Development of a pterin-based fluorescent probe for screening dihydropteroate synthase

Bioconjugate Chemistry

Volumn 22, Issue 10, 2011, Pages 2110-2117

  Zhao, Ying ^a   Hammoudeh, Dalia ^a   Lin, Wenwei ^a   Das, Sourav ^a   Yun, Mi Kyung ^a   Li, Zhenmei ^a   Griffith, Elizabeth ^a   Chen, Taosheng ^a   White, Stephen W ^a   Lee, Richard E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL AGENTS; ASSAYS; FLUORESCENCE; PROBES; SULFUR COMPOUNDS;

DESIGN APPROACHES; DIHYDROPTEROATE SYNTHASE; FLUORESCENCE POLARIZATION; FLUORESCENT PROBES; SIDE EFFECT; SITE-SPECIFIC; STRUCTURE BASED DRUG DESIGNS; SUBSITES; SULPHONAMIDES; SYNTHASE INHIBITOR;

AMINO ACIDS;

4 AMINOBENZOIC ACID; AMIDE; DIHYDROPTEROATE SYNTHASE; DIHYDROPTEROATE SYNTHASE INHIBITOR; DIMETHYL SULFOXIDE; ENZYME INHIBITOR; N [2 [2 [2 [(2 AMINO 5 NITROSO 6 OXO 1,6 DIHYDROPYRIMIDIN 4 YL)AMINO]ETHOXY]ETHOXY]ETHYL] 3,6 DIHYDROXY 3' OXO 3'H,10H SPIRO[ANTHRACENE 9,1' ISOBENZOFURAN] 5' CARBOXAMIDE; N [2 [2 [2 [2 (7 AMINO 1 METHYL 4,5 DIOXO 1,4,5,6 TETRAHYDROPYRIDAZINO[3,4 D]PYRIMIDIN 3 YL)PROPANAMIDO]ETHOXY]ETHOXY]ETHYL] 3',6' DIHYDROXY 3 OXO 3H SPIRO[ISOBENZOFURAN 1,9' XANTHENE] 5 CARBOXAMIDE; PTERIN DERIVATIVE; PTEROID ACID; SULFAMETHOXAZOLE; SULFANILAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS ANTHRACIS; BINDING SITE; DRUG DESIGN; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION; SYNTHESIS; VALIDATION STUDY;

EID: 80054824090     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200346e     Document Type: Article

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