MicroRNA functional network in pancreatic cancer: From biology to biomarkers of disease

Journal of Biosciences

Volumn 36, Issue 3, 2011, Pages 481-491

  Wang, Jin ^a   Sen, Subrata ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

3' untranslated region; Cellular pathways; genetic network; microRNA; pancreatic cancer; tumorigenic transformation

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 1B; INSULIN RECEPTOR; MEMBRANE RECEPTOR; MICRORNA; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGRAMMED DEATH 4 RECEPTOR; PROTEIN BCL 2; PROTEIN P27; S6 KINASE; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

BIOLOGY; BIOMARKER; CANCER; DISEASE INCIDENCE; GENETIC ANALYSIS; PHENOTYPE; PROTEIN; RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CDKN1B GENE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL STRESS; DRUG TARGETING; FOXO1 GENE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; INSR GENE; MALIGNANT TRANSFORMATION; MEDICAL LITERATURE; ONCOGENE; PANCREAS CANCER; PDCD4 GENE; PHENOTYPE; PROGNOSIS; PROTO ONCOGENE; PTEN GENE; RPS6KB1 GENE; TUMOR SUPPRESSOR GENE;

CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; GENOME COMPONENTS; HUMANS; MICRORNAS; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 80054826238     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-011-9083-4     Document Type: Article

References (43)

1. V Ambros 2004 The functions of animal microRNAs Nature (London) 431 350 355 10.1038/nature02871 1:CAS:528:DC%2BD2cXnsFaiu7g%3D (Pubitemid 39265675)
2. LA Asangani SAK Rasheed DA Nikolova JH Leupold NH Colburn S Post H Allgayer 2008 MicroRNA-21 (miR-21) post-transcriptionally downregulates Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer Oncogene 27 2128 2136 17968323 10.1038/sj.onc.1210856 1:CAS:528: DC%2BD1cXktFCnsrc%3D (Pubitemid 351485639)
3. DP Bartel 2004 MicroRNAs: genomics, biogenesis, mechanism and function Cell 116 281 297 14744438 10.1016/S0092-8674(04)00045-5 1:CAS:528: DC%2BD2cXhtVals7o%3D (Pubitemid 38167318)
4. M Bloomston WL Frankel F Petrocca S Volinia H Alder JP Hagan CG Liu D Bhatt, et al. 2007 MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis JAMA 297 1901 8 17473300 10.1001/jama.297.17.1901 1:CAS:528:DC%2BD2sXkvFKru7g%3D (Pubitemid 46707844)
5. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, et al. 2002 Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 99 15524-15529 (Pubitemid 35403967)
6. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, et al. 2004 Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl. Acad. Sci. USA 101 2999-3004 (Pubitemid 38327724)
7. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, et al. 2007 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol. Cell 26 745-752 (Pubitemid 46856245)
8. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Ageilan RI, et al. 2005 MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. USA 102 13944-13949 (Pubitemid 41377683)
9. Esquela-Kerscher A and Slack FJ 2006 Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 6 259-269
10. RI Gregory TP Chendrimada N Cooch R Shiekhattar 2005 Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 123 631 640 16271387 10.1016/j.cell.2005.10.022 1:CAS:528:DC%2BD2MXht1yktrjN (Pubitemid 41608466)
11. Greither T, Grochola LF, Udelnow A, Lautenschläger C, Würl P and Taubert H 2010 Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int. J. Cancer 126 73-80
12. Habbe N, Koorstra JB, Mendell JT, Offerhaus GJ, Ryu JK, Feldmann G, Mullendore ME, Goggins MG, et al. 2009 MicroRNA miR-155 is a biomarker of early pancreatic neoplasia. Cancer Biol. Ther. 8 340-346
13. MJ Hayat N Howlader ME Reichman BK Edwards 2007 Cancer statistics, trends and multiple primary cancer analyses from the surveillance, epidemiology and end results. (SEER) program Oncologist 12 20 37 17227898 10.1634/theoncologist. 12-1-20 (Pubitemid 46143500)
14. He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, et al. 2005 The role of microRNA genes in papillary thyroid carcinoma. Proc. Natl. Acad. Sci. USA 10219075-19080 (Pubitemid 43049568)
15. L He GJ Hannon 2004 MicroRNAs: small RNAs with a big role in gene regulation Natl. Rev. Genet. 5 522 531 10.1038/nrg1379 1:CAS:528: DC%2BD2cXltVSmsbw%3D (Pubitemid 38868508)
16. Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S and Wu H 2010 PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res. 70 7114-7124
17. Iorio MV, Piovan C and Croce CM 2010 Interplay between microRNAs and the epigenetic machinery: an intricate network. Biochim. Biophys. Acta 1799 694-701
18. Ji Q, Hao X, Zhang M, Tang W, Yang M, Li L, Xiang D, Desano JT, et al. 2009 MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4 e6816
19. Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF and Wang ED 2010 MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 70 3119-3127
20. A Krek D Grün MN Poy R Wolf L Rosenberg EJ Epstein P MacMenamin I da Piedade, et al. 2005 Combinatorial microRNA target predictions Nat. Genet. 37 495 500 15806104 10.1038/ng1536 1:CAS:528:DC%2BD2MXjsF2ksrw%3D (Pubitemid 40617277)
21. Lee EJ, Gusev Y, Jiang J, Nuovo GJ, Lerner MR, Frankel WL, Morgan DL, Postier RG, et al. 2007 Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer 120 1046-1054 (Pubitemid 46214304)
22. RC Lee RL Feinbaum V Ambros 1993 The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementary to lin-14 Cell 75 843 854 8252621 10.1016/0092-8674(93)90529-Y 1:CAS:528:DyaK2cXpslGqtA%3D%3D (Pubitemid 24014542)
23. Li M, Marin-Muller C, Bharadwaj U, Chow KH, Yao Q and Chen C 2009 MicroRNAs: control and loss of control in human physiology and disease. World J. Surg. 33 667-684
24. J Lu G Getz EA Miska E Alvarez-Saavedra J Lamb D Peck A Sweet-Cordero BL Ebert, et al. 2005 MicroRNA expression profiles classify human cancers Nature (London) 435 834 838 10.1038/nature03702 1:CAS:528:DC%2BD2MXkvVGgsLc%3D (Pubitemid 40839735)
25. McManus MT 2003 MicroRNAs and cancer. Semin. Cancer Biol. 13 253-258 (Pubitemid 38160916)
26. Mees ST, Mardin WA, Wendel C, Baeumer N, Willscher E, Senninger N, Schleicher C, Colombo-Benkmann M, et al. 2010 EP300-a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas. Int. J. Cancer 126 114-124
27. F Meng R Henson H Wehbe-Janek K Ghoshal ST Jacob T Patel 2007 MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 647 658 17681183 10.1053/j.gastro.2007.05.022 1:CAS:528:DC%2BD2sXhtVWqsr3L (Pubitemid 47187346)
28. Moriyama T, Ohuchida K, Mizumoto K, Yu J, Sato N, Nabae T, Takahata S, Toma H, et al. 2009 MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Mol Cancer Ther. 8 1067-1074
29. Y Murakami T Yasuda K Saigo T Urashima H Toyoda T Okanoue K Shimotohno 2006 Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues Oncogene 25 2537 2545 16331254 10.1038/sj.onc.1209283 1:CAS:528:DC%2BD28Xjs1agu7c%3D
30. Nelson KM and Weiss GJ 2008 MicroRNAs and cancer: past, present and potential future. Mol. Cancer Ther. 7 3655-3660
31. JK Park EJ Lee C Esau TD Schmittgen 2009 Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma Pancreas 38 e190 e199 19730150 10.1097/MPA.0b013e3181ba82e1 1:CAS:528:DC%2BD1MXhtFOjtLjM
32. Rachagani S, Kumar S and Batra SK 2010 MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications. Cancer Lett. 292 8-16
33. Rodriguez A, Griffiths-Jones S, Ashurst JL and Bradley A 2004 Identification of mammalian microRNA host genes and transcription units. Genome Res. 14 1902-1910 (Pubitemid 39386503)
34. C Roldo E Missiaglia JP Hagan M Falconi P Capelli S Bersani GA Calin S Volinia, et al. 2006 MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior J. Clin. Oncol. 24 4677 4684 16966691 10.1200/JCO.2005.05.5194 1:CAS:528:DC%2BD28XhtFynsr3M (Pubitemid 46630931)
35. AE Szafranska TS Davison J John T Cannon B Sipos A Maghnouj E Labourier SA Hahn 2007 MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma Oncogene 26 4442 4452 17237814 10.1038/sj.onc.1210228 1:CAS:528:DC%2BD2sXntVCju7w%3D (Pubitemid 47014466)
36. Szafranska AE, Doleshal M, Edmunds HS, Gordon S, Luttges J, Munding JB, Barth RJ Jr, Gutmann EJ, et al. 2008 Analysis of microRNAs in pancreatic fine-needle aspirates can classify benign and malignant tissues. Clin Chem. 54 1716-1724
37. Thomson JM, Newman M. Parker JS, Morin-Kensicki EM, Wright T and Hammond SM 2006 Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20 2202-2207
38. E Tili JJ Michaille A Cimino S Costinean CD Dumitru B Adair M Fabbri H Alder CG Liu, et al. 2007 Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock J. Immunol. 179 5082 5089 17911593 1:CAS:528:DC%2BD2sXhtFWitrvM
39. Torrisani J, Bournet B, du Rieu MC, Bouisson M, Souque A, Escourrou J, Buscail L and Cordelier P 2009 Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression. Hum. Gene Ther. 20 831-844
40. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM and Sen S 2009 MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev. Res. (Phila). 2 807-813
41. HH Wong NR Lemoine 2009 Pancreatic cancer: molecular pathogenesis and new therapeutic targets Nat. Rev. Gastroenterol. Hepatol. 6 412 422 19506583 10.1038/nrgastro.2009.89 1:CAS:528:DC%2BD1MXot12ltLo%3D
42. Y Zeng 2006 Principles of microRNA production and maturation Oncogene 25 6156 6162 17028594 10.1038/sj.onc.1209908 1:CAS:528:DC%2BD28XhtVGjsbnK (Pubitemid 44527845)
43. Zhang Y, Li M, Wang H, Fisher WE, Lin PH, Yao Q and Chen C 2009 Profiling of 95 MicroRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J. Surg. 33 698-709