The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in Cardiovascular Safety Research

Journal of Pharmacological and Toxicological Methods

Volumn 60, Issue 1, 2009, Pages 11-23

  Van Deuren, Bruno ^a   Van Ammel, Karel ^a   Somers, Yves ^a   Cools, Frank ^a   Straetemans, Roel ^a   van der Linde, Henk J ^a   Gallacher, David J ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Anaesthetics; Beagle dog; Cardiovascular safety; Etomidate; Fentanyl; In vivo; Methods; Model; Reference compound

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2 HYDROXYPROPYL BETA CYCLODEXTRIN; ATROPINE; CATECHOLAMINE; DILTIAZEM; DIPYRIDAMOLE; DOFETILIDE; ETOMIDATE; FENTANYL; FLECAINIDE; IBUTILIDE; ISOPRENALINE; JNJ 282; LEMAKALIM; LOFENTANIL; MOXIFLOXACIN; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE; PHENYLEPHRINE; POTASSIUM CHANNEL BLOCKING AGENT; SCOPOLAMINE; SUXAMETHONIUM; TERFENADINE; UNCLASSIFIED DRUG;

ANESTHESIA INDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BOLUS INJECTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PARAMETERS; CONTINUOUS INFUSION; CONTROLLED STUDY; CORE TEMPERATURE; DISEASE MODEL; DOG; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG RESEARCH; DRUG SAFETY; ELECTROCARDIOGRAPHY; EMBRYO; FEMALE; HEART RATE; HEART VENTRICLE FIBRILLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LONG QT SYNDROME; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; QT INTERVAL; QT PROLONGATION; REPRODUCIBILITY; RESPIRATORY TRACT PARAMETERS; SHORT QT INTERVAL; T WAVE; TORSADE DES POINTES; TOXICOKINETICS;

ACTION POTENTIALS; ANESTHETICS, INTRAVENOUS; ANIMALS; CARDIOVASCULAR SYSTEM; DOGS; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; ETOMIDATE; FEMALE; FENTANYL; LONG QT SYNDROME; MALE; MODELS, ANIMAL; PHARMACEUTICAL PREPARATIONS; TORSADES DE POINTES;

CANIS FAMILIARIS;

EID: 68549125133     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.04.195     Document Type: Article

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