULAR NODE; MALE; NONHUMAN; PRIORITY JOURNAL; SINUS NODE;

ADENOSINE; ANIMALS; ATRIOVENTRICULAR NODE; GUINEA PIGS; HEART RATE; MALE; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECEPTORS, PURINERGIC P2; SINOATRIAL NODE; STEREOISOMERISM;

EID: 0031832206     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701891     Document Type: Article

References (34)

1. BELARDINELLI, L., WEST, A., CRAMPTON, R. & BERNE, R.M. (1983). Chronotropic and dromotropic actions of adenosine. In The Regulatory Function of Adenosine. ed. Berne, R., Rall, T. W. & Rubio, R.M. pp. 378-398. The Hague: Martinus Nijhoff.
2. BELARDINELLI, L., LINDEN, J. & BERNE, R.M. (1989). The cardiac effects of adenosine. Prog. Cardiovasc. Dis., 32, 73-97.
3. BLACK, J.W., GERSKOWITCH, V.P., RANDALL, P.J. & TRIST, D.G. (1981). Critical examination of the histamine-cimetidine interaction in guinea-pig heart and brain. Br. J. Pharmacol., 74, 978P.
4. BLACK, J.W., GERSKOWITCH, V.P., LEFF, P. & SHANKLEY, N.P. (1995a). Pharmacological analysis of β-adrenoceptor-mediated agonism in the guinea-pig, isolated, right atrium. Br. J. Pharmacol., 84, 779-785.
5. 2-receptor antagonists on the isolated mouse stomach assay. Br. J. Pharmacol., 86, 581-587.
6. BLACK, J.W., LEFF, P. & SHANKLEY, N.P. (1985c). An operational model of pharmacological agonism: the effect of curve shape on agonist dissociation constant estimation. Br. J. Pharmacol., 84, 561-571.
7. 3H]NECA in rat striatal membranes. Mol. Pharmacol., 29, 331-346.
8. CLEMO, H.F. & BELARDINELLI, L. (1986). Effect of adenosine on atrioventricular conduction. I. Site and characterization of adenosine action in the guinea pig atrioventricular node. Circ. Res., 59, 427-436.
9. 2 receptors in isolated tissues from guinea-pigs. Br. J. Pharmacol., 97, 1274-1278.
10. COLQUHOUN, D. (1986). Caution: agonists are complex. Trends Pharmacol. Sci., 7, 390.
11. DE LEAN, A., STADEL, J.M. & LEFKOWITZ, R.J. (1980). A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J Biol. Chem., 255, 7108-7117.
12. DÖHRING, H.J. & DEHNERT, H. (1986). The isolated perfused heart according to Langendorff: March. West-Germany: Biomesstechnik-Verlag.
13. EVANS, D.B., SCHENDEN, J.A. & BRISTOL, J.A. (1982). Adenosine receptors mediating cardiac depression. Life Sci., 31, 2425-2432.
14. FURCHGOTT, R.R. (1966). The use of β-haloakylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. Adv. Drug Res., 3, 21-25.
15. FREDHOLM, B.B., ABBRACCHIO, M.P. BURNSTOCK, G., DALY, J.W., KENDALL HARDEN, T., JACOBSON, K.A., LEFF, P. & WILLIAMS, M. (1994). IUPHAR Committee on Receptor Nomenclature and Drug Classification. IV. Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
16. GHIA, G., FRANCIS, J.E., WILLIAMS, M., DOTSON, R.A., HOPKINS, M.F., COTE, D.T., GOODMAN, F.R. & ZIMMERMAN, M.B. (1987). Pharmacological characterisation of CGS15943A: A novel nonxanthine adenosine antagonist. J. Pharmacol. Exp. Ther., 242, 784-790.
17. B/gastrin receptors mediating pentagastrin-stimulated gastric acid secretion in the isolated stomach of the immature rat. Br. J. Pharmacol., 119, 1401-1410.
18. HOFFMAN, B.F., PAES DE CARVALHO, A., MELLO, W.C. & CRANEFIELD, P.F. (1959). Electrical activity of single fibres of the atrioventricular node. Circ. Res., 7, 11-18.
19. JENKINS, J.R. & BELARDINELLI, L. (1988). Atrioventricular nodal accommodation in isolated guinea pig hearts: Physiological significance and role of adenosine. Circ. Res., 63, 97-116.
20. 1 of competitive inhibitors of agonist uptake processes in isolated tissues. Naunyn-Schmiedeberg's Arch. Pharmacol., 316, 89-95.
21. KENAKIN, T.P. (1995). Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity. Trends Pharmacol. Sci., 16, 189-192.
22. 3 receptors exist? Gen. Pharmacol., 23, 303-307.
23. KLOTZ, K.N., HESSLING, J., HEGLER, J., OWMAN, C., KULL, B., FREDHOLM, B.B. & LOHSE, M.J. (1998). Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 357, 1-9.
24. 3-receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol. Sci., 15, 298-306.
25. 1 receptor subtype. Mol. Pharmacol., 31, 247-252.
26. 1 receptors by agonist potency orders in the sinoatrial and atrioventricular nodes of the guinea pig. Br. J. Pharmacol., 112, 580P.
27. MEESTER, B.J., SHANKLEY, N.P., WELSH, N.J., MEIJLER, K.L. & BLACK, J.W. (1998). Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea pig. Br. J. Pharmacol., 124, 729-741.
28. PRENTICE, D.J. (1990). Pharmacological analysis of adenosine receptors in the guinea-pig left atrium and taenia caecum. University of London PhD thesis.
29. 3) adenosine receptor. Prog. Neurobiol., 26, 179-209.
30. 1-subtype-selective adenosine receptor antagonist in the guinea pig isolated heart. J. Pharmacol. Exp. Ther., 260, 1292-1299.
31. 1 adenosine receptors. FEBS Lett., 209, 122-128.
32. WAGNER, J.E. & MANNING P.J. (1976). In The Biology of the Guinea-pig. New York: Academic Press.
33. WILLIAMS, M., ERANCIS, J., GHIA, G., BRAUNWALDER, A. PSYCHOYOS, S., STONE, G.A. & CASH, W.D. (1987). Biochemical characterisation of the triazoloquinazoline CGS15943, a novel, non-xanthine adenosine antagonist. J. Pharmacol. Exp. Ther., 241, 415-420.
34. ZHOU, Q.Y., LI, C., OLAH, M.E., JOHNSON, R.A., STILES, G.L. & CIVELLO, O. (1992). Molecular cloning and characterization of an adenosine receptor: The A3 adenosine receptor. Proc. Natl. Acad. Sci. U.S.A., 89, 7432-7436.